Total target volume is a better predictor of whole brain dose from gamma stereotactic radiosurgery than the number, shape, or location of the lesions.
Narayanasamy G, Smith A, Van Meter E, McGarry R, Molloy JA. Total target volume is a better predictor of whole brain dose from gamma stereotactic radiosurgery than the number, shape, or location of the lesions. Med Phys. 2013 Sep; 40(9):091714.