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Connection

Gerald Dienel to Brain

This is a "connection" page, showing publications Gerald Dienel has written about Brain.

 
Connection Strength
  
 
 
10.291
  
  1. Dienel GA, Schousboe A, McKenna MC, Rothman DL. A tribute to Leif Hertz: The historical context of his pioneering studies of the roles of astrocytes in brain energy metabolism, neurotransmission, cognitive functions, and pharmacology identifies important, unresolved topics for future studies. J Neurochem. 2024 05; 168(5):461-495.
    View in: PubMed
    Score: 0.491
  2. Dienel GA. Stop the rot. Enzyme inactivation at brain harvest prevents artifacts: A guide for preservation of the in vivo concentrations of brain constituents. J Neurochem. 2021 09; 158(5):1007-1031.
    View in: PubMed
    Score: 0.423
  3. Dienel GA. Metabolomic and Imaging Mass Spectrometric Assays of Labile Brain Metabolites: Critical Importance of Brain Harvest Procedures. Neurochem Res. 2020 Nov; 45(11):2586-2606.
    View in: PubMed
    Score: 0.411
  4. Dienel GA. Hypothesis: A Novel Neuroprotective Role for Glucose-6-phosphatase (G6PC3) in Brain-To Maintain Energy-Dependent Functions Including Cognitive Processes. Neurochem Res. 2020 Nov; 45(11):2529-2552.
    View in: PubMed
    Score: 0.408
  5. Dienel GA. The "protected" glucose transport through the astrocytic endoplasmic reticulum is too slow to serve as a quantitatively-important highway for nutrient delivery. J Neurosci Res. 2019 08; 97(8):854-862.
    View in: PubMed
    Score: 0.373
  6. Dienel GA. Brain Glucose Metabolism: Integration of Energetics with Function. Physiol Rev. 2019 01 01; 99(1):949-1045.
    View in: PubMed
    Score: 0.365
  7. Dienel GA, Carlson GM. Major Advances in Brain Glycogen Research: Understanding of the Roles of Glycogen Have Evolved from Emergency Fuel Reserve to Dynamic, Regulated Participant in Diverse Brain Functions. Adv Neurobiol. 2019; 23:1-16.
    View in: PubMed
    Score: 0.365
  8. Dienel GA. Metabolomic Assays of Postmortem Brain Extracts: Pitfalls in Extrapolation of Concentrations of Glucose and Amino Acids to Metabolic Dysregulation In Vivo in Neurological Diseases. Neurochem Res. 2019 Oct; 44(10):2239-2260.
    View in: PubMed
    Score: 0.355
  9. Dienel GA, Behar KL, Rothman DL. Cellular Origin of [18F]FDG-PET Imaging Signals During Ceftriaxone-Stimulated Glutamate Uptake: Astrocytes and Neurons. Neuroscientist. 2018 08; 24(4):316-328.
    View in: PubMed
    Score: 0.340
  10. Dienel GA. Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte-neuron lactate shuttle in brain. J Neurosci Res. 2017 11; 95(11):2103-2125.
    View in: PubMed
    Score: 0.319
  11. Dienel GA, Rothman DL, Nordstr?m CH. Microdialysate concentration changes do not provide sufficient information to evaluate metabolic effects of lactate supplementation in brain-injured patients. J Cereb Blood Flow Metab. 2016 11; 36(11):1844-1864.
    View in: PubMed
    Score: 0.311
  12. Dienel GA. The metabolic trinity, glucose-glycogen-lactate, links astrocytes and neurons in brain energetics, signaling, memory, and gene expression. Neurosci Lett. 2017 01 10; 637:18-25.
    View in: PubMed
    Score: 0.279
  13. Dienel GA, Cruz NF. Contributions of glycogen to astrocytic energetics during brain activation. Metab Brain Dis. 2015 Feb; 30(1):281-98.
