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Igor Koturbash

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentCollege of Public Health, College of Provost
DivisionEnvironmental & Occupational Health
Address1238 ED III College of Public Health
220 UAMS Campus Dr.
Mail Slot # 820
Little Rock AR 72205
Phone501-526-6638
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    Collapse Research Funds 
    Collapse research activities
    15JC1V19P00000044     (KOTURBASH, IGOR)Nov 6, 2018 - Sep 30, 2019
    US Department of Justice
    Analysis of hepatotoxicity of the OxyELITE Pro dietary supplement in a mouse model
    Role: Principal Investigator

    7L-CIV02-0942     (KOTURBASH, IGOR)Aug 15, 2017 - Aug 14, 2018
    US Department of Justice
    Analysis of hepatotoxicity of the OxyELITE Pro dietary supplement in a mouse model
    Role: Principal Investigator

    6L-CIV02-0850     (KOTURBASH, IGOR)Aug 15, 2016 - Aug 14, 2017
    US Department of Justice
    Analysis of hepatotoxicity of the OxyELITE Pro dietary supplement in a mouse model
    Role: Principal Investigator

    000500836-020     (KOTURBASH, IGOR)Jul 1, 2016 - Jun 30, 2017
    NIH/Nat. Inst. for Occupational Safety & Health - Pass Through: University of Alabama at Birmingham
    Effects of wood burning-associated smoke on satellite DNA
    Role: Principal Investigator

    P20GM109005     (HAUER-JENSEN, MARTIN)Jun 24, 2015 - Mar 31, 2020
    NIH/NIGMS
    Center for Studies of Host Response to Cancer Therapy
    Role: Co-Investigator

    HHSF223201400183C     (KOTURBASH, IGOR)Sep 30, 2014 - Jan 15, 2018
    Food & Drug Administration
    The Diversity Outbred: A Tool to Improve Preclinical Safety Testing and Pharmacog
    Role: Principal Investigator

    NCC 9-58 95     (BOERMA, MARJAN)Jun 1, 2014 - May 31, 2017
    National Space Biomedical Research Institute
    Center for Research on Cardiac and Vascular Effects of Space Radiation
    Role: Co-Investigator

    NCC9-58     (BOERMA, MARJAN)Jun 1, 2014 - May 31, 2017
    National Space Biomedical Research Institute
    Center for Research on Cardiac and Vascular Effects of Space Radiation
    Role: Co-Investigator

    U54MD002329     (RACZYNSKI, JAMES M)Sep 30, 2007 - Apr 30, 2022
    NIH/NIMHD
    Arkansas Center for Health Disparities (ARCHD): An NIMHD COE
    Role: Co-Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Walker LA, Koturbash I, Kingston R, ElSohly MA, Yates CR, Gurley BJ, Khan I. Cannabidiol (CBD) in Dietary Supplements: Perspectives on Science, Safety, and Potential Regulatory Approaches. J Diet Suppl. 2020 Jun 16; 1-10. PMID: 32543246.
      View in: PubMed
    2. Miousse IR, Tobacyk J, Quick CM, Jamshidi-Parsian A, Skinner CM, Kore R, Melnyk SB, Kutanzi KR, Xia F, Griffin RJ, Koturbash I. Reply to Flugge: the anti-metastatic potential of methionine restriction in melanoma. Carcinogenesis. 2020 May 14; 41(3):390-391. PMID: 31140558.
      View in: PubMed
    3. Skinner CM, Nookaew I, Ewing LE, Wongsurawat T, Jenjaroenpun P, Quick CM, Yee EU, Piccolo BD, ElSohly M, Walker LA, Gurley B, Koturbash I. Potential Probiotic or Trigger of Gut Inflammation - The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract. J Diet Suppl. 2020 May 13; 1-18. PMID: 32400224.
