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Search Results to Vladimir Lupashin

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One or more keywords matched the following properties of Lupashin, Vladimir

overview Our laboratory is interested in understanding the molecular mechanisms responsible for the generation and maintenance of intra-cellular membrane-bounded compartments. In all eukaryotic cells intracellular membrane trafficking is critical for a range of important cellular functions including protein secretion, post-translational modifications, cell signalling, cell polarization, and cell maintenance. Defects in membrane trafficking can underline, or even exacerbate, a number of human diseases including cancer, diabetes mellitus, Alzheimer’s, cystic fibrosis, Hermansky-Pudlak syndrome and Congenital Disorders of Glycosylation. Our research directed towards the understanding of the basic mechanisms of intracellular vesicular trafficking using both yeast and mammalian tissue culture cell model systems. Our lab played a principal role in the discovery of a novel vesicle tethering factors, published more than 60 original papers in high-profile journals, including Journal of Cell Biology, PNAS, Science, Journal of Neuroscience, Molecular Biology of Cell and Nature Communications. My current research has been continuously supported by grants from both NSF and NIH. We have pioneered the functional analysis of the Conserved Oligomeric Golgi (COG), an evolutionarily conserved complex of eight gene products, each of which is critical for the membrane trafficking and protein modifications in the Golgi apparatus. The COG complex interacts with core fusion machinery components including SNAREs, SM proteins, Rabs, coiled-coil tethers and COPI coat to organize specific docking and fusion of transport intermediates with their acceptor membrane. By using state of the art biochemical, genetic and microscopy approaches (including mass-spectrometry, electron and super-resolution microscopy, CRISPR directed gene editing techniques) we would like to determine how the key components of intracellular membrane trafficking machinery work together to direct efficient protein trafficking in human cells in health and disease.

One or more keywords matched the following items that are connected to Lupashin, Vladimir

Item TypeName
Academic Article Cog3p depletion blocks vesicle-mediated Golgi retrograde trafficking in HeLa cells.
Academic Article Chlamydia trachomatis hijacks intra-Golgi COG complex-dependent vesicle trafficking pathway.
Academic Article [Cell wall permeability and export of proteins into the culture broth of Saccharomyces cerevisiae].
Academic Article Identification of a novel secreted glycoprotein of the yeast Saccharomyces cerevisiae stimulated by heat shock.
Academic Article The COG complex, Rab6 and COPI define a novel Golgi retrograde trafficking pathway that is exploited by SubAB toxin.
Academic Article Oxysterol-binding protein (OSBP) is required for the perinuclear localization of intra-Golgi v-SNAREs.
Academic Article Fluorescent microscopy as a tool to elucidate dysfunction and mislocalization of Golgi glycosyltransferases in COG complex depleted mammalian cells.
Academic Article Biochemical requirements for the targeting and fusion of ER-derived transport vesicles with purified yeast Golgi membranes.
Concept Microscopy, Fluorescence
Concept Microscopy, Electron
Concept Microscopy, Confocal
Academic Article Manganese-induced turnover of TMEM165.
Academic Article High-magnification super-resolution FINCH microscopy using birefringent crystal lens interferometers.
Grant Super-Res Holographic Microscopy to Advance Research on Golgi Apparatus Function
Grant Super-Resolution Light Microscope at University of Arkansas for Medical Sciences
Grant Characterization of mammalian COG complex-interacting Golgi trafficking machinery
Grant 120 kV FEI Electron Microscope and Supporting Sample Preparation Equipment for Biological Microscopy

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  • Microscopy