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Search Results to Stavros Manolagas

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One or more keywords matched the following items that are connected to Manolagas, Stavros

Item TypeName
Academic Article Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids.
Academic Article The skeletal effects of glucocorticoid excess override those of orchidectomy in mice.
Academic Article Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs.
Academic Article Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.
Academic Article Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism.
Academic Article Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength.
Academic Article Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation.
Academic Article Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism.
Academic Article Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation.
Academic Article Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor.
Academic Article Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases.
Academic Article What old means to bone.
Academic Article Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts.
Academic Article Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription.
Academic Article Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer.
Academic Article Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice.
Academic Article Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo.
Academic Article Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens.
Academic Article Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha.
Academic Article FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice.
Academic Article Glucocorticoids and tumor necrosis factor a increase oxidative stress and suppress Wnt protein signaling in osteoblasts.
Academic Article For whom the bell tolls: distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases.
Academic Article A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction.
Academic Article Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation.
Academic Article Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice.
Academic Article Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton.
Academic Article Commitment to the osteoblast lineage is not required for RANKL gene expression.
Academic Article LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1.
Academic Article Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass.
Academic Article Transduction of cell survival signals by connexin-43 hemichannels.
Academic Article Suppression of autophagy in osteocytes mimics skeletal aging.
Academic Article Matrix-embedded cells control osteoclast formation.
Academic Article FOXOs attenuate bone formation by suppressing Wnt signaling.
Academic Article Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice.
Academic Article Estrogen receptor-a signaling in osteoblast progenitors stimulates cortical bone accrual.
Academic Article The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone.
Academic Article Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts.
Academic Article Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens.
Academic Article Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids.
Academic Article Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation.
Academic Article Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein.
Academic Article Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms.
Concept Cell Count
Concept Cell Membrane
Concept Cell Division
Concept Cells, Cultured
Concept Cell Differentiation
Concept Bone Marrow Cells
Concept Cell Nucleus
Concept HeLa Cells
Concept Cell Line
Concept Cell Survival
Concept G1 Phase Cell Cycle Checkpoints
Concept Cell Proliferation
Concept Stromal Cells
Concept Cell Lineage
Concept Cell Death
Concept Monocyte-Macrophage Precursor Cells
Concept Stem Cells
Concept Cell Cycle Proteins
Concept Myeloid Cells
Concept Multipotent Stem Cells
Concept Active Transport, Cell Nucleus
Concept Primary Cell Culture
Academic Article In: Principles of Bone Biology. John Bilezikian, Lawrence Raisz, T. John Martin, eds
Academic Article Deletion of FoxO1, 3, and 4 from Osteoprogenitor Cells Increases Bone Mass throughout Life and Attenuates Adiposity in Aged Bone
Academic Article Manipulating Programmed Cell Death for Better Living!
Academic Article Targeted Expression of Catalase to Mitochondria in Cells of the Macrophage/Osteoclast Lineage Inhibits Osteoclastogenesis and Increases Bone Mass
Academic Article Cytokine production and surface antigen expression by peripheral blood mononuclear cells in postmenopausal osteoporosis (reply letter to the editor)
Academic Article FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation.
Academic Article Sirtuin1 (Sirt1) promotes cortical bone formation by preventing ß-catenin sequestration by FoxO transcription factors in osteoblast progenitors.
Academic Article The Effects of Androgens on Murine Cortical Bone Do Not Require AR or ERa Signaling in Osteoblasts and Osteoclasts.
Academic Article Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs.
Academic Article Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone.
Academic Article Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice.
Academic Article PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.
Academic Article The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct.
Academic Article Deletion of FoxO1, 3, and 4 in Osteoblast Progenitors Attenuates the Loss of Cancellous Bone Mass in a Mouse Model of Type 1 Diabetes.
Academic Article DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age.
Academic Article Manipulating Programmed Cell Death for Better Living!
Academic Article Oxidation-specific epitopes restrain bone formation.
Grant OSTEOBLAST COMMITMENT AND DIFFERENTIATION BY ANGELS
Grant 1,25 DIHYDROXY VITAMIN D3 AND CELLULAR IMMUNITY
Grant HORMONAL CONTROL OF CYTOKINES IN BONE AND STROMAL CELLS
Grant Center for Musculoskeletal Disease Research (CMDR)
Grant Molecular and Cellular Mechanisms of Osteoporosis
Grant ESTROGENS AND OSTEOCLASTOGENESIS
Grant Androgens, estrogens, and bone loss in males
Academic Article Elimination of senescent osteoclast progenitors has no effect on the age-associated loss of bone mass in mice.
Academic Article Cxcl12 Deletion in Mesenchymal Cells Increases Bone Turnover and Attenuates the Loss of Cortical Bone Caused by Estrogen Deficiency in Mice.
Academic Article Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors.
Academic Article Increased marrow adipogenesis does not contribute to age-dependent appendicular bone loss in female mice.
Academic Article Neutralization of oxidized phospholipids attenuates age-associated bone loss in mice.

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