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Mohammed Orloff

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentCollege of Public Health, College of Provost
DivisionEpidemiology
Address ED III College of Public Health
220 UAMS Campus Dr.
Mail Slot # 820
Little Rock AR 72205
Phone501-526-6668
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    Collapse Research Funds 
    Collapse research activities
    U01DD001285     (NEMBHARD, WENDY N)Dec 1, 2018 - Aug 31, 2023
    CDC/NCBDD
    RFA-DD-18-001 Birth Defects Study To Evaluate Pregnancy exposureS (BD-STEPS) II
    Role: Co-Investigator

    R15HL126074     (ELFARAMAWI, MOHAMMED)May 23, 2016 - Apr 30, 2019
    NIH/Nat. Heart, Lung & Blood Institute
    Genes,Blood Pressure Variability and Cardiovascular Diseases
    Role: Co-Investigator

    U54MD002329     (RACZYNSKI, JAMES M)Sep 30, 2007 - Apr 30, 2022
    NIH/NIMHD
    Arkansas Center for Health Disparities (ARCHD): An NIMHD COE
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Syed S, Syed M, Syeda HB, Prior F, Zozus M, Penning ML, Orloff M. Document Oriented Graphical Analysis and Prediction. Stud Health Technol Inform. 2020 Jun 16; 270:183-187. PMID: 32570371.
      View in: PubMed
    2. Shen T, Bimali M, Faramawi M, Orloff MS. Consumption of Vitamin K and Vitamin A Are Associated With Reduced Risk of Developing Emphysema: NHANES 2007-2016. Front Nutr. 2020; 7:47. PMID: 32391372.
      View in: PubMed
    3. Rutlen C, Orloff M, Bates J, Porter A. Crop burning and the prevalence of asthma and COPD emergency department treatments in a rural Arkansas county. J Asthma. 2020 Jan 06; 1-6. PMID: 31858858.
      View in: PubMed
    4. Delhey L, Shoults C, Johnson K, Orloff M, Faramawi MF, Delongchamp R. The difference between hypertension determined by self-report versus examination in the adult population of the USA: Continuous NHANES 1999-2016. J Public Health (Oxf). 2019 Nov 28. PMID: 31781770.
      View in: PubMed
    5. Thapa S, Fischbach LA, Delongchamp R, Faramawi MF, Orloff M. The Association between Salt and Potential Mediators of the Gastric Precancerous Process. Cancers (Basel). 2019 Apr 15; 11(4). PMID: 30991669.
      View in: PubMed
    6. Thapa S, Fischbach LA, Delongchamp R, Faramawi MF, Orloff M. Association between Dietary Salt Intake and Progression in the Gastric Precancerous Process. Cancers (Basel). 2019 Apr 03; 11(4). PMID: 30987215.
      View in: PubMed
    7. Thapa S, Fischbach LA, Delongchamp R, Faramawi MF, Orloff MS. Using Machine Learning to Predict Progression in the Gastric Precancerous Process in a Population from a Developing Country Who Underwent a Gastroscopy for Dyspeptic Symptoms. Gastroenterol Res Pract. 2019; 2019:8321942. PMID: 31065263.
      View in: PubMed
    8. Wanchai V, Jin J, Bircan E, Eng C, Orloff M. Genome-wide tracts of homozygosity and exome analyses reveal repetitive elements with Barrets esophagus/esophageal adenocarcinoma risk. BMC Bioinformatics. 2019 Mar 14; 20(Suppl 2):98. PMID: 30871476.
      View in: PubMed
    9. Apopa PL, Alley L, Penney RB, Arnaoutakis K, Steliga MA, Jeffus S, Bircan E, Gopalan B, Jin J, Patumcharoenpol P, Jenjaroenpun P, Wongsurawat T, Shah N, Boysen G, Ussery D, Nookaew I, Fagan P, Bebek G, Orloff MS. PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin. Front Microbiol. 2018; 9:1757. PMID: 30127774.
      View in: PubMed
    10. Makhoul I, Todorova VK, Siegel ER, Erickson SW, Dhakal I, Raj VR, Lee JY, Orloff MS, Griffin RJ, Henry-Tillman RS, Klimberg S, Hutchins LF, Kadlubar SA. Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients. PLoS One. 2017; 12(1):e0168550. PMID: 28045923.
