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overview Dr. Porter’s laboratory generally focuses on developing strategies to direct skeletal tissue repair or prevent tissue degeneration (e.g., associated with osteoarthritis). Currently his group is pursuing two areas of research: one focused on improving the intra-articular delivery of therapeutics within synovial joints to prevent or treat osteoarthritis; the other on overcoming key bottlenecks to stimulating chondrogenesis within skeletal defects. At present, these projects use mouse, rat, and rabbit models of bone and joint injury to help answer specific research questions. This work has been supported by grants from the National Institutes of Health, the Klarman Family Foundation, the UAMS Bone and Joint Initiative, and the Arkansas Biosciences Institute.

One or more keywords matched the following items that are connected to Porter, Ryan

Item TypeName
Concept Bone Diseases
Concept Bone Regeneration
Concept Bone Marrow Cells
Concept Bone and Bones
Concept Bone Morphogenetic Protein 2
Concept Bone Morphogenetic Proteins
Concept Bone Transplantation
Academic Article Effect of dexamethasone withdrawal on osteoblastic differentiation of bone marrow stromal cells.
Academic Article Facilitated endogenous repair: making tissue engineering simple, practical, and economical.
Academic Article Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage.
Academic Article Improvement of tendon repair using muscle grafts transduced with TGF-ß1 cDNA.
Academic Article Rapid and reliable healing of critical size bone defects with genetically modified sheep muscle.
Academic Article Evaluation of BMP-2 gene-activated muscle grafts for cranial defect repair.
Academic Article Contribution of Implanted, Genetically Modified Muscle Progenitor Cells Expressing BMP-2 to New Bone Formation in a Rat Osseous Defect.
Academic Article Osteogenic potential of reamer irrigator aspirator (RIA) aspirate collected from patients undergoing hip arthroplasty.
Academic Article Interaction between living bone particles and rhBMP-2 in large segmental defect healing in the rat femur.
Academic Article Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow.
Academic Article Autologous bone grafting on steroids: preliminary clinical results. A novel treatment for nonunions and segmental bone defects.
Academic Article Ex vivo adenoviral transfer of bone morphogenetic protein 12 (BMP-12) cDNA improves Achilles tendon healing in a rat model.
Academic Article Harnessing extracellular vesicles to direct endochondral repair of large bone defects.
Academic Article Specific, Sensitive, and Stable Reporting of Human Mesenchymal Stromal Cell Chondrogenesis.
Academic Article Sirtuins and FoxOs in osteoporosis and osteoarthritis.
Grant A Transgenic Rat for Noninvasive Assessment of Chondrogenic Activity in vivo
Grant Harnessing Extracellular Vesicles to Direct the Repair of Osseous Defects
Academic Article Increased marrow adipogenesis does not contribute to age-dependent appendicular bone loss in female mice.
Grant Intra-cartilage depot delivery of electrically-charged IL-1RA for targeting osteoarthritis-associated inflammation and catabolism in multiple joint tissues

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  • Bone
  • repair