A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival.

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A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival.

Cohen NA, Stewart ML, Gavathiotis E, Tepper JL, Bruekner SR, Koss B, Opferman JT, Walensky LD. A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chem Biol. 2012 Sep 21; 19(9):1175-86.

View in: PubMed

subject areas

Apoptosis
Cell Survival
Dose-Response Relationship, Drug
High-Throughput Screening Assays
Humans
Models, Molecular
Peptides
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Small Molecule Libraries
Structure-Activity Relationship

authors with profiles

Brian Koss