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Mohammed Orloff

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentEpidemiology, College of Public Health
DivisionEpidemiology
Address ED III College of Public Health
220 UAMS Campus Dr.
Mail Slot # 820
Little Rock AR 72205
Phone501-526-6668
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    Collapse Research 
    Collapse research activities and funding
    6922-03-COVID-S016     (MCELFISH, PEARL A)Apr 1, 2024 - Mar 31, 2028
    Westat - Pass Through: Westat
    FOOD AS MEDICINE: ADDRESSING SOCIAL DETERMINANTS OF HEALTH (FOOD INSECURITY) TO EFFECT CLINICAL OUTCOMES (CEAL)
    Role: Principal Investigator
    U01DD001306     (NEMBHARD, WENDY N)Sep 1, 2023 - Mar 31, 2027
    NIH
    Birth Defects Study to Evaluate Pregnancy exposureS (BD-STEPS) Core? Arkansas Center and Stillbirth
    Role: Principal Investigator
    U01DD001306     (NEMBHARD, WENDY N)Sep 1, 2023 - Mar 31, 2027
    NIH
    Birth Defects Study to Evaluate Pregnancy exposureS (BD-STEPS) Core? Arkansas Center and Stillbirth
    Role: Co-Investigator
    SUB-OTA No. 6922-03-COVID-S016     (MCELFISH, PEARL A)Jul 16, 2023 - Mar 31, 2024
    NIH/Nat. Heart, Lung & Blood Institute - Pass Through: Westat
    Community Engagement Research Alliance (CEAL) 2023-2024 Renewal
    Role: Principal Investigator
    P50MD017319     (CORNELL, CAROL ELLEN)Sep 24, 2021 - Jun 30, 2026
    NIH
    The Center for Research, Health, and Social Justice
    Role: Co-Investigator
    COPH Center for Tobacco Studies     (OLIVETO, ALISON)Mar 6, 2019 - Jan 30, 2022
    UAMS Internal Research Awards
    No FP attached
    Role: Principal Investigator
    U01DD001285     (NEMBHARD, WENDY N)Dec 1, 2018 - Aug 31, 2023
    NIH
    RFA-DD-18-001 Birth Defects Study To Evaluate Pregnancy exposures (BD-STEPS) II Core & Component B Steps -Stillbirth
    Role: Co-Investigator
    CI-Tobacco Prevention Internal Award     (ORLOFF, MOHAMMED S)Jul 1, 2017 - Jun 30, 2019
    UAMS Internal Research Awards
    Interaction of lug microbiome and tobaccorelated insults in lung cancer
    Role: Principal Investigator
    CI-TobaccoPreventionInternalAward     (ORLOFF, MOHAMMED S)Jul 1, 2017 - Jun 30, 2019
    UAMS Internal Research Awards
    Interaction of lug microbiome and tobaccorelated insults in lung cancer
    Role: Principal Investigator
    R15HL126074     (ORLOFF, MOHAMMED S)May 23, 2016 - Apr 30, 2019
    NIH/Nat. Heart, Lung & Blood Institute
    Genes,Blood Pressure Variability and Cardiovascular Diseases
    Role: Co-Investigator
    U54MD002329     (CORNELL, CAROL ELLEN)Sep 30, 2007 - Apr 30, 2024
    NIH
    Arkansas Center for Health Disparities (ARCHD): An NIMHD COE
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Mukherjee N, Bolin EH, Qasim A, Orloff MS, Lupo PJ, Nembhard WN. DNA methylation of the Lamin A/C gene is associated with congenital heart disease. Birth Defects Res. 2024 Jul; 116(7):e2381. PMID: 39073036.
      View in: PubMed
    2. Jones DM, Taylor E, Orloff M, Prewitt TE, Donald K, Cornell CE, Fagan P. Changes in Capacity Building and Sustained Implementation Among a Statewide Coalition to Address Racial/Ethnic COVID-19 Disparities. Am J Public Health. 2024 01; 114(S1):S59-S64. PMID: 38207260.
