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Linda Larson-Prior

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPSY Psychiatry, College of Medicine
DivisionPSY Center for Addiction Research
Address4224 Shuffield Dr.
Mail Slot # 755
Little Rock AR 72205
Phone501-526-8100
ORCID ORCID Icon0000-0002-9334-048X Additional info
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentBiomedical Informatics, College of Medicine

    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentNeurobiology & Developmental Science, College of Medicine

    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentNeurology, College of Medicine

    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentPediatrics, College of Medicine
    DivisionDevelopmental Nutrition


    Collapse Overview 
    Collapse overview
    My laboratory is interested in better understanding the dynamic neural network re-configurations that occur as the brain changes its state under both normal conditions such as sleep, and in abnormal conditions such as induced shifts in conscious awareness (anesthesia) or pathological shifts in cognitive awareness (fluctuating consciousness, sleep parasomnias and neurodegenerative disease states). We have developed the use of simultaneous acquisition of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) to help us better understand these shifts in network connectivity and function as the brain shifts state over the course of 24 hours. As part of the Human Connectome Project, my laboratory worked with a large international team to define the connection patterns in normal adult human subjects using magnetoencephalography (MEG) and fMRI methodologies. The connectomics approach to analysis of large, multi-modal datasets is one my laboratory is actively pursuing to better understand the role of behavioral and neural state on function across the lifespan. I am actively involved in mentoring and mentorship programs and have mentored research professionals at all levels, from high school through early faculty. In addition, I have provided formal mentorship training to both mentors and mentees through workshops and invited lectures. I believe strongly that developing strong and proactive mentorship programs early in professional training will aid students in achieving optimal performance levels throughout their careers.


    Collapse Affiliation 
    Collapse member of
    Society for Neuroscience
    American Association for the Advancement of Science
    American Academy of Sleep Medicine
    Organization for Human Brain Mapping
    IEEE-EMBS
    Collapse collaborator
    OHBM Best Practices Committee
    ENIGMA-MEG Working Group

    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Associate Director
    Center for Childhood Obesity Prevention

    UAMS Institutional Review Board member

    Chair, ZRG1 F03B NIH Review Panel

    Collapse education and training
    Ohio State University, Columbus OHBA1972Anthropology, Arabic
    Case Wester Reserve University, Cleveland OHMA1978Medical Anthropology
    Northeast Ohio Universities College of Medicine, Kent OHPhD1986Neuroscience
    Northwestern University Medical School, Chicago ILPostdoctoral1991Neurophysiology
    University of Chicago Medical School, Chicago ILPostdoctoral1993Computational Neuroscience
    University of Arkansas for Medical Sciences, Little Rock ARMS15/2025Biomedical Informatics

    Collapse Teaching 

    Collapse Research 
    Collapse research activities and funding
    OIA 2217824     (Murray)Sep 1, 2022 - Aug 31, 2026
    NSF
    RII Track-s EPSCoR: Facilitating ubiquitous technology utilizing resilient eco-friendly sensors (FUTURE sensors)
    Role Description: The goal of this proposal is to develop novel sensor technologies that will provide just-in-time information on environmental toxins in soil, air and human beings with a particular emphasis on heavy metal contaminants.
    Role: Co-Investigator
    UO1-DA055352     (Acheson, Ou, McKelvey (MPI))Sep 1, 2022 - Aug 31, 2026
    NIH
    1/6 HBCD Prenatal Experience and Longitudinal Development (PRELUDE)
    Role Description: The HEALthy Brain and Child Development study will recruit approximately 7,5000 pregnant women in the 2nd and 3rd trimester and follow their children to age 10, using neuroimaging, behavioral assessments, EEG, biosample collection, and assessments of parent-child interaction and the home environment. This research will lead to greater understanding of factors affecting early childhood brain development, allowing targeted interventions and improved outcomes for mother-child dyads.
    Role: Co-Investigator
    P20-109096     (Weber)Aug 1, 2022 - Jul 31, 2027
    NIH/NIGMS
    Center for Childhood Obesity Prevention phase 2
    Role Description: The Center for Childhood Obesity Prevention focuses on developing research infrastructure around the theme of childhood obesity prevention and providing junior investigators with formal mentoring, training and research project funding to help them acquire preliminary data to successfully compete for independent research grant support around this theme.
    Role: Other
    ARS 60626-51000-010-06S     (Ferruzzi)Nov 1, 2019 - Oct 31, 2024
    USDA
    Dietary influences on psychological and neuropsychological development and function in children
    Role Description: This Center Grant employs cell/animal models and human clinical studies to examine the roles of nutrition, physical activity, and maternal obesity on early-life programming of long-term health and development
    Role: Other Key Personnel
    U24CA215109     (PRIOR, FRED WILLIAM)Sep 22, 2017 - Jul 31, 2022
    NIH
    TCIA Sustainment and Scalability - Platforms for Quantitative Imaging Informatics in Precision Medicine
    Role: Co-Investigator
    OIA-1632891     (LARSON-PRIOR, LINDA)Sep 1, 2016 - Aug 31, 2020
    National Science Foundation - Pass Through: Louisiana Tech University
    RII Track-2 FEC- Probing and Understanding the Brain: Micro and Macro Dynamics of Seizure and Memory Networks
    Role: Principal Investigator
    R44MH106421     (LARSON-PRIOR, LINDA)Mar 1, 2016 - Jul 31, 2018
    NIH/National Institutes of Health - Pass Through: Electrical Geodesics, Inc.
    Pediatric Head Models for Improved Imaging of Neurological Development
    Role: Principal Investigator
    R29NS030759     (LARSON-PRIOR, LINDA J)Sep 1, 1991 - Aug 31, 1997
    NIH
    SLOW SYNAPTIC TRANSMISSION IN CEREBELLUM
    Role: Principal Investigator

