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Lu Huang

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentMicrobiology & Immunology, College of Medicine
DivisionMicrobiology & Immunology Faculty
Address325 S. Elm St.
Mail Slot # 511
Little Rock AR 72205
ORCID ORCID Icon0000-0002-7820-2177 Additional info
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    Collapse Biography 
    Collapse education and training
    Cornell University, Ithaca, NYPhD05/2014Immunology
    Zhejiang University, Hangzhou, ChinaBS08/2006Bioinformatics

    Collapse Research 
    Collapse research activities and funding
    CA     (HUANG, LU)Jul 1, 2021 - Jun 30, 2024
    American Lung Association
    Deciphering trained immuity in lung resident macrophages to combat tuberculosis
    Role: Principal Investigator
    CA-828143     (HUANG, LU)Jul 1, 2021 - Jun 30, 2024
    American Lung Association
    Deciphering trained immuity in lung resident macrophages to combat tuberculosis
    Role: Principal Investigator
    CA-828143     (Lu Huang)Jul 1, 2021 - Jun 30, 2022
    American Lung Association
    Deciphering trained immunity in lung resident macrophages to combat tuberculosis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse additional bibliographic sources
    The links below are provided by the researcher to provide access to external online bibliographies that they keep independently from the Profiles System.
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Pechous RD, Malaviarachchi PA, Xing Z, Douglas A, Crane SD, Theriot HM, Zhang Z, Ghaffarieh A, Huang L, Yu YE, Zhang X. SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome. Biomedicines. 2024 Feb 28; 12(3). PMID: 38540156.
      View in: PubMed
    2. Mercado MAB, Li Q, Quick CM, Kim Y, Palmer R, Huang L, Li LX. BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia. PLoS Pathog. 2024 Jan; 20(1):e1011983. PMID: 38271477.
      View in: PubMed
    3. Mercado MAB, Li Q, Quick CM, Kim Y, Palmer R, Huang L, Li LX. BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia. bioRxiv. 2023 Nov 05. PMID: 37961221.
      View in: PubMed
    4. Andrews JT, Voth DE, Huang SC, Huang L. Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection. Front Cell Infect Microbiol. 2022; 12:934460. PMID: 35899042.
      View in: PubMed
    5. Benson LN, Liu Y, Wang X, Xiong Y, Rhee SW, Guo Y, Deck KS, Mora CJ, Li LX, Huang L, Andrews JT, Qin Z, Hoover RS, Ko B, Williams RM, Heller DA, Jaimes EA, Mu S. The IFN?-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension. Circ Res. 2022 05 13; 130(10):1550-1564. PMID: 35430873.
      View in: PubMed
    6. Pisu D, Huang L, Narang V, Theriault M, L?-Bury G, Lee B, Lakudzala AE, Mzinza DT, Mhango DV, Mitini-Nkhoma SC, Jambo KC, Singhal A, Mwandumba HC, Russell DG. Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung. J Exp Med. 2021 09 06; 218(9). PMID: 34292313.
      View in: PubMed
    7. Zhang Z, Huang L, Brayboy L. Macrophages: an indispensable piece of ovarian health. Biol Reprod. 2021 03 11; 104(3):527-538. PMID: 33274732.
      View in: PubMed
    8. Giacalone D, Huang L, Tan S. Exploiting Fluorescent Proteins to Understand Mycobacterium tuberculosis Biology. Methods Mol Biol. 2021; 2314:365-383. PMID: 34235663.
      View in: PubMed
    9. Pisu D, Huang L, Rin Lee BN, Grenier JK, Russell DG. Dual RNA-Sequencing of Mycobacterium tuberculosis-Infected Cells from a Murine Infection Model. STAR Protoc. 2020 12 18; 1(3):100123. PMID: 33377017.
      View in: PubMed
    10. Zhang Z, Schlamp F, Huang L, Clark H, Brayboy L. Inflammaging is associated with shifted macrophage ontogeny and polarization in the aging mouse ovary. Reproduction. 2020 03; 159(3):325-337. PMID: 31940276.
      View in: PubMed
    11. Huang L, Ye K, McGee MC, Nidetz NF, Elmore JP, Limper CB, Southard TL, Russell DG, August A, Huang W. Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection Against Mycobacterium tuberculosis Infection. Front Immunol. 2019; 10:3103. PMID: 32038633.
      View in: PubMed
    12. Pisu D, Huang L, Grenier JK, Russell DG. Dual RNA-Seq of Mtb-Infected Macrophages In?Vivo Reveals Ontologically Distinct Host-Pathogen Interactions. Cell Rep. 2020 01 14; 30(2):335-350.e4. PMID: 31940480.
      View in: PubMed
    13. Russell DG, Huang L, VanderVen BC. Immunometabolism at the interface between macrophages and pathogens. Nat Rev Immunol. 2019 05; 19(5):291-304. PMID: 30679807.
      View in: PubMed
    14. Huang L, Nazarova EV, Russell DG. Mycobacterium tuberculosis: Bacterial Fitness within the Host Macrophage. Microbiol Spectr. 2019 03; 7(2). PMID: 30848232.
      View in: PubMed
    15. Nazarova EV, Montague CR, Huang L, La T, Russell D, VanderVen BC. The genetic requirements of fatty acid import by Mycobacterium tuberculosis within macrophages. Elife. 2019 02 08; 8. PMID: 30735132.
