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Robert Mcgehee Jr

TitleDistinguished Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPeds Pediatrics, College of Medicine
DivisionPeds Neonatology
Address159-2 Biomedical Research I
325 S. Elm St.
Mail Slot # 601
Little Rock AR 72205
Phone501-603-1998
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    Other Positions
    TitleAssociate Professor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentPathology, College of Medicine

    TitleAssociate Professor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentPhysiology and Cell Biology, College of Medicine


    Collapse Overview 
    Collapse overview
    A. Personal Statement
    I am currently a Professor of Pediatrics/Neonatology in the UAMS College of Medicine and Arkansas Children’s Hospital, and Dean of the UAMS Graduate School. I have had a longstanding NIH-funded translational/basic science research program in diabetes and obesity and in addition to the current IMSD non-competing renewal, I serve as a Co-PI on an NHLBI SURP award to promote diversity among undergraduate students with interests in health care. I am the associate fellowship director for the neonatal/perinatal subspecialty training program in the Department of Pediatrics and help mentor research projects for pediatric fellows. I am also very engaged with our CTSA award that established the UAMS TRI, and for the first six years of the TRI was the original Director of the Education, Training, and Career Development Core, as well as Director of its KL2 Training Program. In this role, I helped establish the formal CTS training program that includes the Graduate Certificate, MS, and PhD graduate programs. Combined throughout my career, I have had a broad range of successful experience with infrastructure development, mentoring, career development, grant writing, and translational research


    C. Contributions to Science

    1. My lab has always focused in some degree the cellular differentiation of adipocytes. Initially, this was through the use of in vitro murine cell lines such as 3T3-L1’s. We worked on identifying molecular mechanisms that promoted the adipocyte lineage and identified unique molecules that were required for differentiation. These studies were the first to demonstrate a role for two members of the Retinoblastoma tumor suppressor gene family, p107 and p130, in regulating adipogenesis.
    a. McGehee Jr. RE and Habener JF. Nuclear protein DSEB binds to a differentiation-specific element in the promoter of the angiotensinogen gene required for the irreversible induction of gene expression during differentiation of 3T3-L1 adipoblasts to adipocytes. Molec Endocrinology 1995; 9:487-501.
    b. Richon VM, Lyle RE and McGehee Jr. RE. Regulation and expression of retinoblastoma proteins p107 and p130 during 3T3-L1 adipocyte differentiation. J Biol Chem 1997; 272:10117-10124.
    c. Liu K, Guan Y, MacNicol M, MacNicol A and McGehee Jr. RE. Early expression of p107 is associated with 3T3-L1 adipocyte differentiation. Mol Cell Endocrinol 2002; 194:51-61.
    d. Prince AM, May JM, Burton G, Lyle RE and McGehee Jr. RE. Specific degradation of the p130 Tumor suppressor gene by the 26S proteasome during 3T3-L1 adipocyte differentiation. Biophys Res Comm 2002; 290:1066-71.

    2. We went on to show that these proteins were differentially regulated in murine myoblast differentiation and that in aging myoblasts, the pattern of expression was similar to adipocytes; and that these proteins had similar roles in the differentiation of adult derived human adipose stem cells (ADHAS) isolated from lipoaspirates collected following elective liposuction surgery.
    a. Guan Y, Taylor-Jones JM, Peterson CA and McGehee, Jr., RE. p130/p107 expression distinguishes adipogenic potential in primary myoblasts based on age. Biochem Biophys Res Comm 2002; 296:1340-1345.
    b. Taylor-Jones JM, McGehee Jr. RE, Rando TA, Lecka-Cernik B, Lipschitz DA, Peterson CA. Activation of an adipogenic program in adult skeletal myoblasts with age. Mechanisms of Ageing and Development 2002; 123:649-661.
    c. Vertino AM, Taylor-Jones JM, Longo KA, Bearden ED, Lane TF, McGehee RE Jr, Macdougald OA, and Peterson CA. Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Mol Biol Cell 2005; 16:2039-48. PMCID: PMC1073681
    d. Ross AS, Tsang R, Shewmake K, McGehee RE Jr, Expression of p107 and p130 during human adipose-derived stem cell adipogenesis. Biochem Biophys Res Comm 2008; 366:927-931. PMCID: PMC2877912
    3. In collaboration with Drs. Philip Kern and Charlotte Peterson, we began investigating mechanisms of how adipose and adipocytes contribute to insulin resistance.
