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Edward Yeh

TitleDepartment Chairperson
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentDepartment Chairs, College of Medicine
Address324 UAMS Campus Dr.
Mail Slot # 832
Little Rock AR 72205
ORCID ORCID Icon0000-0001-8184-7294 Additional info
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    Collapse Affiliation 
    Collapse member of
    American Society of Clinical Investigation
    American Association of Physicians
    American Association for the Advancement of Science
    American Clinical and Climatology Association

    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Chairman, Department of Internal Medicine

    Collapse education and training
    UC Berkeley, Berkeley CAA.B.05/1976Biochemistry
    UC Davis, Davis CAMD06/1980Medicine
    Collapse awards and honors
    2021 - 2024Scholar, Arkansas Research Alliances

    Collapse Research 
    Collapse research activities and funding
    7R01HL151993     (YEH, EDWARD)Jun 1, 2021 - May 31, 2025
    NIH/Nat. Heart, Lung & Blood Institute
    Prevention of Heart Failure induced by Doxorubicin with Early Administration of Dexrazoxane
    Role: Co-Investigator
    7R01HL126916-06     (YEH, EDWARD)Feb 1, 2021 - Aug 31, 2021
    NIH/Nat. Heart, Lung & Blood Institute
    Doxorubicin-induced Cardiotoxicity: The Role of Topoisomerase 2b
    Role: Principal Investigator
    R01HL126916     (YEH, EDWARD T.H.)Apr 1, 2015 - Aug 31, 2021
    NIH
    Doxorubicin-induced Cardiotoxicity: the Role of Topoisomerase 2b
    Role: Principal Investigator
    R01CA139520     (YEH, EDWARD T.H.)Mar 1, 2009 - Dec 31, 2014
    NIH
    De-SUMOylation and the Hypoxic Response
    Role: Principal Investigator
    R01CA080089     (YEH, EDWARD T.H.)Feb 1, 2000 - Jan 31, 2006
    NIH
    PATHOBIOCHEMISTRY OF ACUTE PROMYELOCYTIC LEUKEMIA
    Role: Principal Investigator
    R21GM057502     (YEH, EDWARD T.H.)Sep 1, 1999 - Aug 31, 2001
    NIH
    STUDIES OF THE SENTRIN FAMILY OF UBIQUITIN-LIKE PROTEINS
    Role: Principal Investigator
    R01HL045851     (YEH, EDWARD T.H.)Feb 1, 1991 - Jul 31, 1999
    NIH
    PATHOBIOLOGY OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse additional bibliographic sources
    The links below are provided by the researcher to provide access to external online bibliographies that they keep independently from the Profiles System.
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Sheng ZF, Zhang H, Phaup JG, Zheng P, Kang X, Liu Z, Chang HM, Yeh ETH, Johnson AK, Pan HL, Li DP. Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension. Cardiovasc Res. 2023 07 06; 119(8):1751-1762. PMID: 37041718.
      View in: PubMed
    2. Gautam N, Mounsey JP, Yeh ETH, Al'Aref SJ. Promises and challenges of machine learning for device therapy in heart failure. Eur Heart J. 2023 05 07; 44(18):1583-1585. PMID: 36806933.
      View in: PubMed
    3. Wang C, Nistala R, Cao M, Pan Y, Behrens M, Doll D, Hammer RD, Nistala P, Chang HM, Yeh ETH, Kang X. Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells. Cell Rep. 2023 02 28; 42(2):112105. PMID: 36807138.
      View in: PubMed
    4. Dufour D, Dumontet T, Sahut-Barnola I, Carusi A, Onzon M, Pussard E, Wilmouth JJ, Olabe J, Lucas C, Levasseur A, Damon-Soubeyrand C, Pointud JC, Roucher-Boulez F, Tauveron I, Bossis G, Yeh ET, Breault DT, Val P, Lefran?ois-Martinez AM, Martinez A. Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice. Nat Commun. 2022 12 21; 13(1):7858. PMID: 36543805.
      View in: PubMed
    5. Zhang H, Sheng ZF, Wang J, Zheng P, Kang X, Chang HM, Yeh ETH, Li DP. Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala. J Neurochem. 2022 06; 161(6):478-491. PMID: 35583089.
      View in: PubMed
    6. Wu YC, Hsu SP, Hu MC, Lan YT, Yeh ETH, Yang FM. PEP-sNASP Peptide Alleviates LPS-Induced Acute Lung Injury Through the TLR4/TRAF6 Axis. Front Med (Lausanne). 2022; 9:832713. PMID: 35386914.
      View in: PubMed
    7. Sheng ZF, Zhang H, Zheng P, Chen S, Gu Z, Zhou JJ, Phaup JG, Chang HM, Yeh ETH, Pan HL, Li DP. Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension. Cardiovasc Res. 2022 01 29; 118(2):585-596. PMID: 33512443.
      View in: PubMed
    8. Yang FM, Chang HM, Yeh ETH. Regulation of TLR4 signaling through the TRAF6/sNASP axis by reversible phosphorylation mediated by CK2 and PP4. Proc Natl Acad Sci U S A. 2021 11 23; 118(47). PMID: 34789577.
      View in: PubMed
    9. Chen X, Zhang Y, Ren X, Su Q, Liu Y, Dang X, Qin Y, Yang X, Xing Z, Shen Y, Wang Y, Bai Z, Yeh ETH, Wu H, Qi Y. The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels. J Biol Chem. 2021 10; 297(4):101183. PMID: 34509475.