    View in: PubMed
    Score: 0.260
  14. Cruz NF, Ball KK, Froehner SC, Adams ME, Dienel GA. Regional registration of [6-(14)C]glucose metabolism during brain activation of a-syntrophin knockout mice. J Neurochem. 2013 Apr; 125(2):247-59.
    View in: PubMed
    Score: 0.244
  15. Lind KR, Ball KK, Cruz NF, Dienel GA. The unfolded protein response to endoplasmic reticulum stress in cultured astrocytes and rat brain during experimental diabetes. Neurochem Int. 2013 Apr; 62(5):784-95.
    View in: PubMed
    Score: 0.242
  16. Dienel GA. Fueling and imaging brain activation. ASN Neuro. 2012 Jul 20; 4(5).
    View in: PubMed
    Score: 0.233
  17. Dienel GA. Brain lactate metabolism: the discoveries and the controversies. J Cereb Blood Flow Metab. 2012 Jul; 32(7):1107-38.
    View in: PubMed
    Score: 0.224
  18. Ball KK, Harik L, Gandhi GK, Cruz NF, Dienel GA. Reduced gap junctional communication among astrocytes in experimental diabetes: contributions of altered connexin protein levels and oxidative-nitrosative modifications. J Neurosci Res. 2011 Dec; 89(12):2052-67.
    View in: PubMed
    Score: 0.214
  19. Gandhi GK, Cruz NF, Ball KK, Theus SA, Dienel GA. Selective astrocytic gap junctional trafficking of molecules involved in the glycolytic pathway: impact on cellular brain imaging. J Neurochem. 2009 Aug; 110(3):857-69.
    View in: PubMed
    Score: 0.187
  20. Dienel GA, Cruz NF. Imaging brain activation: simple pictures of complex biology. Ann N Y Acad Sci. 2008 Dec; 1147:139-70.
    View in: PubMed
    Score: 0.181
  21. Cruz NF, Ball KK, Dienel GA. Functional imaging of focal brain activation in conscious rats: impact of [(14)C]glucose metabolite spreading and release. J Neurosci Res. 2007 11 15; 85(15):3254-66.
    View in: PubMed
    Score: 0.169
  22. Dienel GA, Ball KK, Cruz NF. A glycogen phosphorylase inhibitor selectively enhances local rates of glucose utilization in brain during sensory stimulation of conscious rats: implications for glycogen turnover. J Neurochem. 2007 Jul; 102(2):466-78.
    View in: PubMed
    Score: 0.162
  23. Dienel GA, Cruz NF. Astrocyte activation in working brain: energy supplied by minor substrates. Neurochem Int. 2006 May-Jun; 48(6-7):586-95.
    View in: PubMed
    Score: 0.150
  24. Cruz NF, Lasater A, Zielke HR, Dienel GA. Activation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brain. J Neurochem. 2005 Feb; 92(4):934-47.
    View in: PubMed
    Score: 0.139
  25. Hertz L, Dienel GA. Lactate transport and transporters: general principles and functional roles in brain cells. J Neurosci Res. 2005 Jan 1-15; 79(1-2):11-8.
    View in: PubMed
    Score: 0.138
  26. Dienel GA. Lactate muscles its way into consciousness: fueling brain activation. Am J Physiol Regul Integr Comp Physiol. 2004 Sep; 287(3):R519-21.
    View in: PubMed
    Score: 0.135
  27. Dienel G. Glial biology: functional interactions among glia and neurons. Neurochem Int. 2004 Jul-Aug; 45(2-3):189-90.
    View in: PubMed
    Score: 0.133
  28. Dienel GA, Cruz NF. Nutrition during brain activation: does cell-to-cell lactate shuttling contribute significantly to sweet and sour food for thought? Neurochem Int. 2004 Jul-Aug; 45(2-3):321-51.
    View in: PubMed
    Score: 0.133
  29. Trefz F, Frauendienst-Egger G, Dienel G, Cannet C, Schmidt-Mader B, Haas D, Blau N, Himmelreich N, Spraul M, Freisinger P, Dobrowolski S, Berg D, Pilotto A. Does hyperphenylalaninemia induce brain glucose hypometabolism? Cerebral spinal fluid findings in treated adult phenylketonuric patients. Mol Genet Metab. 2024 May; 142(1):108464.
