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Shannon Rose

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPeds Pediatrics, College of Medicine
DivisionPeds Allergy
Address ACH Research Institute
4104 Outpatient Circle
Mail Slot # 512-41B
Little Rock AR 72205
Phone501-364-4083
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    Collapse Research 
    Collapse research activities and funding
    GR034196     (ROSE, SHANNON P)Aug 1, 2022 - Jul 31, 2023
    NIH/Nat. Inst. of General Medical Sciences - Pass Through: UAMS ACHRI Flow Through
    GR034196 Rose(Weber) COBRE Phase 2 RPL
    Role: Principal Investigator
    GR037153     (ROSE, SHANNON P)Aug 1, 2020 - Jul 31, 2021
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI # TDB     (ROSE, SHANNON P)Feb 4, 2019 - Jan 31, 2021
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI#TDB     (ROSE, SHANNON P)Feb 4, 2019 - Jan 31, 2021
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI # 037099     (ROSE, SHANNON P)Apr 1, 2017 - Sep 30, 2019
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI#037099     (ROSE, SHANNON P)Apr 1, 2017 - Sep 30, 2019
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI # 035730     (ROSE, SHANNON P)Feb 1, 2017 - Jan 31, 2020
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI#035730     (ROSE, SHANNON P)Feb 1, 2017 - Jan 31, 2020
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI #033987     (ROSE, SHANNON P)Jul 1, 2016 - Jun 30, 2019
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI#033987     (ROSE, SHANNON P)Jul 1, 2016 - Jun 30, 2019
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI # TBD     (CHEN, JIN-RAN)May 15, 2016 - Apr 30, 2021
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI#TBD     (CHEN, JIN-RAN)May 15, 2016 - Apr 30, 2021
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Mercado L, Rose S, Escalona-Vargas D, Siegel ER, Whittington JR, Preissl H, Helmich M, Eswaran H. Correlation of fetal heart rate dynamics to inflammatory markers and brain-derived neurotrophic factor during pregnancy. J Perinat Med. 2024 Feb 27. PMID: 38404246.
      View in: PubMed
    2. Frye RE, Rose S, Voinsky I, Gurwitz D. Nitrosative Stress in Autism: Supportive Evidence and Implications for Mitochondrial Dysfunction. Adv Sci (Weinh). 2024 Feb 21; e2304439. PMID: 38380535.
      View in: PubMed
    3. Frye RE, McCarty PJ, Werner BA, Rose S, Scheck AC. Bioenergetic signatures of neurodevelopmental regression. Front Physiol. 2024; 15:1306038. PMID: 38449786.
      View in: PubMed
    4. Santos D, Porter-Gill P, Goode G, Delhey L, S?rensen AE, Rose S, B?rsheim E, Dalgaard LT, Carvalho E. Circulating microRNA levels differ in the early stages of insulin resistance in prepubertal children with obesity. Life Sci. 2023 Jan 01; 312:121246. PMID: 36455651.
      View in: PubMed
    5. Frye RE, Cakir J, McCarty PJ, Rose S, Delhey LM, Palmer RF, Austin C, Curtin P, Yitshak-Sade M, Arora M. Air Pollution and Maximum Temperature Are Associated with Neurodevelopmental Regressive Events in Autism Spectrum Disorder. J Pers Med. 2022 Nov 01; 12(11). PMID: 36579525.
      View in: PubMed
    6. Brister D, Rose S, Delhey L, Tippett M, Jin Y, Gu H, Frye RE. Metabolomic Signatures of Autism Spectrum Disorder. J Pers Med. 2022 Oct 17; 12(10). PMID: 36294866.
      View in: PubMed
    7. Voinsky I, Zoabi Y, Shomron N, Harel M, Cassuto H, Tam J, Rose S, Scheck AC, Karim MA, Frye RE, Aran A, Gurwitz D. Blood RNA Sequencing Indicates Upregulated BATF2 and LY6E and Downregulated ISG15 and MT2A Expression in Children with Autism Spectrum Disorder. Int J Mol Sci. 2022 Aug 30; 23(17). PMID: 36077244.
      View in: PubMed
    8. Gill PS, Dweep H, Rose S, Wickramasinghe PJ, Vyas KK, McCullough S, Porter-Gill PA, Frye RE. Integrated microRNA-mRNA Expression Profiling Identifies Novel Targets and Networks Associated with Autism. J Pers Med. 2022 Jun 01; 12(6). PMID: 35743705.