      View in: PubMed
    10. Chen X, Qin Y, Zhang Y, Yang X, Xing Z, Shen Y, Cheng J, Yeh ETH, Wu H, Qi Y. SENP2-PLC?4 signaling regulates neurogenesis through the maintenance of calcium homeostasis. Cell Death Differ. 2022 02; 29(2):337-350. PMID: 34465891.
      View in: PubMed
    11. Chang HM, Yeh ETH. SUMO: From Bench to Bedside. Physiol Rev. 2020 10 01; 100(4):1599-1619. PMID: 32666886.
      View in: PubMed
    12. Li J, Chang HM, Banchs J, Araujo DM, Hassan SA, Wagar EA, Yeh ETH, Meng QH. Detection of subclinical cardiotoxicity in sarcoma patients receiving continuous doxorubicin infusion or pre-treatment with dexrazoxane before bolus doxorubicin. Cardiooncology. 2020; 6:1. PMID: 32154027.
      View in: PubMed
    13. Yeh ETH, Ewer MS, Moslehi J, Dlugosz-Danecka M, Banchs J, Chang HM, Minotti G. Mechanisms and clinical course of cardiovascular toxicity of cancer treatment I. Oncology. Semin Oncol. 2019 12; 46(6):397-402. PMID: 31753424.
      View in: PubMed
    14. Jiang L, Han X, Wang J, Wang C, Sun X, Xie J, Wu G, Phan H, Liu Z, Yeh ETH, Zhang C, Zhao M, Kang X. Correction: SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-? signaling. J Exp Med. 2018 08 06; 215(8):2227. PMID: 30006358.
      View in: PubMed
    15. Yang FM, Zuo Y, Zhou W, Xia C, Hahm B, Sullivan M, Cheng J, Chang HM, Yeh ET. sNASP inhibits TLR signaling to regulate immune response in sepsis. J Clin Invest. 2018 06 01; 128(6):2459-2472. PMID: 29733298.
      View in: PubMed
    16. Jiang L, Han X, Wang J, Wang C, Sun X, Xie J, Wu G, Phan H, Liu Z, Yeh ETH, Zhang C, Zhao M, Kang X. SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-? signaling. J Exp Med. 2018 05 07; 215(5):1337-1347. PMID: 29669741.
      View in: PubMed
    17. Li J, Lu D, Dou H, Liu H, Weaver K, Wang W, Li J, Yeh ETH, Williams BO, Zheng L, Yang T. Publisher Correction: Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway. Nat Commun. 2018 02 08; 9(1):646. PMID: 29422621.
      View in: PubMed
    18. Lao Y, Yang K, Wang Z, Sun X, Zou Q, Yu X, Cheng J, Tong X, Yeh ETH, Yang J, Yi J. DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages. J Biol Chem. 2018 03 16; 293(11):3965-3980. PMID: 29352108.
      View in: PubMed
    19. Li J, Lu D, Dou H, Liu H, Weaver K, Wang W, Li J, Yeh ETH, Williams BO, Zheng L, Yang T. Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway. Nat Commun. 2018 01 10; 9(1):143. PMID: 29321472.
      View in: PubMed
    20. Chang HM, Okwuosa TM, Scarabelli T, Moudgil R, Yeh ETH. Cardiovascular Complications of Cancer?Therapy: Best Practices in Diagnosis, Prevention, and Management: Part 2. J Am Coll Cardiol. 2017 Nov 14; 70(20):2552-2565. PMID: 29145955.
      View in: PubMed
    21. Chang HM, Moudgil R, Scarabelli T, Okwuosa TM, Yeh ETH. Cardiovascular Complications of Cancer?Therapy: Best Practices in Diagnosis, Prevention, and Management: Part 1. J Am Coll Cardiol. 2017 Nov 14; 70(20):2536-2551. PMID: 29145954.
      View in: PubMed
    22. Yeh ETH, Chang HM. Cancer and Clot: Between a Rock and a Hard Place. J Am Coll Cardiol. 2017 08 22; 70(8):939-941. PMID: 28818203.
      View in: PubMed
    23. Wang R, Liu F, Zhao Y, Wu D, Chen L, Yeh ETH, Huang C. Reversible regulation of ORC2 SUMOylation by PIAS4 and SENP2. Oncotarget. 2017 Sep 19; 8(41):70142-70155. PMID: 29050267.
      View in: PubMed
    24. Chang HM, Yeh ETH. Potential of Oncocardiology-Reply. JAMA Cardiol. 2017 07 01; 2(7):818. PMID: 28273313.
      View in: PubMed
    25. Bawa-Khalfe T, Yang FM, Ritho J, Lin HK, Cheng J, Yeh ET. SENP1 regulates PTEN stability to dictate prostate cancer development. Oncotarget. 2017 Mar 14; 8(11):17651-17664. PMID: 27852060.
      View in: PubMed
    26. Yeh ET, Chang HM. Oncocardiology-Past, Present, and Future: A Review. JAMA Cardiol. 2016 Dec 01; 1(9):1066-1072. PMID: 27541948.
      View in: PubMed
    27. Abe J, Martin JF, Yeh ET. The Future of Onco-Cardiology: We Are Not Just "Side Effect Hunters". Circ Res. 2016 09 30; 119(8):896-9. PMID: 27688305.
      View in: PubMed
    28. Zhou Z, Wang M, Li J, Xiao M, Chin YE, Cheng J, Yeh ET, Yang J, Yi J. SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer. Oncogene. 2016 11 10; 35(45):5826-5838. PMID: 27181202.