      View in: PubMed
    4. Miousse IR, Ewing LE, Skinner CM, Pathak R, Garg S, Kutanzi KR, Melnyk S, Hauer-Jensen M, Koturbash I. Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome. Am J Physiol Gastrointest Liver Physiol. 2020 03 01; 318(3):G439-G450. PMID: 31961718.
      View in: PubMed
    5. Ewing LE, McGill MR, Yee EU, Quick CM, Skinner CM, Kennon-McGill S, Clemens M, Vazquez JH, McCullough SS, Williams DK, Kutanzi KR, Walker LA, ElSohly MA, James LP, Gurley BJ, Koturbash I. Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration. Molecules. 2019 Jun 17; 24(12). PMID: 31212965.
      View in: PubMed
    6. Miousse IR, Skinner CM, Sridharan V, Seawright JW, Singh P, Landes RD, Cheema AK, Hauer-Jensen M, Boerma M, Koturbash I. Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O). Life Sci Space Res (Amst). 2019 Aug; 22:8-15. PMID: 31421852.
      View in: PubMed
    7. Ewing LE, Skinner CM, Quick CM, Kennon-McGill S, McGill MR, Walker LA, ElSohly MA, Gurley BJ, Koturbash I. Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model. Molecules. 2019 Apr 30; 24(9). PMID: 31052254.
      View in: PubMed
    8. Gurley BJ, Miousse IR, Nookaew I, Ewing LE, Skinner CM, Jenjaroenpun P, Wongsurawat T, Kennon-McGill S, Avula B, Bae JY, McGill MR, Ussery D, Khan IA, Koturbash I. Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice. Nutrients. 2019 Apr 03; 11(4). PMID: 30987244.
      View in: PubMed
    9. Koturbash I, Griffin RJ. Harnessing epigenetics and metabolism to modulate tissue response to radiotherapy. Int J Radiat Biol. 2019 04; 95(4):379-381. PMID: 30856046.
      View in: PubMed
    10. Seawright JW, Sridharan V, Landes RD, Cao M, Singh P, Koturbash I, Mao XW, Miousse IR, Singh SP, Nelson GA, Hauer-Jensen M, Boerma M. Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice. Life Sci Space Res (Amst). 2019 Feb; 20:72-84. PMID: 30797436.
      View in: PubMed
    11. Ewing LE, Miousse IR, Pathak R, Skinner CM, Kosanke S, Boerma M, Hauer-Jensen M, Koturbash I. NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity. Int J Radiat Biol. 2020 01; 96(1):93-99. PMID: 30561233.
      View in: PubMed
    12. Skinner CM, Miousse IR, Ewing LE, Sridharan V, Cao M, Lin H, Williams DK, Avula B, Haider S, Chittiboyina AG, Khan IA, ElSohly MA, Boerma M, Gurley BJ, Koturbash I. Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro™ (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments. Food Chem Toxicol. 2018 Dec; 122:21-32. PMID: 30282009.
      View in: PubMed
    13. Miousse IR, Tobacyk J, Quick CM, Jamshidi-Parsian A, Skinner CM, Kore R, Melnyk SB, Kutanzi KR, Xia F, Griffin RJ, Koturbash I. Modulation of dietary methionine intake elicits potent, yet distinct, anticancer effects on primary versus metastatic tumors. Carcinogenesis. 2018 09 21; 39(9):1117-1126. PMID: 29939201.
      View in: PubMed
    14. Koturbash I. 2017 Michael Fry Award Lecture When DNA is Actually Not a Target: Radiation Epigenetics as a Tool to Understand and Control Cellular Response to Ionizing Radiation. Radiat Res. 2018 07; 190(1):5-11. PMID: 29697303.
      View in: PubMed
    15. Miousse IR, Ewing LE, Kutanzi KR, Griffin RJ, Koturbash I. DNA Methylation in Radiation-Induced Carcinogenesis: Experimental Evidence and Clinical Perspectives. Crit Rev Oncog. 2018; 23(1-2):1-11. PMID: 29953365.
