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Tackett, Alan

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My laboratory focuses on histone epigenetic mechanisms that regulate gene transcription and that are coupled to melanoma progression. We utilize a suite of techniques in our studies including proteomics of human biopsies, immunohistochemistry, cell culture, tumorigenicity assays, ChIPseq, biochemical and proteomic approaches for analyses of protein complexes, and cutting-edge mass spectrometry for the analysis of histone post-translational modifications. We have a unique environment that provides for discovery-based studies like proteomics as well as hypothesis-driven studies like those we perform in cell culture and with skin biopsies. In addition to our melanoma work, we develop new technologies for epigenetic studies such as tools for detection of in vivo protein interactions and quantitative assays for histone modifying proteins.

One or more keywords matched the following items that are connected to Tackett, Alan

Item Type	Name
Academic Article	Misregulation of Rad50 expression in melanoma cells.
Academic Article	A quantitative proteomic analysis of FFPE melanoma.
Concept	Melanoma
Concept	Melanoma, Experimental
Concept	gp100 Melanoma Antigen
Academic Article	Cutaneous Melanoma: Molecular Mechanisms and Current Therapeutic Approaches
Academic Article	Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma
Academic Article	Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma.
Academic Article	Role of EZH2 histone methyltrasferase in melanoma progression and metastasis.
Academic Article	Proteomic Findings in Melanoma.
Academic Article	Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma.
Academic Article	Immune surveillance in melanoma: From immune attack to melanoma escape and even counterattack.
Academic Article	Indicators of responsiveness to immune checkpoint inhibitors.
Academic Article	Proteomics and melanoma: a current perspective.
Academic Article	Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma.
Grant	Epigenetic regulation of metabolic stress pathways in melanoma infiltrating lymphocytes- Resubmission
Grant	Identification of Druggable Targets to Complement Melanoma Therapy
Academic Article	Effect of Sulforaphane and 5-Aza-2'-Deoxycytidine on Melanoma Cell Growth.
Academic Article	Current state of melanoma diagnosis and treatment.
Academic Article	Utility of histone H3K27me3 and H4K20me as diagnostic indicators of melanoma.
Academic Article	Proteogenomic analysis of melanoma brain metastases from distinct anatomical sites identifies pathways of metastatic progression.
Academic Article	Dysbiotic stress increases the sensitivity of the tumor vasculature to radiotherapy and c-Met inhibitors.
Academic Article	Characterization of methionine dependence in melanoma cells.
Academic Article	The mycelium of the Trametes versicolor synn. Coriolus versicolor (Turkey tail mushroom) exhibit anti-melanoma activity in vitro.
Academic Article	CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells.
Academic Article	Synthesis and Anti-Melanoma Activity of Acryloyl Pyridinone Analogues.
Academic Article	Characterization of methionine dependence in melanoma cells.
Academic Article	Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma.

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Melanoma