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overview Dr. James is the Director of the Translational Research Institute at the University of Arkansas for Medical Sciences. Her research interest is in translational studies of acetaminophen toxicity. She and her collaborators developed novel approaches for the quantitation of acetaminophen protein adducts in peripheral blood samples. She also directs clinical trials in children to develop safe and effective drug dosing strategies in a number of disease areas.

One or more keywords matched the following items that are connected to James, Laura

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Academic Article Correlation of MCP1 with toxicity in acetaminophen overdose.
Academic Article Acetaminophen-induced hepatotoxicity.
Academic Article Cytokines and toxicity in acetaminophen overdose.
Academic Article Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition.
Academic Article Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation.
Academic Article Acetaminophen-associated hepatic injury: evaluation of acetaminophen protein adducts in children and adolescents with acetaminophen overdose.
Academic Article Mechanisms of acetaminophen-induced liver necrosis.
Academic Article Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice.
Academic Article Acetaminophen hepatotoxicity and HIF-1a induction in acetaminophen toxicity in mice occurs without hypoxia.
Academic Article Pharmacokinetics and tolerability of rabeprazole sodium in subjects aged 12 to 16 years with gastroesophageal reflux disease: an open-label, single- and multiple-dose study.
Academic Article Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure.
Academic Article Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity.
Academic Article Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase.
Academic Article Prescription-acquired acetaminophen use and the risk of asthma in adults: a case-control study.
Academic Article Hair drug testing of children suspected of exposure to the manufacture of methamphetamine.
Academic Article A multicenter, randomized, open-label, pharmacokinetics and safety study of pantoprazole tablets in children and adolescents aged 6 through 16 years with gastroesophageal reflux disease.
Academic Article Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents.
Academic Article K2 toxicity: fatal case of psychiatric complications following AM2201 exposure.
Academic Article Forensic investigation of K2, Spice, and "bath salt" commercial preparations: a three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds.
Academic Article Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice.
Academic Article Population pharmacokinetics of piperacillin using scavenged samples from preterm infants.
Academic Article Population pharmacokinetics of metronidazole evaluated using scavenged samples from preterm infants.
Academic Article Effect of trifluoperazine on toxicity, HIF-1a induction and hepatocyte regeneration in acetaminophen toxicity in mice.
Academic Article UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients.
Academic Article Sulfaphenazole and a-naphthoflavone attenuate the metabolism of the synthetic cannabinoids JWH-018 and AM2201 found in K2/spice.
Academic Article Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases.
Academic Article Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity.
Academic Article Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?
Academic Article Acetaminophen-cysteine adducts during therapeutic dosing and following overdose.
Academic Article Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urine.
Academic Article Ketamine as a neuroprotective and anti-inflammatory agent in children undergoing surgery on cardiopulmonary bypass: a pilot randomized, double-blind, placebo-controlled trial.
Academic Article Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations.
Academic Article Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Academic Article Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection.
Academic Article Predictors of outcome after acetaminophen poisoning in children and adolescents.
Academic Article Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
Academic Article Predicting risk in patients with acetaminophen overdose.
Concept Ethanol
Concept Aminoglycosides
Concept Antigens, Ly
Concept Acetylcysteine
Concept Transaminases
Concept Anti-Inflammatory Agents, Non-Steroidal
Concept Blood Proteins
Concept Analgesics, Opioid
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Concept Cannabidiol
Concept Bronchodilator Agents
Concept Chlorides
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Concept Creatinine
Concept Cysteine
Concept Anti-Infective Agents
Concept Cytochrome P-450 Enzyme System
Concept Coloring Agents
Concept Anti-Bacterial Agents
Concept Deuterium
Concept Aspartate Aminotransferases
Concept Ampicillin
Concept Autoantibodies
Concept Acetaminophen
Concept Antioxidants
Concept Antivenins
Concept Central Nervous System Stimulants
Concept Anti-Ulcer Agents
Concept Amphetamine
Concept Alanine Transaminase
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Concept Antidotes
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Concept Calcitonin
Concept C-Reactive Protein
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Concept Delayed-Action Preparations
Concept Glycodeoxycholic Acid
Concept Drug Resistance
Concept Interleukin-3
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Academic Article Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children.
Academic Article Isoniazid hepatotoxicity: progress in understanding the immunologic component.
Academic Article marijuana-based drugs: Innovateive therapeutics or designer drugs of abuse
Academic Article Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice
Academic Article Adverse Drug Reactions, Handbook of Experimental Pharmacology
Academic Article Pediatric and Neonatal Pharmacology
Academic Article P450-mediated oxidative metabolism of abused synthetic cannabinoids found in “K2/Spice”: identification of novel cannabinoid receptor ligands
Academic Article UGT1A9, UGTB7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients
Academic Article Conjugation of JWH-018 and JWH-073 metabolites by human UDP-glucuronosyltransferases
Academic Article Sympathormimetic drug use in adolescents presenting to a pediatric emergency department with chrest pain
Academic Article Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children.
Academic Article Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure.
Academic Article A Cytochrome P450-Independent Mechanism of Acetaminophen-Induced Injury in Cultured Mouse Hepatocytes.
Academic Article Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity.
Academic Article Translational biomarkers of acetaminophen-induced acute liver injury.
Academic Article The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes.
Academic Article MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity.
Academic Article Comparative Analysis of Ampicillin Plasma and Dried Blood Spot Pharmacokinetics in Neonates.
Academic Article Hsp72 protects against liver injury via attenuation of hepatocellular death, oxidative stress, and JNK signaling.
Academic Article Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures.
Academic Article Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.
Academic Article Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants.
Academic Article A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents.
Academic Article Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways.
Academic Article The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3? and Wnt/?-catenin signaling.
Academic Article Pharmacokinetics, Safety, and Tolerability of Single-Dose Intravenous Moxifloxacin in Pediatric Patients: Dose Optimization in a Phase 1 Study.
Grant AcetaSTAT Rapid Assay for Acetaminophen Liver Injury
Grant Pediatric Pharmacology Research Unit Network
Grant NOVEL THERAPIES FOR ACETAMINOPHEN TOXICITY
Grant Identification of new mechanistic biomarkers of adverse responses to acetaminophe
Grant Dipstick Assay for Detection of Acetaminophen Protein Adducts
Grant Evaluation of a Biomarker for Acetaminophen Toxicity
Academic Article Acute Liver Failure of Indeterminate Etiology: A Comprehensive Systematic Approach by An Expert Committee to Establish Causality.
Academic Article Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen.
Academic Article Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration.
Academic Article Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children.
Academic Article Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5).
Academic Article Nitrosative Stress and Lipid Homeostasis as a Mechanism for Zileuton Hepatotoxicity and Resistance in Genetically Sensitive Mice.
Academic Article The Spice of Death: Sudden Cardiac Arrest After Novel Psychoactive Substance Exposure.
Academic Article Short-Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis.
Academic Article Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations.
Academic Article Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult.

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