    View in: PubMed
    Score: 0.131
  30. Rae CD, Baur JA, Borges K, Dienel G, D?az-Garc?a CM, Douglass SR, Drew K, Duarte JMN, Duran J, Kann O, Kristian T, Lee-Liu D, Lindquist BE, McNay EC, Robinson MB, Rothman DL, Rowlands BD, Ryan TA, Scafidi J, Scafidi S, Shuttleworth CW, Swanson RA, Uruk G, Vardjan N, Zorec R, McKenna MC. Brain energy metabolism: A roadmap for future research. J Neurochem. 2024 05; 168(5):910-954.
    View in: PubMed
    Score: 0.129
  31. DiNuzzo M, Dienel GA, Behar KL, Petroff OA, Benveniste H, Hyder F, Giove F, Michaeli S, Mangia S, Herculano-Houzel S, Rothman DL. Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO2, and pO2. J Neurochem. 2024 05; 168(5):632-662.
    View in: PubMed
    Score: 0.124
  32. Cetin N, Ball K, Gokden M, Cruz NF, Dienel GA. Effect of reactive cell density on net [2-14C]acetate uptake into rat brain: labeling of clusters containing GFAP+- and lectin+-immunoreactive cells. Neurochem Int. 2003 Apr; 42(5):359-74.
    View in: PubMed
    Score: 0.122
  33. Dienel GA, Rothman DL. In vivo calibration of genetically encoded metabolite biosensors must account for metabolite metabolism during calibration and cellular volume. J Neurochem. 2024 05; 168(5):506-532.
    View in: PubMed
    Score: 0.122
  34. Cruz NF, Dienel GA. High glycogen levels in brains of rats with minimal environmental stimuli: implications for metabolic contributions of working astrocytes. J Cereb Blood Flow Metab. 2002 Dec; 22(12):1476-89.
    View in: PubMed
    Score: 0.120
  35. Dienel GA, Wang RY, Cruz NF. Generalized sensory stimulation of conscious rats increases labeling of oxidative pathways of glucose metabolism when the brain glucose-oxygen uptake ratio rises. J Cereb Blood Flow Metab. 2002 Dec; 22(12):1490-502.
    View in: PubMed
    Score: 0.120
  36. Hertz L, Dienel GA. Energy metabolism in the brain. Int Rev Neurobiol. 2002; 51:1-102.
    View in: PubMed
    Score: 0.112
  37. Dienel GA, Hertz L. Glucose and lactate metabolism during brain activation. J Neurosci Res. 2001 Dec 01; 66(5):824-38.
    View in: PubMed
    Score: 0.112
  38. Dienel GA, Rothman DL. Reevaluation of Astrocyte-Neuron Energy Metabolism with Astrocyte Volume Fraction Correction: Impact on Cellular Glucose Oxidation Rates, Glutamate-Glutamine Cycle Energetics, Glycogen Levels and Utilization Rates vs. Exercising Muscle, and Na+/K+ Pumping Rates. Neurochem Res. 2020 Nov; 45(11):2607-2630.
    View in: PubMed
    Score: 0.103
  39. Madsen PL, Cruz NF, Sokoloff L, Dienel GA. Cerebral oxygen/glucose ratio is low during sensory stimulation and rises above normal during recovery: excess glucose consumption during stimulation is not accounted for by lactate efflux from or accumulation in brain tissue. J Cereb Blood Flow Metab. 1999 Apr; 19(4):393-400.
    View in: PubMed
    Score: 0.093
  40. Carlson GM, Dienel GA, Colbran RJ. Introduction to the Thematic Minireview Series: Brain glycogen metabolism. J Biol Chem. 2018 05 11; 293(19):7087-7088.