      View in: PubMed
    16. Koturbash I. LINE-1 in response to exposure to ionizing radiation. Mob Genet Elements. 2017; 7(6):e1393491. PMID: 29209557.
      View in: PubMed
    17. Lin H, Ewing LE, Koturbash I, Gurley BJ, Miousse IR. MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects. Food Chem Toxicol. 2017 Dec; 110:229-239. PMID: 29042291.
      View in: PubMed
    18. Herceg Z, Ghantous A, Wild CP, Sklias A, Casati L, Duthie SJ, Fry R, Issa JP, Kellermayer R, Koturbash I, Kondo Y, Lepeule J, Lima SCS, Marsit CJ, Rakyan V, Saffery R, Taylor JA, Teschendorff AE, Ushijima T, Vineis P, Walker CL, Waterland RA, Wiemels J, Ambatipudi S, Degli Esposti D, Hernandez-Vargas H. Roadmap for investigating epigenome deregulation and environmental origins of cancer. Int J Cancer. 2018 03 01; 142(5):874-882. PMID: 28836271.
      View in: PubMed
    19. Miousse IR, Pathak R, Garg S, Skinner CM, Melnyk S, Pavliv O, Hendrickson H, Landes RD, Lumen A, Tackett AJ, Deutz NEP, Hauer-Jensen M, Koturbash I. Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology. Genes Nutr. 2017; 12:22. PMID: 28904640.
      View in: PubMed
    20. Miousse IR, Skinner CM, Lin H, Ewing LE, Kosanke SD, Williams DK, Avula B, Khan IA, ElSohly MA, Gurley BJ, Koturbash I. Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains. Food Chem Toxicol. 2017 Nov; 109(Pt 1):194-209. PMID: 28843594.
      View in: PubMed
    21. Casero D, Gill K, Sridharan V, Koturbash I, Nelson G, Hauer-Jensen M, Boerma M, Braun J, Cheema AK. Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome. Microbiome. 2017 08 18; 5(1):105. PMID: 28821301.
      View in: PubMed
    22. Seawright JW, Samman Y, Sridharan V, Mao XW, Cao M, Singh P, Melnyk S, Koturbash I, Nelson GA, Hauer-Jensen M, Boerma M. Effects of low-dose rate ?-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart. PLoS One. 2017; 12(7):e0180594. PMID: 28678877.
      View in: PubMed
    23. Miousse IR, Chang J, Shao L, Pathak R, Nzabarushimana É, Kutanzi KR, Landes RD, Tackett AJ, Hauer-Jensen M, Zhou D, Koturbash I. Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation. Int J Mol Sci. 2017 Jul 04; 18(7). PMID: 28677663.
      View in: PubMed
    24. Miousse IR, Tobacyk J, Melnyk S, James SJ, Cheema AK, Boerma M, Hauer-Jensen M, Koturbash I. One-carbon metabolism and ionizing radiation: a multifaceted interaction. Biomol Concepts. 2017 May 24; 8(2):83-92. PMID: 28574375.
      View in: PubMed
    25. Miousse IR, Murphy LA, Lin H, Schisler MR, Sun J, Chalbot MG, Sura R, Johnson K, LeBaron MJ, Kavouras IG, Schnackenberg LK, Beger RD, Rasoulpour RJ, Koturbash I. Dose-response analysis of epigenetic, metabolic, and apical endpoints after short-term exposure to experimental hepatotoxicants. Food Chem Toxicol. 2017 Nov; 109(Pt 1):690-702. PMID: 28495587.
      View in: PubMed
    26. Miousse IR, Kutanzi KR, Koturbash I. Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications. Int J Radiat Biol. 2017 05; 93(5):457-469. PMID: 28134023.