    a. Yao-Borengasser A, Rasouli N, Varma V, Miles LM, Phanavanh B, Starks, TN, Phan J, Spencer, HJ III, McGehee RE Jr, Reue K, Kern PA. Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation. Diabetes 2006; 55:2811-2818.
    b. Spencer M, Unal R, Zhu B, Rasouli N, McGehee RE Jr, Peterson CA, Kern PA. Adipose tissue extracellular matrix and vascular abnormalities in obesity and insulin resistance. J Clin Endocrinol Metab 2011 96:E1990-8.
    c. Kern PA, Spencer M, Finlin B, Unal R, Zhu B, Morris A, Shipp L, Adu A, Erfani R, Campbell M, McGehee RE Jr, Peterson CA. Omega-3 fatty acids reduce adipose tissue macrophages in human subjects with insulin resistance. Diabetes 2013 62:1709-1717.
    d. Kern PA, Finlin BS, Zhu B, Rasouli N, McGehee RE Jr, Westgate PM, Dupont-Versteegden EE. The effects of temperature and seasons on subcutaneous white adipose tissue in humans: evidence for thermogenic gene induction. J Clin Endocrinol Metab. 2014 99:E2772-9.

    4. To extend our investigations into muscle-adipose interactions, we more recently developed a Transwell membrane co-culture model plating ADHAS derived adipocytes and myoblast differentiated from muscle biopsies on the two surfaces. By seeding human macropahges on top of the adipocytes, we have been able to study the mechanisms by which these cells interact with each other in the presence or absence of inflammation in contributing to insulin resistance, metabolic syndrome and diabetes.
    a. Varma V, Yao-Borengasser A, Bodles AM, Rasouli N, Phanavanh B, NolenGT, Nagarajan R, Spencer III HJ, Lee MJ, Fried SK, McGehee RE Jr*, Peterson CA* and Kern PA* (*co senior authors). Thrombospondin-1 (TSP1) is an adipokine associated with obesity, adipose inflammation and insulin resistance. Diabetes 2008; 57:432-439. PMCID: PMC2877915
    b. Varma V, Yao-Borengasser A, Rasouli N, Nolen GT, Phanavanh B, Starks T, Gurley C, Simpson P, McGehee RE Jr, Kern PA, Peterson PA. Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action. Am J Physiol Endocrinol Metab 2009; 296:E1300-10. PMCID: PMC2692398
    c. DiGregorio GB, Yao-Borengasser, Rasouli N, Varma V, Lu T, Miles LM, Ranganathan G, Peterson CA, McGehee RE Jr, and Kern PA. The expression of CD 68 and macrophage chemoattactant protein-1 genes in human adipose and muscle tissue: association with cytokine expression, insulin resistance and reduction by piaglitazone. Diabetes 2005; 54:2305-2313.
    d. Finlin BS, Zhu B, Starnes CP, McGehee RE Jr, Peterson CA, Kern PA. Regulation of Thrombospondin-1 expression in alternatively activated macrophages and adipocytes: role of cellular crosstalk and omega-3 fatty acids. J Nutr Biochem 2013 24:1571-1579.


