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Susan Smyth

TitleDean - College of Medicine
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentCollege of Medicine
Address4200 Shuffield.
Mail Slot # 007
Little Rock AR 72205
ORCID ORCID Icon0000-0001-6840-7892 Additional info
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    Collapse Overview 
    Collapse overview
    Inflammation and Thrombosis Program

    Drawing on a long-standing interest in platelet biology, our group has established animal models for studying the role of platelet membrane proteins in thrombosis and the response to arterial injury, and has delineated specific signaling systems responsible for mediating platelet-leukocyte interactions and for inflammation in the context of arterial injury and cardiac hypertrophy. We are interested in understanding the functional interplay between thrombosis and inflammation has resulted in observations about beneficial effects of antiplatelet drugs in infectious and inflammatory states of pneumonia and sepsis. This work has also spawned clinical trials of the effects of antithrombotic therapy on inflammation and the identification of biomarkers of ischemic heart disease. Current funded work continues to identify novel signaling pathways in platelets, which likely will be the target for future translational studies.

    Lysolipid Signaling Program

    Our group also has a longstanding research interest in the role of bioactive lysophospholipid, such as lysophosphatidic acid (LPA), as mediators of cardiovascular disease. The lysophospholipase D autotaxin (ATX) catalyzes the hydrolysis of circulating or cell-associated lysophosphatidylcholine (LPC) to generate LPA, which has potent, receptor-mediated effects on blood and vascular cells. LPA is a proteotypic member of a family of bioactive lipid phosphoric acids that function as receptor-active mediators with roles in cell growth, differentiation, apoptosis and development. Our contributions to the literature include characterizing pathways for production and metabolism of LPA in the circulation; providing the first evidence of a pathologic role for LPA receptors in the response to arterial injury; identifying key structural and functional elements of ATX and mechanisms for regulation of ATX function by localization along cell surfaces. Current work is focused on identifying mechanistic links between dietary intake of lipids and cardiovascular disease risk. Current investigations are exploring the possibility that choline-containing lipids and adipose-derived ATX serve as links between diet and cardiovascular disease risk.

    LPA can hydrolyzed and inactivated by lipid phosphate phosphatase (LPP) enzymes present on cell membranes. A genome-wide association studies (GWAS) identified the PLPP3/PPAP2B gene encoding LPP3 as a novel loci associated with coronary artery disease susceptibility. We have established that LPP3 expression in mice is critical to attenuate inflammation, reduce smooth muscle cell proliferation, and maintain endothelial barrier function following vascular injury in an LPA-dependent manner. Current studies are focused on understanding how heritable human variation in PLPP3 predisposes to the development and/or complications of atherosclerosis and calcific aortic valve disease, which may ultimately translate into the validation of novel pathways for disease prevention.


    Collapse Affiliation 
    Collapse member of
    Department of Internal Medicine
    Division of Cardiovascular Medicine
    Collapse clinical activities
    Cardiologist

    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Executive Vice Chancellor

    Collapse education and training
    University of North Carolina, Chapel HIllMD05/1994Medicine
    University of North Carolina, Chapel HIllPhD08/1992Pharmacology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Amin S, Gupta V, Du G, McMullen C, Sirrine M, Williams MV, Smyth SS, Chadha R, Stearley S, Li J. Developing and Demonstrating the Viability and Availability of the Multilevel Implementation Strategy for Syncope Optimal Care Through Engagement (MISSION) Syncope App: Evidence-Based Clinical Decision Support Tool. J Med Internet Res. 2021 Nov 16; 23(11):e25192. PMID: 34783669.
      View in: PubMed
    2. Alnabelsi TS, Faulkner SP, Cook M, Freeman K, Shelton J, Paranzino M, Nerusu S, Smyth SS, Gupta VA. Passive antipyretic therapy is not as effective as invasive hypothermia for maintaining normothermia after cardiac arrest. Am J Emerg Med. 2021 Jul 02; 50:202-206. PMID: 34390903.
      View in: PubMed
    3. Zhang Y, Cui J, Zhang G, Wu C, Abdel-Latif A, Smyth SS, Shiroishi T, Mackman N, Wei Y, Tao M, Li Z. Inflammasome activation promotes venous thrombosis through pyroptosis. Blood Adv. 2021 06 22; 5(12):2619-2623. PMID: 34152402.
      View in: PubMed
    4. Clouser JM, Sirrine M, McMullen CA, Cowley AM, Smyth SS, Gupta V, Williams MV, Li J. "Passing Out is a Serious Thing": Patient Expectations for Syncope Evaluation and Management. Patient Prefer Adherence. 2021; 15:1213-1223. PMID: 34113084.
      View in: PubMed
    5. Li J, Smyth SS, Clouser JM, McMullen CA, Gupta V, Williams MV. Planning Implementation Success of Syncope Clinical Practice Guidelines in the Emergency Department Using CFIR Framework. Medicina (Kaunas). 2021 Jun 03; 57(6). PMID: 34204986.
      View in: PubMed
    6. Ai AL, Smyth SS. Depression After Open Heart Surgery: Influences of Optimism, Sex, and Event-Related Medical Factors. J Nerv Ment Dis. 2021 03 01; 209(3):212-217. PMID: 33315797.
      View in: PubMed
    7. Annabathula R, Dugan A, Bhalla V, Davis GA, Smyth SS, Gupta VA. Value-based assessment of implementing a Pulmonary Embolism Response Team (PERT). J Thromb Thrombolysis. 2021 Jan; 51(1):217-225. PMID: 32542527.
      View in: PubMed
    8. Ai AL, McMullen CA, Smyth SS. Preoperative Optimism Related to Low Anxiety in Patients 1 Month After Open Heart Surgery. J Nerv Ment Dis. 2020 12; 208(12):966-973. PMID: 33252897.
      View in: PubMed
    9. Abo-Aly M, George B, Shokri E, Chelvarajan L, El-Helw M, Smyth SS, Abdel-Latif A, Ziada K. Cangrelor in addition to standard therapy reduces cardiac damage and inflammatory markers in patients with ST-segment elevation myocardial infarction. J Thromb Thrombolysis. 2021 Oct; 52(3):934-940. PMID: 33258102.
      View in: PubMed
    10. Xiang B, Zhang G, Zhang Y, Wu C, Joshi S, Morris AJ, Ware J, Smyth SS, Whiteheart SW, Li Z. Calcium Ion Chelation Preserves Platelet Function During Cold Storage. Arterioscler Thromb Vasc Biol. 2021 01; 41(1):234-249. PMID: 33176450.
      View in: PubMed
    11. Alnabelsi T, Annabathula R, Shelton J, Paranzino M, Faulkner SP, Cook M, Dugan AJ, Nerusu S, Smyth SS, Gupta VA. Predicting in-hospital mortality after an in-hospital cardiac arrest: A multivariate analysis. Resusc Plus. 2020 Dec; 4:100039. PMID: 34223316.
