 Leena Maddukuri
| Title | Instructor |
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| Institution | University of Arkansas for Medical Sciences |
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| Department | Biochemistry & Molecular Biology, College of Medicine |
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| Division | Biochem & Molecular Y-Family DNA |
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| Address | B416 LAB Biomedical Research I
325 S. Elm St.
Mail Slot # 516
Little Rock AR 72205
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| Phone | 501-123-4567 |
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| vCard | Download vCard |
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 Research Funds 1903357 (EOFF, ROBERT)Aug 1, 2019 - Jul 31, 2024 National Science Foundation
Replication of G-quadruplex DNA by translesion polymerases
Role: Co-Investigator |
| R01CA183895 (EOFF, ROBERT L)Apr 4, 2014 - Feb 29, 2020 NIH
Translesion DNA polymerase kappa activity in gliomas
Role: Co-Investigator |
| R00GM084460 (EOFF, ROBERT L)Jul 1, 2009 - Dec 31, 2013 NIH
Coordinating Translesion DNA Synthesis Opposite Damaged DNA
Role: Co-Investigator |
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Reed MR, Maddukuri L, Ketkar A, Byrum SD, Zafar MK, Bostian ACL, Tackett AJ, Eoff RL. Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells. NAR Cancer. 2021 Jun; 3(2):zcab014. PMID: 33870196.
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Ketkar A, Smith L, Johnson C, Richey A, Berry M, Hartman JH, Maddukuri L, Reed MR, Gunderson JEC, Leung JWC, Eoff RL. Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs. Nucleic Acids Res. 2021 02 26; 49(4):2065-2084. PMID: 33555350.
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Ketkar A, Maddukuri L, Penthala NR, Reed MR, Zafar MK, Crooks PA, Eoff RL. Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms. ACS Chem Biol. 2019 06 21; 14(6):1337-1351. PMID: 31082191.
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Zafar MK, Maddukuri L, Ketkar A, Penthala NR, Reed MR, Eddy S, Crooks PA, Eoff RL. A Small-Molecule Inhibitor of Human DNA Polymerase ? Potentiates the Effects of Cisplatin in Tumor Cells. Biochemistry. 2018 02 20; 57(7):1262-1273. PMID: 29345908.
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Eddy S, Tillman M, Maddukuri L, Ketkar A, Zafar MK, Eoff RL. Human Translesion Polymerase ? Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA. Biochemistry. 2016 09 20; 55(37):5218-29. PMID: 27525498.
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Byrd AK, Zybailov BL, Maddukuri L, Gao J, Marecki JC, Jaiswal M, Bell MR, Griffin WC, Reed MR, Chib S, Mackintosh SG, MacNicol AM, Baldini G, Eoff RL, Raney KD. Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress. J Biol Chem. 2016 08 19; 291(34):18041-57. PMID: 27369081.
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Bostian AC, Maddukuri L, Reed MR, Savenka T, Hartman JH, Davis L, Pouncey DL, Miller GP, Eoff RL. Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells. Chem Res Toxicol. 2016 Jan 19; 29(1):101-8. PMID: 26651356.
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Eddy S, Maddukuri L, Ketkar A, Zafar MK, Henninger EE, Pursell ZF, Eoff RL. Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA. Biochemistry. 2015 May 26; 54(20):3218-30. PMID: 25903680.
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Maddukuri L, Ketkar A, Eddy S, Zafar MK, Eoff RL. The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa. Nucleic Acids Res. 2014 Oct 29; 42(19):12027-40. PMID: 25294835.
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Eddy S, Ketkar A, Zafar MK, Maddukuri L, Choi JY, Eoff RL. Human Rev1 polymerase disrupts G-quadruplex DNA. Nucleic Acids Res. 2014 Mar; 42(5):3272-85. PMID: 24366879.
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Maddukuri L, Shuck SC, Eoff RL, Zhao L, Rizzo CJ, Guengerich FP, Marnett LJ. Replication, repair, and translesion polymerase bypass of N6-oxopropenyl-2'-deoxyadenosine. Biochemistry. 2013 Dec 03; 52(48):8766-76. PMID: 24171480.