      View in: PubMed
    11. Rogers LJ, Basnakian AG, Orloff MS, Ning B, Yao-Borengasser A, Raj V, Kadlubar S. 2-amino-1-methyl-6-phenylimidazo(4,5-b) pyridine (PhIP) induces gene expression changes in JAK/STAT and MAPK pathways related to inflammation, diabetes and cancer. Nutr Metab (Lond). 2016; 13:54. PMID: 27547236.
      View in: PubMed
    12. Cardenas VM, Orloff MS, Kaminaga J, Cardenas IC, Brown J, Hainline-Williams S, Duthie MS, Gonzalez-Puche AC, Mukasa L, Patil N, Mcelfish PA, Bates JH. Tuberculosis and leprosy infections in the Marshallese population of Arkansas, USA. Lepr Rev. 2016 Mar; 87(1):109-12. PMID: 27255065.
      View in: PubMed
    13. Sutton J, Orloff MS, Michener C, Chiesa-Vottero A, Prayson R, Nowacki AS, Eng C. Association of specific PTEN/10q haplotypes with endometrial cancer phenotypes in African-American and European American women. Gynecol Oncol. 2015 Aug; 138(2):434-40. PMID: 26026735.
      View in: PubMed
    14. Starlard-Davenport A, Orloff MS, Dhakal I, Penney RB, Kadlubar SA. Genotypic and allelic variability in CYP19A1 among populations of African and European ancestry. PLoS One. 2015; 10(2):e0117347. PMID: 25647083.
      View in: PubMed
    15. Zhang L, Orloff MS, Reber S, Li S, Zhao Y, Eng C. cgaTOH: extended approach for identifying tracts of homozygosity. PLoS One. 2013; 8(3):e57772. PMID: 23469237.
      View in: PubMed
    16. Ngeow J, Heald B, Rybicki LA, Orloff MS, Chen JL, Liu X, Yerian L, Willis J, Lehtonen HJ, Lehtonen R, Mester JL, Moline J, Burke CA, Church J, Aaltonen LA, Eng C. Prevalence of germline PTEN, BMPR1A, SMAD4, STK11, and ENG mutations in patients with moderate-load colorectal polyps. Gastroenterology. 2013 Jun; 144(7):1402-9, 1409.e1-5. PMID: 23399955.
      View in: PubMed
    17. Orloff MS, He X, Peterson C, Chen F, Chen JL, Mester JL, Eng C. Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes. Am J Hum Genet. 2013 Jan 10; 92(1):76-80. PMID: 23246288.
      View in: PubMed
    18. Ngeow J, He X, Mester JL, Lei J, Romigh T, Orloff MS, Milas M, Eng C. Utility of PTEN protein dosage in predicting for underlying germline PTEN mutations among patients presenting with thyroid cancer and Cowden-like phenotypes. J Clin Endocrinol Metab. 2012 Dec; 97(12):E2320-7. PMID: 23066114.
      View in: PubMed
    19. Orloff MS, Zhang L, Bebek G, Eng C. Integrative genomic analysis reveals extended germline homozygosity with lung cancer risk in the PLCO cohort. PLoS One. 2012; 7(2):e31975. PMID: 22384118.
      View in: PubMed
    20. Ashida S, Orloff MS, Bebek G, Zhang L, Zheng P, Peehl DM, Eng C. Integrated analysis reveals critical genomic regions in prostate tumor microenvironment associated with clinicopathologic phenotypes. Clin Cancer Res. 2012 Mar 15; 18(6):1578-87. PMID: 22275508.
      View in: PubMed
    21. Tan MH, Mester JL, Ngeow J, Rybicki LA, Orloff MS, Eng C. Lifetime cancer risks in individuals with germline PTEN mutations. Clin Cancer Res. 2012 Jan 15; 18(2):400-7. PMID: 22252256.
      View in: PubMed
    22. Ni Y, He X, Chen J, Moline J, Mester J, Orloff MS, Ringel MD, Eng C. Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53. Hum Mol Genet. 2012 Jan 15; 21(2):300-10. PMID: 21979946.
      View in: PubMed
    23. Bebek G, Orloff M, Eng C. Microenvironmental genomic alterations reveal signaling networks for head and neck squamous cell carcinoma. J Clin Bioinforma. 2011 Aug 02; 1(1):21. PMID: 21884569.
      View in: PubMed
    24. Orloff M, Peterson C, He X, Ganapathi S, Heald B, Yang YR, Bebek G, Romigh T, Song JH, Wu W, David S, Cheng Y, Meltzer SJ, Eng C. Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma. JAMA. 2011 Jul 27; 306(4):410-9. PMID: 21791690.