      View in: PubMed
    12. Tripathi H, Al-Darraji A, Abo-Aly M, Peng H, Shokri E, Chelvarajan L, R Donahue R, Levitan BM, Gao E, Hernandez G, Morris AJ, Smyth SS, Abdel-Latif A. Autotaxin inhibition reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction. J Mol Cell Cardiol. 2020 12; 149:95-114. PMID: 33017574.
      View in: PubMed
    13. Moliterno DJ, Smyth SS, Abdel-Latif A. CYP2C19 Genotyping to Guide Antiplatelet Therapy After Percutaneous Coronary Interventions: One Size Rarely Fits All. JAMA. 2020 08 25; 324(8):747-749. PMID: 32840581.
      View in: PubMed
    14. Smyth SS, Moliterno D, McClure R, Campbell J, Buckler L, McMullen CA, Whayne TF, Endean E, Sekela M, Karpf M. Securing the Future for a Major Academic Cardiovascular Program: Hardwiring a Referral Network and Preparing for a Transition to Value-Based Reimbursement. Hosp Top. 2020 Oct-Dec; 98(4):163-171. PMID: 32804052.
      View in: PubMed
    15. Li J, Gupta V, Smyth SS, Cowley A, Du G, Sirrine M, Stearley S, Chadha R, Bhalla V, Williams MV. Value-based syncope evaluation and management: Perspectives of health care professionals on readiness, barriers and enablers. Am J Emerg Med. 2020 09; 38(9):1867-1874. PMID: 32739858.
      View in: PubMed
    16. Smyth SS, Kraemer M, Yang L, Van Hoose P, Morris AJ. Roles for lysophosphatidic acid signaling in vascular development and disease. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 08; 1865(8):158734. PMID: 32376340.
      View in: PubMed
    17. Wayne NB, Davis GA, Macaulay TE, Beavers CJ, Messerli AW, Dugan A, Smyth SS. Reduced dose thrombolysis with ultrasound-facilitated catheter-directed administration for acute pulmonary embolism reduces length of stay. J Thromb Thrombolysis. 2020 May; 49(4):540-544. PMID: 31797241.
      View in: PubMed
    18. Tsevat J, Smyth SS. Training the translational workforce: Expanding beyond translational research to include translational science. J Clin Transl Sci. 2020 Apr 06; 4(4):360-362. PMID: 33244418.
      View in: PubMed
    19. McMullen CA, Natarajan V, Smyth SS. Lysophospholipids and their receptors: New data and new insights into their function. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 07; 1865(7):158697. PMID: 32179098.
      View in: PubMed
    20. Bhalla V, Lamping OF, Abdel-Latif A, Bhalla M, Ziada K, Smyth SS. Contemporary Meta-Analysis of Extended Direct-Acting Oral Anticoagulant Thromboprophylaxis to Prevent Venous Thromboembolism. Am J Med. 2020 09; 133(9):1074-1081.e8. PMID: 32151593.
      View in: PubMed
    21. Sreejit G, Abdel-Latif A, Athmanathan B, Annabathula R, Dhyani A, Noothi SK, Quaife-Ryan GA, Al-Sharea A, Pernes G, Dragoljevic D, Lal H, Schroder K, Hanaoka BY, Raman C, Grant MB, Hudson JE, Smyth SS, Porrello ER, Murphy AJ, Nagareddy PR. Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction. Circulation. 2020 03 31; 141(13):1080-1094. PMID: 31941367.
      View in: PubMed
    22. Kang J, Moser DK, Biddle MJ, Lennie TA, Smyth SS, Vsevolozhskaya OA. Inflammatory properties of diet mediate the effect of depressive symptoms on Framingham risk score in men and women: Results from the National Health and Nutrition Examination Survey (2007-2014). Nutr Res. 2020 02; 74:78-86. PMID: 31958655.
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    23. Smyth SS, Natarajan V, McMullen CA. The 2019 FASEB Science Research Conference on Lysophospholipid and Related Mediators: From Bench to Clinic, July 28 to August 2, 2019, Lisbon, Portugal. FASEB J. 2019 11; 33(11):11622-11624. PMID: 31671503.
      View in: PubMed
    24. Mueller PA, Yang L, Ubele M, Mao G, Brandon J, Vandra J, Nichols TC, Escalante-Alcalde D, Morris AJ, Smyth SS. Coronary Artery Disease Risk-Associated Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis. Arterioscler Thromb Vasc Biol. 2019 11; 39(11):2261-2272. PMID: 31533471.
      View in: PubMed
    25. Kraemer MP, Mao G, Hammill C, Yan B, Li Y, Onono F, Smyth SS, Morris AJ. Effects of diet and hyperlipidemia on levels and distribution of circulating lysophosphatidic acid. J Lipid Res. 2019 11; 60(11):1818-1828. PMID: 31484695.
      View in: PubMed
    26. Mao G, Smyth SS, Morris AJ. Regulation of PLPP3 gene expression by NF-?B family transcription factors. J Biol Chem. 2019 09 20; 294(38):14009-14019. PMID: 31362988.
      View in: PubMed
    27. Hillerson D, Ogunbayo GO, Salih M, Misumida N, Abdel-Latif A, Smyth SS, Messerli AW. Outcomes and Characteristics of Myocardial Infarction in Patients With Cirrhosis. J Invasive Cardiol. 2019 Jul; 31(7):E162-E169. PMID: 31257209.
      View in: PubMed
    28. Wu C, Lu W, Zhang Y, Zhang G, Shi X, Hisada Y, Grover SP, Zhang X, Li L, Xiang B, Shi J, Li XA, Daugherty A, Smyth SS, Kirchhofer D, Shiroishi T, Shao F, Mackman N, Wei Y, Li Z. Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis. Immunity. 2019 06 18; 50(6):1401-1411.e4. PMID: 31076358.
      View in: PubMed
    29. Ogunbayo GO, Pecha R, Misumida N, Goodwin E, Ayoub K, Hillerson D, Elbadawi A, Abdel-Latif A, Elayi CS, Messerli AW, Smyth SS. Outcomes of fibrinolytic therapy for patients with metastatic cancer and acute pulmonary embolism. Pulm Pharmacol Ther. 2019 06; 56:104-107. PMID: 30959093.
      View in: PubMed
    30. Ogunbayo GO, Shrout TA, Misumida N, Abdel-Latif A, Smyth SS, Messerli AW, Ziada KM. Trends, Management Patterns, and Predictors of Leaving Against Medical Advice among Patients with Documented Noncompliance Admitted for Acute Myocardial Infarction. J Gen Intern Med. 2019 04; 34(4):486-488. PMID: 30402820.