      View in: PubMed
    29. Lenihan DJ, Stevens PL, Massey M, Plana JC, Araujo DM, Fanale MA, Fayad LE, Fisch MJ, Yeh ET. The Utility of Point-of-Care Biomarkers to Detect Cardiotoxicity During Anthracycline Chemotherapy: A Feasibility Study. J Card Fail. 2016 Jun; 22(6):433-8. PMID: 27079675.
      View in: PubMed
    30. Fadol AP, Banchs J, Hassan SA, Yeh ET, Fellman B. Withdrawal of Heart Failure Medications in Cancer Survivors With Chemotherapy-Induced Left Ventricular Dysfunction: A Pilot Study. J Card Fail. 2016 Jun; 22(6):481-2. PMID: 27036866.
      View in: PubMed
    31. Huang C, Cheng J, Bawa-Khalfe T, Yao X, Chin YE, Yeh ETH. SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability. Cell Rep. 2016 Apr 05; 15(1):147-157. PMID: 27052177.
      View in: PubMed
    32. Moudgil R, Yeh ET. Mechanisms of Cardiotoxicity of Cancer Chemotherapeutic Agents: Cardiomyopathy and Beyond. Can J Cardiol. 2016 07; 32(7):863-870.e5. PMID: 27117975.
      View in: PubMed
    33. Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE. Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional ? cells. J Clin Invest. 2015 Oct 01; 125(10):3847-60. PMID: 26389676.
      View in: PubMed
    34. Ritho J, Arold ST, Yeh ET. A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress. Cell Rep. 2015 Aug 04; 12(5):734-42. PMID: 26212320.
      View in: PubMed
    35. Yeh ET, Vejpongsa P. Subclinical Cardiotoxicity Associated With?Cancer Therapy: Early Detection and Future Directions. J Am Coll Cardiol. 2015 Jun 16; 65(23):2523-5. PMID: 26065991.
      View in: PubMed
    36. Heo KS, Le NT, Cushman HJ, Giancursio CJ, Chang E, Woo CH, Sullivan MA, Taunton J, Yeh ET, Fujiwara K, Abe J. Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function. J Clin Invest. 2015 Mar 02; 125(3):1299-310. PMID: 25689261.
      View in: PubMed
    37. Cai R, Gu J, Sun H, Liu X, Mei W, Qi Y, Xue S, Ren S, Rabinowitz JE, Wang Y, Yeh ET, Cheng J. Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy. J Mol Cell Cardiol. 2015 Feb; 79:115-22. PMID: 25446185.
      View in: PubMed
    38. Qi Y, Wang J, Bomben VC, Li DP, Chen SR, Sun H, Xi Y, Reed JG, Cheng J, Pan HL, Noebels JL, Yeh ET. Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death. Neuron. 2014 Sep 03; 83(5):1159-71. PMID: 25189211.
      View in: PubMed
    39. Vejpongsa P, Yeh ET. Prevention of anthracycline-induced cardiotoxicity: challenges and opportunities. J Am Coll Cardiol. 2014 Sep 02; 64(9):938-45. PMID: 25169180.
      View in: PubMed
    40. Ren YH, Liu KJ, Wang M, Yu YN, Yang K, Chen Q, Yu B, Wang W, Li QW, Wang J, Hou ZY, Fang JY, Yeh ET, Yang J, Yi J. De-SUMOylation of FOXC2 by SENP3 promotes the epithelial-mesenchymal transition in gastric cancer cells. Oncotarget. 2014 Aug 30; 5(16):7093-104. PMID: 25216525.
      View in: PubMed
    41. Ewer M, Gianni L, Pane F, Sandri MT, Steiner RK, Wojnowski L, Yeh ET, Carver JR, Lipshultz SE, Minotti G, Armstrong GT, Cardinale D, Colan SD, Darby SC, Force TL, Kremer LC, Lenihan DJ, Sallan SE, Sawyer DB, Suter TM, Swain SM, van Leeuwen FE. Report on the international colloquium on cardio-oncology (rome, 12-14 march 2014). Ecancermedicalscience. 2014; 8:433. PMID: 24932213.
      View in: PubMed
    42. Vejpongsa P, Yeh ET. Wrestling with heart failure: SUMO-1 to the rescue. Circ Res. 2014 May 09; 114(10):1561-3. PMID: 24812349.
      View in: PubMed
    43. Simari RD, Pepine CJ, Traverse JH, Henry TD, Bolli R, Spoon DB, Yeh E, Hare JM, Schulman IH, Anderson RD, Lambert C, Sayre SL, Taylor DA, Ebert RF, Moy? LA. Bone marrow mononuclear cell therapy for acute myocardial infarction: a perspective from the cardiovascular cell therapy research network. Circ Res. 2014 May 09; 114(10):1564-8. PMID: 24812350.
      View in: PubMed
    44. Said R, Banchs J, Wheler J, Hess KR, Falchook G, Fu S, Naing A, Hong D, Piha-Paul S, Ye Y, Yeh E, Wolff RA, Tsimberidou AM. The prognostic significance of left ventricular ejection fraction in patients with advanced cancer treated in phase I clinical trials. Ann Oncol. 2014 Jan; 25(1):276-82. PMID: 24356639.
      View in: PubMed
    45. Qi Y, Zuo Y, Yeh ET, Cheng J. An essential role of small ubiquitin-like modifier (SUMO)-specific Protease 2 in myostatin expression and myogenesis. J Biol Chem. 2014 Feb 07; 289(6):3288-93. PMID: 24344126.
