Hui-Ming Chang
Credentials | Active State Medical License, California |
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| Active State Medical License, Massachusetts |
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| Active State Medical License, Texas |
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| American Board of Anesthesiology |
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Title | Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Pharmacology & Toxicology, College of Medicine |
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Address | 325 S. Elm St. Mail Slot # 611 Little Rock AR 72205
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vCard | Download vCard |
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Title | Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Internal Medicine, College of Medicine |
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Division | Cardiovascular Medicine |
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Overview Dr. Hui-Ming Chang is a cross-discipline physician scientist with academic leadership experience in research, administration, education, and clinical medicine. She received her medical degree from National Taiwan University, master of public health in Epidemiology and master of science in Physiology from Harvard Chan School of Public Health. Her post-graduate trainings include internship at George Washington University Medical Center, residency at Boston University Medical Center, and clinical and research fellowship at Harvard Medical School, Boston Children’s Hospital. Dr. Chang came to UAMS from University of Missouri School of Medicine where she was co-director of the Center for Precision Medicine. Prior to U. of Missouri, she was faculty at Harvard Medical School, Massachusetts General Hospital, U. of Texas MD Anderson Cancer Center, and U. of Texas Health Science Center at Houston. Her prior academic positions include vice president for international programs and special advisor to the president at the U. of Texas Health Science Center at Houston, director of senior clinical performance examination at U. of Texas Houston Medical School, and director of education, Department of Palliative Care and Rehabilitation at U. of Texas MD Anderson Cancer Center.
Her services on national and institutional committees include Board of Directors of the American Academy of Pain Medicine, Task Force for clinical practice guidelines-cancer pain management of the American Society of Anesthesiologists, Executive Council of the U. of Texas at Houston, Search Committee for President of the U. of Texas at Houston, and scientific advisory committee of the university clinical research center at the U. of Texas at Houston and M.D. Anderson Cancer Center. She was the recipient of Fleming and Davenport award and medical honoree of American Heart Association Houston Heart Ball. She was nominated for Councilor position, alumni association of Harvard Chan School of Public Health in 2020. Her contributions to medical sciences include opioid effects on evoked substance P release from primary sensory neurons, co-authoring the discovery of SUMO/Sentrin, and the cloning of Class H defect in Glycosylphosphatidylinositol Anchor. Recently she devoted majority of her time on onco-cardiology (cardio-oncology). With her cross-discipline expertise in epidemiology, evidence-based medicine, and basic research, she translated bench laboratory data to bedside clinical trials for prevention of doxorubicin-induced cardiotoxicity. This investigator initiated clinical trials received 3.48 million NIH RO1 award, HL 151993, 6/2020-5/2025.
Biography Co-Director 2016-2020
Center for Precision Medicine
University of Missouri
Columbia, MO
Special Advisor to the President 2001-2008
University of Texas Health Science Center at Houston
Houston, TX
Vice President 2006-2008
International Programs
University of Texas Health Science Center at Houston Houston, TX
Associate Vice President of International Programs 2001-2006
University of Texas Health Science Center at Houston
Houston, TX
Director of Education 2000-2003
Department of Palliative Care and Rehabilitation
University of Texas, M.D. Anderson Cancer Center
Houston, TX
Course Director 1997-2003
Senior Clinical Rotation
(Palliative Care, Pain Management and Symptom Control)
University of Texas Medical School at Houston
University of Texas, M.D. Anderson Cancer Center
Houston, TX
Director 1996-2001
Senior Clinical Performance Examination
(Standardized Patient OSCE Examination)
University of Texas Medical School at Houston
Houston, TX