      View in: PubMed
    3. Joshi A, Su LJ, Orloff MS. Tuberculosis and Risk of Emphysema among US Adults in the NHANES I Epidemiologic Follow-Up Study Cohort, 1971-1992. Epidemiologia (Basel). 2023 Dec 05; 4(4):525-537. PMID: 38131676.
      View in: PubMed
    4. Jones DM, Bullock S, Donald K, Cooper S, Miller W, Davis AH, Cottoms N, Orloff M, Bryant-Moore K, Guy MC, Fagan P. Factors associated with smokefree rules in the homes of Black/African American women smokers residing in low-resource rural communities. Prev Med. 2022 12; 165(Pt B):107340. PMID: 36370892.
      View in: PubMed
    5. Silva CS, Tryndyak VP, Camacho L, Orloff MS, Porter A, Garner K, Mullis L, Azevedo M. Temporal dynamics of SARS-CoV-2 genome and detection of variants of concern in wastewater influent from two metropolitan areas in Arkansas. Sci Total Environ. 2022 Nov 25; 849:157546. PMID: 35914602.
      View in: PubMed
    6. Bircan E, Bezirhan U, Porter A, Fagan P, Orloff MS. Electronic cigarette use and its association with asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome among never cigarette smokers. Tob Induc Dis. 2021; 19:75. PMID: 34720794.
      View in: PubMed
    7. Bircan E, Bezirhan U, Porter A, Fagan P, Orloff MS. Erratum: Electronic cigarette use and its association with asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome among never cigarette smokers. Tob Induc Dis. 2021; 19:74. PMID: 34727146.
      View in: PubMed
    8. Jones DM, Guy MC, Soule E, Sakuma KK, Pokhrel P, Orloff M, Trinidad D, Smith D, Browley S, Walker AP, Bullock S, Eissenberg T, Fagan P. Characterization of Electronic Cigarette Warning Statements Portrayed in YouTube Videos. Nicotine Tob Res. 2021 08 04; 23(8):1358-1366. PMID: 33400781.
      View in: PubMed
    9. Delhey L, Shoults C, Johnson K, Orloff M, Faramawi MF, Delongchamp R. The difference between hypertension determined by self-report versus examination in the adult population of the USA: Continuous NHANES 1999-2016. J Public Health (Oxf). 2021 06 07; 43(2):316-324. PMID: 31781770.
      View in: PubMed
    10. Bircan E, Bezirhan U, Porter A, Fagan P, Orloff MS. Electronic cigarette use and its association with asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome among never cigarette smokers. Tob Induc Dis. 2021; 19:23. PMID: 33841062.
      View in: PubMed
    11. Patel J, Bircan E, Tang X, Orloff M, Hobbs CA, Browne ML, Botto LD, Finnell RH, Jenkins MM, Olshan A, Romitti PA, Shaw GM, Werler MM, Li J, Nembhard WN. Paternal genetic variants and risk of obstructive heart defects: A parent-of-origin approach. PLoS Genet. 2021 03; 17(3):e1009413. PMID: 33684136.
      View in: PubMed
    12. Khouri J, Faiman BM, Grabowski D, Mahfouz RZ, Khan SN, Wei W, Valent J, Dean R, Samaras C, Jha BK, Lazarus H, Campagnaro EL, Malek E, Reed J, Karam MA, Hamilton K, Fada S, Kalaycio M, Liu H, Sobecks R, Saunthararajah Y, Chew Y, Orloff M, Reu FJ. DNA methylation inhibition in myeloma: Experience from a phase 1b study of low-dose continuous azacitidine in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myeloma. Semin Hematol. 2021 01; 58(1):45-55. PMID: 33509443.
      View in: PubMed
    13. Jin J, Robeson H, Fagan P, Orloff MS. Association of PARP1-specific polymorphisms and haplotypes with non-small cell lung cancer subtypes. PLoS One. 2020; 15(12):e0243509. PMID: 33284833.