      View in: PubMed
    27. Koturbash I, Jadavji NM, Kutanzi K, Rodriguez-Juarez R, Kogosov D, Metz GAS, Kovalchuk O. Fractionated low-dose exposure to ionizing radiation leads to DNA damage, epigenetic dysregulation, and behavioral impairment. Environ Epigenet. 2016 Dec; 2(4):dvw025. PMID: 29492301.
      View in: PubMed
    28. Pathak R, Koturbash I, Hauer-Jensen M. Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization (mFISH) and Spectral Karyotyping (SKY) in Irradiated Mice. J Vis Exp. 2017 01 11; (119). PMID: 28117817.
      View in: PubMed
    29. Miousse IR, Koturbash I, Chalbot MC, Hauer-Jensen M, Kavouras I, Pathak R. Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System. J Vis Exp. 2016 12 21; (118). PMID: 28060322.
      View in: PubMed
    30. Kutanzi KR, Lumen A, Koturbash I, Miousse IR. Pediatric Exposures to Ionizing Radiation: Carcinogenic Considerations. Int J Environ Res Public Health. 2016 10 28; 13(11). PMID: 27801855.
      View in: PubMed
    31. Koturbash I, Merrifield M, Kovalchuk O. Fractionated exposure to low doses of ionizing radiation results in accumulation of DNA damage in mouse spleen tissue and activation of apoptosis in a p53/Atm-independent manner. Int J Radiat Biol. 2017 02; 93(2):148-155. PMID: 27758128.
      View in: PubMed
    32. Prior S, Miousse IR, Nzabarushimana E, Pathak R, Skinner C, Kutanzi KR, Allen AR, Raber J, Tackett AJ, Hauer-Jensen M, Nelson GA, Koturbash I. Densely ionizing radiation affects DNA methylation of selective LINE-1 elements. Environ Res. 2016 10; 150:470-481. PMID: 27419368.
      View in: PubMed
    33. Boerma M, Sridharan V, Mao XW, Nelson GA, Cheema AK, Koturbash I, Singh SP, Tackett AJ, Hauer-Jensen M. Effects of ionizing radiation on the heart. Mutat Res. 2016 Oct - Dec; 770(Pt B):319-327. PMID: 27919338.
      View in: PubMed
    34. Pathak R, Bachri A, Ghosh SP, Koturbash I, Boerma M, Binz RK, Sawyer JR, Hauer-Jensen M. The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage. Pharm Res. 2016 09; 33(9):2117-25. PMID: 27216753.
      View in: PubMed
    35. Koturbash I, Miousse IR, Sridharan V, Nzabarushimana E, Skinner CM, Melnyk SB, Pavliv O, Hauer-Jensen M, Nelson GA, Boerma M. Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart. Mutat Res. 2016 May; 787:43-53. PMID: 26963372.
      View in: PubMed
    36. Pirela SV, Lu X, Miousse I, Sisler JD, Qian Y, Guo N, Koturbash I, Castranova V, Thomas T, Godleski J, Demokritou P. Effects of intratracheally instilled laser printer-emitted engineered nanoparticles in a mouse model: A case study of toxicological implications from nanomaterials released during consumer use. NanoImpact. 2016 Jan; 1:1-8. PMID: 26989787.
      View in: PubMed
    37. Boerma M, Nelson GA, Sridharan V, Mao XW, Koturbash I, Hauer-Jensen M. Space radiation and cardiovascular disease risk. World J Cardiol. 2015 Dec 26; 7(12):882-8. PMID: 26730293.
      View in: PubMed
    38. Ramadan SS, Sridharan V, Koturbash I, Miousse IR, Hauer-Jensen M, Nelson GA, Boerma M. A priming dose of protons alters the early cardiac cellular and molecular response to (56)Fe irradiation. Life Sci Space Res (Amst). 2016 Feb; 8:8-13. PMID: 26948008.