      View in: PubMed
    46. Vejpongsa P, Yeh ET. Topoisomerase 2?: a promising molecular target for primary prevention of anthracycline-induced cardiotoxicity. Clin Pharmacol Ther. 2014 Jan; 95(1):45-52. PMID: 24091715.
      View in: PubMed
    47. Ky B, Vejpongsa P, Yeh ET, Force T, Moslehi JJ. Emerging paradigms in cardiomyopathies associated with cancer therapies. Circ Res. 2013 Aug 30; 113(6):754-64. PMID: 23989717.
      View in: PubMed
    48. Heo KS, Chang E, Le NT, Cushman H, Yeh ET, Fujiwara K, Abe J. De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis. Circ Res. 2013 Mar 15; 112(6):911-23. PMID: 23381569.
      View in: PubMed
    49. Lee YC, Jin JK, Cheng CJ, Huang CF, Song JH, Huang M, Brown WS, Zhang S, Yu-Lee LY, Yeh ET, McIntyre BW, Logothetis CJ, Gallick GE, Lin SH. Targeting constitutively activated ?1 integrins inhibits prostate cancer metastasis. Mol Cancer Res. 2013 Apr; 11(4):405-17. PMID: 23339185.
      View in: PubMed
    50. Cai R, Yu T, Huang C, Xia X, Liu X, Gu J, Xue S, Yeh ET, Cheng J. SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1a. J Biol Chem. 2012 Dec 28; 287(53):44464-70. PMID: 23152500.
      View in: PubMed
    51. Zhang S, Liu X, Bawa-Khalfe T, Lu LS, Lyu YL, Liu LF, Yeh ET. Identification of the molecular basis of doxorubicin-induced cardiotoxicity. Nat Med. 2012 Nov; 18(11):1639-42. PMID: 23104132.
      View in: PubMed
    52. Willerson JT, Yeh ET, Perin EC. Cytokine profile and ST-elevation myocardial infarction. Circ Res. 2012 Oct 26; 111(10):1256-7. PMID: 23104875.
      View in: PubMed
    53. Bawa-Khalfe T, Lu LS, Zuo Y, Huang C, Dere R, Lin FM, Yeh ET. Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17466-71. PMID: 23045645.
      View in: PubMed
    54. Yeh ET, Willerson JT. Heparin and bone marrow-derived cell therapy: friend or foe? Circ Res. 2012 Sep 14; 111(7):819-20. PMID: 22982868.
      View in: PubMed
    55. Wang Q, Xia N, Li T, Xu Y, Zou Y, Zuo Y, Fan Q, Bawa-Khalfe T, Yeh ET, Cheng J. SUMO-specific protease 1 promotes prostate cancer progression and metastasis. Oncogene. 2013 May 09; 32(19):2493-8. PMID: 22733136.
      View in: PubMed
    56. Van Nguyen T, Angkasekwinai P, Dou H, Lin FM, Lu LS, Cheng J, Chin YE, Dong C, Yeh ET. SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation. Mol Cell. 2012 Jan 27; 45(2):210-21. PMID: 22284677.
      View in: PubMed
    57. Schwartz RJ, Yeh ET. Weighing in on heart failure: the role of SERCA2a SUMOylation. Circ Res. 2012 Jan 20; 110(2):198-9. PMID: 22267837.
      View in: PubMed
    58. Calabr? P, Golia E, Yeh ET. Role of C-reactive protein in acute myocardial infarction and stroke: possible therapeutic approaches. Curr Pharm Biotechnol. 2012 Jan; 13(1):4-16. PMID: 21470166.
      View in: PubMed
    59. Yeh ET. Microphthalmia-associated transcription factor, melanoma, and renal carcinoma: the small ubiquitin-like modifier connection. Pigment Cell Melanoma Res. 2011 Dec; 24(6):1079-80. PMID: 22216437.
      View in: PubMed
    60. Wang J, Najjar A, Zhang S, Rabinovich B, Willerson JT, Gelovani JG, Yeh ET. Molecular imaging of mesenchymal stem cell: mechanistic insight into cardiac repair after experimental myocardial infarction. Circ Cardiovasc Imaging. 2012 Jan; 5(1):94-101. PMID: 22135400.
      View in: PubMed
    61. Yeh ET, Lau SC, Su WJ, Tsai DJ, Tu YY, Lai YL. An examination of cancer-related fatigue through proposed diagnostic criteria in a sample of cancer patients in Taiwan. BMC Cancer. 2011 Sep 06; 11:387. PMID: 21896191.
      View in: PubMed
    62. Lin FM, Yeh ET. Balancing act during development: lessons from a SUMO-less SF-1. Dev Cell. 2011 Aug 16; 21(2):191-2. PMID: 21839916.
      View in: PubMed
    63. Lee MH, Mabb AM, Gill GB, Yeh ET, Miyamoto S. NF-?B induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress. Mol Cell. 2011 Jul 22; 43(2):180-91. PMID: 21777808.
      View in: PubMed
    64. Chen CT, Yamaguchi H, Lee HJ, Du Y, Lee HH, Xia W, Yu WH, Hsu JL, Yen CJ, Sun HL, Wang Y, Yeh ET, Hortobagyi GN, Hung MC. Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase. Mol Cancer Ther. 2011 Aug; 10(8):1327-36. PMID: 21610170.