      View in: PubMed
    14. Syed S, Syed M, Syeda HB, Prior F, Zozus M, Penning ML, Orloff M. Document Oriented Graphical Analysis and Prediction. Stud Health Technol Inform. 2020 Jun 16; 270:183-187. PMID: 32570371.
      View in: PubMed
    15. Shen T, Bimali M, Faramawi M, Orloff MS. Consumption of Vitamin K and Vitamin A Are Associated With Reduced Risk of Developing Emphysema: NHANES 2007-2016. Front Nutr. 2020; 7:47. PMID: 32391372.
      View in: PubMed
    16. Rutlen C, Orloff M, Bates J, Porter A. Crop burning and the prevalence of asthma and COPD emergency department treatments in a rural Arkansas county. J Asthma. 2021 03; 58(3):293-298. PMID: 31858858.
      View in: PubMed
    17. Thapa S, Fischbach LA, Delongchamp R, Faramawi MF, Orloff M. The Association between Salt and Potential Mediators of the Gastric Precancerous Process. Cancers (Basel). 2019 Apr 15; 11(4). PMID: 30991669.
      View in: PubMed
    18. Thapa S, Fischbach LA, Delongchamp R, Faramawi MF, Orloff M. Association between Dietary Salt Intake and Progression in the Gastric Precancerous Process. Cancers (Basel). 2019 Apr 03; 11(4). PMID: 30987215.
      View in: PubMed
    19. Thapa S, Fischbach LA, Delongchamp R, Faramawi MF, Orloff MS. Using Machine Learning to Predict Progression in the Gastric Precancerous Process in a Population from a Developing Country Who Underwent a Gastroscopy for Dyspeptic Symptoms. Gastroenterol Res Pract. 2019; 2019:8321942. PMID: 31065263.
      View in: PubMed
    20. Wanchai V, Jin J, Bircan E, Eng C, Orloff M. Genome-wide tracts of homozygosity and exome analyses reveal repetitive elements with Barrets esophagus/esophageal adenocarcinoma risk. BMC Bioinformatics. 2019 Mar 14; 20(Suppl 2):98. PMID: 30871476.
      View in: PubMed
    21. Apopa PL, Alley L, Penney RB, Arnaoutakis K, Steliga MA, Jeffus S, Bircan E, Gopalan B, Jin J, Patumcharoenpol P, Jenjaroenpun P, Wongsurawat T, Shah N, Boysen G, Ussery D, Nookaew I, Fagan P, Bebek G, Orloff MS. PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin. Front Microbiol. 2018; 9:1757. PMID: 30127774.
      View in: PubMed
    22. Makhoul I, Todorova VK, Siegel ER, Erickson SW, Dhakal I, Raj VR, Lee JY, Orloff MS, Griffin RJ, Henry-Tillman RS, Klimberg S, Hutchins LF, Kadlubar SA. Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients. PLoS One. 2017; 12(1):e0168550. PMID: 28045923.
      View in: PubMed
    23. Rogers LJ, Basnakian AG, Orloff MS, Ning B, Yao-Borengasser A, Raj V, Kadlubar S. 2-amino-1-methyl-6-phenylimidazo(4,5-b) pyridine (PhIP) induces gene expression changes in JAK/STAT and MAPK pathways related to inflammation, diabetes and cancer. Nutr Metab (Lond). 2016; 13:54. PMID: 27547236.
      View in: PubMed
    24. Cardenas VM, Orloff MS, Kaminaga J, Cardenas IC, Brown J, Hainline-Williams S, Duthie MS, Gonzalez-Puche AC, Mukasa L, Patil N, Mcelfish PA, Bates JH. Tuberculosis and leprosy infections in the Marshallese population of Arkansas, USA. Lepr Rev. 2016 Mar; 87(1):109-12. PMID: 27255065.