      View in: PubMed
    9. Barbosa P, Landes RD, Graw S, Byrum SD, Bennuri S, Delhey L, Randolph C, MacLeod S, Reis A, B?rsheim E, Rose S, Carvalho E. Effect of excess weight and insulin resistance on DNA methylation in prepubertal children. Sci Rep. 2022 05 19; 12(1):8430. PMID: 35589784.
      View in: PubMed
    10. Werner BA, McCarty PJ, Lane AL, Singh I, Karim MA, Rose S, Frye RE. Time dependent changes in the bioenergetics of peripheral blood mononuclear cells: processing time, collection tubes and cryopreservation effects. Am J Transl Res. 2022; 14(3):1628-1639. PMID: 35422946.
      View in: PubMed
    11. Frye RE, Rose S, Boles RG, Rossignol DA. A Personalized Approach to Evaluating and Treating Autism Spectrum Disorder. J Pers Med. 2022 Jan 24; 12(2). PMID: 35207636.
      View in: PubMed
    12. Frye RE, Lionnard L, Singh I, Karim MA, Chajra H, Frechet M, Kissa K, Racine V, Ammanamanchi A, McCarty PJ, Delhey L, Tippett M, Rose S, Aouacheria A. Mitochondrial morphology is associated with respiratory chain uncoupling in autism spectrum disorder. Transl Psychiatry. 2021 10 13; 11(1):527. PMID: 34645790.
      View in: PubMed
    13. Frye RE, Rose S, McCullough S, Bennuri SC, Porter-Gill PA, Dweep H, Gill PS. MicroRNA Expression Profiles in Autism Spectrum Disorder: Role for miR-181 in Immunomodulation. J Pers Med. 2021 Sep 17; 11(9). PMID: 34575699.
      View in: PubMed
    14. Barbosa P, Melnyk S, Bennuri SC, Delhey L, Reis A, Moura GR, B?rsheim E, Rose S, Carvalho E. Redox Imbalance and Methylation Disturbances in Early Childhood Obesity. Oxid Med Cell Longev. 2021; 2021:2207125. PMID: 34457110.
      View in: PubMed
    15. Frye RE, Cakir J, Rose S, Palmer RF, Austin C, Curtin P. Physiological mediators of prenatal environmental influences in autism spectrum disorder. Bioessays. 2021 09; 43(9):e2000307. PMID: 34260745.
      View in: PubMed
    16. Hakkak R, Rose S, Spray B, Kozaczek M, Korourian S. Effects of obesity and 10 weeks metformin treatment on liver steatosis. Biomed Rep. 2021 Jun; 14(6):49. PMID: 33859820.
      View in: PubMed
    17. Frye RE, Cakir J, Rose S, Palmer RF, Austin C, Curtin P, Arora M. Mitochondria May Mediate Prenatal Environmental Influences in Autism Spectrum Disorder. J Pers Med. 2021 Mar 18; 11(3). PMID: 33803789.
      View in: PubMed
    18. Frye RE, Cakir J, Rose S, Delhey L, Bennuri SC, Tippett M, Melnyk S, James SJ, Palmer RF, Austin C, Curtin P, Arora M. Prenatal air pollution influences neurodevelopment and behavior in autism spectrum disorder by modulating mitochondrial physiology. Mol Psychiatry. 2021 05; 26(5):1561-1577. PMID: 32963337.
      View in: PubMed
    19. Frye RE, Cakir J, Rose S, Delhey L, Bennuri SC, Tippett M, Palmer RF, Austin C, Curtin P, Arora M. Early life metal exposure dysregulates cellular bioenergetics in children with regressive autism spectrum disorder. Transl Psychiatry. 2020 07 07; 10(1):223. PMID: 32636364.
      View in: PubMed
    20. Voinsky I, Bennuri SC, Svigals J, Frye RE, Rose S, Gurwitz D. Peripheral Blood Mononuclear Cell Oxytocin and Vasopressin Receptor Expression Positively Correlates with Social and Behavioral Function in Children with Autism. Sci Rep. 2019 09 17; 9(1):13443. PMID: 31530830.
      View in: PubMed
    21. Harville T, Rhodes-Clark B, Bennuri SC, Delhey L, Slattery J, Tippett M, Wynne R, Rose S, Kahler S, Frye RE. Inheritance of HLA-Cw7 Associated With Autism Spectrum Disorder (ASD). Front Psychiatry. 2019; 10:612. PMID: 31572230.
