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Institution

Eugenia Carvalho

TitleInstructor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentGeriatrics, College of Medicine
DivisionGeriatrics Faculty
Address1120 Marshall Street
Mail Slot # ACHRI R2122
Little Rock AR 72202
Phone501-364-3057
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    1. García-Casarrubios E, de Moura C, Arroba AI, Pescador N, Calderon-Dominguez M, Garcia L, Herrero L, Serra D, Cadenas S, Reis F, Carvalho E, Obregon MJ, Valverde ÁM. Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes. Biochim Biophys Acta. 2016 Dec; 1861(12 Pt A):1929-1941. PMID: 27686967.
      View in: PubMed
    2. Emanuelli T, Burgeiro A, Carvalho E. Effects of insulin on the skin: possible healing benefits for diabetic foot ulcers. Arch Dermatol Res. 2016 Dec; 308(10):677-694. PMID: 27655635.
      View in: PubMed
    3. Pinheiro BS, Lemos C, Neutzling Kaufmann F, Marques JM, da Silva-Santos CS, Carvalho E, Mackie K, Rodrigues RJ, Cunha RA, Köfalvi A. Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res Bull. 2016 Jun; 124:222-30. PMID: 27208730.
      View in: PubMed
    4. Carvalho E, Lopaschuk GD, Børsheim E, Burgeiro A. Reply to Katlandur, Ozbek, and Keser. Am J Physiol Endocrinol Metab. 2016 May 15; 310(10):E863. PMID: 27182058; PMCID: PMC5005270 [Available on 05/15/17].
    5. Tellechea A, Leal EC, Kafanas A, Auster ME, Kuchibhotla S, Ostrovsky Y, Tecilazich F, Baltzis D, Zheng Y, Carvalho E, Zabolotny JM, Weng Z, Petra A, Patel A, Panagiotidou S, Pradhan-Nabzdyk L, Theoharides TC, Veves A. Mast Cells Regulate Wound Healing in Diabetes. Diabetes. 2016 Jul; 65(7):2006-19. PMID: 27207516; PMCID: PMC4915574 [Available on 07/01/17].
    6. Moura J, Rodrigues J, Gonçalves M, Amaral C, Lima M, Carvalho E. Impaired T-cell differentiation in diabetic foot ulceration. Cell Mol Immunol. 2017 Sep; 14(9):758-769. PMID: 26996067.
      View in: PubMed
    7. Burgeiro A, Fuhrmann A, Cherian S, Espinoza D, Jarak I, Carvalho RA, Loureiro M, Patrício M, Antunes M, Carvalho E. Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes. Am J Physiol Endocrinol Metab. 2016 Apr 01; 310(7):E550-64. PMID: 26814014; PMCID: PMC4824138 [Available on 04/01/17].
    8. Godinho R, Mega C, Teixeira-de-Lemos E, Carvalho E, Teixeira F, Fernandes R, Reis F. The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A "Me Too" or "the Special One" Antidiabetic Class? J Diabetes Res. 2015; 2015:806979. PMID: 26075286; PMCID: PMC4449938.
    9. Leal EC, Carvalho E, Tellechea A, Kafanas A, Tecilazich F, Kearney C, Kuchibhotla S, Auster ME, Kokkotou E, Mooney DJ, LoGerfo FW, Pradhan-Nabzdyk L, Veves A. Substance P promotes wound healing in diabetes by modulating inflammation and macrophage phenotype. Am J Pathol. 2015 Jun; 185(6):1638-48. PMID: 25871534; PMCID: PMC4450333.
    10. Sereno J, Vala H, Nunes S, Rocha-Pereira P, Carvalho E, Alves R, Teixeira F, Reis F. Cyclosporine A-induced nephrotoxicity is ameliorated by dose reduction and conversion to sirolimus in the rat. J Physiol Pharmacol. 2015 Apr; 66(2):285-99. PMID: 25903959.
      View in: PubMed
    11. Moura J, Børsheim E, Carvalho E. The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing. Genes (Basel). 2014 Sep 29; 5(4):926-56. PMID: 25268390; PMCID: PMC4276920.
    12. Pereira MJ, Palming J, Rizell M, Aureliano M, Carvalho E, Svensson MK, Eriksson JW. Cyclosporine A and tacrolimus reduce the amount of GLUT4 at the cell surface in human adipocytes: increased endocytosis as a potential mechanism for the diabetogenic effects of immunosuppressive agents. J Clin Endocrinol Metab. 2014 Oct; 99(10):E1885-94. PMID: 25004245.
