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Frederick Barr

TitleDepartment Chairperson
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPediatrics, College of Medicine
Address800 Marshall Street
Mail Slot # 512-1
Little Rock AR 72202
Phone501-364-5262
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    Collapse Research Funds 
    Collapse research activities
    UG1HD090848     (BARR, FREDERICK E)Sep 21, 2016 - Aug 31, 2020
    NIH/NICHD
    Mississippi Pediatric Clinical Trials Center
    Role: Principal Investigator

    UG1OD024942     (BARR, FREDERICK E)Sep 21, 2016 - Aug 31, 2020
    NIH
    Mississippi Pediatric Clinical Trials Center
    Role: Principal Investigator

    R01HL073317     (BARR, FREDERICK E)Dec 1, 2003 - Nov 30, 2009
    NIH/NHLBI
    Nitric Oxide Precursors and Congenital Heart Surgery
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Majumdar S, Tirona R, Mashegu H, Desai J, Shannon NT, Summar M, Cunningham G, Darbari D, Nickel R, Campbell A, Barr FE. A phase 1 dose-finding study of intravenous L-citrulline in sickle cell disease: a potential novel therapy for sickle cell pain crisis. Br J Haematol. 2019 02; 184(4):634-636. PMID: 29411862.
      View in: PubMed
    2. Patterson GD, Mashegu H, Rutherford J, Seals S, Josey D, Karlson C, McNaull M, May W, Carroll C, Barr FE, Majumdar S. Recurrent Acute Chest Syndrome in Pediatric Sickle Cell Disease: Clinical Features and Risk Factors. J Pediatr Hematol Oncol. 2018 01; 40(1):51-55. PMID: 29200151.
      View in: PubMed
    3. Todd Tzanetos DR, Housley JJ, Barr FE, May WL, Landers CD. Implementation of an inhaled nitric oxide protocol decreases direct cost associated with its use. Respir Care. 2015 May; 60(5):644-50. PMID: 25650437.
      View in: PubMed
    4. Agarwal HS, Wolfram KB, Slayton JM, Saville BR, Cutrer WB, Bichell DP, Harris ZL, Barr FE, Deshpande JK. Template of patient-specific summaries facilitates education and outcomes in paediatric cardiac surgery units. Interact Cardiovasc Thorac Surg. 2013 Oct; 17(4):704-9. PMID: 23832839.
      View in: PubMed
    5. Spratt DE, Reddy VK, Choxi AA, Simon SD, Shay SD, Davidson MA, Barr FE, Summar ML, Mericle RA. Dexamethasone significantly attenuates sub-arachnoid hemorrhage-induced elevation in cerebrospinal fluid citrulline and leukocytes. J Neurosurg Sci. 2012 Dec; 56(4):363-71. PMID: 23111298.
      View in: PubMed
    6. Smith HA, Fuchs DC, Pandharipande PP, Barr FE, Ely EW. Delirium: an emerging frontier in the management of critically ill children. Anesthesiol Clin. 2011 Dec; 29(4):729-50. PMID: 22078920.
      View in: PubMed
    7. Wong HR, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Shanley TP, Bigham MT, Wheeler DS, Doughty LA, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Varisco BM, Barr FE. Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med. 2011 Nov; 39(11):2511-7. PMID: 21705885.
      View in: PubMed
    8. Todd Tzanetos DR, Yu C, Hernanz-Schulman M, Barr FE, Brown NJ. Prospective study of the incidence and predictors of thrombus in children undergoing palliative surgery for single ventricle physiology. Intensive Care Med. 2012 Jan; 38(1):105-12. PMID: 21979273.
      View in: PubMed
    9. Smith HA, Boyd J, Fuchs DC, Melvin K, Berry P, Shintani A, Eden SK, Terrell MK, Boswell T, Wolfram K, Sopfe J, Barr FE, Pandharipande PP, Ely EW. Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit. Crit Care Med. 2011 Jan; 39(1):150-7. PMID: 20959783.
