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Manolagas, Stavros

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Item Type	Name
Academic Article	Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids.
Academic Article	The skeletal effects of glucocorticoid excess override those of orchidectomy in mice.
Academic Article	In vivo visualization of aging-associated gene transcription: evidence for free radical theory of aging.
Academic Article	Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs.
Academic Article	Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.
Academic Article	Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism.
Academic Article	Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength.
Academic Article	Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis.
Academic Article	Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation.
Academic Article	IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice.
Academic Article	Response to Windahl et al.
Academic Article	Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism.
Academic Article	Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation.
Academic Article	Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor.
Academic Article	Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases.
Academic Article	Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription.
Academic Article	De-fense! De-fense! De-fense: scavenging H2O2 while making cholesterol.
Academic Article	Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer.
Academic Article	Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice.
Academic Article	Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo.
Academic Article	Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens.
Academic Article	Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha.
Academic Article	FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice.
Academic Article	Glucocorticoids and tumor necrosis factor a increase oxidative stress and suppress Wnt protein signaling in osteoblasts.
Academic Article	A novel locus on the X chromosome regulates post-maturity bone density changes in mice.
Academic Article	Interspecies synteny mapping identifies a quantitative trait locus for bone mineral density on human chromosome Xp22.
Academic Article	The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice.
Academic Article	A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction.
Academic Article	Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation.
Academic Article	Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice.
Academic Article	Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton.
Academic Article	Commitment to the osteoblast lineage is not required for RANKL gene expression.
Academic Article	Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass.
Academic Article	Receptor activator of nuclear factor ?B ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss.
Academic Article	Control of bone mass and remodeling by PTH receptor signaling in osteocytes.
Academic Article	LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1.
Academic Article	Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass.
Academic Article	Transduction of cell survival signals by connexin-43 hemichannels.
Academic Article	Suppression of autophagy in osteocytes mimics skeletal aging.
Academic Article	Matrix-embedded cells control osteoclast formation.
Academic Article	FOXOs attenuate bone formation by suppressing Wnt signaling.
Academic Article	Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice.
Academic Article	Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids.
Academic Article	Estrogen receptor-a signaling in osteoblast progenitors stimulates cortical bone accrual.
Academic Article	The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone.
Academic Article	Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts.
Academic Article	Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss.
Academic Article	Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens.
Academic Article	Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates cortical porosity with age.
Academic Article	Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation.
Academic Article	Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms.
Concept	Mice, Inbred C57BL
Concept	Mice, Inbred BALB C
Concept	Mice, Transgenic
Concept	Mice, Knockout
Concept	Mice, Mutant Strains
Concept	Mice
Concept	Mice, 129 Strain
Academic Article	An Estrogen Dendrimer Conjugate Incapable of Stimulating the Nuclear-initiated Actions of Estrogen Receptors Prevents the Loss of Cortical Bone Mass in Estrogen Deficient Mice
Academic Article	Gain or Loss of FoxO Function in Osteoclasts alter Bone Mass in Mice
Academic Article	FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation.
Academic Article	Sirtuin1 (Sirt1) promotes cortical bone formation by preventing ?-catenin sequestration by FoxO transcription factors in osteoblast progenitors.
Academic Article	Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency.
Academic Article	Suppression of autophagy in osteocytes does not modify the adverse effects of glucocorticoids on cortical bone.
Academic Article	The Effects of Androgens on Murine Cortical Bone Do Not Require AR or ERa Signaling in Osteoblasts and Osteoclasts.
Academic Article	Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs.
Academic Article	Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone.
Academic Article	Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice.
Academic Article	PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.
Academic Article	The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct.
Academic Article	Deletion of FoxO1, 3, and 4 in Osteoblast Progenitors Attenuates the Loss of Cancellous Bone Mass in a Mouse Model of Type 1 Diabetes.
Academic Article	DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age.
Academic Article	Old age causes de novo intracortical bone remodeling and porosity in mice.
Academic Article	The Pathophysiological Sequence of Glucocorticoid-Induced Osteonecrosis of the Femoral Head in Male Mice.
Academic Article	The Quest for Osteoporosis Mechanisms and Rational Therapies: How Far We've Come, How Much Further We Need to Go.
Academic Article	Oxidation-specific epitopes restrain bone formation.
Grant	1,25 DIHYDROXY VITAMIN D3 AND CELLULAR IMMUNITY
Grant	HORMONAL CONTROL OF CYTOKINES IN BONE AND STROMAL CELLS
Grant	Molecular and Cellular Mechanisms of Osteoporosis
Grant	ESTROGENS AND OSTEOCLASTOGENESIS
Grant	Androgens, estrogens, and bone loss in males
Academic Article	Elimination of senescent osteoclast progenitors has no effect on the age-associated loss of bone mass in mice.
Academic Article	Cxcl12 Deletion in Mesenchymal Cells Increases Bone Turnover and Attenuates the Loss of Cortical Bone Caused by Estrogen Deficiency in Mice.
Academic Article	Osteocalcin promotes bone mineralization but is not a hormone.
Academic Article	Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors.
Academic Article	A Neutralizing Antibody Targeting Oxidized Phospholipids Promotes Bone Anabolism in Chow-Fed Young Adult Mice.
Academic Article	Increased marrow adipogenesis does not contribute to age-dependent appendicular bone loss in female mice.
Academic Article	Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency.
Academic Article	Neutralization of oxidized phospholipids attenuates age-associated bone loss in mice.
Academic Article	Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass.
Academic Article	Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency.
Academic Article	RETRACTED: Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass
Academic Article	RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1?- and RNA-dependent co-activator of osteoclast gene expression.

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