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Justin Wai Chung Leung

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentRadiation Oncology, College of Medicine
DivisionRadiation Oncology Laboratory
Address4130 Sheffield
Mail Slot # 771
Little Rock AR 72205
Phone501-526-6990 x8934
ORCID ORCID Icon0000-0003-4601-390X Additional info
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    Other Positions
    TitleAssociate Professor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentBiochemistry & Molecular Biology, College of Medicine


    Collapse Research 
    Collapse research activities and funding
    R01CA244261     (LEUNG, JUSTIN WAI CHUNG)Mar 1, 2021 - Feb 28, 2026
    NIH
    Mechanistic characterization of the cell cycle-dependent DNA repair pathway- Resubmission
    Role: Principal Investigator
    American Cancer Society     (Leung, Justin Wai Chung)Jan 1, 2021 - Dec 31, 2024
    American Cancer Society
    Mechanistic Characterization of cell cycle-dependent DNA repair
    Role: Principal Investigator
    R35GM137798     (LEUNG, JUSTIN WAI CHUNG)Sep 1, 2020 - Aug 31, 2025
    NIH/Nat. Inst. of General Medical Sciences
    Deciphering the chromatin-based DNA damage response pathway
    Role: Principal Investigator
    ABCRP     (Leung, Justin Wai Chung)Sep 1, 2020 - Aug 31, 2022
    Arkansas Breast Cancer Research Program
    Ubiquitin Signaling in BRCA1 Regulation at DNA Double Strand Break
    Role: Principal Investigator
    FY20 ABCRP awards     (Leung, Justin Wai Chung)Sep 1, 2019 - Aug 31, 2021
    Arkansas Breast Cancer Research Program
    Mechanistic Caracterization of BRCA1 Regulation at Damaged Chromatin
    Role: Principal Investigator
    K22CA204354     (LEUNG, JUSTIN WAI CHUNG)Jan 1, 2018 - Dec 31, 2020
    NIH/Nat. Cancer Institute
    The role of macroH2A-ZMYM3 in genome stability and tumorigenesis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Lee D, Apelt K, Lee SO, Chan HR, Luijsterburg MS, Leung JWC, Miller KM. ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination. Nucleic Acids Res. 2022 04 22; 50(7):3922-3943. PMID: 35253893.
      View in: PubMed
    2. Ketkar A, Smith L, Johnson C, Richey A, Berry M, Hartman JH, Maddukuri L, Reed MR, Gunderson JEC, Leung JWC, Eoff RL. Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs. Nucleic Acids Res. 2021 02 26; 49(4):2065-2084. PMID: 33555350.
      View in: PubMed
    3. Jenkins SV, Alimohammadi M, Terry AS, Griffin RJ, Tackett AJ, Leung JW, Vang KB, Byrum SD, Dings RPM. Dysbiotic stress increases the sensitivity of the tumor vasculature to radiotherapy and c-Met inhibitors. Angiogenesis. 2021 08; 24(3):597-611. PMID: 33629198.
      View in: PubMed
    4. Dong C, West KL, Tan XY, Li J, Ishibashi T, Yu CH, Sy SMH, Leung JWC, Huen MSY. Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin. Proc Natl Acad Sci U S A. 2020 07 21; 117(29):17019-17030. PMID: 32611815.
      View in: PubMed
    5. Kelliher JL, West KL, Gong Q, Leung JWC. Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination. Nat Commun. 2020 05 18; 11(1):2462. PMID: 32424115.
      View in: PubMed
    6. Sadhukhan R, Leung JWC, Garg S, Krager KJ, Savenka AV, Basnakian AG, Pathak R. Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose. Sci Rep. 2020 05 07; 10(1):7734. PMID: 32382091.
      View in: PubMed
    7. West KL, Kelliher JL, Xu Z, An L, Reed MR, Eoff RL, Wang J, Huen MSY, Leung JWC. LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation. Nucleic Acids Res. 2019 07 09; 47(12):6236-6249. PMID: 30982887.
      View in: PubMed
    8. Makharashvili N, Arora S, Yin Y, Fu Q, Wen X, Lee JH, Kao CH, Leung JW, Miller KM, Paull TT. Sae2/CtIP prevents R-loop accumulation in eukaryotic cells. Elife. 2018 12 07; 7. PMID: 30523780.
      View in: PubMed
    9. Leung JWC, Emery LE, Miller KM. CRISPR/Cas9 Gene Editing of Human Histone H2A Variant H2AX and MacroH2A. Methods Mol Biol. 2018; 1832:255-269. PMID: 30073532.
      View in: PubMed
    10. Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM. ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair. Genes Dev. 2017 02 01; 31(3):260-274. PMID: 28242625.
      View in: PubMed
    11. O'Connor HF, Lyon N, Leung JW, Agarwal P, Swaim CD, Miller KM, Huibregtse JM. Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners. EMBO Rep. 2015 Dec; 16(12):1699-712. PMID: 26508657.
      View in: PubMed
    12. Gong F, Chiu LY, Cox B, Aymard F, Clouaire T, Leung JW, Cammarata M, Perez M, Agarwal P, Brodbelt JS, Legube G, Miller KM. Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination. Genes Dev. 2015 Jan 15; 29(2):197-211. PMID: 25593309.