      View in: PubMed
    31. Xenos ES, Davis GA, He Q, Green A, Smyth SS. The implementation of a pulmonary embolism response team in the management of intermediate- or high-risk pulmonary embolism. J Vasc Surg Venous Lymphat Disord. 2019 07; 7(4):493-500. PMID: 30930079.
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    32. Murph MM, Liu S, Jia W, Nguyen H, MacFarlane MA, Smyth SS, Kuppa SS, Dobbin KK. Diet-regulated behavior: FVB/N mice fed a lean diet exhibit increased nocturnal bouts of aggression between littermates. Lab Anim. 2020 Apr; 54(2):159-170. PMID: 30880558.
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    33. Yang L, Kraemer M, Fang XF, Angel PM, Drake RR, Morris AJ, Smyth SS. LPA receptor 4 deficiency attenuates experimental atherosclerosis. J Lipid Res. 2019 05; 60(5):972-980. PMID: 30796085.
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    34. Brandon JA, Kraemer M, Vandra J, Halder S, Ubele M, Morris AJ, Smyth SS. Adipose-derived autotaxin regulates inflammation and steatosis associated with diet-induced obesity. PLoS One. 2019; 14(2):e0208099. PMID: 30730895.
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    35. Ogunbayo GO, Pecha R, Misumida N, Hillerson D, Elbadawi A, Abdel-Latif A, Elayi CS, Messerli AW, Smyth SS. Relation of CHA2DS2VASC Score With Hemorrhagic Stroke and Mortality in Patients Undergoing Fibrinolytic Therapy for ST Elevation Myocardial Infarction. Am J Cardiol. 2019 01 15; 123(2):212-217. PMID: 30415795.
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    36. Ogunbayo GO, Messerli AW, Ha LD, Elbadawi A, Olorunfemi O, Darrat Y, Guglin M, Okwechime R, Akanya D, Abdel-Latif A, Smyth SS, Elayi CS. Trends in the Incidence and In-Hospital Outcomes of Patients With Atrial Fibrillation Complicated by Non-ST-Segment Elevation Myocardial Infarction. Angiology. 2019 Apr; 70(4):317-324. PMID: 30231624.
      View in: PubMed
    37. Bhalla V, Abdel-Latif A, Bhalla M, Ziada K, Williams MV, Smyth SS. Meta-Analysis Comparing the Efficacy, Safety, and Cost-Benefit of Direct Acting Oral Anticoagulants Versus Enoxaparin Thromboprophylaxis to Prevent Venous Thromboembolism Among Hospitalized Patients. Am J Cardiol. 2018 10 01; 122(7):1236-1243. PMID: 30082040.
      View in: PubMed
    38. Federico L, Yang L, Brandon J, Panchatcharam M, Ren H, Mueller P, Sunkara M, Escalante-Alcalde D, Morris AJ, Smyth SS. Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice. PLoS One. 2018; 13(6):e0198063. PMID: 29889835.
      View in: PubMed
    39. Kuppa SS, Jia W, Liu S, Nguyen H, Smyth SS, Mills GB, Dobbin KK, Hardman WJ, Murph MM. Autotaxin exacerbates tumor progression by enhancing MEK1 and overriding the function of miR-489-3p. Cancer Lett. 2018 09 28; 432:84-92. PMID: 29859298.
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    40. Becker RC, Sexton T, Smyth SS. Translational Implications of Platelets as Vascular First Responders. Circ Res. 2018 02 02; 122(3):506-522. PMID: 29420211.
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    41. Kraemer MP, Halder S, Smyth SS, Morris AJ. Measurement of Lysophosphatidic Acid and Sphingosine-1-Phosphate by Liquid Chromatography-Coupled Electrospray Ionization Tandem Mass Spectrometry. Methods Mol Biol. 2018; 1697:31-42. PMID: 28770493.
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    42. Butt MU, Buzsaki LA, Smyth SS, Elayi SC. Deep Vein Thrombosis Complicated by Spontaneous Iliopsoas Hematoma in Patient with Septic Shock. Am J Case Rep. 2017 Oct 30; 18:1148-1152. PMID: 29081491.
      View in: PubMed
    43. Dong A, Mueller P, Yang F, Yang L, Morris A, Smyth SS. Direct thrombin inhibition with dabigatran attenuates pressure overload-induced cardiac fibrosis and dysfunction in mice. Thromb Res. 2017 Nov; 159:58-64. PMID: 28982031.
      View in: PubMed
    44. Ogunbayo GO, Misumida N, Olorunfemi O, Elbadawi A, Saheed D, Messerli A, Elayi CS, Smyth SS. Comparison of Outcomes in Patients Having Acute Myocardial Infarction With Versus Without Sickle-Cell Anemia. Am J Cardiol. 2017 Nov 15; 120(10):1768-1771. PMID: 28867123.
      View in: PubMed
    45. Ogunbayo GO, Charnigo R, Darrat Y, Morales G, Kotter J, Olorunfemi O, Elbadawi A, Sorrell VL, Smyth SS, Elayi CS. Incidence, predictors, and outcomes associated with pneumothorax during cardiac electronic device implantation: A 16-year review in over 3.7 million patients. Heart Rhythm. 2017 12; 14(12):1764-1770. PMID: 28735733.
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    46. Morris AJ, Smyth SS. Regulation of Lysophosphatidic Acid Metabolism and Signaling by Lipoproteins. Arterioscler Thromb Vasc Biol. 2016 10; 36(10):2029-30. PMID: 27655776.
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    47. Sexton TR, Wallace EL, Chen A, Charnigo RJ, Reda HK, Ziada KM, Gurley JC, Smyth SS. Thromboinflammatory response and predictors of outcomes in patients undergoing transcatheter aortic valve replacement. J Thromb Thrombolysis. 2016 Apr; 41(3):384-93. PMID: 26743061.
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    48. Sexton T, Wallace EL, Smyth SS. Anti-Thrombotic Effects of Statins in Acute Coronary Syndromes: At the Intersection of Thrombosis, Inflammation, and Platelet-Leukocyte Interactions. Curr Cardiol Rev. 2016; 12(4):324-329. PMID: 27142048.
      View in: PubMed
    49. Abdel-Latif A, Heron PM, Morris AJ, Smyth SS. Lysophospholipids in coronary artery and chronic ischemic heart disease. Curr Opin Lipidol. 2015 Oct; 26(5):432-7. PMID: 26270808.
      View in: PubMed
    50. Xiang B, Zhang G, Ye S, Zhang R, Huang C, Liu J, Tao M, Ruan C, Smyth SS, Whiteheart SW, Li Z. Characterization of a Novel Integrin Binding Protein, VPS33B, Which Is Important for Platelet Activation and In Vivo Thrombosis and Hemostasis. Circulation. 2015 Dec 15; 132(24):2334-44. PMID: 26399659.
