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Search Results to Ryan Porter

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One or more keywords matched the following properties of Porter, Ryan

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overview My research program focuses on chondrocyte biology and articular cartilage regenerative medicine. Articular cartilage is vital to the function of synovial joints, and its loss is a central feature of osteoarthritis (OA). A long term goal of this research is to develop better strategies to protect articular cartilage from degeneration in response to joint injury or aging, two major risk factors for developing OA. Current projects can be divided into two themes. The first seeks to understand why chondrocytes, the lone cells within cartilage, fail to maintain this tissue during the onset of OA. The second theme aims to improve therapeutic drug delivery to articular cartilage, in order to prevent tissue loss and/or stimulate repair. To accomplish these goals, my lab uses preclinical models of post-traumatic and age-associated OA. This work has been supported by the National Institutes of Health, the Arkansas Biosciences Institute, and the UAMS College of Medicine’s Bone and Joint Initiative.

One or more keywords matched the following items that are connected to Porter, Ryan

Item TypeName
Concept Bone Diseases
Concept Bone Regeneration
Concept Bone Marrow Cells
Concept Bone and Bones
Concept Bone Morphogenetic Protein 2
Concept Bone Morphogenetic Proteins
Concept Bone Transplantation
Academic Article Effect of dexamethasone withdrawal on osteoblastic differentiation of bone marrow stromal cells.
Academic Article Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage.
Academic Article Rapid and reliable healing of critical size bone defects with genetically modified sheep muscle.
Academic Article Evaluation of BMP-2 gene-activated muscle grafts for cranial defect repair.
Academic Article Contribution of Implanted, Genetically Modified Muscle Progenitor Cells Expressing BMP-2 to New Bone Formation in a Rat Osseous Defect.
Academic Article Osteogenic potential of reamer irrigator aspirator (RIA) aspirate collected from patients undergoing hip arthroplasty.
Academic Article Interaction between living bone particles and rhBMP-2 in large segmental defect healing in the rat femur.
Academic Article Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow.
Academic Article Autologous bone grafting on steroids: preliminary clinical results. A novel treatment for nonunions and segmental bone defects.
Academic Article Ex vivo adenoviral transfer of bone morphogenetic protein 12 (BMP-12) cDNA improves Achilles tendon healing in a rat model.
Academic Article Harnessing extracellular vesicles to direct endochondral repair of large bone defects.
Academic Article Specific, Sensitive, and Stable Reporting of Human Mesenchymal Stromal Cell Chondrogenesis.
Academic Article Sirtuins and FoxOs in osteoporosis and osteoarthritis.
Grant Harnessing Extracellular Vesicles to Direct the Repair of Osseous Defects
Academic Article Increased marrow adipogenesis does not contribute to age-dependent appendicular bone loss in female mice.
Academic Article IL-1Ra gene transfer potentiates BMP2-mediated bone healing by redirecting osteogenesis toward endochondral ossification.
Grant Role of subchondral bone osteocytes in post-traumatic osteoarthritis
Grant A Transgenic Rat for Noninvasive Assessment of Chondrogenic Activity in vivo

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