    Collapse Outreach 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
    List All   |   Timeline
    1. Alatorre-Cruz GC, Downs H, Hagood D, Sorensen ST, Williams DK, Larson-Prior LJ. Effect of Obesity on Arithmetic Processing in Preteens With High and Low Math Skills: An Event-Related Potentials Study. Front Hum Neurosci. 2022; 16:760234. PMID: 35360282.
      View in: PubMed
    2. Syeda HB, Glover A, Pillai L, Kemp AS, Spencer H, Lotia M, Larson-Prior LJ, Virmani T. Amplitude setting and dopamine response of finger tapping and gait are related in Parkinson's disease. Sci Rep. 2022 03 09; 12(1):4180. PMID: 35264705.
      View in: PubMed
    3. Scott H, Griffin C, Coggins W, Elberson B, Abdeldayem M, Virmani T, Larson-Prior LJ, Petersen E. Virtual Reality in the Neurosciences: Current Practice and Future Directions. Front Surg. 2021; 8:807195. PMID: 35252318.
      View in: PubMed
    4. Bona J, Kemp AS, Cox C, Nolan TS, Pillai L, Das A, Galvin JE, Larson-Prior L, Virmani T, Prior F. Semantic Integration of Multi-Modal Data and Derived Neuroimaging Results Using the Platform for Imaging in Precision Medicine (PRISM) in the Arkansas Imaging Enterprise System (ARIES). Front Artif Intell. 2021; 4:649970. PMID: 35224477.
      View in: PubMed
    5. Merten JE, Villarrubia SA, Holly KS, Kemp AS, Kumler AC, Larson-Prior LJ, Murray TA. The use of rodent models to better characterize the relationship among epilepsy, sleep, and memory. Epilepsia. 2022 03; 63(3):525-536. PMID: 34985784.
      View in: PubMed
    6. Elam JS, Glasser MF, Harms MP, Sotiropoulos SN, Andersson JLR, Burgess GC, Curtiss SW, Oostenveld R, Larson-Prior LJ, Schoffelen JM, Hodge MR, Cler EA, Marcus DM, Barch DM, Yacoub E, Smith SM, Ugurbil K, Van Essen DC. The Human Connectome Project: A retrospective. Neuroimage. 2021 12 01; 244:118543. PMID: 34508893.
      View in: PubMed
    7. Levitis E, van Praag CDG, Gau R, Heunis S, DuPre E, Kiar G, Bottenhorn KL, Glatard T, Nikolaidis A, Whitaker KJ, Mancini M, Niso G, Afyouni S, Alonso-Ortiz E, Appelhoff S, Arnatkeviciute A, Atay SM, Auer T, Baracchini G, Bayer JMM, Beauvais MJS, Bijsterbosch JD, Bilgin IP, Bollmann S, Bollmann S, Botvinik-Nezer R, Bright MG, Calhoun VD, Chen X, Chopra S, Chuan-Peng H, Close TG, Cookson SL, Craddock RC, De La Vega A, De Leener B, Demeter DV, Di Maio P, Dickie EW, Eickhoff SB, Esteban O, Finc K, Frigo M, Ganesan S, Ganz M, Garner KG, Garza-Villarreal EA, Gonzalez-Escamilla G, Goswami R, Griffiths JD, Grootswagers T, Guay S, Guest O, Handwerker DA, Herholz P, Heuer K, Huijser DC, Iacovella V, Joseph MJE, Karakuzu A, Keator DB, Kobeleva X, Kumar M, Laird AR, Larson-Prior LJ, Lautarescu A, Lazari A, Legarreta JH, Li XY, Lv J, Mansour L S, Meunier D, Moraczewski D, Nandi T, Nastase SA, Nau M, Noble S, Norgaard M, Obungoloch J, Oostenveld R, Orchard ER, Pinho AL, Poldrack RA, Qiu A, Raamana PR, Rokem A, Rutherford S, Sharan M, Shaw TB, Syeda WT, Testerman MM, Toro R, Valk SL, Van Den Bossche S, Varoquaux G, Váša F, Veldsman M, Vohryzek J, Wagner AS, Walsh RJ, White T, Wong FT, Xie X, Yan CG, Yang YF, Yee Y, Zanitti GE, Van Gulick AE, Duff E, Maumet C. Centering inclusivity in the design of online conferences-An OHBM-Open Science perspective. Gigascience. 2021 08 20; 10(8). PMID: 34414422.
      View in: PubMed
