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Kirk West

TitlePost Doctoral Fellow
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentRadiation Oncology, College of Medicine
DivisionRadiation Oncology Laboratory
AddressB405 Biomedical Research I
4104 Outpatient Circle
Mail Slot # 771
Little Rock AR 72205
Phone501-526-6990 x2494
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    Collapse Research 
    Collapse research activities and funding
    P20GM152281     (EOFF, ROBERT L)Mar 5, 2024 - Dec 31, 2028
    NIH
    Center for Molecular Interactions in Cancer (CMIC)
    Role: Principal Investigator
    P20GM121293     (BYRD, ALICIA K)Jul 1, 2022 - Jun 30, 2027
    NIH/Nat. Inst. of General Medical Sciences - Pass Through: Arkansas Children's Research Institute
    Role of HELB in the Replication Stress Response Dr. Tacketts COBRA through ACRI
    Role: Co-Investigator
    865850     (WEST, KIRK L)Jan 1, 2022 - Dec 31, 2024
    American Cancer Society, Inc.
    Defining the role of LC8-TLK1/2 axis in the DNA repair pathway
    Role: Principal Investigator
    PF-21-083-01-DMC     (WEST, KIRK L)Jan 1, 2022 - Dec 31, 2024
    American Cancer Society, Inc.
    Defining the role of LC8-TLK1/2 axis in the DNA repair pathway
    Role: Principal Investigator
    R01CA244261     (EOFF, ROBERT L)Mar 1, 2021 - Feb 28, 2027
    NIH/Nat. Cancer Institute
    Mechanistic characterization of the cell cycle-dependent DNA repair pathway- Resubmission
    Role: Principal Investigator
    RSG-20-131-01-DMC     (WEST, KIRK L)Jan 1, 2021 - Dec 31, 2024
    American Cancer Society, Inc.
    Mechanistic characterization of the cell cycle-dependent DNA repair pathway
    Role: Principal Investigator
    R35GM137798     (LEUNG, JUSTIN WAI CHUNG)Sep 1, 2020 - Aug 31, 2025
    NIH/Nat. Inst. of General Medical Sciences
    Deciphering the chromatin-based DNA damage response pathway
    Role: Co-Investigator
    R21ES025268     (TACKETT, ALAN)Apr 8, 2015 - Mar 31, 2018
    NIH
    Identifying the Epigenetic Regulation of Arsenic Exposure
    Role: Co-Investigator
    R01GM106024     (TAVERNA, SEAN D.)Jul 1, 2013 - Apr 30, 2018
    NIH
    Using ChAP-MS to Study Macromolecular Chromatin Composition during Transcription
    Role: Co-Investigator
    PF     (ARNAOUTAKIS, KONSTANTINOS)Nov 22, 2011
    Pfizer, Inc.
    Pfizer A7471009, A Randomized Double Blind Phase 3 Efficacy and Safety Study of PF-00299804 versus Erlotinib for the Treatment of Advanced Non-Small C
    Role: Principal Investigator
    RSG     (MACNICOL, ANGUS)Mar 1, 2002 - Feb 28, 2006
    American Cancer Society, Inc.
    MRNA translational Control of Cell Cycle Progression
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Li J, Xiong N, West KL, Leung M, Ching YP, Huang J, Yuan J, Yu CH, Leung J, Huen M. Nuclear F-actin assembly on damaged chromatin is regulated by DYRK1A and Spir1 phosphorylation. Nucleic Acids Res. 2024 Aug 27; 52(15):8897-8912. PMID: 38966995.
      View in: PubMed
    2. West KL, Kreiling N, Raney KD, Ghosal G, Leung JW. Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction. bioRxiv. 2024 Apr 26. PMID: 38712247.
      View in: PubMed
    3. Osei B, May BH, Stiefel CM, West KL, Zafar MK, Thompson MD, Bergstrom E, Leung JW, Enemark EJ, Byrd AK. Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB. bioRxiv. 2024 Mar 02. PMID: 38464108.
      View in: PubMed
    4. Dong C, West KL, Tan XY, Li J, Ishibashi T, Yu CH, Sy SMH, Leung JWC, Huen MSY. Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin. Proc Natl Acad Sci U S A. 2020 07 21; 117(29):17019-17030. PMID: 32611815.
      View in: PubMed
    5. Kelliher JL, West KL, Gong Q, Leung JWC. Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination. Nat Commun. 2020 05 18; 11(1):2462. PMID: 32424115.
      View in: PubMed
    6. West KL, Kelliher JL, Xu Z, An L, Reed MR, Eoff RL, Wang J, Huen MSY, Leung JWC. LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation. Nucleic Acids Res. 2019 07 09; 47(12):6236-6249. PMID: 30982887.
      View in: PubMed
    7. Gao J, Byrd AK, Zybailov BL, Marecki JC, Guderyon MJ, Edwards AD, Chib S, West KL, Waldrip ZJ, Mackintosh SG, Gao Z, Putnam AA, Jankowsky E, Raney KD. DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA. Chem Commun (Camb). 2019 Apr 11; 55(31):4467-4470. PMID: 30855040.
      View in: PubMed
    8. West KL, Byrum SD, Mackintosh SG, Edmondson RD, Taverna SD, Tackett AJ. Proteomic characterization of the arsenic response locus in S. cerevisiae. Epigenetics. 2019 02; 14(2):130-145. PMID: 30739529.
      View in: PubMed
    9. Shields BD, Koss B, Taylor EM, Storey AJ, West KL, Byrum SD, Mackintosh SG, Edmondson R, Mahmoud F, Shalin SC, Tackett AJ. Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma. Cancer Res. 2019 03 15; 79(6):1113-1123. PMID: 30674537.
      View in: PubMed
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