    Collapse Research 
    Collapse research activities and funding
    R25HL108825     (THOMAS, BILLY R)Jun 15, 2011 - May 31, 2026
    NIH
    UAMS Summer Undergraduate Research Program to Increase Diversity in Research
    Role: Co-Investigator
    R01DK071349     (MCGEHEE JR, ROBERT E)Apr 1, 2010 - Mar 31, 2012
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases - Pass Through: University of Kentucky Research Foundation
    Mechanisms Underlying Metabolic Syndrome in Obesity
    Role: Principal Investigator
    UL1RR029884     (JAMES, LAURA P)Jul 14, 2009 - Mar 31, 2016
    NIH/National Center for Advancing Translational Sciences
    Arkansas Center for Clinical & Translational Research
    Role: Co-Investigator
    UL1TR000039     (JAMES, LAURA P)Jul 14, 2009 - Mar 31, 2016
    NIH
    Arkansas Center for Clinical and Translational Research
    Role: Co-Investigator
    R25GM083247     (THOMAS, BILLY R)Feb 1, 2008 - Jan 31, 2024
    NIH
    The University of Arkansas for Medical Sciences Initiative for Maximizing Student Development Program
    Role: Co-Principal Investigator
    R01DK071277     (MCGEHEE JR, ROBERT E)Jun 1, 2005 - May 31, 2010
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases
    Mechanisms Underlying Metabolic Syndrome in Obesity
    Role: Principal Investigator
    R01DK071346     (MCGEHEE JR, ROBERT E)Jun 1, 2005 - May 31, 2010
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases
    Mechanisms Underlying Metabolic Syndrome in Obesity
    Role: Principal Investigator
    ACHRI #034232     (MCGEHEE JR, ROBERT E)Sep 1, 2002 - Aug 31, 2003
    Centers for Disease Control & Prevention
    Center’s of Excellence for Surveilance, Research Service and Evaluation of Birth Defects
    Role: Principal Investigator
    ACHRI #5R01 HD39054-03     (MCGEHEE JR, ROBERT E)Sep 1, 2002 - Aug 31, 2003
    NIH/Nat. Inst. of Child Health & Human Development
    Genes, Micronutrients and Homeobox Related Malformations
    Role: Principal Investigator
    ACHRI#034232     (MCGEHEE JR, ROBERT E)Sep 1, 2002 - Aug 31, 2003
    Centers for Disease Control & Prevention
    Center’s of Excellence for Surveilance, Research Service and Evaluation of Birth Defects
    Role: Principal Investigator
    R01CA78845     (MCGEHEE JR, ROBERT E)Jul 1, 1998 - Apr 30, 2005
    NIH/Nat. Cancer Institute
    Regulation of Adipogenesis by Retinoblastoma Proteins
    Role: Principal Investigator
    R01HD39054     (MCGEHEE JR, ROBERT E)
    NIH/Nat. Inst. of Child Health & Human Development
    Genes, Micronutrients, and Homeobox Related Malformations
    Role: Principal Investigator
    U50 CCU61326-05     (MCGEHEE JR, ROBERT E)
    Centers for Disease Control & Prevention
    Centers of Excellence for Surveilance, Research Service and Evaluation Aimed at Birth Defects
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. McGehee Jr. RE, Diekman A, Graham J, Tariq SG, Quick M, Ellis SK. Impact of Team-Based Learning on Medical Student Performance in Biochemisty and Cell Biology. 2013.
    2. Finlin BS, Bodles-Brakhop AM, Yao-Borengasser A, Zhu B, Starnes CP, McGehee Jr. RE, Peterson CA, Kern PA, Rasouli N. Regulation of small ubiquitin-like modifier-1, nuclear receptor co-receptor, histone deacetylase 3, and peroxisome proliferator-activated receptor-gamma in human adipose tissue. Metab Syndr Relat Discord. 2012.
    3. Mondal AK, Das SK, Varma V, Nolen GT, McGehee Jr. RE, Elbein SC, Wei JY, Ranganathan G. Effect of endoplasmic reticulum on inflammation and adiponectin regulation in human adipocytes. Metab Syndr Relat Discord. 2012.
    4. Yao-Borengasser A, Varma V, Rasouli N, Phanavanh B, Nolen GT, Starks T, McGehee Jr. RE, Peterson CA, Kern PA. Adipose Tissue Collagen Vla and Connective Tissue Growth Factor (CTGF) Expression are Increased in Insulin Resistance and Obesity. 2009.
    5. Varma V, Yao-Borengasser A, Rasouli N, Nolen GT, Phanavanh B, Starks T, Gurley C, Simpson P, McGehee Jr. RE, Kern PA, Peterson CA. Muscle Inflammation is Associated with Obesity and Insulin Resistance. 2009.
