| Item Type | Name |
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Concept
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Acetanilides
|
|
Concept
|
Acetylcysteine
|
|
Concept
|
Acyltransferases
|
|
Concept
|
Anti-Inflammatory Agents, Non-Steroidal
|
|
Concept
|
Blood Proteins
|
|
Concept
|
Amino Acid Chloromethyl Ketones
|
|
Concept
|
Cannabidiol
|
|
Concept
|
Bronchodilator Agents
|
|
Concept
|
Allopurinol
|
|
Concept
|
Boron Compounds
|
|
Concept
|
Creatinine
|
|
Concept
|
Cysteine
|
|
Concept
|
Dexamethasone
|
|
Concept
|
Acetylglucosamine
|
|
Concept
|
Cytochrome P-450 Enzyme System
|
|
Concept
|
Amiodarone
|
|
Concept
|
Anthracenes
|
|
Concept
|
Diosgenin
|
|
Concept
|
Drug Evaluation, Preclinical
|
|
Concept
|
Endonucleases
|
|
Concept
|
Alkaline Phosphatase
|
|
Concept
|
Antithrombin III
|
|
Concept
|
Acetaminophen
|
|
Concept
|
Antioxidants
|
|
Concept
|
Central Nervous System Stimulants
|
|
Concept
|
Amphetamine
|
|
Concept
|
Alanine Transaminase
|
|
Concept
|
Anesthetics, Local
|
|
Concept
|
Anti-Inflammatory Agents
|
|
Concept
|
Antidotes
|
|
Concept
|
Albuterol
|
|
Concept
|
Alcohol Dehydrogenase
|
|
Concept
|
Haptoglobins
|
|
Concept
|
Aldehyde Dehydrogenase
|
|
Concept
|
Alanine
|
|
Concept
|
Furosemide
|
|
Concept
|
Cathepsin B
|
|
Concept
|
Fatty Acids
|
|
Concept
|
Cannabis
|
|
Concept
|
Carbachol
|
|
Concept
|
Carbon Tetrachloride
|
|
Concept
|
Microtubule-Associated Proteins
|
|
Concept
|
Argininosuccinate Synthase
|
|
Concept
|
Ketones
|
|
Concept
|
Dose-Response Relationship, Drug
|
|
Concept
|
Bile Acids and Salts
|
|
Concept
|
Carrier Proteins
|
|
Concept
|
C-Reactive Protein
|
|
Concept
|
Binding Sites
|
|
Concept
|
Glycodeoxycholic Acid
|
|
Concept
|
Immunoglobulin M
|
|
Concept
|
Pharmaceutical Preparations
|
|
Concept
|
L-Lactate Dehydrogenase
|
|
Concept
|
Enzyme Inhibitors
|
|
Concept
|
Dipeptides
|
|
Concept
|
Glutathione Reductase
|
|
Concept
|
DNA, Mitochondrial
|
|
Concept
|
Drug Synergism
|
|
Concept
|
Glutamate Dehydrogenase
|
|
Concept
|
Glutamine
|
|
Concept
|
Myoglobin
|
|
Concept
|
Plant Extracts
|
|
Concept
|
Sulfates
|
|
Concept
|
Caspases
|
|
Concept
|
Taurine
|
|
Concept
|
Cytochrome P-450 CYP1A2
|
|
Concept
|
Sulfhydryl Reagents
|
|
Concept
|
Interleukin-6
|
|
Concept
|
Oxidants
|
|
Concept
|
Triglycerides
|
|
Concept
|
Proteins
|
|
Concept
|
Connexin 43
|
|
Concept
|
Proliferating Cell Nuclear Antigen
|
|
Concept
|
Tyrosine
|
|
Concept
|
Chaperonins
|
|
Concept
|
Aldehyde Oxidase
|
|
Concept
|
Apoptosis Inducing Factor
|
|
Concept
|
Taurocholic Acid
|
|
Concept
|
Receptor-Interacting Protein Serine-Threonine Kinases
|
|
Concept
|
N-Acetylglucosaminyltransferases
|
|
Concept
|
Benzyl Alcohol
|
|
Concept
|
Mitochondrial Proteins
|
|
Concept
|
HMGB1 Protein
|
|
Concept
|
Glutathione Transferase
|
|
Concept
|
Glycochenodeoxycholic Acid
|
|
Concept
|
Glutathione
|
|
Concept
|
