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Search Results to Rosalia Simmen

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overview I am Full Professor, Department of Physiology & Biophysics and Faculty Affiliate in the Winthrop P Rockefeller Cancer Institute Breast Cancer Program. I have been conducting basic and translational research in hormone-related aspects of women’s diseases for the last 30 years. I have a broad background in molecular, cellular and developmental biology, with specific training and expertise in steroid hormone receptors, signaling pathways, and tumor biology. As PI or Co-I on numerous university, Department of Defense, USDA and NIH-funded grants over the span of my independent academic career, I have collaborated with many groups of scientists to study the mechanistic underpinnings of steroid hormone receptors and associated co-regulators in the biology and pathobiology of the female reproductive tract. Our studies were the first to identify the Sp-related transcription factors Kruppel-like (KLF) family members KLF 9 and KLF13, as novel regulators of steroid receptor signaling in vivo and in vitro and to delineate their mechanisms of gene activation in concert with progesterone receptor and estrogen receptor, in endometrial and myometrial cells. These studies have provided strong support for the involvement of these and other KLFs in human uterine pathologies (endometriosis, endometrial cancer, and prolonged labor). In recent years, my research has established the infrastructure for elucidating the pathogenesis of endometriosis. In particular, we have developed an immunocompetent mouse model of endometriosis and have fortified our collaborations with clinicians within and outside of UAMS to provide medical translational relevance to our basic research on endometriosis. My research program in mammary biology aims to understand how early exposure to a favorable ‘nutritional’ milieu influences neonatal/perinatal mammary development to promote molecular events favoring increased tissue differentiation and increase resistance to genetic and epigenetic changes that drive breast cancer. My group is one of the first to demonstrate that specific dietary factors regulate mammary tumor risk by targeting oncogenes and tumor suppressor genes in mammary epithelial populations with tumor initiating potential. We have found that a major target of dietary factors is the tumor suppressor PTEN via cross-talk with insulin and p53 signaling. My team also showed that very early developmental events in utero can alter mammary gland biology in female progeny to increase predisposition to tumor risk. Our research aims to mechanistically evaluate the epigenome and the metabolome as regulatory nexus by which the maternal environment controls breast cancer risk in progeny.

One or more keywords matched the following items that are connected to Simmen, Rosalia

Item TypeName
Academic Article Inhibition of NMU-induced mammary tumorigenesis by dietary soy.
Academic Article Selective interactions of Kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells.
Academic Article Tp53-associated growth arrest and DNA damage repair gene expression is attenuated in mammary epithelial cells of rats fed whey proteins.
Academic Article Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors.
Academic Article Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cells.
Academic Article Dysregulation of intestinal crypt cell proliferation and villus cell migration in mice lacking Kruppel-like factor 9.
Academic Article The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN.
Academic Article Null mutation of Kruppel-like factor9/basic transcription element binding protein-1 alters peri-implantation uterine development in mice.
Academic Article Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase.
Academic Article Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Kr?ppel-like factor 9/basic transcription element binding protein-1.
Academic Article Early soy exposure via maternal diet regulates rat mammary epithelial differentiation by paracrine signaling from stromal adipocytes.
Academic Article Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates beta-catenin signaling in mammary epithelial cells.
Academic Article Kr?ppel-like factor 9 loss-of-expression in human endometrial carcinoma links altered expression of growth-regulatory genes with aberrant proliferative response to estrogen.
Academic Article The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein.
Academic Article Repression of mammary adipogenesis by genistein limits mammosphere formation of human MCF-7 cells.
Academic Article The reproductive phenotype of mice null for transcription factor Kr?ppel-like factor 13 suggests compensatory function of family member Kr?ppel-like factor 9 in the peri-implantation uterus.
Academic Article Dietary exposure to whey proteins alters rat mammary gland proliferation, apoptosis, and gene expression during postnatal development.
Academic Article Enhancer- and silencer-like sequences that mediate insulin-like growth factor-binding protein-2 gene expression in uterine cells of pregnancy.
Academic Article Tumor-protective and tumor-promoting actions of dietary whey proteins in an N-methyl-N-nitrosourea model of rat mammary carcinogenesis.