      View in: PubMed
    51. Klyachkin YM, Nagareddy PR, Ye S, Wysoczynski M, Asfour A, Gao E, Sunkara M, Brandon JA, Annabathula R, Ponnapureddy R, Solanki M, Pervaiz ZH, Smyth SS, Ratajczak MZ, Morris AJ, Abdel-Latif A. Pharmacological Elevation of Circulating Bioactive Phosphosphingolipids Enhances Myocardial Recovery After Acute Infarction. Stem Cells Transl Med. 2015 Nov; 4(11):1333-43. PMID: 26371341.
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    52. Beavers CJ, Heron P, Smyth SS, Bain JA, Macaulay TE. Obesity and Antiplatelets-Does One Size Fit All? Thromb Res. 2015 Oct; 136(4):712-6. PMID: 26205154.
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    53. Reschen ME, Gaulton KJ, Lin D, Soilleux EJ, Morris AJ, Smyth SS, O'Callaghan CA. Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding. PLoS Genet. 2015 Apr; 11(4):e1005061. PMID: 25835000.
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    54. George B, Wallace EL, Charnigo R, Wingerter KE, Kapadia P, Gurley JC, Smyth SS. A retrospective analysis of catheter-based thrombolytic therapy for acute submassive and massive pulmonary embolism. Vasc Med. 2015 Apr; 20(2):122-30. PMID: 25832600.
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    55. Mueller P, Ye S, Morris A, Smyth SS. Lysophospholipid mediators in the vasculature. Exp Cell Res. 2015 May 01; 333(2):190-194. PMID: 25825155.
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    56. Ferraris VA, Boral LI, Cohen AJ, Smyth SS, White GC. Consensus review of the treatment of cardiovascular disease in people with hemophilia A and B. Cardiol Rev. 2015 Mar-Apr; 23(2):53-68. PMID: 25436468.
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    57. Sexton TR, Wallace EL, Macaulay TE, Charnigo RJ, Evangelista V, Campbell CL, Bailey AL, Smyth SS. The effect of rosuvastatin on thromboinflammation in the setting of acute coronary syndrome. J Thromb Thrombolysis. 2015 Feb; 39(2):186-95. PMID: 25307674.
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    58. Sexton TR, Wallace EL, Macaulay TE, Charnigo RJ, Evangelista V, Campbell CL, Bailey AL, Smyth SS. The effect of rosuvastatin on platelet-leukocyte interactions in the setting of acute coronary syndrome. J Am Coll Cardiol. 2015 Jan 27; 65(3):306-7. PMID: 25614429.
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    59. Morris AJ, Smyth SS. Lipid phosphate phosphatases: more than one way to put the brakes on LPA signaling? J Lipid Res. 2014 Nov; 55(11):2195-7. PMID: 25271297.
      View in: PubMed
    60. Yang F, Dong A, Ahamed J, Sunkara M, Smyth SS. Granule cargo release from bone marrow-derived cells sustains cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2014 Nov 15; 307(10):H1529-38. PMID: 25239803.
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    61. Ye S, Huang Y, Joshi S, Zhang J, Yang F, Zhang G, Smyth SS, Li Z, Takai Y, Whiteheart SW. Platelet secretion and hemostasis require syntaxin-binding protein STXBP5. J Clin Invest. 2014 Oct; 124(10):4517-28. PMID: 25244094.
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    62. Totani L, Piccoli A, Dell'Elba G, Concetta A, Di Santo A, Martelli N, Federico L, Pamuklar Z, Smyth SS, Evangelista V. Phosphodiesterase type 4 blockade prevents platelet-mediated neutrophil recruitment at the site of vascular injury. Arterioscler Thromb Vasc Biol. 2014 Aug; 34(8):1689-96. PMID: 24925970.
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    63. Nagareddy PR, Kraakman M, Masters SL, Stirzaker RA, Gorman DJ, Grant RW, Dragoljevic D, Hong ES, Abdel-Latif A, Smyth SS, Choi SH, Korner J, Bornfeldt KE, Fisher EA, Dixit VD, Tall AR, Goldberg IJ, Murphy AJ. Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metab. 2014 May 06; 19(5):821-35. PMID: 24807222.
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    64. Steinhubl SR, Eikelboom JW, Hylek EM, Dauerman HL, Smyth SS, Becker RC. Antiplatelet therapy in prevention of cardio- and venous thromboembolic events. J Thromb Thrombolysis. 2014 Apr; 37(3):362-71. PMID: 24221804.
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    65. Panchatcharam M, Salous AK, Brandon J, Miriyala S, Wheeler J, Patil P, Sunkara M, Morris AJ, Escalante-Alcalde D, Smyth SS. Mice with targeted inactivation of ppap2b in endothelial and hematopoietic cells display enhanced vascular inflammation and permeability. Arterioscler Thromb Vasc Biol. 2014 Apr; 34(4):837-45. PMID: 24504738.
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    66. Bain J, Oyler DR, Smyth SS, Macaulay TE. Pathophysiology and pharmacologic treatment of venous thromboembolism. Curr Drug Targets. 2014 Feb; 15(2):199-209. PMID: 24102472.
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    67. Smyth SS, Mueller P, Yang F, Brandon JA, Morris AJ. Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):479-86. PMID: 24482375.
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    68. Storey RF, Kotha J, Smyth SS, Moliterno DJ, Rorick TL, Moccetti T, Valgimigli M, Dery JP, Cornel JH, Thomas GS, Huber K, Harrington RA, Hord E, Judge HM, Chen E, Strony J, Mahaffey KW, Tricoci P, Becker RC, Jennings LK. Effects of vorapaxar on platelet reactivity and biomarker expression in non-ST-elevation acute coronary syndromes. The TRACER Pharmacodynamic Substudy. Thromb Haemost. 2014 May 05; 111(5):883-91. PMID: 24402559.
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    69. Sexton T, Smyth SS. Novel mediators and biomarkers of thrombosis. J Thromb Thrombolysis. 2014 Jan; 37(1):1-3. PMID: 24356857.
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    70. Wu T, Kooi CV, Shah P, Charnigo R, Huang C, Smyth SS, Morris AJ. Integrin-mediated cell surface recruitment of autotaxin promotes persistent directional cell migration. FASEB J. 2014 Feb; 28(2):861-70. PMID: 24277575.
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    71. Park GY, Lee YG, Berdyshev E, Nyenhuis S, Du J, Fu P, Gorshkova IA, Li Y, Chung S, Karpurapu M, Deng J, Ranjan R, Xiao L, Jaffe HA, Corbridge SJ, Kelly EA, Jarjour NN, Chun J, Prestwich GD, Kaffe E, Ninou I, Aidinis V, Morris AJ, Smyth SS, Ackerman SJ, Natarajan V, Christman JW. Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation. Am J Respir Crit Care Med. 2013 Oct 15; 188(8):928-40. PMID: 24050723.
