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Search Results to Robert Reis
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One or more keywords matched the following properties of
Reis, Robert
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overview
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My research group has been focused for the last 5 years on two areas: (1.) the role of PI 3-kinase in insulin-like signaling and extreme longevity, extending to a 10-fold increase in lifespan for C. elegans nematodes carrying a null mutation; and (2.) protein aggregation as a unifying feature of many or all age-progressive diseases. We have pursued specific aggregate proteins that favor the formation of aggregates (by promoting protein coallescence) or disrupt their clearance (through interference with proteasomes and autophagosomes). We use proteomics to identify proteins in aggregates of Alzheimer's and other human neurodegenerative diseases; their known or predicted structures allow molecular-dynamic simulations of protein-protein and protein-drug interactions. Predictions from in silico studies are then tested in vivo using models of Alzheimer’s and other human neurodegenerative diseases, in the nematode C. elegans, in cultured human cells, and in mouse models of neuropathy. Molecular genetics and bioinformatics provide complementary tools to discover and understand functional interactions.
Water under the bridge (previous research):
From the start of my research career, I have been fascinated by the genetic regulation of longevity and age-associated diseases. My group characterized a number of mutations that have large effects on lifespan in the nematode C. elegans. We also used gene mapping combined with bioinformatics approaches to discover and characterize the natural variation in genes that modulate lifespan. We found that Rec-8 protein (a cohesin) alters lifespan in nematodes and yeast, and a colleague then showed that it also contributed to the exceptional longevity of bowhead whales. In mammalian genetics, we were the first to identify the Pirin gene on the X chromosome as a determinant of post-menopausal bone loss in women, a discovery subsequently confirmed in a Chinese population. We also pioneered studies of homologous recombination (HR) and its roles in the etiology and subsequent progression of myeloma, prostate and breast cancers. Data from our laboratory, and subsequently many others, support the hypothesis that HR generates genetic diversity from which more highly oncogenic clones emerge by cell selection. We have exploited the heavy dependence of cancer cells on HR to develop synergistic combinations of chemotherapeutic drugs.
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One or more keywords matched the following items that are connected to
Reis, Robert
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Academic Article
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A novel locus on the X chromosome regulates post-maturity bone density changes in mice.
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Extrachromosomal circular DNA and aging cells.
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Interspecies synteny mapping identifies a quantitative trait locus for bone mineral density on human chromosome Xp22.
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Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strains.
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Concept
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Chromosome Mapping
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Chromosomes, Human
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X Chromosome
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Chromosomes, Artificial, Yeast
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Concept
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Chromosomes, Human, X
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Longevity-determining genes in Caenorhabditis elegans: chromosomal mapping of multiple noninteractive loci.
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Genetic loci modulating fitness and life span in Caenorhabditis elegans: categorical trait interval mapping in CL2a x Bergerac-BO recombinant-inbred worms.
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Defining genes that govern longevity in Caenorhabditis elegans.
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Anchor polymerase chain reaction display: a high-throughput method to resolve, score, and isolate dimorphic genetic markers based on interspersed repetitive DNA elements.
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Carcinogens stimulate intrachromosomal homologous recombination at an endogenous locus in human diploid fibroblasts.
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Diverse Caenorhabditis elegans genes that are upregulated in dauer larvae also show elevated transcript levels in long-lived, aged, or starved adults.
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Quantitative trait loci define genes and pathways underlying genetic variation in longevity.
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Academic Article
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Genetic mapping of quantitative trait loci governing longevity of Caenorhabditis elegans in recombinant-inbred progeny of a Bergerac-BO x RC301 interstrain cross.
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Academic Article
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Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans, and replicative lifespan in S. cerevisiae.
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Animal models for discovery and assessment of genetic determinants of osteoporosis.
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Quantitative trait loci controlling halothane sensitivity in Caenorhabditis elegans.
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From QTL mapping to genes: the long and winding road.
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