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Connection

William Steinbach to Calcineurin

This is a "connection" page, showing publications William Steinbach has written about Calcineurin.

 
Connection Strength
  
 
 
8.771
  
  1. Juvvadi PR, Bobay BG, Gobeil SMC, Cole DC, Venters RA, Heitman J, Spicer LD, Steinbach WJ. FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2020 05 21; 526(1):48-54.
    View in: PubMed
    Score: 0.636
  2. Juvvadi PR, Fox D, Bobay BG, Hoy MJ, Gobeil SMC, Venters RA, Chang Z, Lin JJ, Averette AF, Cole DC, Barrington BC, Wheaton JD, Ciofani M, Trzoss M, Li X, Lee SC, Chen YL, Mutz M, Spicer LD, Schumacher MA, Heitman J, Steinbach WJ. Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents. Nat Commun. 2019 09 19; 10(1):4275.
    View in: PubMed
    Score: 0.615
  3. Juvvadi PR, Cole DC, Falloon K, Waitt G, Soderblom EJ, Moseley MA, Steinbach WJ. Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2018 11 02; 505(3):740-746.
    View in: PubMed
    Score: 0.576
  4. Juvvadi PR, Moseley MA, Hughes CJ, Soderblom EJ, Lennon S, Perkins SR, Thompson JW, Geromanos SJ, Wildgoose J, Richardson K, Langridge JI, Vissers JPC, Steinbach WJ. Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs. J Proteome Res. 2018 02 02; 17(2):780-793.
    View in: PubMed
    Score: 0.546
  5. Juvvadi PR, Lee SC, Heitman J, Steinbach WJ. Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach. Virulence. 2017 02 17; 8(2):186-197.
    View in: PubMed
    Score: 0.491
  6. Juvvadi PR, Pemble CW, Ma Y, Steinbach WJ. Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus. FEBS Lett. 2016 Feb; 590(4):501-8.
    View in: PubMed
    Score: 0.480
  7. Juvvadi PR, Mu?oz A, Lamoth F, Soderblom EJ, Moseley MA, Read ND, Steinbach WJ. Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus. Antimicrob Agents Chemother. 2015 Aug; 59(8):4946-55.
    View in: PubMed
    Score: 0.457
  8. Lamoth F, Alexander BD, Juvvadi PR, Steinbach WJ. Antifungal activity of compounds targeting the Hsp90-calcineurin pathway against various mould species. J Antimicrob Chemother. 2015 May; 70(5):1408-11.
    View in: PubMed
    Score: 0.444
  9. Juvvadi PR, Lamoth F, Steinbach WJ. Calcineurin-mediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus. Mycopathologia. 2014 Dec; 178(5-6):341-8.
    View in: PubMed
    Score: 0.432
  10. Juvvadi PR, Gehrke C, Fortwendel JR, Lamoth F, Soderblom EJ, Cook EC, Hast MA, Asfaw YG, Moseley MA, Creamer TP, Steinbach WJ. Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus. PLoS Pathog. 2013; 9(8):e1003564.
    View in: PubMed
    Score: 0.404
  11. Juvvadi PR, Fortwendel JR, Rogg LE, Burns KA, Randell SH, Steinbach WJ. Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus. Mol Microbiol. 2011 Dec; 82(5):1235-59.
    View in: PubMed
    Score: 0.357
  12. Mennink-Kersten MA, Ruegebrink D, Verweij PE, Steinbach WJ. Calcineurin-dependent galactomannan release in Aspergillus fumigatus. Eur J Clin Microbiol Infect Dis. 2011 Apr; 30(4):551-3.
    View in: PubMed
    Score: 0.334
  13. Geunes-Boyer S, Heitman J, Wright JR, Steinbach WJ. Surfactant protein D binding to Aspergillus fumigatus hyphae is calcineurin-sensitive. Med Mycol. 2010 Jun; 48(4):580-8.
    View in: PubMed
    Score: 0.323
  14. Fortwendel JR, Juvvadi PR, Perfect BZ, Rogg LE, Perfect JR, Steinbach WJ. Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin. Antimicrob Agents Chemother. 2010 Apr; 54(4):1555-63.
    View in: PubMed
    Score: 0.316