      View in: PubMed
    10. Le TM, Willis AS, Barr FE, Cunningham GR, Canter JA, Owens SE, Apple RK, Ayodo G, Reich D, Summar ML. An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro. Mol Genet Metab. 2010 Sep; 101(1):55-61. PMID: 20655259.
      View in: PubMed
    11. Barr FE, Macrae D. Inhaled nitric oxide and related therapies. Pediatr Crit Care Med. 2010 Mar; 11(2 Suppl):S30-6. PMID: 20216160.
      View in: PubMed
    12. Ananthakrishnan M, Barr FE, Summar ML, Smith HA, Kaplowitz M, Cunningham G, Magarik J, Zhang Y, Fike CD. L-Citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets. Am J Physiol Lung Cell Mol Physiol. 2009 Sep; 297(3):L506-11. PMID: 19617312.
      View in: PubMed
    13. Smith HA, Fuchs DC, Pandharipande PP, Barr FE, Ely EW. Delirium: an emerging frontier in the management of critically ill children. Crit Care Clin. 2009 Jul; 25(3):593-614, x. PMID: 19576533.
      View in: PubMed
    14. Neill MA, Aschner J, Barr F, Summar ML. Quantitative RT-PCR comparison of the urea and nitric oxide cycle gene transcripts in adult human tissues. Mol Genet Metab. 2009 Jun; 97(2):121-7. PMID: 19345634.
      View in: PubMed
    15. Barr FE. Pulmonary function and shunt size after single ventricle palliation--classic cardiopulmonary interactions. Pediatr Crit Care Med. 2009 Jan; 10(1):139. PMID: 19131877.
      View in: PubMed
    16. Barr FE, Tirona RG, Taylor MB, Rice G, Arnold J, Cunningham G, Smith HA, Campbell A, Canter JA, Christian KG, Drinkwater DC, Scholl F, Kavanaugh-McHugh A, Summar ML. Pharmacokinetics and safety of intravenously administered citrulline in children undergoing congenital heart surgery: potential therapy for postoperative pulmonary hypertension. J Thorac Cardiovasc Surg. 2007 Aug; 134(2):319-26. PMID: 17662768.
      View in: PubMed
    17. Creech CB, Johnson BG, Bartilson RE, Yang E, Barr FE. Increasing use of extracorporeal life support in methicillin-resistant Staphylococcus aureus sepsis in children. Pediatr Crit Care Med. 2007 May; 8(3):231-5; quiz 247. PMID: 17417114.
      View in: PubMed
    18. Canter JA, Summar ML, Smith HB, Rice GD, Hall LD, Ritchie MD, Motsinger AA, Christian KG, Drinkwater DC, Scholl FG, Dyer KL, Kavanaugh-McHugh AL, Barr FE. Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: a validated genetic association study. Mitochondrion. 2007 May; 7(3):204-10. PMID: 17188582.
      View in: PubMed
    19. Smith HA, Canter JA, Christian KG, Drinkwater DC, Scholl FG, Christman BW, Rice GD, Barr FE, Summar ML. Nitric oxide precursors and congenital heart surgery: a randomized controlled trial of oral citrulline. J Thorac Cardiovasc Surg. 2006 Jul; 132(1):58-65. PMID: 16798303.
      View in: PubMed
    20. Curley MA, Arnold JH, Thompson JE, Fackler JC, Grant MJ, Fineman LD, Cvijanovich N, Barr FE, Molitor-Kirsch S, Steinhorn DM, Matthay MA, Hibberd PL. Clinical trial design--effect of prone positioning on clinical outcomes in infants and children with acute respiratory distress syndrome. J Crit Care. 2006 Mar; 21(1):23-32; discussion 32-7. PMID: 16616620.
