 Connection
Robert Eoff to DNA-Directed DNA Polymerase
This is a "connection" page, showing publications Robert Eoff has written about DNA-Directed DNA Polymerase.
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Connection Strength |
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7.454 |
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Ketkar A, Maddukuri L, Penthala NR, Reed MR, Zafar MK, Crooks PA, Eoff RL. Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms. ACS Chem Biol. 2019 06 21; 14(6):1337-1351.
Score: 0.642
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Zafar MK, Maddukuri L, Ketkar A, Penthala NR, Reed MR, Eddy S, Crooks PA, Eoff RL. A Small-Molecule Inhibitor of Human DNA Polymerase ? Potentiates the Effects of Cisplatin in Tumor Cells. Biochemistry. 2018 02 20; 57(7):1262-1273.
Score: 0.586
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Eddy S, Tillman M, Maddukuri L, Ketkar A, Zafar MK, Eoff RL. Human Translesion Polymerase ? Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA. Biochemistry. 2016 09 20; 55(37):5218-29.
Score: 0.532
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Bostian AC, Maddukuri L, Reed MR, Savenka T, Hartman JH, Davis L, Pouncey DL, Miller GP, Eoff RL. Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells. Chem Res Toxicol. 2016 Jan 19; 29(1):101-8.
Score: 0.507
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Eddy S, Maddukuri L, Ketkar A, Zafar MK, Henninger EE, Pursell ZF, Eoff RL. Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA. Biochemistry. 2015 May 26; 54(20):3218-30.
Score: 0.485
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Zafar MK, Ketkar A, Lodeiro MF, Cameron CE, Eoff RL. Kinetic analysis of human PrimPol DNA polymerase activity reveals a generally error-prone enzyme capable of accurately bypassing 7,8-dihydro-8-oxo-2'-deoxyguanosine. Biochemistry. 2014 Oct 21; 53(41):6584-94.
Score: 0.466
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Maddukuri L, Ketkar A, Eddy S, Zafar MK, Eoff RL. The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa. Nucleic Acids Res. 2014 Oct 29; 42(19):12027-40.
Score: 0.466
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Ketkar A, Zafar MK, Banerjee S, Marquez VE, Egli M, Eoff RL. Differential furanose selection in the active sites of archaeal DNA polymerases probed by fixed-conformation nucleotide analogues. Biochemistry. 2012 Nov 13; 51(45):9234-44.
Score: 0.407
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Maddukuri L, Ketkar A, Eddy S, Zafar MK, Griffin WC, Eoff RL. Enhancement of human DNA polymerase ? activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome protein. J Biol Chem. 2012 Dec 07; 287(50):42312-23.
Score: 0.406
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Ketkar A, Zafar MK, Banerjee S, Marquez VE, Egli M, Eoff RL. A nucleotide-analogue-induced gain of function corrects the error-prone nature of human DNA polymerase iota. J Am Chem Soc. 2012 Jun 27; 134(25):10698-705.
Score: 0.397
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Eoff RL, McGrath CE, Maddukuri L, Salamanca-Pinz?n SG, Marquez VE, Marnett LJ, Guengerich FP, Egli M. Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues. Angew Chem Int Ed Engl. 2010 Oct 04; 49(41):7481-5.
Score: 0.353
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Eoff RL, Stafford JB, Szekely J, Rizzo CJ, Egli M, Guengerich FP, Marnett LJ. Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct. Biochemistry. 2009 Aug 04; 48(30):7079-88.
Score: 0.326
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Eoff RL, Sanchez-Ponce R, Guengerich FP. Conformational changes during nucleotide selection by Sulfolobus solfataricus DNA polymerase Dpo4. J Biol Chem. 2009 Jul 31; 284(31):21090-9.
Score: 0.322
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Christov PP, Richie-Jannetta R, Kingsley PJ, Vemulapalli A, Kim K, Sulikowski GA, Rizzo CJ, Ketkar A, Eoff RL, Rouzer CA, Marnett LJ. Site-Specific Synthesis of Oligonucleotides Containing 6-Oxo-M1dG, the Genomic Metabolite of M1dG, and Liquid Chromatography-Tandem Mass Spectrometry Analysis of Its In Vitro Bypass by Human Polymerase ?. Chem Res Toxicol. 2021 12 20; 34(12):2567-2578.