    6. Varma V, Yao-Borengasser A, Rasouli N, Phanavanh B, Nolen GT, McGehee Jr. RE, Peterson CA, Kern PA. Free Fatty Acids Synergize with Macrophages to Drive an Inflammatory Phenotype in Muscle Cells in vitro. 2009.
    7. Yao-Borengasser A, Rassouli N, Varma V, Bodles AM, Unal R, Phanavanh B, McGehee Jr. RE, Kern PA. Stearoyl-CoA Desaturase 1 (SCD1) Gene Expression Increases Following Pioglitazone Treatment and is Associated with PPARy Responsiveness in Humans. 2009.
    8. Yao-Borengasser A, Rasouli N, Varma V, Bodles AM, Unal R, Phanavanh B, Ranganathan G, McGehee Jr. RE, Kern PA. Stearoyl-CoA desaturase 1(SCD1) gene expression increases following pioglitazone treatment and is associated with PPAR-gamma responsiveness. J Clin endocrinol Metab. 2008; 93:4431-9.
    9. Varma V,, Yao-Borengasser A, Bodles AM, Rasouli N, Phanavanh B, Nolen GT, Nagarajan R, Spencer III HJ, Lee MJ, Fried SK, McGehee RE Jr*, Peterson CA*, Kern PA* (co-senior authors). Thrombospondin-1 (TSP1) is an adipokine associated with obesity, adipose inflammation and insulin resistance. Diabetes. 2008; 57:432-439.
    10. Yao-Borengasser A, Rasouli N, Varma V, Bodles AM, Unal R, Phanavanh B, Ranganathan G, McGehee RE Jr, Kern PA. Stearoyl-CoA desaturase 1 (SCD1) gene expression increases following pioglitazone treatment and is associated with PPAR-gamma responsiveness. J Clin Endocrinol Metab. 2008; 93:4431-9.
    11. Peterson CA, Vijayalakshmi V, Yao-Borengasser A, Bodies AM, Rasouli N, Phanavanh B, McGehee RE, Jr, Kern P. Thrombospondin-1 (TSP1) is an Adipokine associated with Obesity, Insulin Resistance and Inflammation. 2007.
    12. Boerma M, Wang J, McGehee Jr. RE, Hauer-Jensen M. Comparative expression profiling in primary and immortalized endothelial cells: changes in gene expression in response to HMG-CoA reductase inhibition. Blood Coagul Fibrinolysis. 2006; 3:173-180.
    13. Vijayalakshmi V, Yao-Borengasser A, Rasouli N, Bodles AM, Phanavanh B, Lee MJ, Starks T, Kern LM, Spencer HJ III, McGehee Jr. RE, Fried SK, Kern PA. Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipid and inflammation. J Clin Endo and Met. 2006.
    14. DiGregorio GB, Yao-Borengasser, Rasouli N, Varma V, Lu T, Miles LM, Ranganathan G, Peterson CA, McGehee Jr. RE, Kern PA. The expression of CD 68 and macrophage chemoattactant protein-1 genes in human adipose and muscle tissue: association with cytokine expression, insulin resistance and reduction by piaglitazone. Diabetes. 2005; 54:2305-2313.
    15. Burton GR, McGehee Jr. RE. Microarray analysis of early 3T3-L1 adipocyte differentiation. Nutrition. 2004; 20:109-114.
    16. Burton GR, Nagarajan R, Lyle RE, McGehee Jr. RE. Analysis of gene expression profile during early 3T3-L1 adipogenesis. Gene. 2002; 293:21-31.
    17. Rasmussen SA, Lammer EJ, Shaw GM, McGehee Jr. RE, Et. al. Integration of a DNA sample collection into a multi-site birth defects case-control study. Teratology. 2002; 66:177-84.
    18. Prince AM, May JM, Burton G, Lyle RE, McGehee Jr. RE. Specific degradation of the p130 Tumor suppressor gene by the 26S proteasome during 3T3-L1 adipocyte differentiation. Biophys Res Comm. 2002; 290:1066-71.
    19. Taylor-Jones JM, McGehee Jr. RE, Rando TA, Lecka-Cernik B, Lipschitz DA, Peterson CA. Activation of an adipogenic program in adult skeletal myoblasts with age. Mechanisms of Ageing and Development. 2002; 123:649-661.
