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Oliveto, Alison
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research overview
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A behavioral pharmacologist by training, I have been a funded NIH researcher for over four decades, conducting translational research focused mainly on opioid and/or stimulant use disorders. Much of my work has focused on developing human laboratory and clinical trial study designs that serve as models for studying efficacious treatments. For instance, I participated in the development and testing of a methodological advance in human drug discrimination procedures (novel-response option) and applied this methodological advance to a human laboratory model of opioid withdrawal, through which two nonopioid compounds were identified as potential opioid withdrawal treatments. Moreover, my Yale colleague, Dr. Patrick O’Connor, and I piloted the first trial of office-based buprenorphine treatment for opioid use disorder. In addition, I developed in collaboration with Dr. Thomas Kosten a relapse paradigm for stimulant use disorder trials and identified the SSRI sertraline as a potentially efficacious relapse prevention treatment. I also mentored Dr. Michael Mancino (UAMS) on the development of a rigorous amphetamine withdrawal paradigm for his COBRE project (PI: Garcia-Rill) and Dr. Michael Wilson (UAMS) on developing a human laboratory model of “agitation”, which often occurs among methamphetamine users presenting to the ED. I am currently leading the Arkansas Statewide Epidemiology Outcomes Workgroup, monitoring substance use trends and related outcomes to help guide successful substance use prevention efforts in the state. Along these lines, I have been working with Dr. Ronald Thompson (UAMS) on developing and testing the efficacy of an adolescent game-based nonmusical prescription drug use prevention intervention along with a caregiver educational component. Meanwhile, I have returned to my behavioral pharmacology roots, piloting the effects of cannabis in older adults.
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Oliveto, Alison