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    72. Navab M, Hough G, Buga GM, Su F, Wagner AC, Meriwether D, Chattopadhyay A, Gao F, Grijalva V, Danciger JS, Van Lenten BJ, Org E, Lusis AJ, Pan C, Anantharamaiah GM, Farias-Eisner R, Smyth SS, Reddy ST, Fogelman AM. Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid. J Lipid Res. 2013 Dec; 54(12):3403-18. PMID: 24085744.
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    73. Nagareddy P, Smyth SS. Inflammation and thrombosis in cardiovascular disease. Curr Opin Hematol. 2013 Sep; 20(5):457-63. PMID: 23892572.
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    74. Salous AK, Panchatcharam M, Sunkara M, Mueller P, Dong A, Wang Y, Graf GA, Smyth SS, Morris AJ. Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice. J Lipid Res. 2013 Oct; 54(10):2775-84. PMID: 23948545.
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    75. Wallace EL, Smyth SS. Targeting platelet thrombin receptor signaling to prevent thrombosis. Pharmaceuticals (Basel). 2013 Aug 02; 6(8):915-28. PMID: 24276376.
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    76. Wallace EL, Kotter JR, Charnigo R, Kuvlieva LB, Smyth SS, Ziada KM, Campbell CL. Fibrinolytic therapy versus primary percutaneous coronary interventions for ST-segment elevation myocardial infarction in Kentucky: time to establish systems of care? South Med J. 2013 Jul; 106(7):391-8. PMID: 23820318.
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    77. Moliterno DJ, Smyth SS. Tissue necrosis factor a and targeting its receptor in ischaemic heart disease. Heart. 2013 Sep; 99(18):1305-6. PMID: 23697653.
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    78. Bledzka K, Smyth SS, Plow EF. Integrin aIIbß3: from discovery to efficacious therapeutic target. Circ Res. 2013 Apr 12; 112(8):1189-200. PMID: 23580774.
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    79. Rodés-Cabau J, Dauerman HL, Cohen MG, Mehran R, Small EM, Smyth SS, Costa MA, Mega JL, O'Donoghue ML, Ohman EM, Becker RC. Antithrombotic treatment in transcatheter aortic valve implantation: insights for cerebrovascular and bleeding events. J Am Coll Cardiol. 2013 Dec 24; 62(25):2349-2359. PMID: 23583252.
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    80. Morris AJ, Smyth SS. Lysophosphatidic acid and cardiovascular disease: seeing is believing. J Lipid Res. 2013 May; 54(5):1153-5. PMID: 23509404.
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    81. Karapetyan AV, Klyachkin YM, Selim S, Sunkara M, Ziada KM, Cohen DA, Zuba-Surma EK, Ratajczak J, Smyth SS, Ratajczak MZ, Morris AJ, Abdel-Latif A. Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction. Stem Cells Dev. 2013 Jun 01; 22(11):1645-56. PMID: 23282236.
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    82. Gross AK, Dunn SP, Feola DJ, Martin CA, Charnigo R, Li Z, Abdel-Latif A, Smyth SS. Clopidogrel treatment and the incidence and severity of community acquired pneumonia in a cohort study and meta-analysis of antiplatelet therapy in pneumonia and critical illness. J Thromb Thrombolysis. 2013 Feb; 35(2):147-54. PMID: 23124575.
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    83. Xiang B, Zhang G, Guo L, Li XA, Morris AJ, Daugherty A, Whiteheart SW, Smyth SS, Li Z. Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway. Nat Commun. 2013; 4:2657. PMID: 24150174.
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    84. Xiang B, Zhang G, Ren H, Sunkara M, Morris AJ, Gartner TK, Smyth SS, Li Z. The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism. PLoS One. 2012; 7(12):e51037. PMID: 23236426.
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    85. Wallace EL, Smyth SS. Spontaneous coronary thrombosis following thrombolytic therapy for acute cardiovascular accident and stroke: a case study. J Thromb Thrombolysis. 2012 Nov; 34(4):548-51. PMID: 22684577.
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    86. Panchatcharam M, Miriyala S, Salous A, Wheeler J, Dong A, Mueller P, Sunkara M, Escalante-Alcalde D, Morris AJ, Smyth SS. Lipid phosphate phosphatase 3 negatively regulates smooth muscle cell phenotypic modulation to limit intimal hyperplasia. Arterioscler Thromb Vasc Biol. 2013 Jan; 33(1):52-9. PMID: 23104851.
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    87. Yang F, Dong A, Mueller P, Caicedo J, Sutton AM, Odetunde J, Barrick CJ, Klyachkin YM, Abdel-Latif A, Smyth SS. Coronary artery remodeling in a model of left ventricular pressure overload is influenced by platelets and inflammatory cells. PLoS One. 2012; 7(8):e40196. PMID: 22916095.
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    88. Dong A, Sunkara M, Panchatcharam M, Salous A, Selim S, Morris AJ, Smyth SS. Synergistic effect of anemia and red blood cells transfusion on inflammation and lung injury. Adv Hematol. 2012; 2012:924042. PMID: 22919395.
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    89. Ren H, Panchatcharam M, Mueller P, Escalante-Alcalde D, Morris AJ, Smyth SS. Lipid phosphate phosphatase (LPP3) and vascular development. Biochim Biophys Acta. 2013 Jan; 1831(1):126-32. PMID: 22835522.
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    90. Abdel-Latif A, Smyth SS. Preventing platelet thrombosis with a PAR1 pepducin. Circulation. 2012 Jul 03; 126(1):13-5. PMID: 22705888.
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    91. Bailey AL, Smyth SS. Invasive coronary vasoreactivity testing to diagnose microvascular dysfunction in women. JACC Cardiovasc Interv. 2012 Jun; 5(6):654-5. PMID: 22721661.
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    92. Federico L, Ren H, Mueller PA, Wu T, Liu S, Popovic J, Blalock EM, Sunkara M, Ovaa H, Albers HM, Mills GB, Morris AJ, Smyth SS. Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice. Mol Endocrinol. 2012 May; 26(5):786-97. PMID: 22474126.
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    93. Rowley JW, Finn AV, French PA, Jennings LK, Bluestein D, Gross PL, Freedman JE, Steinhubl SR, Zimmerman GA, Becker RC, Dauerman HL, Smyth SS. Cardiovascular devices and platelet interactions: understanding the role of injury, flow, and cellular responses. Circ Cardiovasc Interv. 2012 Apr; 5(2):296-304. PMID: 22511738.
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    94. Wang TY, Angiolillo DJ, Cushman M, Sabatine MS, Bray PF, Smyth SS, Dauerman HL, French PA, Becker RC. Platelet biology and response to antiplatelet therapy in women: implications for the development and use of antiplatelet pharmacotherapies for cardiovascular disease. J Am Coll Cardiol. 2012 Mar 06; 59(10):891-900. PMID: 22381424.