      View in: PubMed
    65. Dou H, Huang C, Van Nguyen T, Lu LS, Yeh ET. SUMOylation and de-SUMOylation in response to DNA damage. FEBS Lett. 2011 Sep 16; 585(18):2891-6. PMID: 21486569.
      View in: PubMed
    66. Yeh ET. Onco-cardiology: the time has come. Tex Heart Inst J. 2011; 38(3):246-7. PMID: 21748048.
      View in: PubMed
    67. Yan S, Sun X, Xiang B, Cang H, Kang X, Chen Y, Li H, Shi G, Yeh ET, Wang B, Wang X, Yi J. Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90. EMBO J. 2010 Nov 17; 29(22):3773-86. PMID: 20924358.
      View in: PubMed
    68. Xu Y, Zuo Y, Zhang H, Kang X, Yue F, Yi Z, Liu M, Yeh ET, Chen G, Cheng J. Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis. J Biol Chem. 2010 Nov 19; 285(47):36682-8. PMID: 20841360.
      View in: PubMed
    69. Dou H, Huang C, Singh M, Carpenter PB, Yeh ET. Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex. Mol Cell. 2010 Aug 13; 39(3):333-45. PMID: 20705237.
      View in: PubMed
    70. Leja MJ, Yeh ET. Cardiovascular risk associated with androgen deprivation therapy. Oncology (Williston Park). 2010 Aug; 24(9):799, 803, 806. PMID: 20923032.
      View in: PubMed
    71. Kang X, Li J, Zou Y, Yi J, Zhang H, Cao M, Yeh ET, Cheng J. PIASy stimulates HIF1a SUMOylation and negatively regulates HIF1a activity in response to hypoxia. Oncogene. 2010 Oct 14; 29(41):5568-78. PMID: 20661221.
      View in: PubMed
    72. Bawa-Khalfe T, Yeh ET. SUMO Losing Balance: SUMO Proteases Disrupt SUMO Homeostasis to Facilitate Cancer Development and Progression. Genes Cancer. 2010 Jul; 1(7):748-752. PMID: 21152235.
      View in: PubMed
    73. Bawa-Khalfe T, Cheng J, Lin SH, Ittmann MM, Yeh ET. SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms. J Biol Chem. 2010 Aug 13; 285(33):25859-66. PMID: 20551310.
      View in: PubMed
    74. Wang J, Zhang S, Rabinovich B, Bidaut L, Soghomonyan S, Alauddin MM, Bankson JA, Shpall E, Willerson JT, Gelovani JG, Yeh ET. Human CD34+ cells in experimental myocardial infarction: long-term survival, sustained functional improvement, and mechanism of action. Circ Res. 2010 Jun 25; 106(12):1904-11. PMID: 20448213.
      View in: PubMed
    75. Kang X, Qi Y, Zuo Y, Wang Q, Zou Y, Schwartz RJ, Cheng J, Yeh ET. SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Mol Cell. 2010 Apr 23; 38(2):191-201. PMID: 20417598.
      View in: PubMed
    76. Darby SC, Cutter DJ, Boerma M, Constine LS, Fajardo LF, Kodama K, Mabuchi K, Marks LB, Mettler FA, Pierce LJ, Trott KR, Yeh ET, Shore RE. Radiation-related heart disease: current knowledge and future prospects. Int J Radiat Oncol Biol Phys. 2010 Mar 01; 76(3):656-65. PMID: 20159360.
      View in: PubMed
    77. Han Y, Huang C, Sun X, Xiang B, Wang M, Yeh ET, Chen Y, Li H, Shi G, Cang H, Sun Y, Wang J, Wang W, Gao F, Yi J. SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress. J Biol Chem. 2010 Apr 23; 285(17):12906-15. PMID: 20181954.
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    78. Bawa-Khalfe T, Yeh ET. The in vivo functions of desumoylating enzymes. Subcell Biochem. 2010; 54:170-83. PMID: 21222282.
      View in: PubMed
    79. Huang C, Han Y, Wang Y, Sun X, Yan S, Yeh ET, Chen Y, Cang H, Li H, Shi G, Cheng J, Tang X, Yi J. SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J. 2009 Sep 16; 28(18):2748-62. PMID: 19680224.
      View in: PubMed
    80. Yeh ET, Bickford CL. Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management. J Am Coll Cardiol. 2009 Jun 16; 53(24):2231-47. PMID: 19520246.
      View in: PubMed
    81. Calabr? P, Golia E, Yeh ET. CRP and the risk of atherosclerotic events. Semin Immunopathol. 2009 Jun; 31(1):79-94. PMID: 19415283.
      View in: PubMed
    82. Willerson JT, Cable G, Yeh ET. PROCLAIM: pilot study to examine the effects of clopidogrel on inflammatory markers in patients with metabolic syndrome receiving low-dose aspirin. Tex Heart Inst J. 2009; 36(6):530-9. PMID: 20069077.
      View in: PubMed
    83. Yeh ET. Adult progenitor cells for cardiac repair: preclinical studies. Tex Heart Inst J. 2009; 36(2):150-1. PMID: 19436811.
      View in: PubMed
    84. Yeh ET. SUMOylation and De-SUMOylation: wrestling with life's processes. J Biol Chem. 2009 Mar 27; 284(13):8223-7. PMID: 19008217.
      View in: PubMed
    85. Daher IN, Yeh ET. Vascular complications of selected cancer therapies. Nat Clin Pract Cardiovasc Med. 2008 Dec; 5(12):797-805. PMID: 18852710.