      View in: PubMed
    39. Lu X, Miousse IR, Pirela SV, Moore JK, Melnyk S, Koturbash I, Demokritou P. In vivo epigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles. Nanotoxicology. 2016; 10(5):629-39. PMID: 26559097.
      View in: PubMed
    40. Koturbash I, Tolleson WH, Guo L, Yu D, Chen S, Hong H, Mattes W, Ning B. microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment. Biomark Med. 2015; 9(11):1153-76. PMID: 26501795.
      View in: PubMed
    41. Miousse IR, Koturbash I. The Fine LINE: Methylation Drawing the Cancer Landscape. Biomed Res Int. 2015; 2015:131547. PMID: 26448926.
      View in: PubMed
    42. Miousse IR, Chalbot MC, Pathak R, Lu X, Nzabarushimana E, Krager K, Aykin-Burns N, Hauer-Jensen M, Demokritou P, Kavouras IG, Koturbash I. In Vitro Toxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter. Toxicol Sci. 2015 Dec; 148(2):473-87. PMID: 26342214.
      View in: PubMed
    43. Nzabarushimana E, Prior S, Miousse IR, Pathak R, Allen AR, Latendresse J, Olsen RH, Raber J, Hauer-Jensen M, Nelson GA, Koturbash I. Combined exposure to protons and (56)Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lung. Life Sci Space Res (Amst). 2015 Nov; 7:1-8. PMID: 26553631.
      View in: PubMed
    44. Miousse IR, Currie R, Datta K, Ellinger-Ziegelbauer H, French JE, Harrill AH, Koturbash I, Lawton M, Mann D, Meehan RR, Moggs JG, O'Lone R, Rasoulpour RJ, Pera RA, Thompson K. Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute. Toxicology. 2015 Sep 01; 335:11-9. PMID: 26134581.
      View in: PubMed
    45. Pirela SV, Miousse IR, Lu X, Castranova V, Thomas T, Qian Y, Bello D, Kobzik L, Koturbash I, Demokritou P. Effects of Laser Printer-Emitted Engineered Nanoparticles on Cytotoxicity, Chemokine Expression, Reactive Oxygen Species, DNA Methylation, and DNA Damage: A Comprehensive in Vitro Analysis in Human Small Airway Epithelial Cells, Macrophages, and Lymphoblasts. Environ Health Perspect. 2016 Feb; 124(2):210-9. PMID: 26080392.
      View in: PubMed
    46. Goodson WH, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon EY, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Vondrácek J, Raju J, Roman J, Wise JP, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky-Wegman P, Thompson PA, Dent P, Heneberg P, Darbre P, Sing Leung P, Nangia-Makker P, Cheng QS, Robey RB, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Abd Hamid R, Langie SA, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Eriksson S, Forte S, Casey SC, Luanpitpong S, Lee TJ, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell WK, Engström W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis. 2015 Jun; 36 Suppl 1:S254-96. PMID: 26106142.
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    47. Ochieng J, Nangami GN, Ogunkua O, Miousse IR, Koturbash I, Odero-Marah V, McCawley LJ, Nangia-Makker P, Ahmed N, Luqmani Y, Chen Z, Papagerakis S, Wolf GT, Dong C, Zhou BP, Brown DG, Colacci AM, Hamid RA, Mondello C, Raju J, Ryan EP, Woodrick J, Scovassi AI, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Amedei A, Al-Temaimi R, Al-Mulla F, Bisson WH, Eltom SE. The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis. Carcinogenesis. 2015 Jun; 36 Suppl 1:S128-59. PMID: 26106135.
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    48. Miousse IR, Chalbot MC, Lumen A, Ferguson A, Kavouras IG, Koturbash I. Response of transposable elements to environmental stressors. Mutat Res Rev Mutat Res. 2015 Jul-Sep; 765:19-39. PMID: 26281766.