      View in: PubMed
    25. Sutton J, Orloff MS, Michener C, Chiesa-Vottero A, Prayson R, Nowacki AS, Eng C. Association of specific PTEN/10q haplotypes with endometrial cancer phenotypes in African-American and European American women. Gynecol Oncol. 2015 Aug; 138(2):434-40. PMID: 26026735.
      View in: PubMed
    26. Starlard-Davenport A, Orloff MS, Dhakal I, Penney RB, Kadlubar SA. Genotypic and allelic variability in CYP19A1 among populations of African and European ancestry. PLoS One. 2015; 10(2):e0117347. PMID: 25647083.
      View in: PubMed
    27. Zhang L, Orloff MS, Reber S, Li S, Zhao Y, Eng C. cgaTOH: extended approach for identifying tracts of homozygosity. PLoS One. 2013; 8(3):e57772. PMID: 23469237.
      View in: PubMed
    28. Ngeow J, Heald B, Rybicki LA, Orloff MS, Chen JL, Liu X, Yerian L, Willis J, Lehtonen HJ, Lehtonen R, Mester JL, Moline J, Burke CA, Church J, Aaltonen LA, Eng C. Prevalence of germline PTEN, BMPR1A, SMAD4, STK11, and ENG mutations in patients with moderate-load colorectal polyps. Gastroenterology. 2013 Jun; 144(7):1402-9, 1409.e1-5. PMID: 23399955.
      View in: PubMed
    29. Orloff MS, He X, Peterson C, Chen F, Chen JL, Mester JL, Eng C. Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes. Am J Hum Genet. 2013 Jan 10; 92(1):76-80. PMID: 23246288.
      View in: PubMed
    30. Ngeow J, He X, Mester JL, Lei J, Romigh T, Orloff MS, Milas M, Eng C. Utility of PTEN protein dosage in predicting for underlying germline PTEN mutations among patients presenting with thyroid cancer and Cowden-like phenotypes. J Clin Endocrinol Metab. 2012 Dec; 97(12):E2320-7. PMID: 23066114.
      View in: PubMed
    31. Orloff MS, Zhang L, Bebek G, Eng C. Integrative genomic analysis reveals extended germline homozygosity with lung cancer risk in the PLCO cohort. PLoS One. 2012; 7(2):e31975. PMID: 22384118.
      View in: PubMed
    32. Ashida S, Orloff MS, Bebek G, Zhang L, Zheng P, Peehl DM, Eng C. Integrated analysis reveals critical genomic regions in prostate tumor microenvironment associated with clinicopathologic phenotypes. Clin Cancer Res. 2012 Mar 15; 18(6):1578-87. PMID: 22275508.
      View in: PubMed
    33. Tan MH, Mester JL, Ngeow J, Rybicki LA, Orloff MS, Eng C. Lifetime cancer risks in individuals with germline PTEN mutations. Clin Cancer Res. 2012 Jan 15; 18(2):400-7. PMID: 22252256.
      View in: PubMed
    34. Ni Y, He X, Chen J, Moline J, Mester J, Orloff MS, Ringel MD, Eng C. Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53. Hum Mol Genet. 2012 Jan 15; 21(2):300-10. PMID: 21979946.
      View in: PubMed
    35. Bebek G, Orloff M, Eng C. Microenvironmental genomic alterations reveal signaling networks for head and neck squamous cell carcinoma. J Clin Bioinforma. 2011 Aug 02; 1(1):21. PMID: 21884569.
      View in: PubMed
    36. Orloff M, Peterson C, He X, Ganapathi S, Heald B, Yang YR, Bebek G, Romigh T, Song JH, Wu W, David S, Cheng Y, Meltzer SJ, Eng C. Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma. JAMA. 2011 Jul 27; 306(4):410-9. PMID: 21791690.
      View in: PubMed
    37. Tan MH, De S, Bebek G, Orloff MS, Wesolowski R, Downs-Kelly E, Budd GT, Stark GR, Eng C. Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer. Breast Cancer Res Treat. 2012 Feb; 131(3):849-58. PMID: 21479552.