    View in: PubMed
    Score: 0.086
  41. Dienel GA, Cruz NF, Adachi K, Sokoloff L, Holden JE. Determination of local brain glucose level with [14C]methylglucose: effects of glucose supply and demand. Am J Physiol. 1997 11; 273(5):E839-49.
    View in: PubMed
    Score: 0.084
  42. Cruz NF, Dienel GA, Patrick PA, Cooper AJL. Organ Distribution of 13N Following Intravenous Injection of [13N]Ammonia into Portacaval-Shunted Rats. Neurochem Res. 2017 Jun; 42(6):1683-1696.
    View in: PubMed
    Score: 0.079
  43. Nakanishi H, Cruz NF, Adachi K, Sokoloff L, Dienel GA. Influence of glucose supply and demand on determination of brain glucose content with labeled methylglucose. J Cereb Blood Flow Metab. 1996 May; 16(3):439-49.
    View in: PubMed
    Score: 0.076
  44. Dienel GA, Tofel-Grehl B, Cruz CC, Luludis K, Pettigrew K, Sokoloff L, Gibson GE. Determination of local rates of 45Ca influx into rat brain by quantitative autoradiography: studies of aging. Am J Physiol. 1995 Aug; 269(2 Pt 2):R453-62.
    View in: PubMed
    Score: 0.072
  45. Dienel GA, Cruz NF. Biochemical, Metabolic, and Behavioral Characteristics of Immature Chronic Hyperphenylalanemic Rats. Neurochem Res. 2016 Feb; 41(1-2):16-32.
    View in: PubMed
    Score: 0.072
  46. Dienel GA, Cruz NF, Sokoloff L, Driscoll BF. Determination of Glucose Utilization Rates in Cultured Astrocytes and Neurons with [14C]deoxyglucose: Progress, Pitfalls, and Discovery of Intracellular Glucose Compartmentation. Neurochem Res. 2017 Jan; 42(1):50-63.
    View in: PubMed
    Score: 0.072
  47. Adachi K, Cruz NF, Sokoloff L, Dienel GA. Labeling of metabolic pools by [6-14C]glucose during K(+)-induced stimulation of glucose utilization in rat brain. J Cereb Blood Flow Metab. 1995 Jan; 15(1):97-110.
    View in: PubMed
    Score: 0.069
  48. Cruz NF, Dienel GA. Brain glucose levels in portacaval-shunted rats with chronic, moderate hyperammonemia: implications for determination of local cerebral glucose utilization. J Cereb Blood Flow Metab. 1994 Jan; 14(1):113-24.
    View in: PubMed
    Score: 0.064
  49. Mergenthaler P, Lindauer U, Dienel GA, Meisel A. Sugar for the brain: the role of glucose in physiological and pathological brain function. Trends Neurosci. 2013 Oct; 36(10):587-97.
    View in: PubMed
    Score: 0.063
  50. Dienel GA, Cruz NF. Synthesis of deoxyglucose-1-phosphate, deoxyglucose-1,6-bisphosphate, and other metabolites of 2-deoxy-D-[14C]glucose in rat brain in vivo: influence of time and tissue glucose level. J Neurochem. 1993 Jun; 60(6):2217-31.
    View in: PubMed
    Score: 0.062
  51. Dienel GA, Cruz NF, Sokoloff L. Metabolites of 2-deoxy-[14C]glucose in plasma and brain: influence on rate of glucose utilization determined with deoxyglucose method in rat brain. J Cereb Blood Flow Metab. 1993 Mar; 13(2):315-27.
    View in: PubMed
    Score: 0.061
  52. Dienel GA, Cruz NF, Nakanishi H, Melzer P, Moulis P, Sokoloff L. Comparison of rates of local cerebral glucose utilization determined with deoxy[1-14C]glucose and deoxy[6-14C]glucose. J Neurochem. 1992 Oct; 59(4):1430-6.
    View in: PubMed
    Score: 0.059
  53. Adam-Vizi V, Dienel GA, Schousboe A, McKenna MC. The 9th International Conference on Brain Energy Metabolism, Mitochondrial-Cytosolic Interactions. Introduction. J Neurosci Res. 2011 Dec; 89(12):1895-6.