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    95. Granada JF, Price MJ, French PA, Steinhubl SR, Cutlip DE, Becker RC, Smyth SS, Dauerman HL. Platelet-mediated thrombosis and drug-eluting stents. Circ Cardiovasc Interv. 2011 Dec 01; 4(6):629-37. PMID: 22186107.
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    96. Selim S, Sunkara M, Salous AK, Leung SW, Berdyshev EV, Bailey A, Campbell CL, Charnigo R, Morris AJ, Smyth SS. Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions. Clin Sci (Lond). 2011 Dec; 121(12):565-72. PMID: 21749329.
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    97. Smyth SS. Anti-platelet therapy. Curr Drug Targets. 2011 Nov; 12(12):1790-1. PMID: 21718241.
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    98. Cheng HY, Dong A, Panchatcharam M, Mueller P, Yang F, Li Z, Mills G, Chun J, Morris AJ, Smyth SS. Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling. Arterioscler Thromb Vasc Biol. 2012 Jan; 32(1):24-32. PMID: 22015657.
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    99. Zhao J, He D, Berdyshev E, Zhong M, Salgia R, Morris AJ, Smyth SS, Natarajan V, Zhao Y. Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways. Biochem J. 2011 Oct 01; 439(1):45-55. PMID: 21696367.
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    100. Zhang G, Xiang B, Ye S, Chrzanowska-Wodnicka M, Morris AJ, Gartner TK, Whiteheart SW, White GC, Smyth SS, Li Z. Distinct roles for Rap1b protein in platelet secretion and integrin aIIbß3 outside-in signaling. J Biol Chem. 2011 Nov 11; 286(45):39466-77. PMID: 21940635.
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    101. Li Z, Smyth SS. Connexin 37 counteracts clotting. Circulation. 2011 Aug 23; 124(8):873-5. PMID: 21859981.
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    102. Song Z, Jin R, Yu S, Rivet JJ, Smyth SS, Nanda A, Granger DN, Li G. CD40 is essential in the upregulation of TRAF proteins and NF-kappaB-dependent proinflammatory gene expression after arterial injury. PLoS One. 2011; 6(8):e23239. PMID: 21876738.
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    103. Fulkerson Z, Wu T, Sunkara M, Kooi CV, Morris AJ, Smyth SS. Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. J Biol Chem. 2011 Oct 07; 286(40):34654-63. PMID: 21832043.
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    104. Zhang G, Xiang B, Dong A, Skoda RC, Daugherty A, Smyth SS, Du X, Li Z. Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation. Blood. 2011 Sep 29; 118(13):3670-9. PMID: 21803853.
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    105. Bailey AL, Smyth SS, Campbell CL. The case against routine aspirin use for primary prevention in low-risk adults. Am Fam Physician. 2011 Jun 15; 83(12):1387-90. PMID: 21671539.
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    106. Campbell CL, Steinhubl SR, Hooper WC, Jozic J, Smyth SS, Bernstein D, De Staercke C, Syros G, Negus BH, Stuckey T, Stone GW, Mehran R, Dangas G. Bleeding events are associated with an increase in markers of inflammation in acute coronary syndromes: an ACUITY trial substudy. J Thromb Thrombolysis. 2011 Feb; 31(2):139-45. PMID: 20872045.
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    107. Hausmann J, Kamtekar S, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HM, van Meeteren LA, Houben AJ, van Zeijl L, Jansen S, Andries M, Hall T, Pegg LE, Benson TE, Kasiem M, Harlos K, Kooi CW, Smyth SS, Ovaa H, Bollen M, Morris AJ, Moolenaar WH, Perrakis A. Structural basis of substrate discrimination and integrin binding by autotaxin. Nat Struct Mol Biol. 2011 Feb; 18(2):198-204. PMID: 21240271.
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    108. Williams MS, Weiss EJ, Sabatine MS, Simon DI, Bahou WF, Becker LC, Parise LV, Dauerman HL, French PA, Smyth SS, Becker RC. Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2372-84. PMID: 21084706.
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    109. Smyth SS. Platelets unplugged: an ATVB special series focused on platelet biology. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2339-40. PMID: 21084705.
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    110. Li Z, Yang F, Dunn S, Gross AK, Smyth SS. Platelets as immune mediators: their role in host defense responses and sepsis. Thromb Res. 2011 Mar; 127(3):184-8. PMID: 21075430.
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    111. Xiang B, Zhang G, Liu J, Morris AJ, Smyth SS, Gartner TK, Li Z. A G(i) -independent mechanism mediating Akt phosphorylation in platelets. J Thromb Haemost. 2010 Sep; 8(9):2032-41. PMID: 20586915.
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    112. Abdel-Latif A, Zuba-Surma EK, Ziada KM, Kucia M, Cohen DA, Kaplan AM, Van Zant G, Selim S, Smyth SS, Ratajczak MZ. Evidence of mobilization of pluripotent stem cells into peripheral blood of patients with myocardial ischemia. Exp Hematol. 2010 Dec; 38(12):1131-1142.e1. PMID: 20800644.
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    113. Ren H, Federico L, Huang H, Sunkara M, Drennan T, Frohman MA, Smyth SS, Morris AJ. A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis. Mol Biol Cell. 2010 Sep 15; 21(18):3171-81. PMID: 20660155.
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    114. Dong A, Caicedo J, Han SG, Mueller P, Saha S, Smyth SS, Gairola CG. Enhanced platelet reactivity and thrombosis in Apoe-/- mice exposed to cigarette smoke is attenuated by P2Y12 antagonism. Thromb Res. 2010 Oct; 126(4):e312-7. PMID: 20451958.
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    115. Dauerman HL, Bhatt DL, Gretler DD, French PA, Smyth SS, Becker RC. Bridging the gap between clinical trials of antiplatelet therapies and applications among elderly patients. Am Heart J. 2010 Apr; 159(4):508-517.e1. PMID: 20362707.
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    116. Albers HM, Dong A, van Meeteren LA, Egan DA, Sunkara M, van Tilburg EW, Schuurman K, van Tellingen O, Morris AJ, Smyth SS, Moolenaar WH, Ovaa H. Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7257-62. PMID: 20360563.
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    117. Panchatcharam M, Miriyala S, Yang F, Leitges M, Chrzanowska-Wodnicka M, Quilliam LA, Anaya P, Morris AJ, Smyth SS. Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling. Int J Biochem Cell Biol. 2010 Jun; 42(6):965-74. PMID: 20184965.
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    118. Miriyala S, Subramanian T, Panchatcharam M, Ren H, McDermott MI, Sunkara M, Drennan T, Smyth SS, Spielmann HP, Morris AJ. Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells. J Biol Chem. 2010 Apr 30; 285(18):13918-29. PMID: 20110354.
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    119. Smyth SS, McEver RP, Weyrich AS, Morrell CN, Hoffman MR, Arepally GM, French PA, Dauerman HL, Becker RC. Platelet functions beyond hemostasis. J Thromb Haemost. 2009 Nov; 7(11):1759-66. PMID: 19691483.
