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Search Results to Alan Tackett

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One or more keywords matched the following properties of Tackett, Alan

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overview My laboratory focuses on histone epigenetic mechanisms that regulate gene transcription and that are coupled to melanoma progression. We utilize a suite of techniques in our studies including proteomics of human biopsies, immunohistochemistry, cell culture, tumorigenicity assays, ChIPseq, biochemical and proteomic approaches for analyses of protein complexes, and cutting-edge mass spectrometry for the analysis of histone post-translational modifications. We have a unique environment that provides for discovery-based studies like proteomics as well as hypothesis-driven studies like those we perform in cell culture and with skin biopsies. In addition to our melanoma work, we develop new technologies for epigenetic studies such as tools for detection of in vivo protein interactions and quantitative assays for histone modifying proteins.

One or more keywords matched the following items that are connected to Tackett, Alan

Item TypeName
Academic Article MassSQUIRM: An assay for quantitative measurement of lysine demethylase activity.
Concept Epigenomics
Academic Article A CRISPR-based approach for proteomic analysis of a single genomic locus.
Academic Article Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma.
Academic Article Role of EZH2 histone methyltrasferase in melanoma progression and metastasis.
Academic Article Chromatin-mediated regulators of meiotic recombination revealed by proteomics of a recombination hotspot.
Grant Using ChAP-MS to Study Macromolecular Chromatin Composition during Transcription
Grant Development of MassSQUIRM to Quantitatively Measure Lysine Methylation
Grant Development of technology for high resolution epigenetic profiling of chromatin
Grant Technology for Identification of Epiproteomes in Tissue Samples
Grant Identifying the Epigenetic Regulation of Arsenic Exposure
Academic Article Proteomic characterization of the arsenic response locus in S. cerevisiae.
Grant Epigenetic profiling and enzymatic regulation of H3K23me3 during cellular differentiation
Grant Epigenetic regulation of metabolic stress pathways in melanoma infiltrating lymphocytes- Resubmission
Academic Article Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion.
Academic Article Expression of integrin ?-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics.

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  • Epigenomics