Justin Wai Chung Leung
Title | Assistant Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Radiation Oncology, College of Medicine |
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Division | Radiation Oncology Laboratory |
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Address | 4130 Sheffield Mail Slot # 771 Little Rock AR 72205
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Phone | 501-526-6990 x8934 |
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ORCID
.gif) | 0000-0003-4601-390X  |
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vCard | Download vCard |
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Title | Assistant Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Biochemistry & Molecular Biology, College of Medicine |
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Research Funds R35GM137798 (LEUNG, JUSTIN WAI CHUNG)Sep 1, 2020 - Aug 31, 2025 NIH/Nat. Inst. of General Medical Sciences Deciphering the chromatin-based DNA damage response pathway Role: Principal Investigator |
| K22CA204354 (LEUNG, JUSTIN WAI CHUNG)Jan 1, 2018 - Dec 31, 2020 NIH/Nat. Cancer Institute The role of macroH2A-ZMYM3 in genome stability and tumorigenesis Role: Principal Investigator |
| P20GM121293 (ZYBAYLOV, BORIS)Jul 1, 2017 - Jun 30, 2022 NIH/National Institutes of Health - Pass Through: Arkansas Children's Hospital Microbiome-Derived Therapeutic Targets for Chronic Kidney Disease - Continuation Role: Principal Investigator |
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Dong C, West KL, Tan XY, Li J, Ishibashi T, Yu CH, Sy SMH, Leung JWC, Huen MSY. Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin. Proc Natl Acad Sci U S A. 2020 07 21; 117(29):17019-17030. PMID: 32611815.
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Kelliher JL, West KL, Gong Q, Leung JWC. Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination. Nat Commun. 2020 05 18; 11(1):2462. PMID: 32424115.
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Sadhukhan R, Leung JWC, Garg S, Krager KJ, Savenka AV, Basnakian AG, Pathak R. Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose. Sci Rep. 2020 05 07; 10(1):7734. PMID: 32382091.
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West KL, Kelliher JL, Xu Z, An L, Reed MR, Eoff RL, Wang J, Huen MSY, Leung JWC. LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation. Nucleic Acids Res. 2019 07 09; 47(12):6236-6249. PMID: 30982887.
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Makharashvili N, Arora S, Yin Y, Fu Q, Wen X, Lee JH, Kao CH, Leung JW, Miller KM, Paull TT. Sae2/CtIP prevents R-loop accumulation in eukaryotic cells. Elife. 2018 12 07; 7. PMID: 30523780.
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Leung JWC, Emery LE, Miller KM. CRISPR/Cas9 Gene Editing of Human Histone H2A Variant H2AX and MacroH2A. Methods Mol Biol. 2018; 1832:255-269. PMID: 30073532.
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Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM. ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair. Genes Dev. 2017 02 01; 31(3):260-274. PMID: 28242625.
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O'Connor HF, Lyon N, Leung JW, Agarwal P, Swaim CD, Miller KM, Huibregtse JM. Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners. EMBO Rep. 2015 Dec; 16(12):1699-712. PMID: 26508657.
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Gong F, Chiu LY, Cox B, Aymard F, Clouaire T, Leung JW, Cammarata M, Perez M, Agarwal P, Brodbelt JS, Legube G, Miller KM. Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination. Genes Dev. 2015 Jan 15; 29(2):197-211. PMID: 25593309.
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Huang Y, Leung JW, Lowery M, Matsushita N, Wang Y, Shen X, Huong D, Takata M, Chen J, Li L. Modularized functions of the Fanconi anemia core complex. Cell Rep. 2014 Jun 26; 7(6):1849-57. PMID: 24910428.
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Leung JW, Agarwal P, Canny MD, Gong F, Robison AD, Finkelstein IJ, Durocher D, Miller KM. Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling. PLoS Genet. 2014 Mar; 10(3):e1004178. PMID: 24603765.
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Wang Y, Han X, Wu F, Leung JW, Lowery MG, Do H, Chen J, Shi C, Tian C, Li L, Gong W. Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response. Cell Res. 2013 Oct; 23(10):1215-28. PMID: 23999858.
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Wang Y, Leung JW, Jiang Y, Lowery MG, Do H, Vasquez KM, Chen J, Wang W, Li L. FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions. Mol Cell. 2013 Mar 07; 49(5):997-1009. PMID: 23333308.