    View in: PubMed
    Score: 0.055
  54. Dienel GA, Cruz NF, Mori K, Holden JE, Sokoloff L. Direct measurement of the lambda of the lumped constant of the deoxyglucose method in rat brain: determination of lambda and lumped constant from tissue glucose concentration or equilibrium brain/plasma distribution ratio for methylglucose. J Cereb Blood Flow Metab. 1991 Jan; 11(1):25-34.
    View in: PubMed
    Score: 0.052
  55. Dienel GA, Cruz NF, Mori K, Sokoloff L. Acid lability of metabolites of 2-deoxyglucose in rat brain: implications for estimates of kinetic parameters of deoxyglucose phosphorylation and transport between blood and brain. J Neurochem. 1990 Apr; 54(4):1440-8.
    View in: PubMed
    Score: 0.050
  56. Dienel GA, Nelson T, Cruz NF, Jay T, Crane AM, Sokoloff L. Over-estimation of glucose-6-phosphatase activity in brain in vivo. Apparent difference in rates of [2-3H]glucose and [U-14C]glucose utilization is due to contamination of precursor pool with 14C-labeled products and incomplete recovery of 14C-labeled metabolites. J Biol Chem. 1988 Dec 25; 263(36):19697-708.
    View in: PubMed
    Score: 0.046
  57. Dienel GA, Pulsinelli WA. Uptake of radiolabeled ions in normal and ischemia-damaged brain. Ann Neurol. 1986 May; 19(5):465-72.
    View in: PubMed
    Score: 0.038
  58. Dienel GA, Cruz NF, Rosenfeld SJ. Temporal profiles of proteins responsive to transient ischemia. J Neurochem. 1985 Feb; 44(2):600-10.
    View in: PubMed
    Score: 0.035
  59. Dienel GA. Regional accumulation of calcium in postischemic rat brain. J Neurochem. 1984 Oct; 43(4):913-25.
    View in: PubMed
    Score: 0.034
  60. Dienel GA, Cruz NF. Induction of brain ornithine decarboxylase during recovery from metabolic, mechanical, thermal, or chemical injury. J Neurochem. 1984 Apr; 42(4):1053-61.
    View in: PubMed
    Score: 0.033
  61. Dienel GA, Cruz NF. Neighborly interactions of metabolically-activated astrocytes in vivo. Neurochem Int. 2003 Sep-Oct; 43(4-5):339-54.
    View in: PubMed
    Score: 0.031
  62. Theriault JE, Shaffer C, Dienel GA, Sander CY, Hooker JM, Dickerson BC, Barrett LF, Quigley KS. A functional account of stimulation-based aerobic glycolysis and its role in interpreting BOLD signal intensity increases in neuroimaging experiments. Neurosci Biobehav Rev. 2023 10; 153:105373.
    View in: PubMed
    Score: 0.031
  63. Seo GY, Neal ES, Han F, Vidovic D, Nooru-Mohamed F, Dienel GA, Sullivan MA, Borges K. Brain glycogen content is increased in the acute and interictal chronic stages of the mouse pilocarpine model of epilepsy. Epilepsia Open. 2022 06; 7(2):361-367.
    View in: PubMed
    Score: 0.029
  64. Rothman DL, Dienel GA, Behar KL, Hyder F, DiNuzzo M, Giove F, Mangia S. Glucose sparing by glycogenolysis (GSG) determines the relationship between brain metabolism and neurotransmission. J Cereb Blood Flow Metab. 2022 05; 42(5):844-860.
    View in: PubMed
    Score: 0.028
  65. Uc EY, Dienel GA, Cruz NF, Harik SI. ?-Adrenergics enhance brain extraction of levodopa. Mov Disord. 2002 01; 17(1):54-9.
    View in: PubMed
    Score: 0.028
  66. Dienel GA, Popp D, Drew PD, Ball K, Krisht A, Cruz NF. Preferential labeling of glial and meningial brain tumors with [2-(14)C]acetate. J Nucl Med. 2001 Aug; 42(8):1243-50.