      View in: PubMed
    22. Jyonouchi H, Geng L, Toruner GA, Rose S, Bennuri SC, Frye RE. Serum microRNAs in ASD: Association With Monocyte Cytokine Profiles and Mitochondrial Respiration. Front Psychiatry. 2019; 10:614. PMID: 31551826.
      View in: PubMed
    23. Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, B?rsheim E. A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab. 2019 09 01; 317(3):E503-E512. PMID: 31211617.
      View in: PubMed
    24. Bennuri SC, Rose S, Frye RE. Mitochondrial Dysfunction Is Inducible in Lymphoblastoid Cell Lines From Children With Autism and May Involve the TORC1 Pathway. Front Psychiatry. 2019; 10:269. PMID: 31133888.
      View in: PubMed
    25. Jyonouchi H, Geng L, Rose S, Bennuri SC, Frye RE. Variations in Mitochondrial Respiration Differ in IL-1?/IL-10 Ratio Based Subgroups in Autism Spectrum Disorders. Front Psychiatry. 2019; 10:71. PMID: 30842746.
      View in: PubMed
    26. Vargason T, Kruger U, Roth E, Delhey LM, Tippett M, Rose S, Bennuri SC, Slattery JC, Melnyk S, James SJ, Frye RE, Hahn J. Comparison of Three Clinical Trial Treatments for Autism Spectrum Disorder Through Multivariate Analysis of Changes in Metabolic Profiles and Adaptive Behavior. Front Cell Neurosci. 2018; 12:503. PMID: 30618645.
      View in: PubMed
    27. Rose S, Niyazov DM, Rossignol DA, Goldenthal M, Kahler SG, Frye RE. Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder. Mol Diagn Ther. 2018 10; 22(5):571-593. PMID: 30039193.
      View in: PubMed
    28. Connery K, Tippett M, Delhey LM, Rose S, Slattery JC, Kahler SG, Hahn J, Kruger U, Cunningham MW, Shimasaki C, Frye RE. Intravenous immunoglobulin for the treatment of autoimmune encephalopathy in children with autism. Transl Psychiatry. 2018 08 10; 8(1):148. PMID: 30097568.
      View in: PubMed
    29. Howsmon DP, Vargason T, Rubin RA, Delhey L, Tippett M, Rose S, Bennuri SC, Slattery JC, Melnyk S, James SJ, Frye RE, Hahn J. Multivariate techniques enable a biochemical classification of children with autism spectrum disorder versus typically-developing peers: A comparison and validation study. Bioeng Transl Med. 2018 May; 3(2):156-165. PMID: 30065970.
      View in: PubMed
    30. Delhey LM, Tippett M, Rose S, Bennuri SC, Slattery JC, Melnyk S, James SJ, Frye RE. Comparison of Treatment for Metabolic Disorders Associated with Autism:Reanalysis of Three Clinical Trials. Front Neurosci. 2018; 12:19. PMID: 29483858.
      View in: PubMed
    31. Rose S, Bennuri SC, Davis JE, Wynne R, Slattery JC, Tippett M, Delhey L, Melnyk S, Kahler SG, MacFabe DF, Frye RE. Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism. Transl Psychiatry. 2018 02 02; 8(1):42. PMID: 29391397.
      View in: PubMed
    32. Frye RE, Nankova B, Bhattacharyya S, Rose S, Bennuri SC, MacFabe DF. Modulation of Immunological Pathways in Autistic and Neurotypical Lymphoblastoid Cell Lines by the Enteric Microbiome Metabolite Propionic Acid. Front Immunol. 2017; 8:1670. PMID: 29312285.
      View in: PubMed
    33. Rose S, Bennuri SC, Murray KF, Buie T, Winter H, Frye RE. Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study. PLoS One. 2017; 12(10):e0186377. PMID: 29028817.
      View in: PubMed
    34. Burger BJ, Rose S, Bennuri SC, Gill PS, Tippett ML, Delhey L, Melnyk S, Frye RE. Autistic Siblings with Novel Mutations in Two Different Genes: Insight for Genetic Workups of Autistic Siblings and Connection to Mitochondrial Dysfunction. Front Pediatr. 2017; 5:219. PMID: 29075622.