      View in: PubMed
    21. Summar ML, Barr F, Dawling S, Smith W, Lee B, Singh RH, Rhead WJ, Sniderman King L, Christman BW. Unmasked adult-onset urea cycle disorders in the critical care setting. Crit Care Clin. 2005 Oct; 21(4 Suppl):S1-8. PMID: 16227111.
      View in: PubMed
    22. Curley MA, Hibberd PL, Fineman LD, Wypij D, Shih MC, Thompson JE, Grant MJ, Barr FE, Cvijanovich NZ, Sorce L, Luckett PM, Matthay MA, Arnold JH. Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial. JAMA. 2005 Jul 13; 294(2):229-37. PMID: 16014597.
      View in: PubMed
    23. Barr FE. Calpain: A new target in pulmonary hypertension? Crit Care Med. 2005 Mar; 33(3):693. PMID: 15753778.
      View in: PubMed
    24. Summar ML, Hall L, Christman B, Barr F, Smith H, Kallianpur A, Brown N, Yadav M, Willis A, Eeds A, Cermak E, Summar S, Wilson A, Arvin M, Putnam A, Wills M, Cunningham G. Environmentally determined genetic expression: clinical correlates with molecular variants of carbamyl phosphate synthetase I. Mol Genet Metab. 2004 Apr; 81 Suppl 1:S12-9. PMID: 15050969.
      View in: PubMed
    25. Potts AL, Barr FE, Gregory DF, Wright L, Patel NR. Computerized physician order entry and medication errors in a pediatric critical care unit. Pediatrics. 2004 Jan; 113(1 Pt 1):59-63. PMID: 14702449.
      View in: PubMed
    26. Halasa NB, Barr FE, Johnson JE, Edwards KM. Fatal pulmonary hypertension associated with pertussis in infants: does extracorporeal membrane oxygenation have a role? Pediatrics. 2003 Dec; 112(6 Pt 1):1274-8. PMID: 14654596.
      View in: PubMed
    27. Willis AS, Freeman ML, Summar SR, Barr FE, Williams SM, Dawson E, Summar ML. Ethnic diversity in a critical gene responsible for glutathione synthesis. Free Radic Biol Med. 2003 Jan 01; 34(1):72-6. PMID: 12498981.
      View in: PubMed
    28. Barr FE, Beverley H, VanHook K, Cermak E, Christian K, Drinkwater D, Dyer K, Raggio NT, Moore JH, Christman B, Summar M. Effect of cardiopulmonary bypass on urea cycle intermediates and nitric oxide levels after congenital heart surgery. J Pediatr. 2003 Jan; 142(1):26-30. PMID: 12520250.
      View in: PubMed
    29. Drinkwater DC, Aharon AS, Quisling SV, Dodd D, Reddy VS, Kavanaugh-McHugh A, Doyle T, Patel NR, Barr FE, Kambam JK, Graham TP, Chang PA. Modified Norwood operation for hypoplastic left heart syndrome. Ann Thorac Surg. 2001 Dec; 72(6):2081-6; discussion 2087. PMID: 11789798.
      View in: PubMed
    30. Barr FE, Pedigo H, Johnson TR, Shepherd VL. Surfactant protein-A enhances uptake of respiratory syncytial virus by monocytes and U937 macrophages. Am J Respir Cell Mol Biol. 2000 Nov; 23(5):586-92. PMID: 11062136.
      View in: PubMed
    31. Barr FE, Patel NR, Newth CJ. The pharmacologic mechanism by which inhaled epinephrine reduces airway obstruction in respiratory syncytial virus-associated bronchiolitis. J Pediatr. 2000 May; 136(5):699-700. PMID: 10802508.
      View in: PubMed
    32. Haselton DJ, Klekamp JG, Christman BW, Barr FE. Use of high-dose corticosteroids and high-frequency oscillatory ventilation for treatment of a child with diffuse alveolar hemorrhage after bone marrow transplantation: case report and review of the literature. Crit Care Med. 2000 Jan; 28(1):245-8. PMID: 10667532.
      View in: PubMed
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