      View in: PubMed
    16. Xu Y, Huang L, Kirschman JL, Vanover DA, Tiwari PM, Santangelo PJ, Shen X, Russell DG. Exploitation of Synthetic mRNA To Drive Immune Effector Cell Recruitment and Functional Reprogramming In Vivo. J Immunol. 2019 01 15; 202(2):608-617. PMID: 30541883.
      View in: PubMed
    17. Huang L, Kushner NL, Theriault ME, Pisu D, Tan S, McNamara CW, Petrassi HM, Russell DG, Brown AC. The Deconstructed Granuloma: A Complex High-Throughput Drug Screening Platform for the Discovery of Host-Directed Therapeutics Against Tuberculosis. Front Cell Infect Microbiol. 2018; 8:275. PMID: 30155446.
      View in: PubMed
    18. Xu Y, Wang L, Zimmerman MD, Chen KY, Huang L, Fu DJ, Kaya F, Rakhilin N, Nazarova EV, Bu P, Dartois V, Russell DG, Shen X. Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis. PLoS Pathog. 2018 04; 14(4):e1006974. PMID: 29698476.
      View in: PubMed
    19. Huang L, Nazarova EV, Tan S, Liu Y, Russell DG. Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny. J Exp Med. 2018 04 02; 215(4):1135-1152. PMID: 29500179.
      View in: PubMed
    20. Huang L, Russell DG. Protective immunity against tuberculosis: what does it look like and how do we find it? Curr Opin Immunol. 2017 Oct; 48:44-50. PMID: 28826036.
      View in: PubMed
    21. Kannan AK, Mohinta S, Huang W, Huang L, Koylass N, Appleton JA, August A. T-Bet independent development of IFN? secreting natural T helper 1 cell population in the absence of Itk. Sci Rep. 2017 04 13; 7:45935. PMID: 28406139.
      View in: PubMed
    22. VanderVen BC, Huang L, Rohde KH, Russell DG. The Minimal Unit of Infection: Mycobacterium tuberculosis in the Macrophage. Microbiol Spectr. 2016 12; 4(6). PMID: 28084213.
      View in: PubMed
    23. Huang L, Appleton JA. Eosinophils in Helminth Infection: Defenders and Dupes. Trends Parasitol. 2016 10; 32(10):798-807. PMID: 27262918.
      View in: PubMed
    24. Liu Y, Tan S, Huang L, Abramovitch RB, Rohde KH, Zimmerman MD, Chen C, Dartois V, VanderVen BC, Russell DG. Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo. J Exp Med. 2016 05 02; 213(5):809-25. PMID: 27114608.
      View in: PubMed
    25. Huang L, Beiting DP, Gebreselassie NG, Gagliardo LF, Ruyechan MC, Lee NA, Lee JJ, Appleton JA. Eosinophils and IL-4 Support Nematode Growth Coincident with an Innate Response to Tissue Injury. PLoS Pathog. 2015 Dec; 11(12):e1005347. PMID: 26720604.
      View in: PubMed
    26. Feng KH, Gonzalez G, Deng L, Yu H, Tse VL, Huang L, Huang K, Wasik BR, Zhou B, Wentworth DE, Holmes EC, Chen X, Varki A, Murcia PR, Parrish CR. Equine and Canine Influenza H3N8 Viruses Show Minimal Biological Differences Despite Phylogenetic Divergence. J Virol. 2015 Jul; 89(13):6860-73. PMID: 25903329.
      View in: PubMed
    27. Huang L, Hinchman M, Mendez S. Coinjection with TLR2 agonist Pam3CSK4 reduces the pathology of leishmanization in mice. PLoS Negl Trop Dis. 2015 Mar; 9(3):e0003546. PMID: 25738770.
      View in: PubMed
    28. Huang L, Gebreselassie NG, Gagliardo LF, Ruyechan MC, Luber KL, Lee NA, Lee JJ, Appleton JA. Eosinophils mediate protective immunity against secondary nematode infection. J Immunol. 2015 Jan 01; 194(1):283-90. PMID: 25429065.
      View in: PubMed
    29. Huang L, Gebreselassie NG, Gagliardo LF, Ruyechan MC, Lee NA, Lee JJ, Appleton JA. Eosinophil-derived IL-10 supports chronic nematode infection. J Immunol. 2014 Oct 15; 193(8):4178-87. PMID: 25210122.
      View in: PubMed
    30. Wu W, Huang L, Mendez S. A live Leishmania major vaccine containing CpG motifs induces the de novo generation of Th17 cells in C57BL/6 mice. Eur J Immunol. 2010 Sep; 40(9):2517-27. PMID: 20683901.
      View in: PubMed
    31. Mendez S, Traslavina R, Hinchman M, Huang L, Green P, Cynamon MH, Welch JT. The antituberculosis drug pyrazinamide affects the course of cutaneous leishmaniasis in vivo and increases activation of macrophages and dendritic cells. Antimicrob Agents Chemother. 2009 Dec; 53(12):5114-21. PMID: 19770283.
      View in: PubMed
    32. Huang LZ, Winzer-Serhan UH. Effects of paraformaldehyde fixation on nicotinic acetylcholine receptor binding in adult and developing rat brain sections. J Neurosci Methods. 2006 Jun 15; 153(2):312-7. PMID: 16406107.
      View in: PubMed
    33. Huang LZ, Hsiao SH, Trzeciakowski J, Frye GD, Winzer-Serhan UH. Chronic nicotine induces growth retardation in neonatal rat pups. Life Sci. 2006 Feb 23; 78(13):1483-93. PMID: 16324718.
      View in: PubMed
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