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Search Results to Alan Tackett

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overview My laboratory focuses on histone epigenetic mechanisms that regulate gene transcription and that are coupled to melanoma progression. We utilize a suite of techniques in our studies including proteomics of human biopsies, immunohistochemistry, cell culture, tumorigenicity assays, ChIPseq, biochemical and proteomic approaches for analyses of protein complexes, and cutting-edge mass spectrometry for the analysis of histone post-translational modifications. We have a unique environment that provides for discovery-based studies like proteomics as well as hypothesis-driven studies like those we perform in cell culture and with skin biopsies. In addition to our melanoma work, we develop new technologies for epigenetic studies such as tools for detection of in vivo protein interactions and quantitative assays for histone modifying proteins.

One or more keywords matched the following items that are connected to Tackett, Alan

Item TypeName
Academic Article Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
Academic Article Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro.
Academic Article I-DIRT, a general method for distinguishing between specific and nonspecific protein interactions.
Academic Article CYP2E1 active site residues in substrate recognition sequence 5 identified by photoaffinity labeling and homology modeling.
Academic Article NS3 helicase from the hepatitis C virus can function as a monomer or oligomer depending on enzyme and substrate concentrations.
Academic Article Hepatitis C virus NS3 helicase forms oligomeric structures that exhibit optimal DNA unwinding activity in vitro.
Academic Article Identification of the major phosphorylation site in Bcl-xL induced by microtubule inhibitors and analysis of its functional significance.
Academic Article Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen.
Academic Article Misregulation of Rad50 expression in melanoma cells.
Academic Article A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.
Academic Article Myogenin recruits the histone chaperone facilitates chromatin transcription (FACT) to promote nucleosome disassembly at muscle-specific genes.
Academic Article Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini.
Academic Article Physical and functional interaction between yeast Pif1 helicase and Rim1 single-stranded DNA binding protein.
Academic Article A noncanonical bromodomain in the AAA ATPase protein Yta7 directs chromosomal positioning and barrier chromatin activity.
Academic Article Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates.
Academic Article Mapping the local protein interactome of the NuA3 histone acetyltransferase.
Academic Article ChAP-MS: a method for identification of proteins and histone posttranslational modifications at a single genomic locus.
Academic Article Analysis of stable and transient protein-protein interactions.
Academic Article Ringo/cyclin-dependent kinase and mitogen-activated protein kinase signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes.
Academic Article Identification of PTHrP(12-48) as a plasma biomarker associated with breast cancer bone metastasis.
Academic Article GINS motion reveals replication fork progression is remarkably uniform throughout the yeast genome.
Academic Article Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs.
Academic Article Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit.
Academic Article Development and evaluation of a structural model for SF1B helicase Dda.
Academic Article Purification of a specific native genomic locus for proteomic analysis.
Academic Article Hepatitis C virus NS3 and simian virus 40 T antigen helicases displace streptavidin from 5'-biotinylated oligonucleotides but not from 3'-biotinylated oligonucleotides: evidence for directional bias in translocation on single-stranded DNA.
Concept Protein Denaturation
Concept Protein Kinases
Concept HMGB2 Protein
Concept Staphylococcal Protein A
Concept Protein Processing, Post-Translational
Concept Sequence Analysis, Protein
Concept Protein Interaction Mapping
Concept MyoD Protein
Concept Parathyroid Hormone-Related Protein
Concept Protein Structure, Quaternary
Concept Myeloid-Lymphoid Leukemia Protein
Concept Protein Binding
Concept Tumor Suppressor Protein p53
Concept Protein Interaction Maps
Concept Poly(A)-Binding Protein I
Concept Ubiquitin-Protein Ligases
Concept bcl-X Protein
Concept Protein Stability
Concept Glial Fibrillary Acidic Protein
Concept Retinoblastoma-Binding Protein 2
Concept Protein Biosynthesis
Concept Protein Phosphatase 2
Concept Mitogen-Activated Protein Kinase Kinases
Concept Protein Kinase Inhibitors
Concept E1A-Associated p300 Protein
Concept bcl-2-Associated X Protein
Concept Protein Structure, Tertiary
Concept Protein Interaction Domains and Motifs
Concept Zonula Occludens-1 Protein
Concept DNA-Activated Protein Kinase
Academic Article Mitotic phosphorylation of histone H3 threonine 80.
Academic Article IDIRT, A General Method for Distinguished Between Specific and Non Specific Protein Interactions
Academic Article TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells.
Academic Article A CRISPR-based approach for proteomic analysis of a single genomic locus.
Academic Article A PWWP domain-containing protein targets the NuA3 acetyltransferase complex via histone H3 lysine 36 trimethylation to coordinate transcriptional elongation at coding regions.
Academic Article Purification of specific chromatin loci for proteomic analysis.
Academic Article Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis.
Academic Article The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3.
Academic Article Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma.
Academic Article Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA.
Academic Article Proteomic Identification of DNA-PK Involvement within the RET Signaling Pathway.
Academic Article Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication.
Academic Article Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma.
Academic Article Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles.
Academic Article Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation.
Academic Article Role of EZH2 histone methyltrasferase in melanoma progression and metastasis.
Academic Article Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls.
Academic Article Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans.
Academic Article KDM5 lysine demethylases are involved in maintenance of 3'UTR length.
Academic Article DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes.
Academic Article Proteomic identification of histone post-translational modifications and proteins enriched at a DNA double-strand break.
Academic Article An N6-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cells.
Grant Sirt3: A Key Player Against PCB-Induced Mitochondrial Injury
Grant Melanocortin-4 Receptor Traffic and Signaling
Grant Using ChAP-MS to Study Macromolecular Chromatin Composition during Transcription
Grant Early Events in Alzheimer Pathogenesis
Grant Analysis of Proteins Involed in Genome Duplication
Grant Control of pituitary cell plasticity through regulated mRNA translation
Grant Development of technology for high resolution epigenetic profiling of chromatin
Grant Role of the Leprecan Genes in Skeletal Formation
Grant Biochemistry of recombination in meiosis
Grant Identifying the Epigenetic Regulation of Arsenic Exposure
Grant Lipid Stress and MC4R
Grant Transgenic analysis of platelet receptor expression
Grant NIH COBRE Center for Protein Structure and Function
Academic Article Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation.
Grant Identification of Druggable Targets to Complement Melanoma Therapy
Academic Article Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations.
Academic Article Histone Modifications as Biomarkers for Immunotherapy.
Academic Article Exploiting Correlations between Protein Abundance and the Functional Status of saeRS and sarA To Identify Virulence Factors of Potential Importance in the Pathogenesis of Staphylococcus aureus Osteomyelitis.
Academic Article Utility of histone H3K27me3 and H4K20me as diagnostic indicators of melanoma.
Academic Article ProteoViz: a tool for the analysis and interactive visualization of phosphoproteomics data.
Academic Article Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion.
Academic Article Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity.
Academic Article ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism.
Academic Article Dysbiotic stress increases the sensitivity of the tumor vasculature to radiotherapy and c-Met inhibitors.
Academic Article A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing.
Academic Article Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy.
Academic Article Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic.

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