Harvard Medical School, Boston Children's Hospital, Boston MA | | 02/1988 | Clinical Fellow | Harvard Medical School, Boston Children's Hospital, Boston MA | | 02/1988 | Research Fellow | Boston University Medical Center, Boston MA | | 06/1986 | Resident, Anesthesiology | George Washington University Medical Center, Washington DC | | 6/1984 | Intern | Harvard Chan School of Public Health, Boston MA | MPH | 6/1982 | Epidemiology | Harvard Chan School of Public Health, Boston MA | MS | 6/1983 | Physiology | National Taiwan University, Taipei Taiwan | MD | 6/1980 | 7 year medical school |
2020 | Nominated, Councilor position, Alumni Association, Harvard Chan School of Public Health | 2011 | Medical Honoree, American Heart Association, Houston Heart Ball | 2001 - 2006 | Fleming and Davenport Awards, University of Texas MD Anderson Cancer Center | 1981 | Scholar, Harvard Alumni Association, Taipei |
Research 5R01HL151993-05 (CHANG, HUI-MING)Jun 1, 2021 - May 31, 2025 NIH/Nat. Heart, Lung & Blood Institute Prevention of Heart Failure induced by Doxorubicin with Early Administration of Dexrazoxane Role: Principal Investigator |
| 7R01HL151993 (YEH, EDWARD)Jun 1, 2021 - May 31, 2025 NIH/Nat. Heart, Lung & Blood Institute Prevention of Heart Failure induced by Doxorubicin with Early Administration of Dexrazoxane Role: Principal Investigator |
| 7R01HL151993-02 (CHANG, HUI-MING)Jun 1, 2021 - May 31, 2025 NIH/Nat. Heart, Lung & Blood Institute Prevention of Heart Failure induced by Doxorubicin with Early Administration of Dexrazoxane Role: Principal Investigator |
| R01HL151993 (CHANG, HUI-MING)Jun 1, 2021 - May 31, 2025 NIH/Nat. Heart, Lung & Blood Institute Prevention of Heart Failure induced by Doxorubicin with Early Administration of Dexrazoxane Role: Principal Investigator |
| R01CA080089 (YEH, EDWARD T.H.)Feb 1, 2000 - Jan 31, 2006 NIH PATHOBIOCHEMISTRY OF ACUTE PROMYELOCYTIC LEUKEMIA Role: Co-Investigator |
| R21GM057502 (YEH, EDWARD T.H.)Sep 1, 1999 - Aug 31, 2001 NIH STUDIES OF THE SENTRIN FAMILY OF UBIQUITIN-LIKE PROTEINS Role: Co-Investigator |
| R01HL045851 (YEH, EDWARD T.H.)Feb 1, 1991 - Jul 31, 1999 NIH PATHOBIOLOGY OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA Role: Co-Investigator |
Outreach Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Sheng ZF, Zhang H, Phaup JG, Zheng P, Kang X, Liu Z, Chang HM, Yeh ETH, Johnson AK, Pan HL, Li DP. Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension. Cardiovasc Res. 2023 07 06; 119(8):1751-1762. PMID: 37041718.
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Wang C, Nistala R, Cao M, Pan Y, Behrens M, Doll D, Hammer RD, Nistala P, Chang HM, Yeh ETH, Kang X. Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells. Cell Rep. 2023 02 28; 42(2):112105. PMID: 36807138.
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Zhang H, Sheng ZF, Wang J, Zheng P, Kang X, Chang HM, Yeh ETH, Li DP. Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala. J Neurochem. 2022 06; 161(6):478-491. PMID: 35583089.
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Sheng ZF, Zhang H, Zheng P, Chen S, Gu Z, Zhou JJ, Phaup JG, Chang HM, Yeh ETH, Pan HL, Li DP. Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension. Cardiovasc Res. 2022 01 29; 118(2):585-596. PMID: 33512443.
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Yang FM, Chang HM, Yeh ETH. Regulation of TLR4 signaling through the TRAF6/sNASP axis by reversible phosphorylation mediated by CK2 and PP4. Proc Natl Acad Sci U S A. 2021 11 23; 118(47). PMID: 34789577.
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Chang HM, Yeh ETH. SUMO: From Bench to Bedside. Physiol Rev. 2020 10 01; 100(4):1599-1619. PMID: 32666886.
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Li J, Chang HM, Banchs J, Araujo DM, Hassan SA, Wagar EA, Yeh ETH, Meng QH. Detection of subclinical cardiotoxicity in sarcoma patients receiving continuous doxorubicin infusion or pre-treatment with dexrazoxane before bolus doxorubicin. Cardiooncology. 2020; 6:1. PMID: 32154027.
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Yeh ETH, Ewer MS, Moslehi J, Dlugosz-Danecka M, Banchs J, Chang HM, Minotti G. Mechanisms and clinical course of cardiovascular toxicity of cancer treatment I. Oncology. Semin Oncol. 2019 12; 46(6):397-402. PMID: 31753424.
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Yang FM, Zuo Y, Zhou W, Xia C, Hahm B, Sullivan M, Cheng J, Chang HM, Yeh ET. sNASP inhibits TLR signaling to regulate immune response in sepsis. J Clin Invest. 2018 06 01; 128(6):2459-2472. PMID: 29733298.
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Chang HM, Okwuosa TM, Scarabelli T, Moudgil R, Yeh ETH. Cardiovascular Complications of Cancer?Therapy: Best Practices in Diagnosis, Prevention, and Management: Part 2. J Am Coll Cardiol. 2017 Nov 14; 70(20):2552-2565. PMID: 29145955.
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Chang HM, Moudgil R, Scarabelli T, Okwuosa TM, Yeh ETH. Cardiovascular Complications of Cancer?Therapy: Best Practices in Diagnosis, Prevention, and Management: Part 1. J Am Coll Cardiol. 2017 Nov 14; 70(20):2536-2551. PMID: 29145954.