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    120. Li G, Jin R, Norris RA, Zhang L, Yu S, Wu F, Markwald RR, Nanda A, Conway SJ, Smyth SS, Granger DN. Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway. Atherosclerosis. 2010 Feb; 208(2):358-65. PMID: 19695571.
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    121. Morris AJ, Panchatcharam M, Cheng HY, Federico L, Fulkerson Z, Selim S, Miriyala S, Escalante-Alcalde D, Smyth SS. Regulation of blood and vascular cell function by bioactive lysophospholipids. J Thromb Haemost. 2009 Jul; 7 Suppl 1:38-43. PMID: 19630765.
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    122. Barrick CJ, Dong A, Waikel R, Corn D, Yang F, Threadgill DW, Smyth SS. Parent-of-origin effects on cardiac response to pressure overload in mice. Am J Physiol Heart Circ Physiol. 2009 Sep; 297(3):H1003-9. PMID: 19561308.
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    123. Barrick CJ, Roberts RB, Rojas M, Rajamannan NM, Suitt CB, O'Brien KD, Smyth SS, Threadgill DW. Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. Am J Physiol Heart Circ Physiol. 2009 Jul; 297(1):H65-75. PMID: 19448146.
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    124. Oestreich JH, Holt J, Dunn SP, Smyth SS, Campbell CL, Charnigo R, Akers WS, Steinhubl SR. Considerable variability in platelet activity among patients with coronary artery disease in response to an increased maintenance dose of clopidogrel. Coron Artery Dis. 2009 May; 20(3):207-13. PMID: 19318928.
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    125. Morris AJ, Selim S, Salous A, Smyth SS. Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation. Trends Cardiovasc Med. 2009 May; 19(4):135-40. PMID: 19818950.
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    126. Bailey AL, Scantlebury DC, Smyth SS. Thrombosis and antithrombotic therapy in women. Arterioscler Thromb Vasc Biol. 2009 Mar; 29(3):284-8. PMID: 19221205.
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    127. Oestreich JH, Smyth SS, Campbell CL. Platelet function analysis: at the edge of meaning. Thromb Haemost. 2009 Feb; 101(2):217-9. PMID: 19190799.
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    128. Meredith D, Panchatcharam M, Miriyala S, Tsai YS, Morris AJ, Maeda N, Stouffer GA, Smyth SS. Dominant-negative loss of PPARgamma function enhances smooth muscle cell proliferation, migration, and vascular remodeling. Arterioscler Thromb Vasc Biol. 2009 Apr; 29(4):465-71. PMID: 19179641.
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    129. Pamuklar Z, Federico L, Liu S, Umezu-Goto M, Dong A, Panchatcharam M, Fulkerson Z, Fulerson Z, Berdyshev E, Natarajan V, Fang X, van Meeteren LA, Moolenaar WH, Mills GB, Morris AJ, Smyth SS. Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis. J Biol Chem. 2009 Mar 13; 284(11):7385-94. PMID: 19139100.
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    130. Smyth SS, Woulfe DS, Weitz JI, Gachet C, Conley PB, Goodman SG, Roe MT, Kuliopulos A, Moliterno DJ, French PA, Steinhubl SR, Becker RC. G-protein-coupled receptors as signaling targets for antiplatelet therapy. Arterioscler Thromb Vasc Biol. 2009 Apr; 29(4):449-57. PMID: 19023091.
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    131. Panchatcharam M, Miriyala S, Yang F, Rojas M, End C, Vallant C, Dong A, Lynch K, Chun J, Morris AJ, Smyth SS. Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure. Circ Res. 2008 Sep 12; 103(6):662-70. PMID: 18703779.
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    132. Federico L, Pamuklar Z, Smyth SS, Morris AJ. Therapeutic potential of autotaxin/lysophospholipase d inhibitors. Curr Drug Targets. 2008 Aug; 9(8):698-708. PMID: 18691016.
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    133. Smyth SS, Cheng HY, Miriyala S, Panchatcharam M, Morris AJ. Roles of lysophosphatidic acid in cardiovascular physiology and disease. Biochim Biophys Acta. 2008 Sep; 1781(9):563-70. PMID: 18586114.
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    134. Pamuklar Z, Lee JS, Cheng HY, Panchatcharam M, Steinhubl S, Morris AJ, Charnigo R, Smyth SS. Individual heterogeneity in platelet response to lysophosphatidic acid: evidence for a novel inhibitory pathway. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):555-61. PMID: 18202325.
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    135. Smyth SS, Monroe DM, Wysokinski WE, McBane RD, Whiteheart SW, Becker RC, Steinhubl SR. Platelet activation and its patient-specific consequences. Thromb Res. 2008; 122(4):435-41. PMID: 17949794.
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    136. Stansfield WE, Rojas M, Corn D, Willis M, Patterson C, Smyth SS, Selzman CH. Characterization of a model to independently study regression of ventricular hypertrophy. J Surg Res. 2007 Oct; 142(2):387-93. PMID: 17574596.
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    137. Li G, Keenan AC, Young JC, Hall MJ, Pamuklar Z, Ohman EM, Steinhubl SR, Smyth SS. Effects of unfractionated heparin and glycoprotein IIb/IIIa antagonists versus bivalirdin on myeloperoxidase release from neutrophils. Arterioscler Thromb Vasc Biol. 2007 Aug; 27(8):1850-6. PMID: 17525363.
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    138. Dorsch MP, Lee JS, Lynch DR, Dunn SP, Rodgers JE, Schwartz T, Colby E, Montague D, Smyth SS. Aspirin resistance in patients with stable coronary artery disease with and without a history of myocardial infarction. Ann Pharmacother. 2007 May; 41(5):737-41. PMID: 17456544.
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    139. Lee JS, Dunn SP, Marshall HM, Cohen MG, Smyth SS. A case report of simultaneous thrombosis of two coronary artery stents in association with clopidogrel resistance. Clin Cardiol. 2007 Apr; 30(4):200-3. PMID: 17443655.
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    140. Matsuo O, Lijnen HR, Ueshima S, Kojima S, Smyth SS. A guide to murine fibrinolytic factor structure, function, assays, and genetic alterations. J Thromb Haemost. 2007 Apr; 5(4):680-9. PMID: 17403202.
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    141. Emeis JJ, Jirouskova M, Muchitsch EM, Shet AS, Smyth SS, Johnson GJ. A guide to murine coagulation factor structure, function, assays, and genetic alterations. J Thromb Haemost. 2007 Apr; 5(4):670-9. PMID: 17403201.
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    142. Morris AJ, Smyth SS. Measurement of autotaxin/lysophospholipase D activity. Methods Enzymol. 2007; 434:89-104. PMID: 17954243.