    20. Cowherd RM, Lyle RE, McGehee Jr. RE. Regulation of Adipocyte Differentiation. Semin Cell Dev Biol. 1999; 10:3-10.
    21. Lyle RE, Corley JD, McGehee Jr. RE. Human breast milk and commercial infant formulas stimulate in vitro adipocyte differentiation in 3T3-L1 cells. Pediatr Res. 1998; 44:798-803.
    22. Lyle RE, Richon VM, McGehee, Jr. RE. TNF alpha disrupts mitotic clonal expansion and regulation of retinoblastoma proteins during 3T3-L1 adipocyte differentiation. Biochem Biophys Res Comm. 1998; 247:373-378.
    23. McGehee, Jr. RE, Ronis MJJ, Badger TM. Regulation of the hepatic CYP 2E1 gene during chronic ethanol exposure: Lack of an ethanol response element in the proximal 5'- flanking sequence. DNA and Cell Biology. 1997; 6:725-736.
    24. Lyle RE, Habener JF, McGehee Jr. RE. Antisense oligonucleotides to differentiation-specific element binding protein (DSEB) inhibit adipocyte differentiation. Biochem Biophys Res Comm. 1996; 228:709-715.
    25. McGehee Jr. RE, Habener JF. Nuclear protein DSEB binds to a differentiation-specific element in the promoter of the angiotensinogen gene required for the irreversible induction of gene expression during differentiation of 3T3-L1 adipoblasts to adipocytes. Molec Endocrinology. 1995; 9:487-501.
    26. Miller CP, McGehee Jr. RE, Habener JF. IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO Journal. 1994; 13:1145-1156.
    27. McGehee Jr. RE, Ron D, Habener JF. Differentiation-Specific Element (DSE): A cisacting developmental switch required for the sustained transcriptional expression of the angiotensinogen gene during hormonal pulse-induced differentiation of 3T3-L1 fibroblasts to adipocytes. Molec Endocrinol. 1993; 7:551-560.
    28. Ron D, Brasier AR, McGehee Jr. RE, Habener JR. Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP). J Clin Invest. 1992; 89:223-233.
    29. McGehee Jr. RE, Cornett LE. Alternative mRNAs encoding the alpha-one-b-adrenergic receptor are expressed in a tissue-dependent manner in the Sprague-Dawley rat. J Receptor Research. 1991; 11:773-790.
    30. McGehee Jr. RE. Developmental regulation and tissue-specific expression of mRNAs encoding the rat alpha-one-adrenergic receptor. 1990.
    31. McGehee Jr. RE, Rossby SP, Cornett LE. Detection by Northern analysis of alpha-one-adrenergic receptor gene transcripts in the rat. Mol and Cell Endocrinol. 1990; 74:1-9.
    32. McGehee Jr. RE, Nash AA, Norris JS, Cornett LE. Disgestion of partially purified alpha one adrenergic receptor by staphylococcus aureus V-8 protease. 1989; 3:A747.
    33. McGehee Jr. RE, Cornett LE. Tissue-Specific expression of two mRNAs encoding the alpha one adrenergic receptor in rat liver transcribed from one gene. 72nd Annual Meeting of the Endocrine Society.
    34. McGehee Jr. RE, Lyle RE. TNF alpha discrupts mitotic clonal expansion and regulation of retinoblastoma proteins p180 and p107 during 3T3-L1 adipocyte differentiation. American Federation of Clinical Research Regional Meeting, Southern Section.
    35. McGehee Jr. RE, Lyle RE, Richon VM. Retinoblastoma protein family members p107 and p130 are regulated uring in vitro adipocyte differentiation. 10th International Congress of Endocrinology.
    36. McGehee Jr. RE, Lyle RE. Differential expression of mRNAs encoding homeotic transcription factors during hormonal-pulse induced adipocyte differentiation 3T3-L1 fibroblasts, A742. 76th Annual Meeting of the Endocrine Society.
    37. Prince AM, Wewers JM, Yao Y, Lyle RE, McGehee Jr. RE. Hormanal regulation of the p107 tumor suppressor gene during 3T3-L1 adipocyte differentiation. Southern Society for Pediatric Research, Southern Regional.
