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Tackett, Alan

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My laboratory focuses on histone epigenetic mechanisms that regulate gene transcription and that are coupled to melanoma progression. We utilize a suite of techniques in our studies including proteomics of human biopsies, immunohistochemistry, cell culture, tumorigenicity assays, ChIPseq, biochemical and proteomic approaches for analyses of protein complexes, and cutting-edge mass spectrometry for the analysis of histone post-translational modifications. We have a unique environment that provides for discovery-based studies like proteomics as well as hypothesis-driven studies like those we perform in cell culture and with skin biopsies. In addition to our melanoma work, we develop new technologies for epigenetic studies such as tools for detection of in vivo protein interactions and quantitative assays for histone modifying proteins.

One or more keywords matched the following items that are connected to Tackett, Alan

Item Type	Name
Academic Article	Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
Academic Article	The mobile nucleoporin Nup2p and chromatin-bound Prp20p function in endogenous NPC-mediated transcriptional control.
Academic Article	Proteomic and genomic characterization of chromatin complexes at a boundary.
Academic Article	Identification of the major phosphorylation site in Bcl-xL induced by microtubule inhibitors and analysis of its functional significance.
Academic Article	Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen.
Academic Article	Misregulation of Rad50 expression in melanoma cells.
Academic Article	A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.
Academic Article	Myogenin recruits the histone chaperone facilitates chromatin transcription (FACT) to promote nucleosome disassembly at muscle-specific genes.
Academic Article	A noncanonical bromodomain in the AAA ATPase protein Yta7 directs chromosomal positioning and barrier chromatin activity.
Academic Article	Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates.
Academic Article	ChAP-MS: a method for identification of proteins and histone posttranslational modifications at a single genomic locus.
Academic Article	Ringo/cyclin-dependent kinase and mitogen-activated protein kinase signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes.
Academic Article	Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs.
Academic Article	Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit.
Concept	Cell Cycle
Concept	Cell Movement
Concept	Cell Line, Transformed
Concept	Cell Transformation, Neoplastic
Concept	Cells, Cultured
Concept	Cell Differentiation
Concept	HeLa Cells
Concept	Hematopoietic Stem Cells
Concept	Cell Line
Concept	Cell Survival
Concept	Jurkat Cells
Concept	Programmed Cell Death 1 Receptor
Concept	Cell Proliferation
Concept	Cell Death
Concept	MCF-7 Cells
Concept	HEK293 Cells
Concept	Endothelial Cells
Concept	Cell Line, Tumor
Concept	Tumor Cells, Cultured
Concept	Neoplastic Stem Cells
Concept	Cell Cycle Proteins
Concept	Induced Pluripotent Stem Cells
Concept	Carcinoma, Merkel Cell
Concept	Cell Culture Techniques
Concept	COS Cells
Concept	Active Transport, Cell Nucleus
Concept	Cell Cycle Checkpoints
Academic Article	Mitotic phosphorylation of histone H3 threonine 80.
Academic Article	Genetic and Biochemical Evaluation of the Importance of Cdc6 in Regulating Mitotic ExitD?
Academic Article	Proteomic and genomic characterization of chromatin complexes at boundary
Academic Article	Yng 1 PHD finger binding to histone H3 trimethylated at lysine 4 promotes NuA3 HAT activity at lysine 14 of H3 and transcriptional at a subset of targeted ORFs
Academic Article	TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells.
Academic Article	A PWWP domain-containing protein targets the NuA3 acetyltransferase complex via histone H3 lysine 36 trimethylation to coordinate transcriptional elongation at coding regions.
Academic Article	A selective phenelzine analogue inhibitor of histone demethylase LSD1.
Academic Article	Purification of specific chromatin loci for proteomic analysis.
Academic Article	The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3.
Academic Article	Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma.
Academic Article	Proteomic Identification of DNA-PK Involvement within the RET Signaling Pathway.
Academic Article	Bioorthogonal labeling cell-surface proteins expressed in pancreatic cancer cells to identify potential diagnostic/therapeutic biomarkers.
Academic Article	Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication.
Academic Article	Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma.
Academic Article	Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles.
Academic Article	Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation.
Academic Article	DNA methylation on N(6)-adenine in mammalian embryonic stem cells.
Academic Article	ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.
Academic Article	Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls.
Academic Article	Densely ionizing radiation affects DNA methylation of selective LINE-1 elements.
Academic Article	A Proteomic Study of Human Merkel Cell Carcinoma.
Academic Article	KDM5 lysine demethylases are involved in maintenance of 3'UTR length.
Academic Article	CD109 Overexpression in Pancreatic Cancer Identified by Cell-Surface Glycoprotein Capture.
Academic Article	Immune surveillance in melanoma: From immune attack to melanoma escape and even counterattack.
Academic Article	DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes.
Academic Article	Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation.
Academic Article	Vulvar squamous cell carcinoma aggressiveness is associated with differential expression of collagen and STAT1.
Academic Article	Indicators of responsiveness to immune checkpoint inhibitors.
Academic Article	Oxidation resistance 1 is a novel senolytic target.
Academic Article	Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis.
Academic Article	An N6-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cells.
Academic Article	Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma.
Grant	Regulation of hepatic stellate cells by intracellular calcium
Grant	Melanocortin-4 Receptor Traffic and Signaling
Grant	Using ChAP-MS to Study Macromolecular Chromatin Composition during Transcription
Grant	Control of pituitary cell plasticity through regulated mRNA translation
Grant	Development of MassSQUIRM to Quantitatively Measure Lysine Methylation
Grant	Discovery and Target Identification of Senolytic Agents
Grant	Technology for Identification of Epiproteomes in Tissue Samples
Grant	Role of the Leprecan Genes in Skeletal Formation
Grant	Lipid Stress and MC4R
Grant	Epigenetic regulation of metabolic stress pathways in melanoma infiltrating lymphocytes- Resubmission
Academic Article	Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation.
Academic Article	Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations.
Academic Article	Effect of Sulforaphane and 5-Aza-2'-Deoxycytidine on Melanoma Cell Growth.
Academic Article	PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation.
Academic Article	Molecular events in MSC exosome mediated cytoprotection in cardiomyocytes.
Academic Article	Delivery of phosphatidylethanolamine blunts stress in hepatoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum.
Academic Article	ProteoViz: a tool for the analysis and interactive visualization of phosphoproteomics data.
Academic Article	Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion.
Academic Article	Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity.
Academic Article	MSC exosome-mediated cardioprotection in ischemic mouse heart comparative proteomics of infarct and peri-infarct areas.
Academic Article	ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism.
Academic Article	Dysbiotic stress increases the sensitivity of the tumor vasculature to radiotherapy and c-Met inhibitors.
Academic Article	A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing.
Academic Article	Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer.
Academic Article	Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells.
Academic Article	Phase separation drives aberrant chromatin looping and cancer development.
Academic Article	Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy.
Academic Article	A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells.
Academic Article	Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle.
Academic Article	Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy.
Academic Article	Characterization of methionine dependence in melanoma cells.
Academic Article	Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer.
Academic Article	CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells.
Academic Article	Oncogenic signaling-mediated regulation of chromatin during tumorigenesis.
Academic Article	Synthesis and Anti-Melanoma Activity of Acryloyl Pyridinone Analogues.
Academic Article	Characterization of methionine dependence in melanoma cells.
Academic Article	TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons.
Grant	Proteogenomic analysis of responders versus nonresponders in a Phase I clinical trial of Th17-inducing dendritic cell vaccination for advanced stage ovarian cancer

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