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Search Results to Rosalia Simmen

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One or more keywords matched the following properties of Simmen, Rosalia

overview I am Full Professor, Department of Physiology & Biophysics and Faculty Affiliate in the Winthrop P Rockefeller Cancer Institute Breast Cancer Program. I have been conducting basic and translational research in hormone-related aspects of women’s diseases for the last 30 years. I have a broad background in molecular, cellular and developmental biology, with specific training and expertise in steroid hormone receptors, signaling pathways, and tumor biology. As PI or Co-I on numerous university, Department of Defense, USDA and NIH-funded grants over the span of my independent academic career, I have collaborated with many groups of scientists to study the mechanistic underpinnings of steroid hormone receptors and associated co-regulators in the biology and pathobiology of the female reproductive tract. Our studies were the first to identify the Sp-related transcription factors Kruppel-like (KLF) family members KLF 9 and KLF13, as novel regulators of steroid receptor signaling in vivo and in vitro and to delineate their mechanisms of gene activation in concert with progesterone receptor and estrogen receptor, in endometrial and myometrial cells. These studies have provided strong support for the involvement of these and other KLFs in human uterine pathologies (endometriosis, endometrial cancer, and prolonged labor). In recent years, my research has established the infrastructure for elucidating the pathogenesis of endometriosis. In particular, we have developed an immunocompetent mouse model of endometriosis and have fortified our collaborations with clinicians within and outside of UAMS to provide medical translational relevance to our basic research on endometriosis. My research program in mammary biology aims to understand how early exposure to a favorable ‘nutritional’ milieu influences neonatal/perinatal mammary development to promote molecular events favoring increased tissue differentiation and increase resistance to genetic and epigenetic changes that drive breast cancer. My group is one of the first to demonstrate that specific dietary factors regulate mammary tumor risk by targeting oncogenes and tumor suppressor genes in mammary epithelial populations with tumor initiating potential. We have found that a major target of dietary factors is the tumor suppressor PTEN via cross-talk with insulin and p53 signaling. My team also showed that very early developmental events in utero can alter mammary gland biology in female progeny to increase predisposition to tumor risk. Our research aims to mechanistically evaluate the epigenome and the metabolome as regulatory nexus by which the maternal environment controls breast cancer risk in progeny.

One or more keywords matched the following items that are connected to Simmen, Rosalia

Item TypeName
Academic Article Krüppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis.
Concept Endometriosis
Academic Article Krüppel-like factor 9 deficiency in uterine endometrial cells promotes ectopic lesion establishment associated with activated notch and hedgehog signaling in a mouse model of endometriosis.
Academic Article Krüppel-like factor 9 and progesterone receptor co-regulation of decidualizing stromal cells: implications for the pathogenesis of endometriosis
Academic Article Aberrant Activation of Stem Cell-Associated Regulatory Pathways and Pro-Inflammatory Cytokine Expression with Absence of Endometrial Kruppel-like Factor 9 (KLF9) in a Mouse Model of Endometriosis
Academic Article Krüppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis.
Academic Article Reversal of fortune: estrogen receptor-ß in endometriosis.
Academic Article High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated With Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status.
Academic Article Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis.
Grant Uteroferrin gene expression during development
Grant Co-Morbid Conditions of Type 1 Diabetes and Endometriosis: A Pilot Study
Academic Article Seeing red: diet and endometriosis risk.
Academic Article Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus.
Academic Article Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice.

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  • Endometriosis