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Mitchell Mcgill to Humans

This is a "connection" page, showing publications Mitchell Mcgill has written about Humans.

 
Connection Strength
  
 
 
0.807
  
  1. McGill MR. The Role of Mechanistic Biomarkers in Understanding Acetaminophen Hepatotoxicity in Humans. Drug Metab Dispos. 2024 Jul 16; 52(8):729-739.
    View in: PubMed
    Score: 0.039
  2. Layman AJ, Alsbrook SM, Koturbash IK, McGill MR. Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements. J Diet Suppl. 2025; 22(1):105-122.
    View in: PubMed
    Score: 0.038
  3. Price JR, Hagrass H, Filip AB, McGill MR. LDH and the MELD-LDH in Severe Acute Liver Injury and Acute Liver Failure: Preliminary Confirmation of a Novel Prognostic Score for Risk Stratification. J Appl Lab Med. 2023 05 04; 8(3):504-513.
    View in: PubMed
    Score: 0.036
  4. McGill MR, James LP, McCullough SS, Moran JH, Mathews SE, Peterson EC, Fleming DP, Tripod ME, Vazquez JH, Kennon-McGill S, Spencer HJ, Dranoff JA. Short-Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis. Hepatol Commun. 2022 02; 6(2):361-373.
    View in: PubMed
    Score: 0.032
  5. McGill MR, Hinson JA. The development and hepatotoxicity of acetaminophen: reviewing over a century of progress. Drug Metab Rev. 2020 11; 52(4):472-500.
    View in: PubMed
    Score: 0.030
  6. Vazquez JH, Clemens MM, Allard FD, Yee EU, Kennon-McGill S, Mackintosh SG, Jaeschke H, Hambuchen MD, McGill MR. Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations. Toxicol Sci. 2020 02 01; 173(2):244-254.
    View in: PubMed
    Score: 0.028
  7. McGill MR, Jaeschke H. Biomarkers of drug-induced liver injury. Adv Pharmacol. 2019; 85:221-239.
    View in: PubMed
    Score: 0.027
  8. McGill MR, Jaeschke H. Animal models of drug-induced liver injury. Biochim Biophys Acta Mol Basis Dis. 2019 05 01; 1865(5):1031-1039.
    View in: PubMed
    Score: 0.026
  9. McGill MR. The Problem With Predictive Values: Are We Using the Right Metrics for Preclinical Prediction of Drug Hepatotoxicity? Toxicol Sci. 2018 09 01; 165(1):3-4.
    View in: PubMed
    Score: 0.026
  10. McGill MR, Jaeschke H. Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation. Expert Rev Mol Diagn. 2018 09; 18(9):797-807.
    View in: PubMed
    Score: 0.026
  11. Lutkewitte AJ, Schweitzer GG, Kennon-McGill S, Clemens MM, James LP, Jaeschke H, Finck BN, McGill MR. Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration. Food Chem Toxicol. 2018 May; 115:273-283.
    View in: PubMed
    Score: 0.025
  12. McGill MR, Gronowski AM. Increased C-Reactive Protein in Healthy Controls. Clin Chem. 2018 01; 64(1):242-243.
    View in: PubMed
    Score: 0.025
  13. McGill MR, Vijayan A, Trulock EP, Witt CA, Kohler GD, Scott MG. Falsely Elevated Plasma Creatinine Due to an Immunoglobulin M Paraprotein. Am J Kidney Dis. 2016 Nov; 68(5):789-792.
    View in: PubMed
    Score: 0.022
  14. McGill MR, Du K, Weemhoff JL, Jaeschke H. Critical review of resveratrol in xenobiotic-induced hepatotoxicity. Food Chem Toxicol. 2015 Dec; 86:309-18.
    View in: PubMed
    Score: 0.021
  15. Jaeschke H, McGill MR. Cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity. Toxicol Lett. 2015 Jun 15; 235(3):216-7.
    View in: PubMed
    Score: 0.020
  16. McGill MR, Du K, Xie Y, Bajt ML, Ding WX, Jaeschke H. The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury. Xenobiotica. 2015 May; 45(5):442-9.
    View in: PubMed
    Score: 0.020
  17. McGill MR, Staggs VS, Sharpe MR, Lee WM, Jaeschke H. Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome. Hepatology. 2014 Oct; 60(4):1336-45.
    View in: PubMed
    Score: 0.020
  18. McGill MR, Jaeschke H. Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients. Expert Opin Drug Metab Toxicol. 2014 Jul; 10(7):1005-17.
    View in: PubMed
    Score: 0.019
  19. McGill MR, Cao M, Svetlov A, Sharpe MR, Williams CD, Curry SC, Farhood A, Jaeschke H, Svetlov SI. Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans. Biomarkers. 2014 May; 19(3):222-30.
    View in: PubMed
    Score: 0.019
  20. McGill MR, Jaeschke H. Apoptosis or necrosis in acetaminophen-induced acute liver failure? New insights from mechanistic biomarkers*. Crit Care Med. 2013 Nov; 41(11):2653-4.
    View in: PubMed
    Score: 0.018
  21. McGill MR, Li F, Sharpe MR, Williams CD, Curry SC, Ma X, Jaeschke H. Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans. Arch Toxicol. 2014 Feb; 88(2):391-401.
    View in: PubMed
    Score: 0.018