Academic Article In utero and lactational exposure to blueberry via maternal diet promotes mammary epithelial differentiation in prepubescent female rats.
Academic Article PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation.
Academic Article Secretory leukocyte protease inhibitor mediates proliferation of human endometrial epithelial cells by positive and negative regulation of growth-associated genes.
Academic Article Functional differentiation of uterine stromal cells involves cross-regulation between bone morphogenetic protein 2 and Kruppel-like factor (KLF) family members KLF9 and KLF13.
Academic Article Bidirectional signaling of mammary epithelium and stroma: implications for breast cancer--preventive actions of dietary factors.
Academic Article The Kr?ppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression.
Academic Article Dietary suppression of the mammary CD29(hi)CD24(+) epithelial subpopulation and its cytokine/chemokine transcriptional signatures modifies mammary tumor risk in MMTV-Wnt1 transgenic mice.
Academic Article Sulforaphane induces SLPI secretion in the nasal mucosa.
Academic Article Enhanced mammary progesterone receptor-A isoform activity in the promotion of mammary tumor progression by dietary soy in rats.
Academic Article Uterine androgen receptors: roles in estrogen-mediated gene expressionand DNA synthesis.
Academic Article Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like/progenitor cells.
Academic Article Kr?ppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis.
Academic Article Direct interaction of the Kr?ppel-like family (KLF) member, BTEB1, and PR mediates progesterone-responsive gene expression in endometrial epithelial cells.
Academic Article Uterine phenotype of young adult rats exposed to dietary soy or genistein during development.
Academic Article Paracrine-acting adiponectin promotes mammary epithelial differentiation and synergizes with genistein to enhance transcriptional response to estrogen receptor ? signaling.
Academic Article Molecular cloning of porcine estrogen receptor-beta complementary DNAs and developmental expression in periimplantation embryos.
Concept Cell Cycle
Concept Cell Movement
Concept Cell Division
Concept Cell Adhesion
Concept Cell Transformation, Neoplastic
Concept Cells, Cultured
Concept Cell Differentiation
Concept Epithelial Cells
Concept Cell Nucleus
Concept Paneth Cells
Concept Cell Line
Concept Cell Survival
Concept Proliferating Cell Nuclear Antigen
Concept HT29 Cells
Concept Cell Proliferation
Concept Stromal Cells
Concept Cell Lineage
Concept MCF-7 Cells
Concept Caco-2 Cells
Concept Goblet Cells
Concept Cell Line, Tumor
Concept 3T3-L1 Cells
Concept Stem Cells
Concept Tumor Cells, Cultured
Concept Neoplastic Stem Cells
Concept Cell Cycle Proteins
Concept COS Cells
Academic Article Kr?ppel-like factor 9 deficiency in uterine endometrial cells promotes ectopic lesion establishment associated with activated notch and hedgehog signaling in a mouse model of endometriosis.
Academic Article Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers.
Academic Article The tumor suppressor PTEN mediates the pro-apoptotic activity of dietary genistein on mammary epithelial cells: implications for mammary cancer protection
Academic Article Identification of uterine endometrial epithelial cell growth factors: stimulation by IGF-I/-II and inhibition by TGF-beta 1 of endometrial cells in vitro
Academic Article Structure, expression and evolution of calmodulin genes
Academic Article Porcine uterine luminal fluid contains epithelial cell growth stimulating factors
Academic Article Polyamine regulation of porcine endometrial cell proliferation during peri-implantation
Academic Article Calmodulin and calmodulin binding proteins in liver nuclear matrix
Academic Article Krüppel-like factor 9 and progesterone receptor co-regulation of decidualizing stromal cells: implications for the pathogenesis of endometriosis
Academic Article Nuclear receptor co-regulator Kruppel-like factor-9 and prohibitin 2 expression in oestrogen-induced epithelial cell proliferation in the mouse uterus
Academic Article Estrogen receptor (ER)-beta and estrogen (E)-regulated transcripts in porcine trophoblastic cells
Academic Article Insulin-like growth factor-II (IGF-II) and insulin-like growth factor binding protein-2 (IGFBP-2) stimulate uterine epithelial cell proliferation through distinct signaling pathways
Academic Article Chinese J Physiol
Academic Article Bone morphogenetic protein 2 (BMP2) and Kruppel-like factor 9 (KLF9) cross-regulation in uterine stromal cells promotes timing of uterine endometrial receptivity