      View in: PubMed
    13. Lopes PC, Fuhrmann A, Carvalho F, Sereno J, Santos MR, Pereira MJ, Eriksson JW, Reis F, Carvalho E. Cyclosporine A enhances gluconeogenesis while sirolimus impairs insulin signaling in peripheral tissues after 3 weeks of treatment. Biochem Pharmacol. 2014 Sep 01; 91(1):61-73. PMID: 24960264.
      View in: PubMed
    14. Sereno J, Rodrigues-Santos P, Vala H, Rocha-Pereira P, Alves R, Fernandes J, Santos-Silva A, Carvalho E, Teixeira F, Reis F. Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in vivo rat model. Int J Mol Sci. 2014 May 20; 15(5):8979-97. PMID: 24853130; PMCID: PMC4057770.
    15. Lopes PC, Fuhrmann A, Sereno J, Espinoza DO, Pereira MJ, Eriksson JW, Reis F, Carvalho E. Short and long term in vivo effects of Cyclosporine A and Sirolimus on genes and proteins involved in lipid metabolism in Wistar rats. Metabolism. 2014 May; 63(5):702-15. PMID: 24656168.
      View in: PubMed
    16. Fuhrmann A, Lopes P, Sereno J, Pedro J, Espinoza DO, Pereira MJ, Reis F, Eriksson JW, Carvalho E. Molecular mechanisms underlying the effects of cyclosporin A and sirolimus on glucose and lipid metabolism in liver, skeletal muscle and adipose tissue in an in vivo rat model. Biochem Pharmacol. 2014 Mar 15; 88(2):216-28. PMID: 24462915.
      View in: PubMed
    17. Tecilazich F, Dinh T, Pradhan-Nabzdyk L, Leal E, Tellechea A, Kafanas A, Gnardellis C, Magargee ML, Dejam A, Toxavidis V, Tigges JC, Carvalho E, Lyons TE, Veves A. Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers. PLoS One. 2013; 8(12):e83314. PMID: 24358275; PMCID: PMC3865213.
    18. Moura LI, Cruz MT, Carvalho E. The effect of neurotensin in human keratinocytes--implication on impaired wound healing in diabetes. Exp Biol Med (Maywood). 2014 Jan; 239(1):6-12. PMID: 24198343.
      View in: PubMed
    19. Moura LI, Dias AM, Suesca E, Casadiegos S, Leal EC, Fontanilla MR, Carvalho L, de Sousa HC, Carvalho E. Neurotensin-loaded collagen dressings reduce inflammation and improve wound healing in diabetic mice. Biochim Biophys Acta. 2014 Jan; 1842(1):32-43. PMID: 24161538.
      View in: PubMed
    20. Moura LI, Dias AM, Leal EC, Carvalho L, de Sousa HC, Carvalho E. Chitosan-based dressings loaded with neurotensin--an efficient strategy to improve early diabetic wound healing. Acta Biomater. 2014 Feb; 10(2):843-57. PMID: 24121197.
      View in: PubMed
    21. Moura LI, Silva L, Leal EC, Tellechea A, Cruz MT, Carvalho E. Neurotensin modulates the migratory and inflammatory response of macrophages under hyperglycemic conditions. Biomed Res Int. 2013; 2013:941764. PMID: 24000330; PMCID: PMC3755412.
    22. Soares E, Prediger RD, Nunes S, Castro AA, Viana SD, Lemos C, De Souza CM, Agostinho P, Cunha RA, Carvalho E, Fontes Ribeiro CA, Reis F, Pereira FC. Spatial memory impairments in a prediabetic rat model. Neuroscience. 2013 Oct 10; 250:565-77. PMID: 23912035.
      View in: PubMed
    23. Moura J, da Silva L, Cruz MT, Carvalho E. Molecular and cellular mechanisms of bone morphogenetic proteins and activins in the skin: potential benefits for wound healing. Arch Dermatol Res. 2013 Sep; 305(7):557-69. PMID: 23800970.