Glycerol-3-Phosphate O-Acyltransferase
|
|
Concept
|
Herb-Drug Interactions
|
|
Concept
|
DNA
|
|
Concept
|
Lipopolysaccharides
|
|
Concept
|
Tetrazoles
|
|
Concept
|
NF-kappa B
|
|
Concept
|
Receptors, Proteinase-Activated
|
|
Concept
|
MAP Kinase Kinase 4
|
|
Concept
|
Phosphatidic Acids
|
|
Concept
|
RNA, Messenger
|
|
Concept
|
Ethylmaleimide
|
|
Concept
|
Cytochrome P-450 CYP2E1
|
|
Concept
|
Chaperonin 60
|
|
Concept
|
Lactic Acid
|
|
Concept
|
Glutathione Disulfide
|
|
Concept
|
Adenosylhomocysteinase
|
|
Concept
|
Electron Transport Chain Complex Proteins
|
|
Concept
|
Drug Delivery Systems
|
|
Concept
|
Galactosamine
|
|
Concept
|
Plant Preparations
|
|
Concept
|
Carnitine
|
|
Concept
|
Phosphoenolpyruvate Carboxykinase (ATP)
|
|
Concept
|
5-Methylcytosine
|
|
Concept
|
JNK Mitogen-Activated Protein Kinases
|
|
Concept
|
Dimethyl Sulfoxide
|
|
Concept
|
Pyruvic Acid
|
|
Concept
|
Nerve Tissue Proteins
|
|
Concept
|
Ligands
|
|
Concept
|
Granzymes
|
|
Concept
|
Metallothionein
|
|
Concept
|
Methamphetamine
|
|
Concept
|
Paraproteins
|
|
Concept
|
Oxypurinol
|
|
Concept
|
Stilbenes
|
|
Concept
|
Vitamins
|
|
Concept
|
Pyridines
|
|
Concept
|
Phosphatidate Phosphatase
|
|
Concept
|
Glucuronosyltransferase
|
|
Concept
|
Tumor Necrosis Factor-alpha
|
|
Concept
|
Chemokines
|
|
Concept
|
Cysteine Proteinase Inhibitors
|
|
Concept
|
Xenobiotics
|
|
Concept
|
Peptide Hydrolases
|
|
Concept
|
Sulfonamides
|
|
Concept
|
Reactive Oxygen Species
|
|
Concept
|
Apoptosis
|
|
Concept
|
tert-Butylhydroperoxide
|
|
Concept
|
3-Hydroxybutyric Acid
|
|
Concept
|
Xanthine Oxidase
|
|
Concept
|
Glucuronides
|
|
Concept
|
Cyclosporine
|
|
Concept
|
Protective Agents
|
|
Concept
|
Sulfotransferases
|
|
Concept
|
NF-E2-Related Factor 2
|
|
Concept
|
Drug Administration Schedule
|
|
Concept
|
Interleukin-10
|
|
Concept
|
Connexins
|
|
Concept
|
Reactive Nitrogen Species
|
|
Concept
|
Antipyretics
|
|
Concept
|
Peroxynitrous Acid
|
|
Concept
|
Anti-Obesity Agents
|
|
Concept
|
beta Catenin
|
|
Concept
|
Caspase 3
|
|
Concept
|
Caspase Inhibitors
|
|
Concept
|
Receptors, Formyl Peptide
|
|
Concept
|
Analgesics, Non-Narcotic
|
|
Concept
|
Drug Overdose
|
|
Concept
|
Inflammasomes
|
|
Concept
|
Cytochrome P-450 CYP3A
|
|
Concept
|
TOR Serine-Threonine Kinases
|
|
Concept
|
Keratin-18
|
|
Concept
|
ortho-Aminobenzoates
|
|
Concept
|
Purinergic P2X Receptor Antagonists
|
|
Concept
|
MicroRNAs
|
|
Concept
|
Nuclear Proteins
|
|
Concept
|
Recombinant Fusion Proteins
|
|
Concept
|
Cytokines
|
|
Academic Article
|
Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.
|
|
Academic Article
|
Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice.
|
|
Academic Article
|
Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity.
|
|
Academic Article
|
Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.
|
|
Academic Article
|
Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis.
