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Search Results to Thomas Kelly Jr

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One or more keywords matched the following properties of Kelly Jr, Thomas

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overview We are defining the mechanisms of cross-talk between activated fibroblasts and tumor associated macrophages that results in facilitation of breast cancer growth and progression that ultimately kills people with breast cancer. Specifically, we are investigating if activated fibroblasts are capable of converting immune activating macrophages (M1) to immune suppressive macrophages (M2). We are also investigating if immune suppressive macrophages can cause fibroblast activation. Steven R. Post and I have shown that SR-A mediated adhesion of macrophages to modified collagen results in PGE2 production and this PGE2 feeds back onto the macrophages and modulates cytokine production towards an M2 phenotype as evidenced by decreased TNF-alpha and increased IL-10 production (Nikolic et al, 2015, J. Leukocyte Biol. Feb 25. pii: jlb.2A1014-471RR. [Epub ahead of print]). We are currently looking to determine if adhesion of macrophages to FAP-modified collagen also promotes the M2 phenotype. I am an experienced PI with a broad background in cellular biology, and since 1992, I have focused my research on two matrix degrading enzymes—fibroblast activation protein-a (FAP) and heparanase—and their relationship to breast cancer. For over 20 years, I have led an independent research group that studies mechanisms of breast cancer metastasis that has been continuously funded by DoD-BCRP, NIH, and Industry grants and contracts. As a result, I am experienced in successfully administering research projects (e.g., staffing, research protections and budget) and collaborating with both basic and clinical scientists. My research has been published in prestigious cancer journals, such as Cancer Research and Blood. Through this research, my team and I have developed extensive experience with FAP biology in breast cancer.

One or more keywords matched the following items that are connected to Kelly Jr, Thomas

Item TypeName
Academic Article Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasis.
Academic Article Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies.
Academic Article Deficiency in surface expression of E-selectin ligand promotes lung colonization in a mouse model of breast cancer.
Academic Article Partners in research: benefits of a summer research program.
Academic Article Synergistic enhancement of selective nanophotothermolysis with gold nanoclusters: potential for cancer therapy.
Academic Article High heparanase activity in multiple myeloma is associated with elevated microvessel density.
Academic Article Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases.
Academic Article Fructose as a carbon source induces an aggressive phenotype in MDA-MB-468 breast tumor cells.
Academic Article Suppression of Wnt1-induced mammary tumor growth and lower serum insulin in offspring exposed to maternal blueberry diet suggest early dietary influence on developmental programming.
Academic Article In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells.
Academic Article Progressive tumor features accompany epithelial-mesenchymal transition induced in mitochondrial DNA-depleted cells.
Academic Article Clinical significance of increased gelatinolytic activity in the rectal mucosa during external beam radiation therapy of prostate cancer.
Academic Article Tumor-derived syndecan-1 mediates distal cross-talk with bone that enhances osteoclastogenesis.
Academic Article The utility of PAX-2 and renal cell carcinoma marker immunohistochemistry in distinguishing papillary renal cell carcinoma from nonrenal cell neoplasms with papillary features.
Academic Article Seprase, a membrane-bound protease, is overexpressed by invasive ductal carcinoma cells of human breast cancers.
Academic Article Fibroblast activation protein-alpha and dipeptidyl peptidase IV (CD26): cell-surface proteases that activate cell signaling and are potential targets for cancer therapy.
Concept Breast Neoplasms
Concept Bone Neoplasms
Concept Prostatic Neoplasms
Concept Vulvar Neoplasms
Concept Lung Neoplasms
Concept Pancreatic Neoplasms
Concept Kidney Neoplasms
Concept Mammary Neoplasms, Experimental
Concept Mammary Neoplasms, Animal
Concept Early Detection of Cancer
Concept Neoplasms
Academic Article The Cancer Degradome - Proteases in Cancer Biology, Eds: Ed. D. Edwards, G. Hoyer-Hansen, F. Blasi, and B. F. Sloane
Academic Article Perineural Invasion Is an Independent Pathologic Indicator of Recurrence in Vulvar Squamous Cell Carcinoma.
Academic Article A fibromyxoid stromal response is associated with an infiltrative tumor morphology, perineural invasion, and lymph node metastasis in squamous cell carcinoma of the vulva.
Academic Article Fibroblast activation protein-a promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions.
Academic Article A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells.
Academic Article Membrane proteases as potential diagnostic and therapeutic targets for breast malignancy.
Academic Article Seprase promotes rapid tumor growth and increased microvessel density in a mouse model of human breast cancer.
Academic Article Proteolysis of extracellular matrix by invadopodia facilitates human breast cancer cell invasion and is mediated by matrix metalloproteinases.
Academic Article Seprase, a membrane-bound protease, alleviates the serum growth requirement of human breast cancer cells.
Academic Article Seprase complexes in cellular invasiveness.
Academic Article Binding and localization of M(r) 72,000 matrix metalloproteinase at cell surface invadopodia.
Academic Article Cleavage of Type I Collagen by Fibroblast Activation Protein-a Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion.
Academic Article Pathologic features of aggressive vulvar carcinoma are associated with epithelial-mesenchymal transition.
Grant In vivo molecular laser detection and treatment of circulating cancer stem cells
Grant Photoswitchable nanoprobes for in vivo flow cytometry
Grant Student Partners in Cancer Research and Education
Grant Lymph liquid biopsy in cancer
Grant Suppressing Breast Cancer Tumor Growth with Inhibitor-a
Grant Student Partners in Cancer Research and Education
Academic Article Phosphorylation Regulates CAP1 (Cyclase-Associated Protein 1) Functions in the Motility and Invasion of Pancreatic Cancer Cells.
Grant Partnership in Cancer Research (PCAR)
Academic Article VT68.2: An Antibody to Chondroitin Sulfate Proteoglycan 4 (CSPG4) Displays Reactivity against a Tumor-Associated Carbohydrate Antigen.
Grant Suppressing Breast Cancer Tumor Growth with Inhibitor-a
Grant In vivo, noninvasive, ultrasensitive photoacoustic detection of early breast cancer metastasis in bone
Academic Article Repurposing live attenuated trivalent MMR vaccine as cost-effective cancer immunotherapy.
Academic Article Partnership in Cancer Research (PCAR) Program Increases Medical Student Knowledge and Confidence to Perform Cancer Research.
Academic Article The Tumor Microenvironment and Immune Response in Breast Cancer.
Grant SR-A as a therapeutic target in breast cancer

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