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Miller, Grover

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My goals are to assess the biological significance of metabolic activation and clearance of molecules especially related to pharmacological and toxicological effects. In practice, my group leverages powerful analytical and biochemical tools to identify and quantitate small molecules including drugs, pollutants, and food additives during metabolism and correlate findings to biological activity and in vivo outcomes such as liver toxicity. Individual projects aim to (1) determine metabolic mechanisms, efficiencies, and fluxes for activation and elimination of toxic molecules, (2) identify metabolite biomarkers in humans and animal models for correlating in vitro findings to in vivo outcomes and leveraging their diagnostic, theragnostic, and prognostic potential, and (3) develop computational models for drug bioactivation and clearance contributing to adverse drug events to make drugs safer for clinical use. Moreover, I seek translation of novel analytical and diagnostic tools into practical, commercially viable tools. Over time, my research expanded from detailed in vitro metabolic studies to metabolite profiling for translational studies and development of models of metabolism, structure, and reactivity that were made possible through strong, interdisciplinary collaborations.

One or more keywords matched the following items that are connected to Miller, Grover

Item Type	Name
Academic Article	Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin.
Academic Article	Assessing cytochrome P450 and UDP-glucuronosyltransferase contributions to warfarin metabolism in humans.
Academic Article	Assays and applications in warfarin metabolism: what we know, how we know it and what we need to know.
Academic Article	Advances in the interpretation and prediction of CYP2E1 metabolism from a biochemical perspective.
Academic Article	Differences in butadiene adduct formation between rats and mice not due to selective inhibition of CYP2E1 by butadiene metabolites.
Academic Article	Inhibitory potency of 4-carbon alkanes and alkenes toward CYP2E1 activity.
Academic Article	Site of reactivity models predict molecular reactivity of diverse chemicals with glutathione.
Academic Article	Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates.
Academic Article	Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells.
Academic Article	1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice.
Academic Article	Computational Approach to Structural Alerts: Furans, Phenols, Nitroaromatics, and Thiophenes.
Academic Article	Toxicological Implications of Mitochondrial Localization of CYP2E1.
Academic Article	Computationally Assessing the Bioactivation of Drugs by N-Dealkylation.
Academic Article	Lamisil (terbinafine) toxicity: Determining pathways to bioactivation through computational and experimental approaches.
Grant	Computationally modeling the impact of ontogeny on drug metabolic fate
Grant	DATA AND TOOLS FOR MODELING METABOLISM AND REACTIVITY
Grant	Structure-Function of UDP-Glucuronosyltransferases
Grant	Toxicological Significance of Alkylbenzene Metabolism
Academic Article	CYP2C19 and 3A4 Dominate Metabolic Clearance and Bioactivation of Terbinafine Based on Computational and Experimental Approaches.
Academic Article	A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes.
Academic Article	Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam.
Academic Article	Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam.
Academic Article	Impacts of diphenylamine NSAID halogenation on bioactivation risks.
Academic Article	Editorial: Advancements in computational studies of drug toxicity.

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toxicity