      View in: PubMed
    38. Nagy R, Ganapathi S, Comeras I, Peterson C, Orloff M, Porter K, Eng C, Ringel MD, Kloos RT. Frequency of germline PTEN mutations in differentiated thyroid cancer. Thyroid. 2011 May; 21(5):505-10. PMID: 21417916.
      View in: PubMed
    39. Tan MH, Mester J, Peterson C, Yang Y, Chen JL, Rybicki LA, Milas K, Pederson H, Remzi B, Orloff MS, Eng C. A clinical scoring system for selection of patients for PTEN mutation testing is proposed on the basis of a prospective study of 3042 probands. Am J Hum Genet. 2011 Jan 07; 88(1):42-56. PMID: 21194675.
      View in: PubMed
    40. He X, Wang Y, Zhu J, Orloff M, Eng C. Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling. Cancer Lett. 2011 Feb 28; 301(2):168-76. PMID: 21168265.
      View in: PubMed
    41. Wang Y, Romigh T, He X, Orloff MS, Silverman RH, Heston WD, Eng C. Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines. Hum Mol Genet. 2010 Nov 15; 19(22):4319-29. PMID: 20729295.
      View in: PubMed
    42. Heald B, Mester J, Rybicki L, Orloff MS, Burke CA, Eng C. Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers. Gastroenterology. 2010 Dec; 139(6):1927-33. PMID: 20600018.
      View in: PubMed
    43. Hansel DE, Platt E, Orloff M, Harwalker J, Sethu S, Hicks JL, De Marzo A, Steinle RE, Hsi ED, Theodorescu D, Ching CB, Eng C. Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma. Am J Pathol. 2010 Jun; 176(6):3062-72. PMID: 20395440.
      View in: PubMed
    44. Shiovitz S, Everett J, Huang SC, Orloff MS, Eng C, Gruber SB. Head circumference in the clinical detection of PTEN hamartoma tumor syndrome in a clinic population at high-risk of breast cancer. Breast Cancer Res Treat. 2010 Nov; 124(2):459-65. PMID: 20349131.
      View in: PubMed
    45. Waddell N, Arnold J, Cocciardi S, da Silva L, Marsh A, Riley J, Johnstone CN, Orloff M, Assie G, Eng C, Reid L, Keith P, Yan M, Fox S, Devilee P, Godwin AK, Hogervorst FB, Couch F, Grimmond S, Flanagan JM, Khanna K, Simpson PT, Lakhani SR, Chenevix-Trench G. Subtypes of familial breast tumours revealed by expression and copy number profiling. Breast Cancer Res Treat. 2010 Oct; 123(3):661-77. PMID: 19960244.
      View in: PubMed
    46. Eng C, Leone G, Orloff MS, Ostrowski MC. Genomic alterations in tumor stroma. Cancer Res. 2009 Sep 01; 69(17):6759-64. PMID: 19706759.
      View in: PubMed
    47. Ni Y, Zbuk KM, Sadler T, Patocs A, Lobo G, Edelman E, Platzer P, Orloff MS, Waite KA, Eng C. Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes. Am J Hum Genet. 2008 Aug; 83(2):261-8. PMID: 18678321.
      View in: PubMed
    48. Song K, Orloff MS, Lu Q, Elston RC. Fine-mapping using the weighted average method for a case-control study. BMC Genet. 2005 Dec 30; 6 Suppl 1:S67. PMID: 16451680.
      View in: PubMed
    49. Orloff MS, Iyengar SK, Winkler CA, Goddard KA, Dart RA, Ahuja TS, Mokrzycki M, Briggs WA, Korbet SM, Kimmel PL, Simon EE, Trachtman H, Vlahov D, Michel DM, Berns JS, Smith MC, Schelling JR, Sedor JR, Kopp JB. Variants in the Wilms' tumor gene are associated with focal segmental glomerulosclerosis in the African American population. Physiol Genomics. 2005 Apr 14; 21(2):212-21. PMID: 15687485.
      View in: PubMed
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