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Coggins GE, Maddukuri L, Penthala NR, Hartman JH, Eddy S, Ketkar A, Crooks PA, Eoff RL. N-Aroyl indole thiobarbituric acids as inhibitors of DNA repair and replication stress response polymerases. ACS Chem Biol. 2013 Aug 16; 8(8):1722-9. PMID: 23679919.
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Ketkar A, Zafar MK, Maddukuri L, Yamanaka K, Banerjee S, Egli M, Choi JY, Lloyd RS, Eoff RL. Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity. Chem Res Toxicol. 2013 Feb 18; 26(2):221-32. PMID: 23305233.
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Maddukuri L, Ketkar A, Eddy S, Zafar MK, Griffin WC, Eoff RL. Enhancement of human DNA polymerase ? activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome protein. J Biol Chem. 2012 Dec 07; 287(50):42312-23. PMID: 23045531.
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Kotapati S, Maddukuri L, Wickramaratne S, Seneviratne U, Goggin M, Pence MG, Villalta P, Guengerich FP, Marnett L, Tretyakova N. Translesion synthesis across 1,N6-(2-hydroxy-3-hydroxymethylpropan-1,3-diyl)-2'-deoxyadenosine (1,N6-?-HMHP-dA) adducts by human and archebacterial DNA polymerases. J Biol Chem. 2012 Nov 09; 287(46):38800-11. PMID: 22977231.
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Uddin MJ, Schulte MI, Maddukuri L, Harp J, Marnett LJ. Semisynthesis of 6-chloropurine-2'-deoxyriboside 5'-dimethoxytrityl 3'-(2-cyanoethyl-N,N-diisopropylamino)phosphoramidite and its use in the synthesis of fluorescently labeled oligonucleotides. Nucleosides Nucleotides Nucleic Acids. 2010 Nov; 29(11):831-40. PMID: 21128170.
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Eoff RL, McGrath CE, Maddukuri L, Salamanca-Pinzón SG, Marquez VE, Marnett LJ, Guengerich FP, Egli M. Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues. Angew Chem Int Ed Engl. 2010 Oct 04; 49(41):7481-5. PMID: 20814997.
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Maddukuri L, Eoff RL, Choi JY, Rizzo CJ, Guengerich FP, Marnett LJ. In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases ?, ?, and Rev1. Biochemistry. 2010 Sep 28; 49(38):8415-24. PMID: 20726503.
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Maddukuri L, Speina E, Christiansen M, Dudzinska D, Zaim J, Obtulowicz T, Kabaczyk S, Komisarski M, Bukowy Z, Szczegielniak J, Wójcik A, Kusmierek JT, Stevnsner T, Bohr VA, Tudek B. Cockayne syndrome group B protein is engaged in processing of DNA adducts of lipid peroxidation product trans-4-hydroxy-2-nonenal. Mutat Res. 2009 06 18; 666(1-2):23-31. PMID: 19481676.
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Maddukuri L, Dudzinska D, Tudek B. Bacterial DNA repair genes and their eukaryotic homologues: 4. The role of nucleotide excision DNA repair (NER) system in mammalian cells. Acta Biochim Pol. 2007; 54(3):469-82. PMID: 17893751.
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Pereira M, Mason P, Szczesny RJ, Maddukuri L, Dziwura S, Jedrzejczak R, Paul E, Wojcik A, Dybczynska L, Tudek B, Bartnik E, Klysik J, Bohr VA, Stepien PP. Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality. Mech Ageing Dev. 2007 Nov-Dec; 128(11-12):609-17. PMID: 17961633.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 2007 | 2 | | 2009 | 1 | | 2010 | 3 | | 2012 | 2 | | 2013 | 4 | | 2014 | 1 | | 2015 | 2 | | 2016 | 2 | | 2018 | 1 | | 2019 | 1 | | 2021 | 2 |
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