      View in: PubMed
    86. Khakoo AY, Yeh ET. Therapy insight: Management of cardiovascular disease in patients with cancer and cardiac complications of cancer therapy. Nat Clin Pract Oncol. 2008 Nov; 5(11):655-67. PMID: 18797437.
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    91. Cheng J, Kang X, Zhang S, Yeh ET. SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell. 2007 Nov 02; 131(3):584-95. PMID: 17981124.
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    94. Calabro P, Yeh ET. Obesity, inflammation, and vascular disease: the role of the adipose tissue as an endocrine organ. Subcell Biochem. 2007; 42:63-91. PMID: 17612046.
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    96. Yeh ET, Khan BV. The potential role of antiplatelet agents in modulating inflammatory markers in atherothrombosis. J Thromb Haemost. 2006 Nov; 4(11):2308-16. PMID: 16961584.
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    111. Izumiya Y, Ellison TJ, Yeh ET, Jung JU, Luciw PA, Kung HJ. Kaposi's sarcoma-associated herpesvirus K-bZIP represses gene transcription via SUMO modification. J Virol. 2005 Aug; 79(15):9912-25. PMID: 16014952.
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    113. Cheng J, Perkins ND, Yeh ET. Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases. J Biol Chem. 2005 Apr 15; 280(15):14492-8. PMID: 15701643.
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    114. Zhang S, Wang D, Estrov Z, Raj S, Willerson JT, Yeh ET. Both cell fusion and transdifferentiation account for the transformation of human peripheral blood CD34-positive cells into cardiomyocytes in vivo. Circulation. 2004 Dec 21; 110(25):3803-7. PMID: 15596566.
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    115. Calabro P, Samudio I, Willerson JT, Yeh ET. Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways. Circulation. 2004 Nov 23; 110(21):3335-40. PMID: 15545519.
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    116. Yeh ET. C-reactive protein is an essential aspect of cardiovascular risk factor stratification. Can J Cardiol. 2004 Aug; 20 Suppl B:93B-96B. PMID: 15309212.
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    117. Cheng J, Wang D, Wang Z, Yeh ET. SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. Mol Cell Biol. 2004 Jul; 24(13):6021-8. PMID: 15199155.
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    118. Yeh ET, Tong AT, Lenihan DJ, Yusuf SW, Swafford J, Champion C, Durand JB, Gibbs H, Zafarmand AA, Ewer MS. Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management. Circulation. 2004 Jun 29; 109(25):3122-31. PMID: 15226229.
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    119. Yeh ET. CRP as a mediator of disease. Circulation. 2004 Jun 01; 109(21 Suppl 1):II11-4. PMID: 15173057.
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    122. Calabro P, Yeh ET. Multitasking of the 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor: beyond cardiovascular diseases. Curr Atheroscler Rep. 2004 Jan; 6(1):36-41. PMID: 14662106.
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    125. Calabr? P, Willerson JT, Yeh ET. Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation. 2003 Oct 21; 108(16):1930-2. PMID: 14530191.
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    126. Tanaka T, Kawashima H, Yeh ET, Kamitani T. Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L. J Biol Chem. 2003 Aug 29; 278(35):32905-13. PMID: 12816948.
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    127. Yeh ET, Palusinski RP. C-reactive protein: the pawn has been promoted to queen. Curr Atheroscler Rep. 2003 Mar; 5(2):101-5. PMID: 12573194.
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    128. Nefkens I, Negorev DG, Ishov AM, Michaelson JS, Yeh ET, Tanguay RM, M?ller WE, Maul GG. Heat shock and Cd2+ exposure regulate PML and Daxx release from ND10 by independent mechanisms that modify the induction of heat-shock proteins 70 and 25 differently. J Cell Sci. 2003 Feb 01; 116(Pt 3):513-24. PMID: 12508112.
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    129. Yeh ET, Willerson JT. Coming of age of C-reactive protein: using inflammation markers in cardiology. Circulation. 2003 Jan 28; 107(3):370-1. PMID: 12551854.
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    130. Yeh ET. Ubiquitin, proteasome, and restenosis: a brave new world for cardiovascular research. Circulation. 2002 Jan 29; 105(4):408-10. PMID: 11815419.
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    131. Barry-Lane PA, Patterson C, van der Merwe M, Hu Z, Holland SM, Yeh ET, Runge MS. p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice. J Clin Invest. 2001 Nov; 108(10):1513-22. PMID: 11714743.
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    133. Yeh ET, Anderson HV, Pasceri V, Willerson JT. C-reactive protein: linking inflammation to cardiovascular complications. Circulation. 2001 Aug 28; 104(9):974-5. PMID: 11524386.
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    134. Pasceri V, Cheng JS, Willerson JT, Yeh ET, Chang J. Modulation of C-reactive protein-mediated monocyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs. Circulation. 2001 May 29; 103(21):2531-4. PMID: 11382718.
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    136. Fujise K, Zhang D, Liu J, Yeh ET. Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen. J Biol Chem. 2000 Dec 15; 275(50):39458-65. PMID: 10978339.
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    137. Zoldhelyi P, Beck PJ, Bjercke RJ, Ober JC, Hu X, McNatt JM, Akhtar S, Ahmed M, Clubb FJ, Chen ZQ, Dixon RA, Yeh ET, Willerson JT. Inhibition of coronary thrombosis and local inflammation by a noncarbohydrate selectin inhibitor. Am J Physiol Heart Circ Physiol. 2000 Dec; 279(6):H3065-75. PMID: 11087265.