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Leung JW, Ghosal G, Wang W, Shen X, Wang J, Li L, Chen J. Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress. J Biol Chem. 2013 Mar 01; 288(9):6342-50. PMID: 23329831.
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Fong KW, Leung JW, Li Y, Wang W, Feng L, Ma W, Liu D, Songyang Z, Chen J. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. J Cell Sci. 2013 Feb 01; 126(Pt 3):825-37. PMID: 23264731.
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Wang J, Leung JW, Gong Z, Feng L, Shi X, Chen J. PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis. J Biol Chem. 2013 Feb 01; 288(5):3174-83. PMID: 23229552.
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Ghosal G, Leung JW, Nair BC, Fong KW, Chen J. Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. J Biol Chem. 2012 Oct 05; 287(41):34225-33. PMID: 22902628.
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Mi XS, Chiu K, Van G, Leung JW, Lo AC, Chung SK, Chang RC, So KF. Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma. Neural Regen Res. 2012 Mar 25; 7(9):645-51. PMID: 25745457.
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Leung JW, Wang Y, Fong KW, Huen MS, Li L, Chen J. Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4491-6. PMID: 22396592.
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Leung JW, Wong WT, Koon HW, Mo FM, Tam S, Huang Y, Vanhoutte PM, Chung SS, Chung SK. Transgenic mice over-expressing ET-1 in the endothelial cells develop systemic hypertension with altered vascular reactivity. PLoS One. 2011; 6(11):e26994. PMID: 22096514.
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Cheung SS, Leung JW, Lam AK, Lam KS, Chung SS, Lo AC, Chung SK. Selective over-expression of endothelin-1 in endothelial cells exacerbates inner retinal edema and neuronal death in ischemic retina. PLoS One. 2011; 6(10):e26184. PMID: 22053184.
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Leung JW, Leitch A, Wood JL, Shaw-Smith C, Metcalfe K, Bicknell LS, Jackson AP, Chen J. SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation. J Biol Chem. 2011 Jun 17; 286(24):21393-400. PMID: 21515671.
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Huen MS, Huang J, Leung JW, Sy SM, Leung KM, Ching YP, Tsao SW, Chen J. Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1. Mol Cell. 2010 Mar 26; 37(6):854-64. PMID: 20347427.
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Richards MW, Leung JW, Roe SM, Li K, Chen J, Bayliss R. A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation. J Mol Biol. 2010 Feb 05; 395(5):908-15. PMID: 19925808.
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Yeung PK, Lo AC, Leung JW, Chung SS, Chung SK. Targeted overexpression of endothelin-1 in astrocytes leads to more severe cytotoxic brain edema and higher mortality. J Cereb Blood Flow Metab. 2009 Dec; 29(12):1891-902. PMID: 19707218.
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Leung JW, Chung SS, Chung SK. Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion. Brain Res. 2009 Apr 17; 1266:121-9. PMID: 19230825.
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Leung JW, Ho MC, Lo AC, Chung SS, Chung SK. Endothelial cell-specific over-expression of endothelin-1 leads to more severe cerebral damage following transient middle cerebral artery occlusion. J Cardiovasc Pharmacol. 2004 Nov; 44 Suppl 1:S293-300. PMID: 15838304.
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Huen MS, Hui KM, Leung JW, Sigel E, Baur R, Wong JT, Xue H. Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. Biochem Pharmacol. 2003 Dec 15; 66(12):2397-407. PMID: 14637197.
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Leung JW, Xue H. GABAergic functions and depression: from classical therapies to herbal medicine. Curr Drug Targets CNS Neurol Disord. 2003 Dec; 2(6):363-74. PMID: 14683464.
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Huen MS, Leung JW, Ng W, Lui WS, Chan MN, Wong JT, Xue H. 5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties. Biochem Pharmacol. 2003 Jul 01; 66(1):125-32. PMID: 12818372.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2003 | 3 | 2004 | 1 | 2009 | 3 | 2010 | 1 | 2011 | 3 | 2012 | 5 | 2013 | 3 | 2014 | 2 | 2015 | 2 | 2017 | 1 | 2018 | 2 | 2019 | 1 | 2020 | 3 |
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