      View in: PubMed
    25. Tan MH, De S, Bebek G, Orloff MS, Wesolowski R, Downs-Kelly E, Budd GT, Stark GR, Eng C. Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer. Breast Cancer Res Treat. 2012 Feb; 131(3):849-58. PMID: 21479552.
      View in: PubMed
    26. Nagy R, Ganapathi S, Comeras I, Peterson C, Orloff M, Porter K, Eng C, Ringel MD, Kloos RT. Frequency of germline PTEN mutations in differentiated thyroid cancer. Thyroid. 2011 May; 21(5):505-10. PMID: 21417916.
      View in: PubMed
    27. Tan MH, Mester J, Peterson C, Yang Y, Chen JL, Rybicki LA, Milas K, Pederson H, Remzi B, Orloff MS, Eng C. A clinical scoring system for selection of patients for PTEN mutation testing is proposed on the basis of a prospective study of 3042 probands. Am J Hum Genet. 2011 Jan 07; 88(1):42-56. PMID: 21194675.
      View in: PubMed
    28. He X, Wang Y, Zhu J, Orloff M, Eng C. Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling. Cancer Lett. 2011 Feb 28; 301(2):168-76. PMID: 21168265.
      View in: PubMed
    29. Wang Y, Romigh T, He X, Orloff MS, Silverman RH, Heston WD, Eng C. Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines. Hum Mol Genet. 2010 Nov 15; 19(22):4319-29. PMID: 20729295.
      View in: PubMed
    30. Heald B, Mester J, Rybicki L, Orloff MS, Burke CA, Eng C. Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers. Gastroenterology. 2010 Dec; 139(6):1927-33. PMID: 20600018.
      View in: PubMed
    31. Hansel DE, Platt E, Orloff M, Harwalker J, Sethu S, Hicks JL, De Marzo A, Steinle RE, Hsi ED, Theodorescu D, Ching CB, Eng C. Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma. Am J Pathol. 2010 Jun; 176(6):3062-72. PMID: 20395440.
      View in: PubMed
    32. Shiovitz S, Everett J, Huang SC, Orloff MS, Eng C, Gruber SB. Head circumference in the clinical detection of PTEN hamartoma tumor syndrome in a clinic population at high-risk of breast cancer. Breast Cancer Res Treat. 2010 Nov; 124(2):459-65. PMID: 20349131.
      View in: PubMed
    33. Waddell N, Arnold J, Cocciardi S, da Silva L, Marsh A, Riley J, Johnstone CN, Orloff M, Assie G, Eng C, Reid L, Keith P, Yan M, Fox S, Devilee P, Godwin AK, Hogervorst FB, Couch F, Grimmond S, Flanagan JM, Khanna K, Simpson PT, Lakhani SR, Chenevix-Trench G. Subtypes of familial breast tumours revealed by expression and copy number profiling. Breast Cancer Res Treat. 2010 Oct; 123(3):661-77. PMID: 19960244.
      View in: PubMed
    34. Eng C, Leone G, Orloff MS, Ostrowski MC. Genomic alterations in tumor stroma. Cancer Res. 2009 Sep 01; 69(17):6759-64. PMID: 19706759.
      View in: PubMed
    35. Ni Y, Zbuk KM, Sadler T, Patocs A, Lobo G, Edelman E, Platzer P, Orloff MS, Waite KA, Eng C. Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes. Am J Hum Genet. 2008 Aug; 83(2):261-8. PMID: 18678321.
      View in: PubMed
    36. Song K, Orloff MS, Lu Q, Elston RC. Fine-mapping using the weighted average method for a case-control study. BMC Genet. 2005 Dec 30; 6 Suppl 1:S67. PMID: 16451680.
      View in: PubMed
    37. Orloff MS, Iyengar SK, Winkler CA, Goddard KA, Dart RA, Ahuja TS, Mokrzycki M, Briggs WA, Korbet SM, Kimmel PL, Simon EE, Trachtman H, Vlahov D, Michel DM, Berns JS, Smith MC, Schelling JR, Sedor JR, Kopp JB. Variants in the Wilms' tumor gene are associated with focal segmental glomerulosclerosis in the African American population. Physiol Genomics. 2005 Apr 14; 21(2):212-21. PMID: 15687485.
      View in: PubMed
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