      View in: PubMed
    24. Sereno J, Parada B, Rodrigues-Santos P, Lopes PC, Carvalho E, Vala H, Teixeira-Lemos E, Alves R, Figueiredo A, Mota A, Teixeira F, Reis F. Serum and renal tissue markers of nephropathy in rats under immunosuppressive therapy: cyclosporine versus sirolimus. Transplant Proc. 2013 Apr; 45(3):1149-56. PMID: 23622648.
      View in: PubMed
    25. Lopes P, Fuhrmann A, Sereno J, Pereira MJ, Nunes P, Pedro J, Melão A, Reis F, Carvalho E. Effects of cyclosporine and sirolimus on insulin-stimulated glucose transport and glucose tolerance in a rat model. Transplant Proc. 2013 Apr; 45(3):1142-8. PMID: 23622647.
      View in: PubMed
    26. Moura LI, Dias AM, Carvalho E, de Sousa HC. Recent advances on the development of wound dressings for diabetic foot ulcer treatment--a review. Acta Biomater. 2013 Jul; 9(7):7093-114. PMID: 23542233.
      View in: PubMed
    27. Nunes S, Soares E, Fernandes J, Viana S, Carvalho E, Pereira FC, Reis F. Early cardiac changes in a rat model of prediabetes: brain natriuretic peptide overexpression seems to be the best marker. Cardiovasc Diabetol. 2013 Mar 07; 12:44. PMID: 23497124; PMCID: PMC3599663.
    28. Tellechea A, Kafanas A, Leal EC, Tecilazich F, Kuchibhotla S, Auster ME, Kontoes I, Paolino J, Carvalho E, Nabzdyk LP, Veves A. Increased skin inflammation and blood vessel density in human and experimental diabetes. Int J Low Extrem Wounds. 2013 Mar; 12(1):4-11. PMID: 23446362; PMCID: PMC3688045.
    29. Pereira MJ, Palming J, Rizell M, Aureliano M, Carvalho E, Svensson MK, Eriksson JW. The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue. Mol Cell Endocrinol. 2013 Jan 30; 365(2):260-9. PMID: 23160140.
      View in: PubMed
    30. Cherian S, Lopaschuk GD, Carvalho E. Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease. Am J Physiol Endocrinol Metab. 2012 Oct 15; 303(8):E937-49. PMID: 22895783.
      View in: PubMed
    31. Sereno J, Romão AM, Parada B, Lopes P, Carvalho E, Teixeira F, Reis F. Cardiorenal benefits of early versus late cyclosporine to sirolimus conversion in a rat model. J Pharmacol Pharmacother. 2012 Apr; 3(2):143-8. PMID: 22629089; PMCID: PMC3356955.
    32. Pereira MJ, Palming J, Rizell M, Aureliano M, Carvalho E, Svensson MK, Eriksson JW. mTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes. Mol Cell Endocrinol. 2012 May 15; 355(1):96-105. PMID: 22333157.
      View in: PubMed
    33. da Silva L, Neves BM, Moura L, Cruz MT, Carvalho E. Neurotensin downregulates the pro-inflammatory properties of skin dendritic cells and increases epidermal growth factor expression. Biochim Biophys Acta. 2011 Oct; 1813(10):1863-71. PMID: 21767580.
      View in: PubMed
    34. Pedroso DC, Tellechea A, Moura L, Fidalgo-Carvalho I, Duarte J, Carvalho E, Ferreira L. Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cells. PLoS One. 2011 Jan 24; 6(1):e16114. PMID: 21283630; PMCID: PMC3026015.
    35. da Silva L, Carvalho E, Cruz MT. Role of neuropeptides in skin inflammation and its involvement in diabetic wound healing. Expert Opin Biol Ther. 2010 Oct; 10(10):1427-39. PMID: 20738210.
      View in: PubMed
    36. Passadouro M, Metelo AM, Melão AS, Pedro JR, Faneca H, Carvalho E, Castro MM. Study of the antidiabetic capacity of the VO(dmpp)2 complex. J Inorg Biochem. 2010 Sep; 104(9):987-92. PMID: 20627316.
      View in: PubMed
    37. Pereira MJ, Carvalho E, Eriksson JW, Crans DC, Aureliano M. Effects of decavanadate and insulin enhancing vanadium compounds on glucose uptake in isolated rat adipocytes. J Inorg Biochem. 2009 Dec; 103(12):1687-92. PMID: 19850351.