Academic Article Recombinant porcine insulin-like growth factor-binding protein-2 (IGFBP-2) interacts with human insulin-like growth factor-2 (IGF-II) to modulate human and porcine uterine epithelial cell proliferation
Academic Article The Kruppel-like factor-9 (KLF9) network in HEC-1A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression
Academic Article Direct interaction of the Kruppel-like Family (KLF) member, BTEB1 and Progesterone receptor mediates progesterone-responsive gene expression in endometrial epithelial cells
Academic Article Maternal high diet promotion of mammary tumor risk in adult progeny is associated with early expansion of mammary cancer stem-like cells and increased maternal oxidative environment
Academic Article Regulation of adipocyte lipid homeostasis by genistein alters mammary epithelial cell differentiation: a paracrine mechanism for mammary tumor protection
Academic Article Uterine-associated low molecular weight protease inhibitors stimulate DNA synthesis in endometrial glandular epithelial cells
Academic Article Calcium and Cell Physiology
Academic Article mRNA dependent synthesis of a stable precursor of relaxin in ascites tumor cell-free lysates
Academic Article Porcine endometrial cell cultures as a model to study steroid hormone regulation of antileukoproteinase (ALP) gene expression
Academic Article Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggest diet-mediated targeting of cancer stem-cell like/progenitor cells
Academic Article Aberrant Activation of Stem Cell-Associated Regulatory Pathways and Pro-Inflammatory Cytokine Expression with Absence of Endometrial Kruppel-like Factor 9 (KLF9) in a Mouse Model of Endometriosis
Academic Article Analysis of upstream DNA sequences required for the antileukoproteinase gene expression in endomentrial cells
Academic Article Reversion to the nontransformed ph4enotype of tsSV40-transformed uterine endometrial epithelial cells is accompanied by decreased mitogenic responsiveness to IGFs and by enhanced secretion of at least five different IGF binding proteins
Academic Article Functional interaction between ligand-activated estrogen receptor (ER)-alpha and the transcription factor BTEB1 in uterine cells
Academic Article Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuate expression of fatty acid synthase
Academic Article Functional roles of uterine estrogen receptors (ER): activation of IGF-I and inhibition of IGFBP-2 gene transcription by ER-alpha, but not ER-beta, in human endometrial adenocarcinoma cells (Hec-1A)
Academic Article Overexpression of the Sp/KFL transcription factor BTEB1 alters cells cycle parameters in MCF-7 breast tumor cells
Academic Article Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Kruppel-like factor 9/basic transcription element binding protein-1
Academic Article Molecular markers of endometrial epithelial cell mitogenesis mediated by the Sp/Kruppel-like factor BTEB1
Academic Article Precursor Processing in the Biosynthesis of Proteins
Academic Article A heptamer sequence within the uteroferrin gene 5'-flanking region binds an 80 kda protein ubiquitously expressed in endometrial cells
Academic Article Direct interaction of the Kruppel-like family (KLF) member, BTEB1, and PR mediates progesterone-responsive gene expression in endometrial epithelial cells
Academic Article Maternal metabolic perturbations elicited by high-fat diet promote Wnt-1-induced mammary tumor risk in adult female offspring via long-term effects on mammary and systemic phenotypes.
Academic Article Prolonged pregnancy in women is associated with attenuated myometrial expression of progesterone receptor co-regulator Kr?ppel-like Factor 9.
Academic Article Enhanced gastrointestinal expression of cytosolic malic enzyme (ME1) induces intestinal and liver lipogenic gene expression and intestinal cell proliferation in mice.
Academic Article Kr?ppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis.
Academic Article Kr?ppel-like factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling.
Academic Article Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells.
Academic Article High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated With Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status.
Academic Article Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice.
Academic Article Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice.
Grant Uteroferrin gene expression during development
Academic Article Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells.
Academic Article Metformin regulation of progesterone receptor isoform-B expression in human endometrial cancer cells is glucose-dependent.

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