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Yeh ETH, Chang HM. Cancer and Clot: Between a Rock and a Hard Place. J Am Coll Cardiol. 2017 08 22; 70(8):939-941. PMID: 28818203.
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Chang HM, Yeh ETH. Potential of Oncocardiology-Reply. JAMA Cardiol. 2017 07 01; 2(7):818. PMID: 28273313.
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Yeh ET, Chang HM. Oncocardiology-Past, Present, and Future: A Review. JAMA Cardiol. 2016 Dec 01; 1(9):1066-1072. PMID: 27541948.
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Chang HM. Pain and its management in patients with cancer. Cancer Invest. 2004; 22(5):799-809. PMID: 15581060.
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Chang HM. Educating medical students in pain medicine and palliative care. Pain Med. 2002 Sep; 3(3):194-5. PMID: 15099251.
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Chang HM. Cancer pain management. Med Clin North Am. 1999 May; 83(3):711-36, vii. PMID: 10386122.
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Okura T, Gong L, Kamitani T, Wada T, Okura I, Wei CF, Chang HM, Yeh ET. Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin. J Immunol. 1996 Nov 15; 157(10):4277-81. PMID: 8906799.
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Chang HM, Wang L, Zhang XP, Kream RM, Yeh ET. Modulation of Substance P Release in Primary Sensory Neurons by Misoprostol and Prostaglandins. Am J Ther. 1996 Apr; 3(4):276-279. PMID: 11862261.
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Ware RE, Howard TA, Kamitani T, Chang H-M, Yeh ETH, Seldin MF. Chromosomal assignment of genes involved in glycosylphosphatidylinositol anchor biosynthesis: implications for the pathogenesis of paroxysmal nocturnal hemoglobinuria. Blood. 1994 06 15; 83(12):3753-7. PMID: 8204896.
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Yeh ET, Kamitani T, Chang HM. Biosynthesis and processing of the glycosylphosphatidylinositol anchor in mammalian cells. Semin Immunol. 1994 Apr; 6(2):73-80. PMID: 8054538.
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Kamitani T, Chang HM, Rollins C, Waneck GL, Yeh ET. Correction of the class H defect in glycosylphosphatidylinositol anchor biosynthesis in Ltk- cells by a human cDNA clone. J Biol Chem. 1993 Oct 05; 268(28):20733-6. PMID: 8407896.
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Yeh ET, Chang HM. Pathophysiology and principles of pain management in rheumatic diseases. Curr Opin Rheumatol. 1992 Jun; 4(3):332-6. PMID: 1599812.
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Urakaze M, Kamitani T, DeGasperi R, Sugiyama E, Chang HM, Warren CD, Yeh ET. Identification of a missing link in glycosylphosphatidylinositol anchor biosynthesis in mammalian cells. J Biol Chem. 1992 Apr 05; 267(10):6459-62. PMID: 1313004.
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Thomas LJ, Urakaze M, DeGasperi R, Kamitani T, Sugiyama E, Chang HM, Warren CD, Yeh ET. Differential expression of glycosylphosphatidylinositol-anchored proteins in a murine T cell hybridoma mutant producing limiting amounts of the glycolipid core. Implications for paroxysmal nocturnal hemoglobinuria. J Clin Invest. 1992 Apr; 89(4):1172-7. PMID: 1532587.
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Sugiyama E, DeGasperi R, Urakaze M, Chang HM, Thomas LJ, Hyman R, Warren CD, Yeh ET. Identification of defects in glycosylphosphatidylinositol anchor biosynthesis in the Thy-1 expression mutants. J Biol Chem. 1991 Jul 05; 266(19):12119-22. PMID: 1829456.
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DeGasperi R, Thomas LJ, Sugiyama E, Chang HM, Beck PJ, Orlean P, Albright C, Waneck G, Sambrook JF, Warren CD, et al. Correction of a defect in mammalian GPI anchor biosynthesis by a transfected yeast gene. Science. 1990 Nov 16; 250(4983):988-91. PMID: 1978413.
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Chang HM, Berde CB, Holz GG, Steward GF, Kream RM. Sufentanil, morphine, met-enkephalin, and kappa-agonist (U-50,488H) inhibit substance P release from primary sensory neurons: a model for presynaptic spinal opioid actions. Anesthesiology. 1989 Apr; 70(4):672-7. PMID: 2467589.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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1989 | 1 | 1990 | 1 | 1991 | 1 | 1992 | 3 | 1993 | 1 | 1994 | 2 | 1996 | 2 | 1999 | 1 | 2002 | 1 | 2004 | 1 | 2016 | 1 | 2017 | 4 | 2018 | 1 | 2019 | 1 | 2020 | 2 | 2021 | 1 | 2022 | 2 | 2023 | 2 |
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