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    138. Gong L, Liu M, Jen J, Yeh ET. GNB1L, a gene deleted in the critical region for DiGeorge syndrome on 22q11, encodes a G-protein beta-subunit-like polypeptide. Biochim Biophys Acta. 2000 Nov 15; 1494(1-2):185-8. PMID: 11072084.
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    139. Yeh E, Yang C, Chin E, Maddox P, Salmon ED, Lew DJ, Bloom K. Dynamic positioning of mitotic spindles in yeast: role of microtubule motors and cortical determinants. Mol Biol Cell. 2000 Nov; 11(11):3949-61. PMID: 11071919.
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    140. Pasceri V, Willerson JT, Yeh ET. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation. 2000 Oct 31; 102(18):2165-8. PMID: 11056086.
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    141. Yeh E, Zhou L, Rudzik N, Boulianne GL. Neuralized functions cell autonomously to regulate Drosophila sense organ development. EMBO J. 2000 Sep 01; 19(17):4827-37. PMID: 10970873.
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    143. Gong L, Kamitani T, Millas S, Yeh ET. Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins. J Biol Chem. 2000 May 12; 275(19):14212-6. PMID: 10799498.
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    144. Yeh ET, Gong L, Kamitani T. Ubiquitin-like proteins: new wines in new bottles. Gene. 2000 May 02; 248(1-2):1-14. PMID: 10806345.
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    145. Xu W, Gong L, Haddad MM, Bischof O, Campisi J, Yeh ET, Medrano EE. Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9. Exp Cell Res. 2000 Mar 15; 255(2):135-43. PMID: 10694430.
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    146. Gong L, Millas S, Maul GG, Yeh ET. Differential regulation of sentrinized proteins by a novel sentrin-specific protease. J Biol Chem. 2000 Feb 04; 275(5):3355-9. PMID: 10652325.
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    147. Pasceri V, Wu HD, Willerson JT, Yeh ET. Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activators. Circulation. 2000 Jan 25; 101(3):235-8. PMID: 10645917.
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    148. Kito K, Wada H, Yeh ET, Kamitani T. Identification of novel isoforms of human RAD52. Biochim Biophys Acta. 1999 Dec 23; 1489(2-3):303-14. PMID: 10673031.
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    149. Wada H, Yeh ET, Kamitani T. The von Hippel-Lindau tumor suppressor gene product promotes, but is not essential for, NEDD8 conjugation to cullin-2. J Biol Chem. 1999 Dec 10; 274(50):36025-9. PMID: 10585493.
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    150. Ishov AM, Sotnikov AG, Negorev D, Vladimirova OV, Neff N, Kamitani T, Yeh ET, Strauss JF, Maul GG. PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1. J Cell Biol. 1999 Oct 18; 147(2):221-34. PMID: 10525530.
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    151. Gong L, Yeh ET. Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. J Biol Chem. 1999 Apr 23; 274(17):12036-42. PMID: 10207026.
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    153. Gong L, Li B, Millas S, Yeh ET. Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex. FEBS Lett. 1999 Apr 01; 448(1):185-9. PMID: 10217437.
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    154. Higuchi M, Honda T, Proske RJ, Yeh ET. Regulation of reactive oxygen species-induced apoptosis and necrosis by caspase 3-like proteases. Oncogene. 1998 Nov 26; 17(21):2753-60. PMID: 9840939.
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    155. Higuchi M, Proske RJ, Yeh ET. Inhibition of mitochondrial respiratory chain complex I by TNF results in cytochrome c release, membrane permeability transition, and apoptosis. Oncogene. 1998 Nov 12; 17(19):2515-24. PMID: 9824162.
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    157. Kamitani T, Kito K, Nguyen HP, Wada H, Fukuda-Kamitani T, Yeh ET. Identification of three major sentrinization sites in PML. J Biol Chem. 1998 Oct 09; 273(41):26675-82. PMID: 9756909.
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    161. Patel SS, Thiagarajan R, Willerson JT, Yeh ET. Inhibition of alpha4 integrin and ICAM-1 markedly attenuate macrophage homing to atherosclerotic plaques in ApoE-deficient mice. Circulation. 1998 Jan 6-13; 97(1):75-81. PMID: 9443434.
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    162. Fujise K, Stacy L, Beck P, Yeh ET, Chuang A, Brock TA, Willerson JT. Differential effects of endothelin receptor activation on cyclic flow variations in rat mesenteric arteries. Circulation. 1997 Nov 18; 96(10):3641-6. PMID: 9396466.
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    164. Gong L, Kamitani T, Fujise K, Caskey LS, Yeh ET. Preferential interaction of sentrin with a ubiquitin-conjugating enzyme, Ubc9. J Biol Chem. 1997 Nov 07; 272(45):28198-201. PMID: 9353268.
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    165. Shaw SL, Yeh E, Bloom K, Salmon ED. Imaging green fluorescent protein fusion proteins in Saccharomyces cerevisiae. Curr Biol. 1997 Sep 01; 7(9):701-4. PMID: 9285714.
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    166. Kamitani T, Nguyen HP, Yeh ET. Activation-induced aggregation and processing of the human Fas antigen. Detection with cytoplasmic domain-specific antibodies. J Biol Chem. 1997 Aug 29; 272(35):22307-14. PMID: 9268381.
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    168. Higuchi M, Aggarwal BB, Yeh ET. Activation of CPP32-like protease in tumor necrosis factor-induced apoptosis is dependent on mitochondrial function. J Clin Invest. 1997 Apr 01; 99(7):1751-8. PMID: 9120020.
