Header Logo
Keywords
Last Name
Institution
Announcement

You can now add alternative names! Click here to add other names that you've published under.

Connection

Search Results to Brendan Frett

This is a "connection" page, showing the details of why an item matched the keywords from your search.

                     
                     

One or more keywords matched the following properties of Frett, Brendan

PropertyValue
overview Dr. Brendan Frett received his Ph.D. in Pharmaceutical Sciences with an emphasis in Drug Discovery and Development from the University of Arizona in 2014. He received postdoctoral training in Medicinal Chemistry as well as Pharmaceutics at the University of Arizona. Dr. Frett has successfully transferred academic-based discoveries to pharmaceutical companies for clinical development. He is interested in pursuing translational research projects, where research completed in his laboratory can directly help patients.

One or more keywords matched the following items that are connected to Frett, Brendan

Item TypeName
Concept Adenine
Concept Ethanol
Concept Boronic Acids
Concept Antineoplastic Agents
Concept Aziridines
Concept Carboxylic Acids
Concept Benzimidazoles
Concept Drug Evaluation, Preclinical
Concept Acetamides
Concept Aminoquinolines
Concept Adenosine Triphosphate
Concept Furans
Concept Aza Compounds
Concept Ketones
Concept Dose-Response Relationship, Drug
Concept Binding Sites
Concept Hydrazines
Concept Isoquinolines
Concept Solvents
Concept Pyrimidines
Concept Stereoisomerism
Concept Maleimides
Concept Drug Design
Concept Transforming Growth Factor beta
Concept Carbon
Concept Palladium
Concept Proto-Oncogene Proteins
Concept Proto-Oncogene Proteins p21(ras)
Concept Guanylate Cyclase
Concept Phthalazines
Concept Pyrroles
Concept Small Molecule Libraries
Concept Apoptosis Regulatory Proteins
Concept Receptors, Transforming Growth Factor beta
Concept fms-Like Tyrosine Kinase 3
Concept Drug Discovery
Concept Quinazolines
Concept Smad Proteins
Concept Ligands
Concept Imidazoles
Concept Heterocyclic Compounds
Concept Metals
Concept Oligopeptides
Concept Thiophenes
Concept Phosphoproteins
Concept Pyrazoles
Concept Pyridines
Concept ras Proteins
Concept Receptor, trkB
Concept Intracellular Signaling Peptides and Proteins
Concept Cell Cycle Proteins
Concept Vascular Endothelial Growth Factor Receptor-2
Concept Apoptosis
Concept Proto-Oncogene Proteins c-kit
Concept Drug Resistance, Neoplasm
Concept Proto-Oncogene Proteins c-ret
Concept Protein Kinase Inhibitors
Concept CARD Signaling Adaptor Proteins
Concept Drug Screening Assays, Antitumor
Concept Receptor, trkC
Concept Receptor, trkA
Concept Nitrazepam
Concept Protein Interaction Domains and Motifs
Concept Cyclic Nucleotide Phosphodiesterases, Type 6
Academic Article Targeting the K-Ras/PDEd protein-protein interaction: the solution for Ras-driven cancers or just another therapeutic mirage?
Academic Article Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology.
Academic Article Metal-free, efficient hydrazination of imidazo[1,2-a]pyridine with diethyl azodicarboxylate in neutral media.
Academic Article Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors.
Academic Article Identification of two novel RET kinase inhibitors through MCR-based drug discovery: design, synthesis and evaluation.
Academic Article Therapeutic melting pot of never in mitosis gene a related kinase 2 (Nek2): a perspective on Nek2 as an oncology target and recent advancements in Nek2 small molecule inhibition.
Academic Article Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in?vitro and in?vivo antitumor activities.
Academic Article Facile construction of fused benzimidazole-isoquinolinones that induce cell-cycle arrest and apoptosis in colorectal cancer cells.
Academic Article Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
Academic Article Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts.
Grant Selective RET Kinase and Its Mutant Inhibitors for the Treatment of Medullary Thyroid Cancer
Academic Article The Exploration of Chirality for Improved Druggability within the Human Kinome.
Academic Article One-pot construction of functionalized aziridines and maleimides via a novel pseudo-Knoevenagel cascade reaction.
Academic Article Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology.
Academic Article Discovery of SP-96, the first non-ATP-competitive Aurora Kinase B inhibitor, for reduced myelosuppression.
Academic Article Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation.
Academic Article Pyrazoloadenine Inhibitors of the RET Lung Cancer Oncoprotein Discovered by a Fragment Optimization Approach.
Academic Article Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation.
Academic Article Discovery and biological evaluation of phthalazines as novel non-kinase TGF? pathway inhibitors.
Academic Article Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development.
Academic Article Discovery of 4-aminoquinolines as highly selective TGF?R1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology.
Academic Article Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor.

Search Criteria
  • drug