      View in: PubMed
    49. Lu X, Miousse IR, Pirela SV, Melnyk S, Koturbash I, Demokritou P. Short-term exposure to engineered nanomaterials affects cellular epigenome. Nanotoxicology. 2016; 10(2):140-50. PMID: 25938281.
      View in: PubMed
    50. Camacho L, Basavarajappa MS, Chang CW, Han T, Kobets T, Koturbash I, Surratt G, Lewis SM, Vanlandingham MM, Fuscoe JC, Gamboa da Costa G, Pogribny IP, Delclos KB. Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats. Food Chem Toxicol. 2015 Jul; 81:92-103. PMID: 25862956.
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    51. Chang J, Feng W, Wang Y, Luo Y, Allen AR, Koturbash I, Turner J, Stewart B, Raber J, Hauer-Jensen M, Zhou D, Shao L. Whole-body proton irradiation causes long-term damage to hematopoietic stem cells in mice. Radiat Res. 2015 Feb; 183(2):240-8. PMID: 25635345.
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    52. Kovalchuk IP, Golubov A, Koturbash IV, Kutanzi K, Martin OA, Kovalchuk O. Age-dependent changes in DNA repair in radiation-exposed mice. Radiat Res. 2014 Dec; 182(6):683-94. PMID: 25409128.
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    53. Miousse IR, Shao L, Chang J, Feng W, Wang Y, Allen AR, Turner J, Stewart B, Raber J, Zhou D, Koturbash I. Exposure to low-dose (56)Fe-ion radiation induces long-term epigenetic alterations in mouse bone marrow hematopoietic progenitor and stem cells. Radiat Res. 2014 Jul; 182(1):92-101. PMID: 24960414.
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    54. Fisher J, Yang X, Harris C, Koturbash I, Lumen A. The hypothalamic-pituitary-thyroid axis in infants and children: protection from radioiodines. J Thyroid Res. 2014; 2014:710178. PMID: 24971190.
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    55. Nzabarushimana E, Miousse IR, Shao L, Chang J, Allen AR, Turner J, Stewart B, Raber J, Koturbash I. Long-term epigenetic effects of exposure to low doses of 56Fe in the mouse lung. J Radiat Res. 2014 Jul; 55(4):823-8. PMID: 24585548.
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    56. Miousse IR, Chalbot MC, Aykin-Burns N, Wang X, Basnakian A, Kavouras IG, Koturbash I. Epigenetic alterations induced by ambient particulate matter in mouse macrophages. Environ Mol Mutagen. 2014 Jun; 55(5):428-35. PMID: 24535919.
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    57. de Conti A, Tryndyak V, Koturbash I, Heidor R, Kuroiwa-Trzmielina J, Ong TP, Beland FA, Moreno FS, Pogribny IP. The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway. Carcinogenesis. 2013 Aug; 34(8):1900-6. PMID: 23568954.
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    58. Tryndyak V, de Conti A, Kobets T, Kutanzi K, Koturbash I, Han T, Fuscoe JC, Latendresse JR, Melnyk S, Shymonyak S, Collins L, Ross SA, Rusyn I, Beland FA, Pogribny IP. Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism. FASEB J. 2012 Nov; 26(11):4592-602. PMID: 22872676.
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    59. Von Tungeln LS, Doerge DR, Gamboa da Costa G, Matilde Marques M, Witt WM, Koturbash I, Pogribny IP, Beland FA. Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay. Int J Cancer. 2012 Nov 01; 131(9):2008-15. PMID: 22336951.
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    60. Koturbash I, Beland FA, Pogribny IP. Role of microRNAs in the regulation of drug metabolizing and transporting genes and the response to environmental toxicants. Expert Opin Drug Metab Toxicol. 2012 May; 8(5):597-606. PMID: 22435483.
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    61. Koturbash I, Melnyk S, James SJ, Beland FA, Pogribny IP. Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene. Mol Carcinog. 2013 Apr; 52(4):318-27. PMID: 22213190.