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    171. Fujise K, Revelle BM, Stacy L, Madison EL, Yeh ET, Willerson JT, Beck PJ. A tissue plasminogen activator/P-selectin fusion protein is an effective thrombolytic agent. Circulation. 1997 Feb 04; 95(3):715-22. PMID: 9024162.
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    173. Chang HM, Wang L, Zhang XP, Kream RM, Yeh ET. Modulation of Substance P Release in Primary Sensory Neurons by Misoprostol and Prostaglandins. Am J Ther. 1996 Apr; 3(4):276-279. PMID: 11862261.
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    174. Robinson DR, Urakaze M, Huang R, Taki H, Sugiyama E, Knoell CT, Xu L, Yeh ET, Auron PE. Dietary marine lipids suppress continuous expression of interleukin-1 beta gene transcription. Lipids. 1996 Mar; 31 Suppl:S23-31. PMID: 8729089.
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    175. Yeh E, Skibbens RV, Cheng JW, Salmon ED, Bloom K. Spindle dynamics and cell cycle regulation of dynein in the budding yeast, Saccharomyces cerevisiae. J Cell Biol. 1995 Aug; 130(3):687-700. PMID: 7622568.
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    176. Ware RE, Howard TA, Kamitani T, Chang H-M, Yeh ETH, Seldin MF. Chromosomal assignment of genes involved in glycosylphosphatidylinositol anchor biosynthesis: implications for the pathogenesis of paroxysmal nocturnal hemoglobinuria. Blood. 1994 06 15; 83(12):3753-7. PMID: 8204896.
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    179. Yeh ET. Autoimmunity and the pathogenesis of myocarditis. Circulation. 1994 Mar; 89(3):1318-9. PMID: 8124822.
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    182. Kamitani T, Menon AK, Hallaq Y, Warren CD, Yeh ET. Complexity of ethanolamine phosphate addition in the biosynthesis of glycosylphosphatidylinositol anchors in mammalian cells. J Biol Chem. 1992 Dec 05; 267(34):24611-9. PMID: 1447204.
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    184. Yeh ET, Chang HM. Pathophysiology and principles of pain management in rheumatic diseases. Curr Opin Rheumatol. 1992 Jun; 4(3):332-6. PMID: 1599812.
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    187. Thomas LJ, Urakaze M, DeGasperi R, Kamitani T, Sugiyama E, Chang HM, Warren CD, Yeh ET. Differential expression of glycosylphosphatidylinositol-anchored proteins in a murine T cell hybridoma mutant producing limiting amounts of the glycolipid core. Implications for paroxysmal nocturnal hemoglobinuria. J Clin Invest. 1992 Apr; 89(4):1172-7. PMID: 1532587.
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    189. Zietman AL, Sugiyama E, Ramsay JR, Silobrcic V, Yeh ET, Sedlacek RS, Suit HD. A comparative study on the xenotransplantability of human solid tumors into mice with different genetic immune deficiencies. Int J Cancer. 1991 Mar 12; 47(5):755-9. PMID: 2004856.
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    190. Yeh E, Driscoll R, Coltrera M, Olins A, Bloom K. A dynamin-like protein encoded by the yeast sporulation gene SPO15. Nature. 1991 Feb 21; 349(6311):713-5. PMID: 1825352.
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    193. Yeh ET, Reiser H, Daley J, Rock KL. Stimulation of T cells via the TAP molecule, a member in a family of activating proteins encoded in the Ly-6 locus. J Immunol. 1987 Jan 01; 138(1):91-7. PMID: 3023490.
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    194. Reiser H, Oettgen H, Yeh ET, Terhorst C, Low MG, Benacerraf B, Rock KL. Structural characterization of the TAP molecule: a phosphatidylinositol-linked glycoprotein distinct from the T cell receptor/T3 complex and Thy-1. Cell. 1986 Nov 07; 47(3):365-70. PMID: 2876780.
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    195. Yeh ET, Reiser H, Benacerraf B, Rock KL. Expression of T-cell-activating protein in peripheral lymphocyte subsets. Proc Natl Acad Sci U S A. 1986 Oct; 83(19):7424-8. PMID: 3020545.
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    196. Yeh ET, Reiser H, Benacerraf B, Rock KL. The expression, function, and ontogeny of a novel T cell-activating protein, TAP, in the thymus. J Immunol. 1986 Aug 15; 137(4):1232-8. PMID: 2426356.
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    197. Reiser H, Yeh ET, Gramm CF, Benacerraf B, Rock KL. Gene encoding T-cell-activating protein TAP maps to the Ly-6 locus. Proc Natl Acad Sci U S A. 1986 May; 83(9):2954-8. PMID: 3010324.
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    198. Rock KL, Yeh ET, Gramm CF, Haber SI, Reiser H, Benacerraf B. TAP, a novel T cell-activating protein involved in the stimulation of MHC-restricted T lymphocytes. J Exp Med. 1986 Feb 01; 163(2):315-33. PMID: 2418146.
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    199. Yeh E, Carbon J, Bloom K. Tightly centromere-linked gene (SPO15) essential for meiosis in the yeast Saccharomyces cerevisiae. Mol Cell Biol. 1986 Jan; 6(1):158-67. PMID: 3537684.
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    200. Yeh ET, Benacerraf B, Rock KL. Analysis of thymocyte MHC specificity with thymocyte hybridomas. J Exp Med. 1984 Sep 01; 160(3):799-813. PMID: 6206189.
      View in: PubMed
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