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    143. Barrick CJ, Rojas M, Schoonhoven R, Smyth SS, Threadgill DW. Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal- and background-dependent development of concentric left ventricular hypertrophy. Am J Physiol Heart Circ Physiol. 2007 May; 292(5):H2119-30. PMID: 17172276.
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    144. Evangelista V, Pamuklar Z, Piccoli A, Manarini S, Dell'elba G, Pecce R, Martelli N, Federico L, Rojas M, Berton G, Lowell CA, Totani L, Smyth SS. Src family kinases mediate neutrophil adhesion to adherent platelets. Blood. 2007 Mar 15; 109(6):2461-9. PMID: 17095622.
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    145. Liu P, Patil S, Rojas M, Fong AM, Smyth SS, Patel DD. CX3CR1 deficiency confers protection from intimal hyperplasia after arterial injury. Arterioscler Thromb Vasc Biol. 2006 Sep; 26(9):2056-62. PMID: 16809547.
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    146. Totani L, Piccoli A, Manarini S, Federico L, Pecce R, Martelli N, Cerletti C, Piccardoni P, Lowell CA, Smyth SS, Berton G, Evangelista V. Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin. Biochem J. 2006 May 15; 396(1):89-98. PMID: 16433632.
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    147. Smyth SS, Jennings JL. PPARgamma agonists: a new strategy for antithrombotic therapy. J Thromb Haemost. 2005 Oct; 3(10):2147-8. PMID: 16194191.
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    148. Chrzanowska-Wodnicka M, Smyth SS, Schoenwaelder SM, Fischer TH, White GC. Rap1b is required for normal platelet function and hemostasis in mice. J Clin Invest. 2005 Mar; 115(3):680-7. PMID: 15696195.
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    149. Stouffer GA, Smyth SS. Effects of thrombin on interactions between beta3-integrins and extracellular matrix in platelets and vascular cells. Arterioscler Thromb Vasc Biol. 2003 Nov 01; 23(11):1971-8. PMID: 12947018.
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    150. Smyth SS, Sciorra VA, Sigal YJ, Pamuklar Z, Wang Z, Xu Y, Prestwich GD, Morris AJ. Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity. J Biol Chem. 2003 Oct 31; 278(44):43214-23. PMID: 12909631.
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    151. Sajid M, Zhao R, Pathak A, Smyth SS, Stouffer GA. Alphavbeta3-integrin antagonists inhibit thrombin-induced proliferation and focal adhesion formation in smooth muscle cells. Am J Physiol Cell Physiol. 2003 Nov; 285(5):C1330-8. PMID: 12878490.
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    152. Smyth SS. Tweezing apart von Willebrand factor-glycoprotein Ib-IX adhesive signaling. J Thromb Haemost. 2003 Jun; 1(6):1136-7. PMID: 12871308.
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    153. Evangelista V, Manarini S, Coller BS, Smyth SS. Role of P-selectin, beta2-integrins, and Src tyrosine kinases in mouse neutrophil-platelet adhesion. J Thromb Haemost. 2003 May; 1(5):1048-54. PMID: 12871376.
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    154. Smyth SS, Pathak A, Stouffer GA. In-stent restenosis: more fuel for the fire. Am Heart J. 2002 Oct; 144(4):577-9. PMID: 12360150.
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    155. Smyth SS, Patterson C. Tiny dancers: the integrin-growth factor nexus in angiogenic signaling. J Cell Biol. 2002 Jul 08; 158(1):17-21. PMID: 12105178.
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    156. Jirousková M, Smyth SS, Kudryk B, Coller BS. A hamster antibody to the mouse fibrinogen gamma chain inhibits platelet-fibrinogen interactions and FXIIIa-mediated fibrin cross-linking, and facilitates thrombolysis. Thromb Haemost. 2001 Oct; 86(4):1047-56. PMID: 11686323.
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    157. Zhang ZG, Zhang L, Tsang W, Goussev A, Powers C, Ho KL, Morris D, Smyth SS, Coller BS, Chopp M. Dynamic platelet accumulation at the site of the occluded middle cerebral artery and in downstream microvessels is associated with loss of microvascular integrity after embolic middle cerebral artery occlusion. Brain Res. 2001 Sep 07; 912(2):181-94. PMID: 11532435.
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    158. Smyth SS, Reis ED, Väänänen H, Zhang W, Coller BS. Variable protection of beta 3-integrin--deficient mice from thrombosis initiated by different mechanisms. Blood. 2001 Aug 15; 98(4):1055-62. PMID: 11493451.
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    159. Smyth SS, Reis ED, Zhang W, Fallon JT, Gordon RE, Coller BS. Beta(3)-integrin-deficient mice but not P-selectin-deficient mice develop intimal hyperplasia after vascular injury: correlation with leukocyte recruitment to adherent platelets 1 hour after injury. Circulation. 2001 May 22; 103(20):2501-7. PMID: 11369692.
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    160. Smyth SS, Tsakiris DA, Scudder LE, Coller BS. Structure and function of murine alphaIIbbeta3 (GPIIb/IIIa): studies using monoclonal antibodies and beta3-null mice,. Thromb Haemost. 2000 Dec; 84(6):1103-8. PMID: 11154120.
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    161. Lengweiler S, Smyth SS, Jirouskova M, Scudder LE, Park H, Moran T, Coller BS. Preparation of monoclonal antibodies to murine platelet glycoprotein IIb/IIIa (alphaIIbbeta3) and other proteins from hamster-mouse interspecies hybridomas. Biochem Biophys Res Commun. 1999 Aug 19; 262(1):167-73. PMID: 10448087.
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    162. Peerschke EI, Smyth SS, Teng EI, Dalzell M, Ghebrehiwet B. Human umbilical vein endothelial cells possess binding sites for the globular domain of C1q. J Immunol. 1996 Nov 01; 157(9):4154-8. PMID: 8892652.
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    163. Smyth SS, Parise LV. Regulation of ligand binding to glycoprotein IIb-IIIa (integrin alpha IIb beta 3) in isolated platelet membranes. Biochem J. 1993 Jun 15; 292 ( Pt 3):749-58. PMID: 7686366.
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    164. Smyth SS, Joneckis CC, Parise LV. Regulation of vascular integrins. Blood. 1993 Jun 01; 81(11):2827-43. PMID: 8499621.
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    165. Smyth SS, Hillery CA, Parise LV. Fibrinogen binding to purified platelet glycoprotein IIb-IIIa (integrin alpha IIb beta 3) is modulated by lipids. J Biol Chem. 1992 Aug 05; 267(22):15568-77. PMID: 1639797.
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    166. Hillery CA, Smyth SS, Parise LV. Phosphorylation of human platelet glycoprotein IIIa (GPIIIa). Dissociation from fibrinogen receptor activation and phosphorylation of GPIIIa in vitro. J Biol Chem. 1991 Aug 05; 266(22):14663-9. PMID: 1650365.
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