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Connection

Yuet-Kin Leung to Humans

This is a "connection" page, showing publications Yuet-Kin Leung has written about Humans.

 
Connection Strength
  
 
 
0.644
  
  1. Cortes-Ramirez SA, Ho SM, Leung YK. Endocrine-Disrupting Chemicals: A Looming Threat to Current and Future Generations. Int J Mol Sci. 2024 Jul 27; 25(15).
    View in: PubMed
    Score: 0.039
  2. Leung YK, Lee SG, Wang J, Guruvaiah P, Rusch NJ, Ho SM, Park C, Kim K. The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/?-catenin Signaling via Epigenetic Dysregulation that Enhances Sp1-? catenin-p300 Interactions in Hepatocellular Carcinoma. Adv Sci (Weinh). 2024 Aug; 11(29):e2308539.
    View in: PubMed
    Score: 0.038
  3. Leung YK. A Silent Threat: Exploring the Impact of Endocrine Disruption on Human Health. Int J Mol Sci. 2023 Jun 06; 24(12).
    View in: PubMed
    Score: 0.036
  4. McDermott A, Kim K, Kasper S, Ho SM, Leung YK. The androgen receptor inhibits transcription of GPER1 by preventing Sp1 and Sp3 from binding to the promoters in prostate cancer cells. Oncotarget. 2022; 13:46-60.
    View in: PubMed
    Score: 0.032
  5. Leung YK, Ouyang B, Niu L, Xie C, Ying J, Medvedovic M, Chen A, Weihe P, Valvi D, Grandjean P, Ho SM. Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort. Epigenetics. 2018; 13(3):290-300.
    View in: PubMed
    Score: 0.025
  6. Stevenson M, Alexander B, Baxter CS, Leung YK. Evaluating Endocrine Disruption Activity of Deposits on Firefighting Gear Using a Sensitive and High Throughput Screening Method. J Occup Environ Med. 2015 Dec; 57(12):e153-7.
    View in: PubMed
    Score: 0.021
  7. Zhou Z, Badkas A, Stevenson M, Lee JY, Leung YK. Herceptin conjugated PLGA-PHis-PEG pH sensitive nanoparticles for targeted and controlled drug delivery. Int J Pharm. 2015 Jun 20; 487(1-2):81-90.
    View in: PubMed
    Score: 0.020
  8. Leung YK, Chan QK, Ng CF, Ma FM, Tse HM, To KF, Maranchie J, Ho SM, Lau KM. Hsa-miRNA-765 as a key mediator for inhibiting growth, migration and invasion in fulvestrant-treated prostate cancer. PLoS One. 2014; 9(5):e98037.
    View in: PubMed
    Score: 0.019
  9. Lee MT, Ho SM, Tarapore P, Chung I, Leung YK. Estrogen receptor ? isoform 5 confers sensitivity of breast cancer cell lines to chemotherapeutic agent-induced apoptosis through interaction with Bcl2L12. Neoplasia. 2013 Nov; 15(11):1262-71.
    View in: PubMed
    Score: 0.018
  10. Lee MT, Ouyang B, Ho SM, Leung YK. Differential expression of estrogen receptor beta isoforms in prostate cancer through interplay between transcriptional and translational regulation. Mol Cell Endocrinol. 2013 Aug 25; 376(1-2):125-35.
    View in: PubMed
    Score: 0.018
  11. Leung YK, Lee MT, Lam HM, Tarapore P, Ho SM. Estrogen receptor-beta and breast cancer: translating biology into clinical practice. Steroids. 2012 Jun; 77(7):727-37.
    View in: PubMed
    Score: 0.016
  12. Lam HM, Suresh Babu CV, Wang J, Yuan Y, Lam YW, Ho SM, Leung YK. Phosphorylation of human estrogen receptor-beta at serine 105 inhibits breast cancer cell migration and invasion. Mol Cell Endocrinol. 2012 Jul 06; 358(1):27-35.
    View in: PubMed
    Score: 0.016
  13. Ho SM, Johnson A, Tarapore P, Janakiram V, Zhang X, Leung YK. Environmental epigenetics and its implication on disease risk and health outcomes. ILAR J. 2012; 53(3-4):289-305.
    View in: PubMed
    Score: 0.016
  14. Ho SM, Lee MT, Lam HM, Leung YK. Estrogens and prostate cancer: etiology, mediators, prevention, and management. Endocrinol Metab Clin North Am. 2011 Sep; 40(3):591-614, ix.
    View in: PubMed
    Score: 0.016
  15. Leung YK, Ho SM. Estrogen receptor ?: switching to a new partner and escaping from estrogen. Sci Signal. 2011 Apr 12; 4(168):pe19.