|
|
Academic Article
|
Involvement of connexin43 in acetaminophen-induced liver injury.
|
|
Academic Article
|
Caspase Inhibition Prevents Tumor Necrosis Factor-a-Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in?Vivo and in?Vitro.
|
|
Academic Article
|
Cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity.
|
|
Academic Article
|
Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver.
|
|
Academic Article
|
Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice.
|
|
Academic Article
|
Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation.
|
|
Academic Article
|
Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients.
|
|
Academic Article
|
The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury.
|
|
Academic Article
|
Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.
|
|
Academic Article
|
Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans.
|
|
Academic Article
|
Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans.
|
|
Academic Article
|
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.
|
|
Academic Article
|
Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.
|
|
Academic Article
|
A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen.
|
|
Academic Article
|
Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study.
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|
Academic Article
|
Caveats of using acetaminophen hepatotoxicity models for natural product testing.
|
|
Academic Article
|
Critical review of resveratrol in xenobiotic-induced hepatotoxicity.
|
|
Academic Article
|
Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity.
|
|
Academic Article
|
Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways.
|
|
Academic Article
|
Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.
|
|
Academic Article
|
MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury.
|
|
Academic Article
|
Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity.
|
|
Academic Article
|
Pathophysiological relevance of proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.
|
|
Academic Article
|
Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis.
|
|
Academic Article
|
HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity.
|
|
Academic Article
|
Apoptosis or necrosis in acetaminophen-induced acute liver failure? New insights from mechanistic biomarkers*.
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|
Academic Article
|
Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity.
|
|
Academic Article
|
Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice.
|
|
Academic Article
|
Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome.
|
|
Academic Article
|
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
|
|
Academic Article
|
Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity.
|
|
Academic Article
|
RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity.
|
|
Academic Article
|
Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice.
|
|
Academic Article
|
Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation.
|
|
Academic Article
|
The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation.
|
|
Academic Article
|
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity.
|
|
Academic Article
|
Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients.
|
|
Academic Article
|
Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice.
|
|
Academic Article
|
Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells.
|
|
Academic Article
|
Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes.
|
|
Academic Article
|
Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses.
|
|
Academic Article
|
Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans.
|
|
Academic Article
|
The Problem With Predictive Values: Are We Using the Right Metrics for Preclinical Prediction of Drug Hepatotoxicity?
|
|
Academic Article
|
Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning.
|
|
Academic Article
|
Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.
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|
Academic Article
|
Serum glutamate dehydrogenase--biomarker for liver cell death or mitochondrial dysfunction?
|
|
Academic Article
|
Connexin32: a mediator of acetaminophen-induced liver injury?
|
|
Academic Article
|
The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3? and Wnt/?-catenin signaling.
|
|
Academic Article
|
Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange.
|
|
Academic Article
|
Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.
|
|
Academic Article
|
Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice.
|
|
Academic Article
|
Animal models of drug-induced liver injury.
|
|
Academic Article
|
Expression of drug metabolizing enzymes and transporters in the cochlea: Implications for drug delivery and ototoxicity.
|
|
Academic Article
|
Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration.
|
|
Academic Article
|
Biomarkers of drug-induced liver injury.
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|
Academic Article
|
Mechanisms and biomarkers of liver regeneration after drug-induced liver injury.
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|
Academic Article
|
Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children.
|
|
Academic Article
|
Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations.
|
|
Academic Article
|
Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms.
|
|
Academic Article
|
Effect of bile duct ligation-induced liver dysfunction on methamphetamine pharmacokinetics in male and female rats.
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|
Academic Article
|
Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration.
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|
Academic Article
|
The development and hepatotoxicity of acetaminophen: reviewing over a century of progress.
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|
Academic Article
|
Short-Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis.
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|
Academic Article
|
Radiation Effects on Methamphetamine Pharmacokinetics and Pharmacodynamics in Rats.
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|
Academic Article
|
Generation of pro-and anti-inflammatory mediators after acetaminophen overdose in surviving and non-surviving patients.
|
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Academic Article
|
Hepatotoxicity due to herbal dietary supplements: Past, present and the future.
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|
Academic Article
|
Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations.
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Academic Article
|
Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult.
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Academic Article
|
The Role of Mechanistic Biomarkers in Understanding Acetaminophen Hepatotoxicity in Humans.
|