    8. Giménez DeGeorge E, Fullen C, Gess J, Kleiner J, Larson-Prior L. Effects of age of onset and medication on cognitive performance and quality of life in patients with epilepsy. Epilepsy Behav. 2021 08; 121(Pt A):108008. PMID: 34004525.
      View in: PubMed
    9. Alatorre-Cruz GC, Downs H, Hagood D, Sorensen ST, Williams DK, Larson-Prior L. Effect of obesity on inhibitory control in preadolescents during stop-signal task. An event-related potentials study. Int J Psychophysiol. 2021 07; 165:56-67. PMID: 33872629.
      View in: PubMed
    10. Walden A, Kemp AS, Larson-Prior LJ, Kim T, Gan J, McCoy H, Payakachat N, Ward W, Eswaran H. Establishing a digital health platform in an academic medical center supporting rural communities. J Clin Transl Sci. 2020 Apr 28; 4(5):384-388. PMID: 33244426.
      View in: PubMed
    11. Virmani T, Pillai L, Glover A, Doerhoff SM, Williams DK, Garcia-Rill E, Larson-Prior L. Impaired step-length setting prior to turning in Parkinson's disease patients with freezing of gait. Mov Disord. 2018 11; 33(11):1823-1825. PMID: 30306629.
      View in: PubMed
    12. Virmani T, Gupta H, Shah J, Larson-Prior L. Objective measures of gait and balance in healthy non-falling adults as a function of age. Gait Posture. 2018 09; 65:100-105. PMID: 30558914.
      View in: PubMed
    13. Shah J, Pillai L, Williams DK, Doerhoff SM, Larson-Prior L, Garcia-Rill E, Virmani T. Increased foot strike variability in Parkinson's disease patients with freezing of gait. Parkinsonism Relat Disord. 2018 08; 53:58-63. PMID: 29773512.
      View in: PubMed
    14. La Rosa PS, Brooks TL, Deych E, Shands B, Prior F, Larson-Prior LJ, Shannon WD. Gibbs distribution for statistical analysis of graphical data with a sample application to fcMRI brain images. Stat Med. 2016 Feb 20; 35(4):566-80. PMID: 26608238.
      View in: PubMed
    15. Palanca BJ, Mitra A, Larson-Prior L, Snyder AZ, Avidan MS, Raichle ME. Resting-state Functional Magnetic Resonance Imaging Correlates of Sevoflurane-induced Unconsciousness. Anesthesiology. 2015 Aug; 123(2):346-56. PMID: 26057259.
      View in: PubMed
    16. Hodge MR, Horton W, Brown T, Herrick R, Olsen T, Hileman ME, McKay M, Archie KA, Cler E, Harms MP, Burgess GC, Glasser MF, Elam JS, Curtiss SW, Barch DM, Oostenveld R, Larson-Prior LJ, Ugurbil K, Van Essen DC, Marcus DS. ConnectomeDB--Sharing human brain connectivity data. Neuroimage. 2016 Jan 01; 124(Pt B):1102-1107. PMID: 25934470.
      View in: PubMed
    17. Kelsey M, Prior FW, Larson-Prior LJ. Spatiotemporal analysis of the appearance of gamma-band Microstates in resting state MEG. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:2637-40. PMID: 26736833.
      View in: PubMed
    18. Larson-Prior LJ, Ju YE, Galvin JE. Cortical-subcortical interactions in hypersomnia disorders: mechanisms underlying cognitive and behavioral aspects of the sleep-wake cycle. Front Neurol. 2014; 5:165. PMID: 25309500.
      View in: PubMed
    19. Greve DN, Duntley SP, Larson-Prior L, Krystal AD, Diaz MT, Drummond SP, Thein SG, Kushida CA, Yang R, Thomas RJ. Effect of armodafinil on cortical activity and working memory in patients with residual excessive sleepiness associated with CPAP-Treated OSA: a multicenter fMRI study. J Clin Sleep Med. 2014 Feb 15; 10(2):143-53. PMID: 24532997.
      View in: PubMed