    View in: PubMed
    Score: 0.015
  16. Leung YK, Lam HM, Wu S, Song D, Levin L, Cheng L, Wu CL, Ho SM. Estrogen receptor beta2 and beta5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion. Endocr Relat Cancer. 2010 Sep; 17(3):675-89.
    View in: PubMed
    Score: 0.015
  17. Leung YK, Mak P, Hassan S, Ho SM. Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling. Proc Natl Acad Sci U S A. 2006 Aug 29; 103(35):13162-7.
    View in: PubMed
    Score: 0.011
  18. Leung YK, Gao Y, Lau KM, Zhang X, Ho SM. ICI 182,780-regulated gene expression in DU145 prostate cancer cells is mediated by estrogen receptor-beta/NFkappaB crosstalk. Neoplasia. 2006 Apr; 8(4):242-9.
    View in: PubMed
    Score: 0.011
  19. Puvvula J, Braun JM, DeFranco EA, Ho SM, Leung YK, Huang S, Zhang X, Vuong AM, Kim SS, Percy Z, Chen A. Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta. Epigenetics. 2025 Dec; 20(1):2508067.
    View in: PubMed
    Score: 0.010
  20. Leung YK, Lau KM, Mobley J, Jiang Z, Ho SM. Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis. Cancer Res. 2005 May 01; 65(9):3726-34.
    View in: PubMed
    Score: 0.010
  21. Ho JW, Song JZ, Leung YK. Activation of p53 by specific agents in potential cancer therapy. Curr Med Chem Anticancer Agents. 2005 Mar; 5(2):131-5.
    View in: PubMed
    Score: 0.010
  22. Puvvula J, Song LC, Zalewska KJ, Alexander A, Manz KE, Braun JM, Pennell KD, DeFranco EA, Ho SM, Leung YK, Huang S, Vuong AM, Kim SS, Percy Z, Bhashyam P, Lee R, Jones DP, Tran V, Kim DV, Calafat AM, Botelho JC, Chen A. Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns. Metabolomics. 2025 Jan 25; 21(1):20.
    View in: PubMed
    Score: 0.010
  23. Shahror RA, Shosha E, Ji MH, Morris CA, Wild M, Zaman B, Mitchell CD, Tetelbom P, Leung YK, Phillips PH, Sallam AA, Fouda AY. Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology. Transl Vis Sci Technol. 2024 Aug 01; 13(8):30.
    View in: PubMed
    Score: 0.010
  24. Puvvula J, Manz KE, Braun JM, Pennell KD, DeFranco EA, Ho SM, Leung YK, Huang S, Vuong AM, Kim SS, Percy ZP, Bhashyam P, Lee R, Jones DP, Tran V, Kim DV, Chen A. Maternal and newborn metabolomic changes associated with urinary polycyclic aromatic hydrocarbon metabolite concentrations at delivery: an untargeted approach. Metabolomics. 2023 Dec 14; 20(1):6.
    View in: PubMed
    Score: 0.009
  25. Wang X, DeFilippis RA, Weldemichael T, Gunaganti N, Tran P, Leung YK, Shah NP, Li HY. An imidazo[1,2-a]pyridine-pyridine derivative potently inhibits FLT3-ITD and FLT3-ITD secondary mutants, including gilteritinib-resistant FLT3-ITD/F691L. Eur J Med Chem. 2024 Jan 15; 264:115977.
    View in: PubMed
    Score: 0.009
  26. Wang X, DeFilippis RA, Leung YK, Shah NP, Li HY. N-(3-Methoxyphenyl)-6-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl)pyridin-2-amine is an inhibitor of the FLT3-ITD and BCR-ABL pathways, and potently inhibits FLT3-ITD/D835Y and FLT3-ITD/F691L secondary mutants. Bioorg Chem. 2024 02; 143:106966.
    View in: PubMed
    Score: 0.009
  27. Zhang L, Moccia M, Briggs DC, Bharate JB, Lakkaniga NR, Knowles P, Yan W, Tran P, Kharbanda A, Wang X, Leung YK, Frett B, Santoro M, McDonald NQ, Carlomagno F, Li HY. Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose. J Med Chem. 2022 01 27; 65(2):1536-1551.
    View in: PubMed
    Score: 0.008
  28. Zhang L, Lakkaniga NR, Bharate JB, Mcconnell N, Wang X, Kharbanda A, Leung YK, Frett B, Shah NP, Li HY. Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor. Eur J Med Chem. 2021 Dec 05; 225:113776.
    View in: PubMed
    Score: 0.008
  29. Kharbanda A, Tran P, Zhang L, Leung YK, Li HY, Frett B. Discovery of 4-aminoquinolines as highly selective TGF?R1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology. Eur J Med Chem. 2021 Dec 05; 225:113763.
    View in: PubMed
    Score: 0.008
  30. Kharbanda A, Zhang L, Saha D, Tran P, Xu K, Li MO, Leung YK, Frett B, Li HY. Discovery and biological evaluation of phthalazines as novel non-kinase TGF? pathway inhibitors. Eur J Med Chem. 2021 Nov 05; 223:113660.