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    62. Koturbash I, Simpson NE, Beland FA, Pogribny IP. Alterations in histone H4 lysine 20 methylation: implications for cancer detection and prevention. Antioxid Redox Signal. 2012 Jul 15; 17(2):365-74. PMID: 22035019.
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    63. Shpyleva SI, Muskhelishvili L, Tryndyak VP, Koturbash I, Tokar EJ, Waalkes MP, Beland FA, Pogribny IP. Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver. Toxicol Sci. 2011 Oct; 123(2):433-40. PMID: 21785164.
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    64. Hudson D, Kovalchuk I, Koturbash I, Kolb B, Martin OA, Kovalchuk O. Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals. Aging (Albany NY). 2011 Jun; 3(6):609-20. PMID: 21685513.
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    65. Koturbash I, Scherhag A, Sorrentino J, Sexton K, Bodnar W, Swenberg JA, Beland FA, Pardo-Manuel Devillena F, Rusyn I, Pogribny IP. Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene. Toxicol Sci. 2011 Aug; 122(2):448-56. PMID: 21602187.
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    66. Koturbash I, Beland FA, Pogribny IP. Role of epigenetic events in chemical carcinogenesis--a justification for incorporating epigenetic evaluations in cancer risk assessment. Toxicol Mech Methods. 2011 May; 21(4):289-97. PMID: 21495867.
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    67. Koturbash I, Scherhag A, Sorrentino J, Sexton K, Bodnar W, Tryndyak V, Latendresse JR, Swenberg JA, Beland FA, Pogribny IP, Rusyn I. Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene. Environ Health Perspect. 2011 May; 119(5):635-40. PMID: 21147608.
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    68. Kutanzi KR, Koturbash I, Kovalchuk O. Reversibility of pre-malignant estrogen-induced epigenetic changes. Cell Cycle. 2010 Aug 01; 9(15):3078-84. PMID: 20699652.
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    69. Kutanzi KR, Koturbash I, Bronson RT, Pogribny IP, Kovalchuk O. Imbalance between apoptosis and cell proliferation during early stages of mammary gland carcinogenesis in ACI rats. Mutat Res. 2010 Dec 10; 694(1-2):1-6. PMID: 20659487.
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    70. Koturbash I, Zemp FJ, Pogribny I, Kovalchuk O. Small molecules with big effects: the role of the microRNAome in cancer and carcinogenesis. Mutat Res. 2011 Jun 17; 722(2):94-105. PMID: 20472093.
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    71. Koturbash I, Zemp F, Kolb B, Kovalchuk O. Sex-specific radiation-induced microRNAome responses in the hippocampus, cerebellum and frontal cortex in a mouse model. Mutat Res. 2011 Jun 17; 722(2):114-8. PMID: 20478395.
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    72. Filkowski JN, Ilnytskyy Y, Tamminga J, Koturbash I, Golubov A, Bagnyukova T, Pogribny IP, Kovalchuk O. Hypomethylation and genome instability in the germline of exposed parents and their progeny is associated with altered miRNA expression. Carcinogenesis. 2010 Jun; 31(6):1110-5. PMID: 19959559.
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    73. Koturbash I, Thomas JE, Kovalchuk O, Kovalchuk I. Heat-killed bacteria induce genome instability in mouse small intestine, liver and spleen tissues. Cell Cycle. 2009 Jun 15; 8(12):1935-9. PMID: 19440049.
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    74. Ilnytskyy Y, Koturbash I, Kovalchuk O. Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner. Environ Mol Mutagen. 2009 Mar; 50(2):105-13. PMID: 19107897.
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    75. Tamminga J, Kathiria P, Koturbash I, Kovalchuk O. DNA damage-induced upregulation of miR-709 in the germline downregulates BORIS to counteract aberrant DNA hypomethylation. Cell Cycle. 2008 Dec; 7(23):3731-6. PMID: 19029807.