    20. Schwedt TJ, Larson-Prior L, Coalson RS, Nolan T, Mar S, Ances BM, Benzinger T, Schlaggar BL. Allodynia and descending pain modulation in migraine: a resting state functional connectivity analysis. Pain Med. 2014 Jan; 15(1):154-65. PMID: 24165094.
      View in: PubMed
    21. Larson-Prior LJ, Oostenveld R, Della Penna S, Michalareas G, Prior F, Babajani-Feremi A, Schoffelen JM, Marzetti L, de Pasquale F, Di Pompeo F, Stout J, Woolrich M, Luo Q, Bucholz R, Fries P, Pizzella V, Romani GL, Corbetta M, Snyder AZ. Adding dynamics to the Human Connectome Project with MEG. Neuroimage. 2013 Oct 15; 80:190-201. PMID: 23702419.
      View in: PubMed
    22. Schwedt TJ, Schlaggar BL, Mar S, Nolan T, Coalson RS, Nardos B, Benzinger T, Larson-Prior LJ. Atypical resting-state functional connectivity of affective pain regions in chronic migraine. Headache. 2013 May; 53(5):737-51. PMID: 23551164.
      View in: PubMed
    23. Smith K, Politte D, Reiker G, Nolan TS, Hildebolt C, Mattson C, Tucker D, Prior F, Turovets S, Larson-Prior LJ. Automated measurement of skull circumference, cranial index, and braincase volume from pediatric computed tomography. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:3977-80. PMID: 24110603.
      View in: PubMed
    24. Shannon BJ, Dosenbach RA, Su Y, Vlassenko AG, Larson-Prior LJ, Nolan TS, Snyder AZ, Raichle ME. Morning-evening variation in human brain metabolism and memory circuits. J Neurophysiol. 2013 Mar; 109(5):1444-56. PMID: 23197455.
      View in: PubMed
    25. McAvoy M, Larson-Prior L, Ludwikow M, Zhang D, Snyder AZ, Gusnard DL, Raichle ME, d'Avossa G. Dissociated mean and functional connectivity BOLD signals in visual cortex during eyes closed and fixation. J Neurophysiol. 2012 Nov; 108(9):2363-72. PMID: 22875902.
      View in: PubMed
    26. Zempel JM, Politte DG, Kelsey M, Verner R, Nolan TS, Babajani-Feremi A, Prior F, Larson-Prior LJ. Characterization of scale-free properties of human electrocorticography in awake and slow wave sleep States. Front Neurol. 2012; 3:76. PMID: 22701446.
      View in: PubMed
    27. Ozcan A, Wong KH, Larson-Prior L, Cho ZH, Mun SK. Background and Mathematical Analysis of Diffusion MRI Methods. Int J Imaging Syst Technol. 2012 Mar 01; 22(1):44-52. PMID: 23661905.
      View in: PubMed
    28. Van Essen DC, Ugurbil K, Auerbach E, Barch D, Behrens TE, Bucholz R, Chang A, Chen L, Corbetta M, Curtiss SW, Della Penna S, Feinberg D, Glasser MF, Harel N, Heath AC, Larson-Prior L, Marcus D, Michalareas G, Moeller S, Oostenveld R, Petersen SE, Prior F, Schlaggar BL, Smith SM, Snyder AZ, Xu J, Yacoub E. The Human Connectome Project: a data acquisition perspective. Neuroimage. 2012 Oct 01; 62(4):2222-31. PMID: 22366334.
      View in: PubMed
    29. Smith K, Politte D, Reiker G, Nolan TS, Hildebolt C, Mattson C, Tucker D, Prior F, Turovets S, Larson-Prior LJ. Automated measurement of pediatric cranial bone thickness and density from clinical computed tomography. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:4462-5. PMID: 23366918.
      View in: PubMed
    30. Kelsey M, Politte D, Verner R, Zempel JM, Nolan T, Babajani-Feremi A, Prior F, Larson-Prior LJ. Determination of neural state classification metrics from the power spectrum of human ECoG. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:4336-40. PMID: 23366887.
      View in: PubMed
    31. Ju YE, Larson-Prior L, Duntley S. RBD and antidepressants. Sleep Med. 2012 Feb; 13(2):211-2. PMID: 21924952.