  15. Fortwendel JR, Juvvadi PR, Pinchai N, Perfect BZ, Alspaugh JA, Perfect JR, Steinbach WJ. Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus. Antimicrob Agents Chemother. 2009 Feb; 53(2):476-82.
    View in: PubMed
    Score: 0.290
  16. Juvvadi PR, Fortwendel JR, Pinchai N, Perfect BZ, Heitman J, Steinbach WJ. Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development. Eukaryot Cell. 2008 Sep; 7(9):1606-10.
    View in: PubMed
    Score: 0.283
  17. Cramer RA, Perfect BZ, Pinchai N, Park S, Perlin DS, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ. Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. Eukaryot Cell. 2008 Jul; 7(7):1085-97.
    View in: PubMed
    Score: 0.279
  18. Steinbach WJ, Reedy JL, Cramer RA, Perfect JR, Heitman J. Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections. Nat Rev Microbiol. 2007 Jun; 5(6):418-30.
    View in: PubMed
    Score: 0.262
  19. Steinbach WJ, Cramer RA, Perfect BZ, Asfaw YG, Sauer TC, Najvar LK, Kirkpatrick WR, Patterson TF, Benjamin DK, Heitman J, Perfect JR. Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus. Eukaryot Cell. 2006 Jul; 5(7):1091-103.
    View in: PubMed
    Score: 0.246
  20. Gobeil SM, Bobay BG, Juvvadi PR, Cole DC, Heitman J, Steinbach WJ, Venters RA, Spicer LD. Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. mBio. 2021 12 21; 12(6):e0300021.
    View in: PubMed
    Score: 0.179
  21. Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Barrington BC, Asfaw YG, Moseley MA, Steinbach WJ. Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus. Mol Microbiol. 2019 07; 112(1):62-80.
    View in: PubMed
    Score: 0.149
  22. Renshaw H, Vargas-Mu?iz JM, Juvvadi PR, Richards AD, Waitt G, Soderblom EJ, Moseley MA, Steinbach WJ. The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth. J Cell Sci. 2018 02 07; 131(3).
    View in: PubMed
    Score: 0.138
  23. Steinbach WJ, Lamoth F, Juvvadi PR. Potential Microbiological Effects of Higher Dosing of Echinocandins. Clin Infect Dis. 2015 Dec 01; 61 Suppl 6:S669-77.
    View in: PubMed
    Score: 0.118
  24. Falloon K, Juvvadi PR, Richards AD, Vargas-Mu?iz JM, Renshaw H, Steinbach WJ. Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus. PLoS One. 2015; 10(9):e0137869.
    View in: PubMed
    Score: 0.116
  25. Steinbach WJ, Juvvadi PR, Fortwendel JR, Rogg LE. Newer combination antifungal therapies for invasive aspergillosis. Med Mycol. 2011 Apr; 49 Suppl 1:S77-81.
    View in: PubMed
    Score: 0.081
  26. Steinbach WJ, Cramer RA, Perfect BZ, Henn C, Nielsen K, Heitman J, Perfect JR. Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus. Antimicrob Agents Chemother. 2007 Aug; 51(8):2979-81.
    View in: PubMed
    Score: 0.065
  27. Dome PA, Jeong P, Nam G, Jang H, Rivera A, Floyd Averette A, Park E, Liao TC, Ciofani M, Wu J, Chi JA, Venters RA, Park HJ, Steinbach WJ, Juvvadi PR, Heitman J, Hong J. Structure-guided design and synthesis of C22- and C32-modified FK520 analogs with enhanced activity against human pathogenic fungi. Proc Natl Acad Sci U S A. 2025 Jan 07; 122(1):e2419883121.
    View in: PubMed
    Score: 0.055
  28. Steinbach WJ, Schell WA, Blankenship JR, Onyewu C, Heitman J, Perfect JR. In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. Antimicrob Agents Chemother. 2004 May; 48(5):1664-9.
    View in: PubMed
    Score: 0.053
  29. Hoy MJ, Park E, Lee H, Lim WY, Cole DC, DeBouver ND, Bobay BG, Pierce PG, Fox D, Ciofani M, Juvvadi PR, Steinbach W, Hong J, Heitman J. Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus. mBio. 2022 06 28; 13(3):e0104922.
    View in: PubMed
    Score: 0.046
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.