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    76. Ilnytskyy Y, Zemp FJ, Koturbash I, Kovalchuk O. Altered microRNA expression patterns in irradiated hematopoietic tissues suggest a sex-specific protective mechanism. Biochem Biophys Res Commun. 2008 Dec 05; 377(1):41-5. PMID: 18823940.
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    77. Koturbash I, Kutanzi K, Hendrickson K, Rodriguez-Juarez R, Kogosov D, Kovalchuk O. Radiation-induced bystander effects in vivo are sex specific. Mutat Res. 2008 Jul 03; 642(1-2):28-36. PMID: 18508093.
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    78. Koturbash I, Zemp FJ, Kutanzi K, Luzhna L, Loree J, Kolb B, Kovalchuk O. Sex-specific microRNAome deregulation in the shielded bystander spleen of cranially exposed mice. Cell Cycle. 2008 Jun 01; 7(11):1658-67. PMID: 18560276.
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    79. Tamminga J, Koturbash I, Baker M, Kutanzi K, Kathiria P, Pogribny IP, Sutherland RJ, Kovalchuk O. Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring. Cell Cycle. 2008 May 01; 7(9):1238-45. PMID: 18418050.
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    80. Koturbash I, Loree J, Kutanzi K, Koganow C, Pogribny I, Kovalchuk O. In vivo bystander effect: cranial X-irradiation leads to elevated DNA damage, altered cellular proliferation and apoptosis, and increased p53 levels in shielded spleen. Int J Radiat Oncol Biol Phys. 2008 Feb 01; 70(2):554-62. PMID: 18207032.
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    81. Yauk C, Polyzos A, Rowan-Carroll A, Somers CM, Godschalk RW, Van Schooten FJ, Berndt ML, Pogribny IP, Koturbash I, Williams A, Douglas GR, Kovalchuk O. Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location. Proc Natl Acad Sci U S A. 2008 Jan 15; 105(2):605-10. PMID: 18195365.
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    82. Sedelnikova OA, Nakamura A, Kovalchuk O, Koturbash I, Mitchell SA, Marino SA, Brenner DJ, Bonner WM. DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models. Cancer Res. 2007 May 01; 67(9):4295-302. PMID: 17483342.
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    83. Koturbash I, Boyko A, Rodriguez-Juarez R, McDonald RJ, Tryndyak VP, Kovalchuk I, Pogribny IP, Kovalchuk O. Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo. Carcinogenesis. 2007 Aug; 28(8):1831-8. PMID: 17347136.
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    84. Loree J, Koturbash I, Kutanzi K, Baker M, Pogribny I, Kovalchuk O. Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis. Int J Radiat Biol. 2006 Nov; 82(11):805-15. PMID: 17148264.
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    85. Koturbash I, Baker M, Loree J, Kutanzi K, Hudson D, Pogribny I, Sedelnikova O, Bonner W, Kovalchuk O. Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo. Int J Radiat Oncol Biol Phys. 2006 Oct 01; 66(2):327-30. PMID: 16965987.
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    86. Cassie S, Koturbash I, Hudson D, Baker M, Ilnytskyy Y, Rodriguez-Juarez R, Weber E, Kovalchuk O. Novel retinoblastoma binding protein RBBP9 modulates sex-specific radiation responses in vivo. Carcinogenesis. 2006 Mar; 27(3):465-74. PMID: 16272168.
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    87. Pogribny I, Koturbash I, Tryndyak V, Hudson D, Stevenson SM, Sedelnikova O, Bonner W, Kovalchuk O. Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus. Mol Cancer Res. 2005 Oct; 3(10):553-61. PMID: 16254189.
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    88. Koturbash I, Pogribny I, Kovalchuk O. Stable loss of global DNA methylation in the radiation-target tissue--a possible mechanism contributing to radiation carcinogenesis? Biochem Biophys Res Commun. 2005 Nov 18; 337(2):526-33. PMID: 16202973.
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