    View in: PubMed
    Score: 0.008
  31. Padala KP, Padala PR, Leung YK, Dennis RA, Ho SM. Untangling the Complex Interactions of Open Burn Pit Exposure and Health Outcomes: Response to Brumage et al. Prim Care Companion CNS Disord. 2021 04 22; 23(2).
    View in: PubMed
    Score: 0.008
  32. Padala KP, Padala PR, Leung YK, Dennis RA, Ho SM. Open Burn Pit Exposure and Concern About the COVID-19 Pandemic. Prim Care Companion CNS Disord. 2020 11 05; 22(6).
    View in: PubMed
    Score: 0.007
  33. Lakkaniga NR, Gunaganti N, Zhang L, Belachew B, Frett B, Leung YK, Li HY. Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation. Eur J Med Chem. 2020 Nov 15; 206:112691.
    View in: PubMed
    Score: 0.007
  34. Wongsurawat T, Jenjaroenpun P, De Loose A, Alkam D, Ussery DW, Nookaew I, Leung YK, Ho SM, Day JD, Rodriguez A. A novel Cas9-targeted long-read assay for simultaneous detection of IDH1/2 mutations and clinically relevant MGMT methylation in fresh biopsies of diffuse glioma. Acta Neuropathol Commun. 2020 06 20; 8(1):87.
    View in: PubMed
    Score: 0.007
  35. Lu Y, Liu X, Zhang E, Kopras EJ, Smith EP, Astreinidis A, Li C, Leung YK, Ho SM, Yu JJ. Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells. PLoS One. 2020; 15(2):e0228894.
    View in: PubMed
    Score: 0.007
  36. Khanal T, Leung YK, Jiang W, Timchenko N, Ho SM, Kim K. NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries. FASEB J. 2019 07; 33(7):8335-8348.
    View in: PubMed
    Score: 0.007
  37. Dworatzek E, Mahmoodzadeh S, Schriever C, Kusumoto K, Kramer L, Santos G, Fliegner D, Leung YK, Ho SM, Zimmermann WH, Lutz S, Regitz-Zagrosek V. Sex-specific regulation of collagen I and III expression by 17?-Estradiol in cardiac fibroblasts: role of estrogen receptors. Cardiovasc Res. 2019 02 01; 115(2):315-327.
    View in: PubMed
    Score: 0.007
  38. Alexander J, Teague AM, Chen J, Aston CE, Leung YK, Chernausek S, Simmons RA, Pinney SE. Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy. PLoS One. 2018; 13(2):e0190698.
    View in: PubMed
    Score: 0.006
  39. Khanal T, Choi K, Leung YK, Wang J, Kim D, Janakiram V, Cho SG, Puga A, Ho SM, Kim K. Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer. Sci Rep. 2017 09 06; 7(1):10662.
    View in: PubMed
    Score: 0.006
  40. Zhou Z, Kennell C, Lee JY, Leung YK, Tarapore P. Calcium phosphate-polymer hybrid nanoparticles for enhanced triple negative breast cancer treatment via co-delivery of paclitaxel and miR-221/222 inhibitors. Nanomedicine. 2017 02; 13(2):403-410.
    View in: PubMed
    Score: 0.006
  41. Cheong A, Zhang X, Cheung YY, Tang WY, Chen J, Ye SH, Medvedovic M, Leung YK, Prins GS, Ho SM. DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk. Epigenetics. 2016 09; 11(9):674-689.
    View in: PubMed
    Score: 0.006
  42. Ho SM, Cheong A, Adgent MA, Veevers J, Suen AA, Tam NNC, Leung YK, Jefferson WN, Williams CJ. Environmental factors, epigenetics, and developmental origin of reproductive disorders. Reprod Toxicol. 2017 03; 68:85-104.
    View in: PubMed
    Score: 0.006
  43. Rizzardi AE, Zhang X, Vogel RI, Kolb S, Geybels MS, Leung YK, Henriksen JC, Ho SM, Kwak J, Stanford JL, Schmechel SC. Quantitative comparison and reproducibility of pathologist scoring and digital image analysis of estrogen receptor ?2 immunohistochemistry in prostate cancer. Diagn Pathol. 2016 Jul 11; 11(1):63.
    View in: PubMed
    Score: 0.006
  44. Miller M, Bailey B, Govindarajah V, Levin L, Metzger T, Pinney SM, Leung YK, Ho SM. A community survey on knowledge of the impact of environmental and epigenetic factors on health and disease. Perspect Public Health. 2016 Nov; 136(6):345-352.