      View in: PubMed
    13. Huang Y, Leung JW, Lowery M, Matsushita N, Wang Y, Shen X, Huong D, Takata M, Chen J, Li L. Modularized functions of the Fanconi anemia core complex. Cell Rep. 2014 Jun 26; 7(6):1849-57. PMID: 24910428.
      View in: PubMed
    14. Leung JW, Agarwal P, Canny MD, Gong F, Robison AD, Finkelstein IJ, Durocher D, Miller KM. Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling. PLoS Genet. 2014 Mar; 10(3):e1004178. PMID: 24603765.
      View in: PubMed
    15. Wang Y, Han X, Wu F, Leung JW, Lowery MG, Do H, Chen J, Shi C, Tian C, Li L, Gong W. Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response. Cell Res. 2013 Oct; 23(10):1215-28. PMID: 23999858.
      View in: PubMed
    16. Wang Y, Leung JW, Jiang Y, Lowery MG, Do H, Vasquez KM, Chen J, Wang W, Li L. FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions. Mol Cell. 2013 Mar 07; 49(5):997-1009. PMID: 23333308.
      View in: PubMed
    17. Leung JW, Ghosal G, Wang W, Shen X, Wang J, Li L, Chen J. Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress. J Biol Chem. 2013 Mar 01; 288(9):6342-50. PMID: 23329831.
      View in: PubMed
    18. Fong KW, Leung JW, Li Y, Wang W, Feng L, Ma W, Liu D, Songyang Z, Chen J. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. J Cell Sci. 2013 Feb 01; 126(Pt 3):825-37. PMID: 23264731.
      View in: PubMed
    19. Wang J, Leung JW, Gong Z, Feng L, Shi X, Chen J. PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis. J Biol Chem. 2013 Feb 01; 288(5):3174-83. PMID: 23229552.
      View in: PubMed
    20. Ghosal G, Leung JW, Nair BC, Fong KW, Chen J. Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. J Biol Chem. 2012 Oct 05; 287(41):34225-33. PMID: 22902628.
      View in: PubMed
    21. Mi XS, Chiu K, Van G, Leung JW, Lo AC, Chung SK, Chang RC, So KF. Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma. Neural Regen Res. 2012 Mar 25; 7(9):645-51. PMID: 25745457.
      View in: PubMed
    22. Leung JW, Wang Y, Fong KW, Huen MS, Li L, Chen J. Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4491-6. PMID: 22396592.
      View in: PubMed
    23. Leung JW, Wong WT, Koon HW, Mo FM, Tam S, Huang Y, Vanhoutte PM, Chung SS, Chung SK. Transgenic mice over-expressing ET-1 in the endothelial cells develop systemic hypertension with altered vascular reactivity. PLoS One. 2011; 6(11):e26994. PMID: 22096514.
      View in: PubMed
    24. Cheung SS, Leung JW, Lam AK, Lam KS, Chung SS, Lo AC, Chung SK. Selective over-expression of endothelin-1 in endothelial cells exacerbates inner retinal edema and neuronal death in ischemic retina. PLoS One. 2011; 6(10):e26184. PMID: 22053184.
      View in: PubMed
    25. Leung JW, Leitch A, Wood JL, Shaw-Smith C, Metcalfe K, Bicknell LS, Jackson AP, Chen J. SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation. J Biol Chem. 2011 Jun 17; 286(24):21393-400. PMID: 21515671.
      View in: PubMed
    26. Huen MS, Huang J, Leung JW, Sy SM, Leung KM, Ching YP, Tsao SW, Chen J. Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1. Mol Cell. 2010 Mar 26; 37(6):854-64. PMID: 20347427.
      View in: PubMed
    27. Richards MW, Leung JW, Roe SM, Li K, Chen J, Bayliss R. A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation. J Mol Biol. 2010 Feb 05; 395(5):908-15. PMID: 19925808.
      View in: PubMed
    28. Yeung PK, Lo AC, Leung JW, Chung SS, Chung SK. Targeted overexpression of endothelin-1 in astrocytes leads to more severe cytotoxic brain edema and higher mortality. J Cereb Blood Flow Metab. 2009 Dec; 29(12):1891-902. PMID: 19707218.
      View in: PubMed
    29. Leung JW, Chung SS, Chung SK. Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion. Brain Res. 2009 Apr 17; 1266:121-9. PMID: 19230825.
      View in: PubMed
    30. Leung JW, Ho MC, Lo AC, Chung SS, Chung SK. Endothelial cell-specific over-expression of endothelin-1 leads to more severe cerebral damage following transient middle cerebral artery occlusion. J Cardiovasc Pharmacol. 2004 Nov; 44 Suppl 1:S293-300. PMID: 15838304.
      View in: PubMed
    31. Huen MS, Hui KM, Leung JW, Sigel E, Baur R, Wong JT, Xue H. Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. Biochem Pharmacol. 2003 Dec 15; 66(12):2397-407. PMID: 14637197.
      View in: PubMed
    32. Leung JW, Xue H. GABAergic functions and depression: from classical therapies to herbal medicine. Curr Drug Targets CNS Neurol Disord. 2003 Dec; 2(6):363-74. PMID: 14683464.
      View in: PubMed
    33. Huen MS, Leung JW, Ng W, Lui WS, Chan MN, Wong JT, Xue H. 5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties. Biochem Pharmacol. 2003 Jul 01; 66(1):125-32. PMID: 12818372.
      View in: PubMed
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