      View in: PubMed
    35. Delhey L, Kilinc EN, Yin L, Slattery J, Tippett M, Wynne R, Rose S, Kahler S, Damle S, Legido A, Goldenthal MJ, Frye RE. Bioenergetic variation is related to autism symptomatology. Metab Brain Dis. 2017 12; 32(6):2021-2031. PMID: 28852932.
      View in: PubMed
    36. Frye RE, Rose S, Wynne R, Bennuri SC, Blossom S, Gilbert KM, Heilbrun L, Palmer RF. Oxidative Stress Challenge Uncovers Trichloroacetaldehyde Hydrate-Induced Mitoplasticity in Autistic and Control Lymphoblastoid Cell Lines. Sci Rep. 2017 06 30; 7(1):4478. PMID: 28667285.
      View in: PubMed
    37. Delhey LM, Nur Kilinc E, Yin L, Slattery JC, Tippett ML, Rose S, Bennuri SC, Kahler SG, Damle S, Legido A, Goldenthal MJ, Frye RE. The Effect of Mitochondrial Supplements on Mitochondrial Activity in Children with Autism Spectrum Disorder. J Clin Med. 2017 Feb 13; 6(2). PMID: 28208802.
      View in: PubMed
    38. Rose S, Bennuri SC, Wynne R, Melnyk S, James SJ, Frye RE. Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study. FASEB J. 2017 03; 31(3):904-909. PMID: 27864377.
      View in: PubMed
    39. Chen JR, Lazarenko OP, Blackburn ML, Rose S, Frye RE, Badger TM, Andres A, Shankar K. Maternal Obesity Programs Senescence Signaling and Glucose Metabolism in Osteo-Progenitors From Rat and Human. Endocrinology. 2016 Nov; 157(11):4172-4183. PMID: 27653035.
      View in: PubMed
    40. Frye RE, Delhey L, Slattery J, Tippett M, Wynne R, Rose S, Kahler SG, Bennuri SC, Melnyk S, Sequeira JM, Quadros E. Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups. Front Neurosci. 2016; 10:80. PMID: 27013943.
      View in: PubMed
    41. Frye RE, Rose S, Slattery J, MacFabe DF. Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome. Microb Ecol Health Dis. 2015; 26:27458. PMID: 25956238.
      View in: PubMed
    42. Rose S, Wynne R, Frye RE, Melnyk S, James SJ. Increased susceptibility to ethylmercury-induced mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines. J Toxicol. 2015; 2015:573701. PMID: 25688267.
      View in: PubMed
    43. Rose S, Frye RE, Slattery J, Wynne R, Tippett M, Pavliv O, Melnyk S, James SJ. Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort. PLoS One. 2014; 9(1):e85436. PMID: 24416410.
      View in: PubMed
    44. Rose S, Melnyk S, Pavliv O, Bai S, Nick TG, Frye RE, James SJ. Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain. Transl Psychiatry. 2012 Jul 10; 2:e134. PMID: 22781167.
      View in: PubMed
    45. Melnyk S, Fuchs GJ, Schulz E, Lopez M, Kahler SG, Fussell JJ, Bellando J, Pavliv O, Rose S, Seidel L, Gaylor DW, James SJ. Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism. J Autism Dev Disord. 2012 Mar; 42(3):367-77. PMID: 21519954.
      View in: PubMed
    46. Rose S, Melnyk S, Trusty TA, Pavliv O, Seidel L, Li J, Nick T, James SJ. Intracellular and extracellular redox status and free radical generation in primary immune cells from children with autism. Autism Res Treat. 2012; 2012:986519. PMID: 22928106.
      View in: PubMed
    47. James SJ, Rose S, Melnyk S, Jernigan S, Blossom S, Pavliv O, Gaylor DW. Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism. FASEB J. 2009 Aug; 23(8):2374-83. PMID: 19307255.
      View in: PubMed
    48. James SJ, Melnyk S, Jernigan S, Hubanks A, Rose S, Gaylor DW. Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism. J Autism Dev Disord. 2008 Nov; 38(10):1976. PMID: 19011973.
      View in: PubMed
    49. James SJ, Jill James S, Melnyk S, Jernigan S, Hubanks A, Rose S, Gaylor DW. Abnormal transmethylation/transsulfuration metabolism and DNA hypomethylation among parents of children with autism. J Autism Dev Disord. 2008 Nov; 38(10):1966-75. PMID: 18512136.
      View in: PubMed
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