    38. McGehee Jr. RE. Increases in angiotensinogen mRNA levels during adipocyte differentiation in 3T3-L1 cells are predominatly regulated at the level of gene transcription, A1778. 73rd Annual Meeting of the Endocrine Society.
    39. McGehee Jr. RE, Ronis MJJ, Badger TM. Regulation of the hepatic CYP 2E1 gene during chronic ethanol exposure: Lack of an ethanol response element in the proximal 5'-flanking sequence. 11th International Symposium of Microsomes and Drug Oxidations.
    40. Holland C, Kincaid S, Bryant J, Scalzo F, Seibert J, McGehee, Jr. RE, Lyle RE. Serum leptin does not predict total body fat i the very low birthweight infant. American Federation of Clinical Research Regional Meeting, Southern Section.
    41. Yao-Borengasser A, Varma V, Bodles AM, Phanavanh B, Ranganathan G, McGehee Jr. RE, Kern PA. Adipose Triglyceride Lipase (ATGL) Has a Role in Muscle Lipid Oxidation and is Upregulated by Pioglitazone in Adipose Tissue of Humans.
    42. Peterson CA, Varma V, Yao-Borengasser A, Bodles AM, Rasouli N, Phanavanh B, McGehee Jr. RE, Kern PA. Thrombospondin-1 (TSP1) is an Adipokine associated with Obesity, Insulin Resistance and Inflammation.
    43. McGehee Jr. RE, Lyle RE. TNF alpha disrupts mitotic clonal expansion and regulation of retinoblastoma proteins p130 and p107 during 3T3-L1 adipocyte differention. 57th Annual Meeting of the American Diabetes Association.
    44. Lyle RE, McGehee Jr. RE. TNF-alpha inhibits adipocyte differentiation and induces apoptosis during 3T3-L1 adipocyte differentiation. Society of Pediatric Research.
    45. McGehee Jr. RE, Dressler H. Differentiation specific element binding protein (DSEB): A 3T3-L1 adipocyte nuclear protein with a novel sequence-specific DNA-binding domain, A1553. The 75th Annual Meeting of The Endocrine Society.
    46. Rossby SP, Lumpkin CK, Taylor JM, McGehee Jr. RE, Cornett LE. Steady-state levels of alpha one adrenergic receptor mRNA in the regenerating rate liver. 71st Annual Meeting of the Endocrine Society.
    47. DiGregorio G, Rasouli N, Yao-Borengasser A, Varma V, McGehee Jr. RE, Kern PA. Adipose Tissue Inflammation and Macrophages: association with insulin sensitivity and effects of Pioglitazone.
    48. Lyle RE, Richon VM, McGehee Jr. RE. A Retinoblastoma p130:p107 switch is associated with mitotic clonal expansion early in 3T3-L1 adipocyte differentiation. American Federation of Clinical Research Regional Meeting.
    49. Lyle RE, Richon VM, McGehee Jr. RE. A Retinoblastoma p130:p107 switch is associated with mitotic clonal expasion early in 3T3-L1 adipocyte differentiation. Keystone Symposia "The Adipose Cell".
    50. Lyle RE, Corley JD, McGehee Jr. RE. Infant formula can induce adipocyte differentiation in vitro. Society for Pediatric Research.
    51. Lyle RE, McGehee Jr. RE. p 21, p27, and p53 Expression during 3T3-L1 adipogenesis and TNF-alpha-induced apoptosis. Society for Pediatric Research.
    52. May JM, Prince AM, Yao Y, Lyle RE, McGehee, Jr. RE. Antisense oligonucleotides to the tumor suppressor gene, p107, inhibit 3T3-L1 adipocyte differentiation. Southern Society for Pediatric Research, Southern Region.
    53. Miller CP, McGehee Jr. RE, Habener JF. IDX-1: Identification and cloning of a homeotic transcription factor expressed exclusively in rat pancreatic islets and duodenum, A1294. 75th Annual Meeting of the Endocine Society.