  22. Jaeschke H, McGill MR. Serum glutamate dehydrogenase--biomarker for liver cell death or mitochondrial dysfunction? Toxicol Sci. 2013 Jul; 134(1):221-2.
    View in: PubMed
    Score: 0.018
  23. McGill MR, Jaeschke H. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res. 2013 Sep; 30(9):2174-87.
    View in: PubMed
    Score: 0.018
  24. Jaeschke H, Williams CD, McGill MR. Caveats of using acetaminophen hepatotoxicity models for natural product testing. Toxicol Lett. 2012 Nov 23; 215(1):40-1.
    View in: PubMed
    Score: 0.017
  25. McGill MR, Sharpe MR, Williams CD, Taha M, Curry SC, Jaeschke H. The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J Clin Invest. 2012 Apr; 122(4):1574-83.
    View in: PubMed
    Score: 0.016
  26. McGill MR, Yan HM, Ramachandran A, Murray GJ, Rollins DE, Jaeschke H. HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity. Hepatology. 2011 Mar; 53(3):974-82.
    View in: PubMed
    Score: 0.015
  27. Poole LG, Wei Z, Schulte A, Cline HM, Bernard MP, Buchweitz JP, McGill MR, Luyendyk JP. Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury. Toxicol Sci. 2025 Jun 01; 205(2):417-427.
    View in: PubMed
    Score: 0.010
  28. Ewing LE, Skinner CM, McGill MR, Kennon-McGill S, Clement K, Quick CM, Yee EU, Williams DK, Walker LA, ElSohly MA, Gurley BJ, Koturbash I. Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract. Drug Chem Toxicol. 2025 May; 48(3):578-585.
    View in: PubMed
    Score: 0.010
  29. Clement K, McGill MR, Miousse IR, Young SG, Melnyk S, Koturbash I. Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells. J Diet Suppl. 2023; 20(6):950-962.
    View in: PubMed
    Score: 0.009
  30. Gurley BJ, McGill MR, Koturbash I. Hepatotoxicity due to herbal dietary supplements: Past, present and the future. Food Chem Toxicol. 2022 Nov; 169:113445.
    View in: PubMed
    Score: 0.009
  31. Woolbright BL, Nguyen NT, McGill MR, Sharpe MR, Curry SC, Jaeschke H. Generation of pro-and anti-inflammatory mediators after acetaminophen overdose in surviving and non-surviving patients. Toxicol Lett. 2022 Aug 15; 367:59-66.
    View in: PubMed
    Score: 0.008
  32. Vazquez JH, Kennon-McGill S, Byrum SD, Mackintosh SG, Jaeschke H, Williams DK, Lee WM, Dranoff JA, McGill MR. Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways. Toxicol Sci. 2022 04 26; 187(1):25-34.
    View in: PubMed
    Score: 0.008
  33. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-G?mez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, ?lvarez ?MC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Ant?n Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Ara?jo WL, Araya J, Arden C, Ar?valo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnaun?-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, ?valos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, B?nr?ti ?, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Baril? D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touz? N, Bellarosa C, Belleudi F, Bell? P?rez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Bur?n MI, Bustos V, B?ttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cair? M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, Canonico B, Cant? C, Cao B, Caraglia M, Caram?s B, Carchman EH, Cardenal-Mu?oz E, Cardenas C, Cardenas L, Cardoso SM, Carew JS, Carle GF, Carleton G, Carloni S, Carmona-Gutierrez D, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382.
    View in: PubMed
    Score: 0.008
  34. Liss KHH, Ek SE, Lutkewitte AJ, Pietka TA, He M, Skaria P, Tycksen E, Ferguson D, Blanc V, Graham MJ, Hall AM, McGill MR, McCommis KS, Finck BN. Monoacylglycerol Acyltransferase 1 Knockdown Exacerbates Hepatic Ischemia/Reperfusion Injury in Mice With Hepatic Steatosis. Liver Transpl. 2021 01; 27(1):116-133.
    View in: PubMed
    Score: 0.007
  35. James LP, McGill MR, Roberts DW, Hinson JA, Lee WM. Advances in biomarker development in acetaminophen toxicity. Adv Clin Chem. 2020; 98:35-50.
    View in: PubMed
    Score: 0.007
  36. McCullough S, Dweep H, McGill MR, Bhattacharyya S, James L, Frankowski S, Woodall A, Kearns G, Gill P. Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children. Microrna. 2020; 9(2):121-132.
    View in: PubMed
    Score: 0.007
  37. Clemens MM, McGill MR, Apte U. Mechanisms and biomarkers of liver regeneration after drug-induced liver injury. Adv Pharmacol. 2019; 85:241-262.
    View in: PubMed
    Score: 0.007