      View in: PubMed
    38. Nunes PM, Carvalho E, Jones JG. Elimination of glucose contamination from adipocyte glycogen extracts. Carbohydr Res. 2008 Jul 07; 343(9):1486-9. PMID: 18452901.
      View in: PubMed
    39. Karagiannides I, Torres D, Tseng YH, Bowe C, Carvalho E, Espinoza D, Pothoulakis C, Kokkotou E. Substance P as a novel anti-obesity target. Gastroenterology. 2008 Mar; 134(3):747-55. PMID: 18325388; PMCID: PMC2359157.
    40. Carvalho E, Kotani K, Peroni OD, Kahn BB. Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle. Am J Physiol Endocrinol Metab. 2005 Oct; 289(4):E551-61. PMID: 15928024.
      View in: PubMed
    41. Yang X, Jansson PA, Nagaev I, Jack MM, Carvalho E, Sunnerhagen KS, Cam MC, Cushman SW, Smith U. Evidence of impaired adipogenesis in insulin resistance. Biochem Biophys Res Commun. 2004 May 14; 317(4):1045-51. PMID: 15094374.
      View in: PubMed
    42. Carvalho E, Schellhorn SE, Zabolotny JM, Martin S, Tozzo E, Peroni OD, Houseknecht KL, Mundt A, James DE, Kahn BB. GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase. J Biol Chem. 2004 May 14; 279(20):21598-605. PMID: 14985357.
      View in: PubMed
    43. Jansson PA, Pellmé F, Hammarstedt A, Sandqvist M, Brekke H, Caidahl K, Forsberg M, Volkmann R, Carvalho E, Funahashi T, Matsuzawa Y, Wiklund O, Yang X, Taskinen MR, Smith U. A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin. FASEB J. 2003 Aug; 17(11):1434-40. PMID: 12890697.
      View in: PubMed
    44. Carvalho E, Jansson PA, Nagaev I, Wenthzel AM, Smith U. Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport. FASEB J. 2001 Apr; 15(6):1101-3. PMID: 11292681.
      View in: PubMed
    45. Carvalho E, Eliasson B, Wesslau C, Smith U. Impaired phosphorylation and insulin-stimulated translocation to the plasma membrane of protein kinase B/Akt in adipocytes from Type II diabetic subjects. Diabetologia. 2000 Sep; 43(9):1107-15. PMID: 11043856.
      View in: PubMed
    46. Rondinone CM, Carvalho E, Rahn T, Manganiello VC, Degerman E, Smith UP. Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor. J Biol Chem. 2000 Apr 07; 275(14):10093-8. PMID: 10744689.
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    47. Carvalho E, Rondinone C, Smith U. Insulin resistance in fat cells from obese Zucker rats--evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4. Mol Cell Biochem. 2000 Mar; 206(1-2):7-16. PMID: 10839189.
      View in: PubMed
    48. Smith U, Carvalho E, Mosialou E, Beguinot F, Formisano P, Rondinone C. PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes. Biochem Biophys Res Commun. 2000 Feb 16; 268(2):315-20. PMID: 10679201.
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    49. Carvalho E, Jansson PA, Axelsen M, Eriksson JW, Huang X, Groop L, Rondinone C, Sjöström L, Smith U. Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM. FASEB J. 1999 Dec; 13(15):2173-8. PMID: 10593864.
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    50. Smith U, Axelsen M, Carvalho E, Eliasson B, Jansson PA, Wesslau C. Insulin signaling and action in fat cells: associations with insulin resistance and type 2 diabetes. Ann N Y Acad Sci. 1999 Nov 18; 892:119-26. PMID: 10842657.
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    51. Rondinone CM, Carvalho E, Wesslau C, Smith UP. Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus. Diabetologia. 1999 Jul; 42(7):819-25. PMID: 10440123.
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    52. Carvalho E, Aasa R, Göthe PO. Electron paramagnetic resonance studies of cobalt-substituted angiotensin I-converting enzyme. J Inorg Biochem. 1996 May 01; 62(2):147-53. PMID: 8729801.
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    53. Carvalho E, Göthe PO, Bauer R, Danielsen E, Hemmingsen L. Effect of inhibitors on the coordination geometries of cadmium at the metal sites in angiotensin-I-converting enzyme. Eur J Biochem. 1995 Dec 15; 234(3):780-5. PMID: 8575435.
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