    View in: PubMed
    Score: 0.027
  67. Dienel GA. Chronic hyperphenylalaninemia produces cerebral hyperglycinemia in immature rats. J Neurochem. 1981 Jan; 36(1):34-43.
    View in: PubMed
    Score: 0.026
  68. Dienel GA, Pulsinelli WA, Duffy TE. Regional protein synthesis in rat brain following acute hemispheric ischemia. J Neurochem. 1980 Nov; 35(5):1216-26.
    View in: PubMed
    Score: 0.026
  69. Dienel G, Ryder E, Greengard O. Distribution of mitochondrial enzymes between the perikaryal and synaptic fractions of immature and adult rat brain. Biochim Biophys Acta. 1977 Feb 28; 496(2):484-94.
    View in: PubMed
    Score: 0.020
  70. Sheu KF, Calingasan NY, Dienel GA, Baker H, Jung EH, Kim KS, Paoletti F, Gibson GE. Regional reductions of transketolase in thiamine-deficient rat brain. J Neurochem. 1996 Aug; 67(2):684-91.
    View in: PubMed
    Score: 0.019
  71. Schmidt KC, Mies G, Dienel GA, Cruz NF, Crane AM, Sokoloff L. Analysis of time courses of metabolic precursors and products in heterogeneous rat brain tissue: limitations of kinetic modeling for predictions of intracompartmental concentrations from total tissue activity. J Cereb Blood Flow Metab. 1995 May; 15(3):474-84.
    View in: PubMed
    Score: 0.018
  72. Frerichs KU, Dienel GA, Cruz NF, Sokoloff L, Hallenbeck JM. Rates of glucose utilization in brain of active and hibernating ground squirrels. Am J Physiol. 1995 Feb; 268(2 Pt 2):R445-53.
    View in: PubMed
    Score: 0.017
  73. Holden JE, Mori K, Dienel GA, Cruz NF, Nelson T, Sokoloff L. Modeling the dependence of hexose distribution volumes in brain on plasma glucose concentration: implications for estimation of the local 2-deoxyglucose lumped constant. J Cereb Blood Flow Metab. 1991 Mar; 11(2):171-82.
    View in: PubMed
    Score: 0.013
  74. Jay TM, Dienel GA, Cruz NF, Mori K, Nelson T, Sokoloff L. Metabolic stability of 3-O-methyl-D-glucose in brain and other tissues. J Neurochem. 1990 Sep; 55(3):989-1000.
    View in: PubMed
    Score: 0.013
  75. Mori K, Cruz N, Dienel G, Nelson T, Sokoloff L. Direct chemical measurement of the lambda of the lumped constant of the [14C]deoxyglucose method in rat brain: effects of arterial plasma glucose level on the distribution spaces of [14C]deoxyglucose and glucose and on lambda. J Cereb Blood Flow Metab. 1989 Jun; 9(3):304-14.
    View in: PubMed
    Score: 0.012
  76. Kiessling M, Dienel GA, Jacewicz M, Pulsinelli WA. Protein synthesis in postischemic rat brain: a two-dimensional electrophoretic analysis. J Cereb Blood Flow Metab. 1986 Dec; 6(6):642-9.
    View in: PubMed
    Score: 0.010
  77. Nelson T, Lucignani G, Atlas S, Crane AM, Dienel GA, Sokoloff L. Reexamination of glucose-6-phosphatase activity in the brain in vivo: no evidence for a futile cycle. Science. 1985 Jul 05; 229(4708):60-2.
    View in: PubMed
    Score: 0.009
  78. Delvalle JA, Dienel G, Greengard O. Comparison of alpha-methylphenylalanine and p-chlorophenylalanine as inducers of chronic hyperphenylalaninaemia in developing rats. Biochem J. 1978 Mar 15; 170(3):449-59.
    View in: PubMed
    Score: 0.001
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