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Search Results to Stavros Manolagas

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One or more keywords matched the following items that are connected to Manolagas, Stavros

Item TypeName
Academic Article The skeletal effects of glucocorticoid excess override those of orchidectomy in mice.
Academic Article Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs.
Academic Article Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.
Academic Article Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism.
Academic Article Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength.
Academic Article Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis.
Academic Article Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation.
Academic Article Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases.
Academic Article Quantifying osteoblast and osteocyte apoptosis: challenges and rewards.
Academic Article De-fense! De-fense! De-fense: scavenging H2O2 while making cholesterol.
Academic Article Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice.
Academic Article Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo.
Academic Article Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens.
Academic Article Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha.
Academic Article FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice.
Academic Article Glucocorticoids and tumor necrosis factor a increase oxidative stress and suppress Wnt protein signaling in osteoblasts.
Academic Article For whom the bell tolls: distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases.
Academic Article A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction.
Academic Article Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice.
Academic Article Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton.
Academic Article Giant osteoclast formation and long-term oral bisphosphonate therapy.
Academic Article Sex steroids and bone.
Academic Article The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone.
Academic Article Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts.
Academic Article Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss.
Academic Article Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens.
Academic Article Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates cortical porosity with age.
Concept TNF-Related Apoptosis-Inducing Ligand
Concept Apoptosis
Academic Article The role of apoptosis in the pathogenesis and treatment of osteoporosis
Academic Article Apoptosis in glucorticoid-induced bone disease
Academic Article In: Principles of Bone Biology. John Bilezikian, Lawrence Raisz, T. John Martin, eds
Academic Article The Pathophysiological Sequence of Glucocorticoid-Induced Osteonecrosis of the Femoral Head in Male Mice.
Grant OSTEOBLAST COMMITMENT AND DIFFERENTIATION BY ANGELS
Grant Molecular and Cellular Mechanisms of Osteoporosis
Academic Article Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors.

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