      View in: PubMed
    32. Ju YE, Larson-Prior L, Duntley S. Changing demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressants. Sleep Med. 2011 Mar; 12(3):278-83. PMID: 21317035.
      View in: PubMed
    33. Larson-Prior LJ, Power JD, Vincent JL, Nolan TS, Coalson RS, Zempel J, Snyder AZ, Schlaggar BL, Raichle ME, Petersen SE. Modulation of the brain's functional network architecture in the transition from wake to sleep. Prog Brain Res. 2011; 193:277-94. PMID: 21854969.
      View in: PubMed
    34. Politte D, Prior F, Ponton C, Nolan T, Larson-Prior L. Sources of non-physiologic noise in simultaneous EEG-fMRI data: a phantom study. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:5129-32. PMID: 21095809.
      View in: PubMed
    35. Larson-Prior LJ, Zempel JM, Nolan TS, Prior FW, Snyder AZ, Raichle ME. Cortical network functional connectivity in the descent to sleep. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4489-94. PMID: 19255447.
      View in: PubMed
    36. Prior FW, Brunsden B, Hildebolt C, Nolan TS, Pringle M, Vaishnavi SN, Larson-Prior LJ. Facial recognition from volume-rendered magnetic resonance imaging data. IEEE Trans Inf Technol Biomed. 2009 Jan; 13(1):5-9. PMID: 19129018.
      View in: PubMed
    37. McAvoy M, Larson-Prior L, Nolan TS, Vaishnavi SN, Raichle ME, d'Avossa G. Resting states affect spontaneous BOLD oscillations in sensory and paralimbic cortex. J Neurophysiol. 2008 Aug; 100(2):922-31. PMID: 18509068.
      View in: PubMed
    38. Vincent JL, Larson-Prior LJ, Zempel JM, Snyder AZ. Moving GLM ballistocardiogram artifact reduction for EEG acquired simultaneously with fMRI. Clin Neurophysiol. 2007 May; 118(5):981-98. PMID: 17368972.
      View in: PubMed
    39. Jewett DL, Hart T, Larson-Prior LJ, Baird B, Olson M, Trumpis M, Makayed K, Bavafa P. Human sensory-evoked responses differ coincident with either "fusion-memory" or "flash-memory", as shown by stimulus repetition-rate effects. BMC Neurosci. 2006 Feb 23; 7:18. PMID: 16504094.
      View in: PubMed
    40. Jewett DL, Caplovitz G, Baird B, Trumpis M, Olson MP, Larson-Prior LJ. The use of QSD (q-sequence deconvolution) to recover superposed, transient evoked-responses. Clin Neurophysiol. 2004 Dec; 115(12):2754-75. PMID: 15546784.
      View in: PubMed
    41. Coates TD, Larson-Prior LJ, Wolpert S, Prior F. Classification of simple stimuli based on detected nerve activity. IEEE Eng Med Biol Mag. 2003 Jan-Feb; 22(1):64-76. PMID: 12683065.
      View in: PubMed
    42. Lu H, Larson-Prior LJ. Serotonergic modulation of evoked responses in turtle cerebellar Purkinje cells. J Neurophysiol. 1996 Nov; 76(5):3102-13. PMID: 8930258.
      View in: PubMed
    43. Larson-Prior LJ, Ulinski PS, Slater NT. Excitatory amino acid receptor-mediated transmission in geniculocortical and intracortical pathways within visual cortex. J Neurophysiol. 1991 Jul; 66(1):293-306. PMID: 1681038.
      View in: PubMed
    44. Larson-Prior LJ, McCrimmon DR, Slater NT. Slow excitatory amino acid receptor-mediated synaptic transmission in turtle cerebellar Purkinje cells. J Neurophysiol. 1990 Mar; 63(3):637-50. PMID: 1970354.
      View in: PubMed

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    Larson-Prior's Networks
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