    54. Guan Yu, Taylor-Jones JM, Lyle RE, Peterson CA, McGehee Jr. RE. p130/p107 expression distinguishes adipogenic potential in old versus young primary myoblasts. Annual Meeting of the Endocine Society.
    55. McGehee Jr. RE, Habener JF. Cloning and characterization of a 3T3-L1 adipocyte cDNA encoding a nuclear protein containing a novel sequence-specific DNA binding domain. The American Federation of Clinical Research Meeting.
    56. McGehee Jr. RE, Lyle RE. Hox gene expression during hormonal-pulse induced adipocyte differentiation in 3T3-L1 fibroblasts. 7th International Congress on Obesity and Cellular and Molecular Biology of Adipose Cell Development and Growth.
    57. Bodles AM, Varma V, Yao-Borengasser A, Phanavanh B, Rashidi AA, McGehee Jr. RE, Rasouli N, Kern PA. Pioglitazone Increases SUMOylation in Human Adipose Tissue.
    58. Bodles A, Varma V, Yao-Borengasser A, Peterson CA, McGehee Jr. RE, Rasouli N, Kern PA. Pioglitazone Induces Macrophage Apoptosis in Human Adipose Tissue.
    59. McGehee Jr. RE, Lyle RE. Characterization of homeobox transcription factor gene expression during adipogenesis in 3T3-L1 cells, P2-587. 77th Annual Meeting of The Endocrine Society.
    60. Cowherd RM, Lyle RE, McGehee Jr. RE. Early expression of homeobox genes during adipocyte differentiation. American Federation of Clinical Research Regional Meeting, Southern Section.
    61. McGehee Jr. RE. Anaylsis of gene expression during adipogenesis. FASEB.
    62. Hakkak R, ElDeib MMR, Ronis MJJ, McGehee Jr. RE, Badger RM. Induction of cytochrome p450 isozymes by classical inducers in the small intestine of the male rate. Society of Toxicology.
    63. Lyle RE, Cowherd RM, McGehee Jr. RE. Homeobox gene expression during adipocyte differentiation. Society for Pediatric Research.
    64. McGehee Jr. RE, Ronis MJJ, Cowherd RM, Badger TM. Characterization of ethanol induction of cytochrome p450-2E1 in a rat hepatoma cell model. 10th International Symposium of Microsomes and Drug Oxidations.
    65. Cowherd RM, Lyle RE, McGehee Jr. RE. Early expression of homeobox genes during adipocyte differentiation. The 80th Annual Meeting of The Endocrine Society.
    66. Burton GR, McGehee Jr. RE. Microarray gene expression profiling and cluster anaylsis during the first 24 hours of 3T3-L1 adipocyte differentiation. Keystone Symposia "Molecular conrol of Adipogenesis and Obesity.
    67. McGehee Jr. RE, Lyle RE. Expression of homeobox transcription factors during adipocyte differentiation. American Federation of Clinical Research Regional Meeting, Southern Section.
    68. Liu K, McGehee Jr. RE. Characterization of the retinoblastoma-related protein, p107 during 3T3-L1 adipogenesis; a dual role in differentiation and cell cycle. Keystone Symposia "Molecular contol of Adipogenesis and Obesity".
    69. Lyle RE, Kincaid S, Bryant J, McGehee Jr. RE. Leptin is present in human milk. Society of Pediatric Research.
    70. McGehee Jr. RE, Ron D, Brasier AR. Identification and characterization of a differentiation-specific DNA binding element (DSE) that mediates angiotensinogen gene transcription during adipocyte differentiation in 3T3-L1 cells, A298. 74th Annual Meeting of The Endocrine Society.
    71. Guan Yu, Taylor-Jones JM, Lyle RE, Peterson CA, McGehee Jr. RE. p130/p107 expression distinguishes adipogenic potential in old versus young primary myoblasts.
    72. Ron D, Brasier AR, McGehee Jr. RE, Wright KA. Tumor necrosis factor (TNF)-induced reversal of the adipocytic phenotype of 3T3-L1 cells is preceded by the rapid degradation of CCAAT/enhancer binding protein (C/EBP), A1383. 73rd Annual Meeting of the Endocrine Society.
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