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Search Results to Vladimir Lupashin

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Lupashin, Vladimir

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Our laboratory is interested in understanding the molecular mechanisms responsible for the generation and maintenance of intra-cellular membrane-bounded compartments. In all eukaryotic cells intracellular membrane trafficking is critical for a range of important cellular functions including protein secretion, post-translational modifications, cell signalling, cell polarization, and cell maintenance. Defects in membrane trafficking can underline, or even exacerbate, a number of human diseases including cancer, diabetes mellitus, Alzheimer’s, cystic fibrosis, Hermansky-Pudlak syndrome and Congenital Disorders of Glycosylation. Our research directed towards the understanding of the basic mechanisms of intracellular vesicular trafficking using both yeast and mammalian tissue culture cell model systems. Our lab played a principal role in the discovery of a novel vesicle tethering factors, published more than 60 original papers in high-profile journals, including Journal of Cell Biology, PNAS, Science, Journal of Neuroscience, Molecular Biology of Cell and Nature Communications. My current research has been continuously supported by grants from both NSF and NIH. We have pioneered the functional analysis of the Conserved Oligomeric Golgi (COG), an evolutionarily conserved complex of eight gene products, each of which is critical for the membrane trafficking and protein modifications in the Golgi apparatus. The COG complex interacts with core fusion machinery components including SNAREs, SM proteins, Rabs, coiled-coil tethers and COPI coat to organize specific docking and fusion of transport intermediates with their acceptor membrane. By using state of the art biochemical, genetic and microscopy approaches (including mass-spectrometry, electron and super-resolution microscopy, CRISPR directed gene editing techniques) we would like to determine how the key components of intracellular membrane trafficking machinery work together to direct efficient protein trafficking in human cells in health and disease.

One or more keywords matched the following items that are connected to Lupashin, Vladimir

Item Type	Name
Academic Article	Golgi tethering factors.
Academic Article	Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex.
Academic Article	Role of tethering factors in secretory membrane traffic.
Academic Article	COG8 deficiency causes new congenital disorder of glycosylation type IIh.
Academic Article	Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter.
Academic Article	Cog3p depletion blocks vesicle-mediated Golgi retrograde trafficking in HeLa cells.
Academic Article	[Cell wall permeability and export of proteins into the culture broth of Saccharomyces cerevisiae].
Academic Article	Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis.
Academic Article	COG complex-mediated recycling of Golgi glycosyltransferases is essential for normal protein glycosylation.
Academic Article	Role of vesicle tethering factors in the ER-Golgi membrane traffic.
Academic Article	Characterization of a novel yeast SNARE protein implicated in Golgi retrograde traffic.
Academic Article	The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network.
Academic Article	Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene.
Academic Article	Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.
Academic Article	The Golgi puppet master: COG complex at center stage of membrane trafficking interactions.
Academic Article	Sec35p, a novel peripheral membrane protein, is required for ER to Golgi vesicle docking.
Academic Article	t-SNARE activation through transient interaction with a rab-like guanosine triphosphatase.
Academic Article	Mislocalization of large ARF-GEFs as a potential mechanism for BFA resistance in COG-deficient cells.
Academic Article	Assembly of the ER to Golgi SNARE complex requires Uso1p.
Academic Article	Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery.
Academic Article	[A new secreted protein from Saccharomyces cerevisiae, stimulated by heat shock].
Academic Article	Biochemical requirements for the targeting and fusion of ER-derived transport vesicles with purified yeast Golgi membranes.
Academic Article	Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p.
Academic Article	Molecular insights into vesicle tethering at the Golgi by the conserved oligomeric Golgi (COG) complex and the golgin TATA element modulatory factor (TMF).
Academic Article	The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins.
Concept	Cell Membrane Permeability
Concept	Cell Membrane
Concept	Membrane Fusion
Concept	Membrane Proteins
Concept	Membrane Glycoproteins
Concept	Serotonin Plasma Membrane Transport Proteins
Concept	Intracellular Membranes
Concept	Membrane Transport Proteins
Academic Article	Study of the Influence of ATP on the activity of membrane-bound chitin synthase of the yeast Saccharomyces carlsbergensis
Academic Article	Serotonin Regulates the Plasma Membrane Expression of Serotonin Transporter Protein Via its Interactions with Rab4
Academic Article	Study of membrane traffic at the yeast cell surface: in vivo and in vitro approaches
Academic Article	The Conserved Oligomeric Golgi complex functional interaction with SNARE and Rab proteins
Academic Article	The COG complex dynamically assembles on the Golgi membrane to regulate intra-Golgi trafficing
Academic Article	In-vitro reconstitution of targeting and fusion of ER-derived vesicles with Golgi membranes in yeast
Academic Article	The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-? during Chlamydia trachomatis infection.
Academic Article	COG lobe B sub-complex engages v-SNARE GS15 and functions via regulated interaction with lobe A sub-complex.
Academic Article	Multipronged interaction of the COG complex with intracellular membranes.
Academic Article	Manganese-induced turnover of TMEM165.
Academic Article	Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway.
Academic Article	Galactose Supplementation in Patients With TMEM165-CDG Rescues the Glycosylation Defects.
Academic Article	Membrane detachment is not essential for COG complex function.
Grant	Super-Res Holographic Microscopy to Advance Research on Golgi Apparatus Function
Grant	Characterization of mammalian COG complex-interacting Golgi trafficking machinery
Academic Article	Maintaining order: COG complex controls Golgi trafficking, processing, and sorting.
Academic Article	Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma.
Academic Article	The Golgi-associated retrograde protein (GARP) complex plays an essential role in the maintenance of the Golgi glycosylation machinery.
Grant	Remodeling of intracellular membrane traffic by Brucella effectors- Washington State Sub
Grant	Remodeling of intracellular membrane traffic by Brucella effectors- Washington State Sub
Grant	Remodeling of intracellular membrane traffic by Brucella effectors- Washington State Sub
Grant	Remodeling of intracellular membrane traffic by Brucella effectors- Washington State Sub
Grant	Remodeling of intracellular membrane traffic by Brucella effectors- Washington State Sub
Grant	Remodeling of intracellular membrane traffic by Brucella effectors- Washington State Sub

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Membranes