Score: 0.191
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Ketkar A, Smith L, Johnson C, Richey A, Berry M, Hartman JH, Maddukuri L, Reed MR, Gunderson JEC, Leung JWC, Eoff RL. Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs. Nucleic Acids Res. 2021 02 26; 49(4):2065-2084.
Score: 0.181
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Kim J, Song I, Jo A, Shin JH, Cho H, Eoff RL, Guengerich FP, Choi JY. Biochemical analysis of six genetic variants of error-prone human DNA polymerase ? involved in translesion DNA synthesis. Chem Res Toxicol. 2014 Oct 20; 27(10):1837-52.
Score: 0.116
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Zhao L, Pence MG, Eoff RL, Yuan S, Fercu CA, Guengerich FP. Elucidation of kinetic mechanisms of human translesion DNA polymerase ? using tryptophan mutants. FEBS J. 2014 Oct; 281(19):4394-410.
Score: 0.115
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Maddukuri L, Shuck SC, Eoff RL, Zhao L, Rizzo CJ, Guengerich FP, Marnett LJ. Replication, repair, and translesion polymerase bypass of N6-oxopropenyl-2'-deoxyadenosine. Biochemistry. 2013 Dec 03; 52(48):8766-76.
Score: 0.110
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Ketkar A, Zafar MK, Maddukuri L, Yamanaka K, Banerjee S, Egli M, Choi JY, Lloyd RS, Eoff RL. Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity. Chem Res Toxicol. 2013 Feb 18; 26(2):221-32.
Score: 0.104
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Choi JY, Eoff RL, Pence MG, Wang J, Martin MV, Kim EJ, Folkmann LM, Guengerich FP. Roles of the four DNA polymerases of the crenarchaeon Sulfolobus solfataricus and accessory proteins in DNA replication. J Biol Chem. 2011 Sep 09; 286(36):31180-93.
Score: 0.093
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Maddukuri L, Eoff RL, Choi JY, Rizzo CJ, Guengerich FP, Marnett LJ. In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases ?, ?, and Rev1. Biochemistry. 2010 Sep 28; 49(38):8415-24.
Score: 0.088
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Zhang H, Eoff RL, Kozekov ID, Rizzo CJ, Egli M, Guengerich FP. Structure-function relationships in miscoding by Sulfolobus solfataricus DNA polymerase Dpo4: guanine N2,N2-dimethyl substitution produces inactive and miscoding polymerase complexes. J Biol Chem. 2009 Jun 26; 284(26):17687-99.
Score: 0.081
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Irimia A, Eoff RL, Guengerich FP, Egli M. Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2'-deoxyguanosine adduct. J Biol Chem. 2009 Aug 14; 284(33):22467-22480.
Score: 0.081
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Voehler MW, Eoff RL, McDonald WH, Guengerich FP, Stone MP. Modulation of the structure, catalytic activity, and fidelity of African swine fever virus DNA polymerase X by a reversible disulfide switch. J Biol Chem. 2009 Jul 03; 284(27):18434-44.
Score: 0.080
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Choi JY, Lim S, Eoff RL, Guengerich FP. Kinetic analysis of base-pairing preference for nucleotide incorporation opposite template pyrimidines by human DNA polymerase iota. J Mol Biol. 2009 Jun 05; 389(2):264-74.
Score: 0.080
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Stafford JB, Eoff RL, Kozekova A, Rizzo CJ, Guengerich FP, Marnett LJ. Translesion DNA synthesis by human DNA polymerase eta on templates containing a pyrimidopurinone deoxyguanosine adduct, 3-(2'-deoxy-beta-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one. Biochemistry. 2009 Jan 20; 48(2):471-80.
Score: 0.078
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Eoff RL, Angel KC, Egli M, Guengerich FP. Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing. J Biol Chem. 2007 May 04; 282(18):13573-84.
Score: 0.069
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Irimia A, Zang H, Loukachevitch LV, Eoff RL, Guengerich FP, Egli M. Calcium is a cofactor of polymerization but inhibits pyrophosphorolysis by the Sulfolobus solfataricus DNA polymerase Dpo4. Biochemistry. 2006 May 16; 45(19):5949-56.
Score: 0.065
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Yamanaka K, Dorjsuren D, Eoff RL, Egli M, Maloney DJ, Jadhav A, Simeonov A, Lloyd RS. A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase ?. PLoS One. 2012; 7(10):e45032.
Score: 0.025
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Connection Strength
The connection strength for concepts is the sum of the scores for each matching publication.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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