Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-?B leads to hyperbilirubinemia.
Fujiwara R, Chen S, Karin M, Tukey RH. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-?B leads to hyperbilirubinemia. Gastroenterology. 2012 Jan; 142(1):109-118.e2.
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Animals
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Animals, Newborn
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Bilirubin
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Disease Models, Animal
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Down-Regulation
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Glucuronosyltransferase
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Humans
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Hyperbilirubinemia, Neonatal
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I-kappa B Kinase
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Infant Formula
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Infant, Newborn
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Intestines
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Mice, Transgenic
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Milk, Human
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NF-kappa B
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Receptors, Cytoplasmic and Nuclear
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Receptors, Steroid
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Signal Transduction
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Time Factors