    View in: PubMed
    Score: 0.005
  45. Schade GR, Holt SK, Zhang X, Song D, Wright JL, Zhao S, Kolb S, Lam HM, Levin L, Leung YK, Ho SM, Stanford JL. Prostate Cancer Expression Profiles of Cytoplasmic ER?1 and Nuclear ER?2 are Associated with Poor Outcomes following Radical Prostatectomy. J Urol. 2016 06; 195(6):1760-6.
    View in: PubMed
    Score: 0.005
  46. Panchanathan R, Liu H, Leung YK, Ho SM, Choubey D. Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells. Mol Cell Endocrinol. 2015 Nov 05; 415:45-55.
    View in: PubMed
    Score: 0.005
  47. Ho SM, Cheong A, Lam HM, Hu WY, Shi GB, Zhu X, Chen J, Zhang X, Medvedovic M, Leung YK, Prins GS. Exposure of Human Prostaspheres to Bisphenol A Epigenetically Regulates SNORD Family Noncoding RNAs via Histone Modification. Endocrinology. 2015 Nov; 156(11):3984-95.
    View in: PubMed
    Score: 0.005
  48. Yang WS, Chadalapaka G, Cho SG, Lee SO, Jin UH, Jutooru I, Choi K, Leung YK, Ho SM, Safe S, Kim K. The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis. Neoplasia. 2014 Dec; 16(12):1059-69.
    View in: PubMed
    Score: 0.005
  49. Knower KC, To SQ, Leung YK, Ho SM, Clyne CD. Endocrine disruption of the epigenome: a breast cancer link. Endocr Relat Cancer. 2014 Apr; 21(2):T33-55.
    View in: PubMed
    Score: 0.005
  50. Langevin SM, Pinney SM, Leung YK, Ho SM. Does epigenetic drift contribute to age-related increases in breast cancer risk? Epigenomics. 2014; 6(4):367-9.
    View in: PubMed
    Score: 0.005
  51. Lee MT, Leung YK, Chung I, Tarapore P, Ho SM. Estrogen receptor ? (ER?1) transactivation is differentially modulated by the transcriptional coregulator Tip60 in a cis-acting element-dependent manner. J Biol Chem. 2013 Aug 30; 288(35):25038-25052.
    View in: PubMed
    Score: 0.004
  52. Brunst KJ, Leung YK, Ryan PH, Khurana Hershey GK, Levin L, Ji H, Lemasters GK, Ho SM. Forkhead box protein 3 (FOXP3) hypermethylation is associated with diesel exhaust exposure and risk for childhood asthma. J Allergy Clin Immunol. 2013 Feb; 131(2):592-4.e1-3.
    View in: PubMed
    Score: 0.004
  53. Ouyang B, Leung YK, Wang V, Chung E, Levin L, Bracken B, Cheng L, Ho SM. a-Methylacyl-CoA racemase spliced variants and their expression in normal and malignant prostate tissues. Urology. 2011 Jan; 77(1):249.e1-7.
    View in: PubMed
    Score: 0.004
  54. Zhang X, Wu M, Xiao H, Lee MT, Levin L, Leung YK, Ho SM. Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancer. Prostate. 2010 May 15; 70(7):765-76.
    View in: PubMed
    Score: 0.004
  55. Haynes EN, Heckel P, Ryan P, Roda S, Leung YK, Sebastian K, Succop P. Environmental manganese exposure in residents living near a ferromanganese refinery in Southeast Ohio: a pilot study. Neurotoxicology. 2010 Sep; 31(5):468-74.
    View in: PubMed
    Score: 0.003
  56. Hess-Wilson JK, Webb SL, Daly HK, Leung YK, Boldison J, Comstock CE, Sartor MA, Ho SM, Knudsen KE. Unique bisphenol A transcriptome in prostate cancer: novel effects on ERbeta expression that correspond to androgen receptor mutation status. Environ Health Perspect. 2007 Nov; 115(11):1646-53.
    View in: PubMed
    Score: 0.003
  57. Mak P, Leung YK, Tang WY, Harwood C, Ho SM. Apigenin suppresses cancer cell growth through ERbeta. Neoplasia. 2006 Nov; 8(11):896-904.
    View in: PubMed
    Score: 0.003
  58. Ho SM, Leung YK, Chung I. Estrogens and antiestrogens as etiological factors and therapeutics for prostate cancer. Ann N Y Acad Sci. 2006 Nov; 1089:177-93.
    View in: PubMed
    Score: 0.003
  59. Zhu X, Leav I, Leung YK, Wu M, Liu Q, Gao Y, McNeal JE, Ho SM. Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis. Am J Pathol. 2004 Jun; 164(6):2003-12.
    View in: PubMed
    Score: 0.002
  60. Ho JW, Leung YK, Chan CP. Herbal medicine in the treatment of cancer. Curr Med Chem Anticancer Agents. 2002 Mar; 2(2):209-14.
    View in: PubMed
    Score: 0.002
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.