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University of Arkansas for Medical Sciences
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INDICES OF BIOTIN NUTRITION
Overview
abstract
The long term goal of this research project is to determine the biotin requirement of normal individuals and individuals in specific clinical circumstances. The investigator proposes five specific aims to determine: 1) the usefulness of potential indicators of biotin status. 2) Whether the increased urinary excretion of 3-HIA detected previously in some adults and children treated chronically with anticonvulsant reflects biotin deficiency. 3) Whether increased urinary excretion of 3-HIA detected previously in some pregnant women reflects biotin deficiency. 4) Whether biotin deficiency of similar severity to that observed either early or late in human gestation causes increased rates of fetal malformation in the mouse. 5) The enzyme(s) responsible for biotin beta-oxidation.
sponsor award id
R01DK036823
Biography
contributor
Principal Investigator
Time
start date
1985-07-01
end date
2002-03-31