  38. Kennedy JL, Kurten RC, McCullough S, Panettieri RA, Koziol-White C, Jones SM, Caid K, Gill PS, Roberts D, Jaeschke H, McGill MR, James L. Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways. Xenobiotica. 2019 Sep; 49(9):1106-1115.
    View in: PubMed
    Score: 0.007
  39. Tesfazghi MT, McGill MR, Yarbrough ML. What's Causing This Dark Brown Plasma? J Appl Lab Med. 2019 07; 4(1):125-129.
    View in: PubMed
    Score: 0.007
  40. Weemhoff JL, Woolbright BL, Jenkins RE, McGill MR, Sharpe MR, Olson JC, Antoine DJ, Curry SC, Jaeschke H. Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis. Liver Int. 2017 03; 37(3):377-384.
    View in: PubMed
    Score: 0.006
  41. Michaut A, Le Guillou D, Moreau C, Bucher S, McGill MR, Martinais S, Gicquel T, Morel I, Robin MA, Jaeschke H, Fromenty B. A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. Toxicol Appl Pharmacol. 2016 Feb 01; 292:40-55.
    View in: PubMed
    Score: 0.005
  42. Du K, McGill MR, Xie Y, Jaeschke H. Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses. Food Chem Toxicol. 2015 Dec; 86:253-61.
    View in: PubMed
    Score: 0.005
  43. Xie Y, McGill MR, Du K, Dorko K, Kumer SC, Schmitt TM, Ding WX, Jaeschke H. Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes. Toxicol Appl Pharmacol. 2015 Dec 01; 289(2):213-22.
    View in: PubMed
    Score: 0.005
  44. Woolbright BL, McGill MR, Yan H, Jaeschke H. Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes. Basic Clin Pharmacol Toxicol. 2016 Feb; 118(2):160-7.
    View in: PubMed
    Score: 0.005
  45. Du K, Xie Y, McGill MR, Jaeschke H. Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity. Expert Opin Drug Metab Toxicol. 2015; 11(11):1769-79.
    View in: PubMed
    Score: 0.005
  46. Xie Y, McGill MR, Cook SF, Sharpe MR, Winefield RD, Wilkins DG, Rollins DE, Jaeschke H. Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells. Xenobiotica. 2015; 45(10):921-9.
    View in: PubMed
    Score: 0.005
  47. Woolbright BL, McGill MR, Staggs VS, Winefield RD, Gholami P, Olyaee M, Sharpe MR, Curry SC, Lee WM, Jaeschke H. Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients. Toxicol Sci. 2014 Dec; 142(2):436-44.
    View in: PubMed
    Score: 0.005
  48. Ward J, Kanchagar C, Veksler-Lublinsky I, Lee RC, McGill MR, Jaeschke H, Curry SC, Ambros VR. Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis. Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):12169-74.
    View in: PubMed
    Score: 0.005
  49. Xie Y, McGill MR, Dorko K, Kumer SC, Schmitt TM, Forster J, Jaeschke H. Mechanisms of acetaminophen-induced cell death in primary human hepatocytes. Toxicol Appl Pharmacol. 2014 Sep 15; 279(3):266-274.
    View in: PubMed
    Score: 0.005
  50. Williams CD, Bajt ML, Sharpe MR, McGill MR, Farhood A, Jaeschke H. Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans. Toxicol Appl Pharmacol. 2014 Mar 01; 275(2):122-33.
    View in: PubMed
    Score: 0.005
  51. Jaeschke H, Williams CD, McGill MR, Xie Y, Ramachandran A. Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products. Food Chem Toxicol. 2013 May; 55:279-89.
    View in: PubMed
    Score: 0.004
  52. Jaeschke H, McGill MR, Williams CD. Pathophysiological relevance of neutrophils in acetaminophen hepatotoxicity. Hepatology. 2013 Jan; 57(1):419.
    View in: PubMed
    Score: 0.004
  53. Woolbright BL, Ramachandran A, McGill MR, Yan HM, Bajt ML, Sharpe MR, Lemasters JJ, Jaeschke H. Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity. Basic Clin Pharmacol Toxicol. 2012 Dec; 111(6):417-25.
    View in: PubMed
    Score: 0.004
  54. Antoine DJ, Jenkins RE, Dear JW, Williams DP, McGill MR, Sharpe MR, Craig DG, Simpson KJ, Jaeschke H, Park BK. RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. J Hepatol. 2012 05; 56(5):1070-1079.
    View in: PubMed
    Score: 0.004
  55. Jaeschke H, McGill MR, Ramachandran A. Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev. 2012 Feb; 44(1):88-106.
    View in: PubMed
    Score: 0.004
  56. Jaeschke H, McGill MR, Ramachandran A. Pathophysiological relevance of proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Jun; 121(2):428-30; author reply 431-3.
    View in: PubMed
    Score: 0.004
  57. Katayama H, McGill M, Kearns A, Brzozowski M, Degner N, Harnett B, Kornilayev B, Matkovic-Calogovic D, Holyoak T, Calvet JP, Gogol EP, Seed J, Fisher MT. Strategies for folding of affinity tagged proteins using GroEL and osmolytes. J Struct Funct Genomics. 2009 Mar; 10(1):57-66.
    View in: PubMed
    Score: 0.003
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.