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Linda Larson-Prior

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPsychiatry, College of Medicine
DivisionPSY Mood Disorders Research
Address4224 Shuffield Dr.
Mail Slot # 755
Little Rock AR 72205
Phone501-526-8100
ORCID ORCID Icon0000-0002-9334-048X Additional info
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentNeurobiology & Developmental Science, College of Medicine

    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentNeurology, College of Medicine


    Collapse Overview 
    Collapse overview
    My laboratory is interested in better understanding the dynamic neural network re-configurations that occur as the brain changes its state under both normal conditions such as sleep, and in abnormal conditions such as induced shifts in conscious awareness (anesthesia) or pathological shifts in cognitive awareness (fluctuating consciousness, sleep parasomnias and neurodegenerative disease states). We have developed the use of simultaneous acquisition of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) to help us better understand these shifts in network connectivity and function as the brain shifts state over the course of 24 hours. As part of the Human Connectome Project, my laboratory worked with a large international team to define the connection patterns in normal adult human subjects using magnetoencephalography (MEG) and fMRI methodologies. The connectomics approach to analysis of large, multi-modal datasets is one my laboratory is actively pursuing to better understand the role of behavioral and neural state on function across the lifespan. I am actively involved in mentoring and mentorship programs and have mentored research professionals at all levels, from high school through early faculty. In addition, I have provided formal mentorship training to both mentors and mentees through workshops and invited lectures. I believe strongly that developing strong and proactive mentorship programs early in professional training will aid students in achieving optimal performance levels throughout their careers.


    Collapse Affiliation 
    Collapse member of
    Society for Neuroscience
    American Association for the Advancement of Science
    American Academy of Sleep Medicine
    Organization for Human Brain Mapping
    IEEE-EMBS

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. La Rosa PS, Brooks TL, Deych E, Shands B, Prior F, Larson-Prior LJ, Shannon WD. Gibbs distribution for statistical analysis of graphical data with a sample application to fcMRI brain images. Stat Med. 2016 Feb 20; 35(4):566-80. PMID: 26608238.
      View in: PubMed
    2. Palanca BJ, Mitra A, Larson-Prior L, Snyder AZ, Avidan MS, Raichle ME. Resting-state Functional Magnetic Resonance Imaging Correlates of Sevoflurane-induced Unconsciousness. Anesthesiology. 2015 Aug; 123(2):346-56. PMID: 26057259; PMCID: PMC4509973.
    3. Hodge MR, Horton W, Brown T, Herrick R, Olsen T, Hileman ME, McKay M, Archie KA, Cler E, Harms MP, Burgess GC, Glasser MF, Elam JS, Curtiss SW, Barch DM, Oostenveld R, Larson-Prior LJ, Ugurbil K, Van Essen DC, Marcus DS. ConnectomeDB--Sharing human brain connectivity data. Neuroimage. 2016 Jan 01; 124(Pt B):1102-7. PMID: 25934470; PMCID: PMC4626437 [Available on 01/01/17].
    4. Kelsey M, Prior FW, Larson-Prior LJ. Spatiotemporal analysis of the appearance of gamma-band Microstates in resting state MEG. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:2637-40. PMID: 26736833.
      View in: PubMed
    5. Larson-Prior LJ, Ju YE, Galvin JE. Cortical-subcortical interactions in hypersomnia disorders: mechanisms underlying cognitive and behavioral aspects of the sleep-wake cycle. Front Neurol. 2014; 5:165. PMID: 25309500; PMCID: PMC4160996.
    6. Greve DN, Duntley SP, Larson-Prior L, Krystal AD, Diaz MT, Drummond SP, Thein SG, Kushida CA, Yang R, Thomas RJ. Effect of armodafinil on cortical activity and working memory in patients with residual excessive sleepiness associated with CPAP-Treated OSA: a multicenter fMRI study. J Clin Sleep Med. 2014 Feb 15; 10(2):143-53. PMID: 24532997; PMCID: PMC3899316.
    7. Schwedt TJ, Larson-Prior L, Coalson RS, Nolan T, Mar S, Ances BM, Benzinger T, Schlaggar BL. Allodynia and descending pain modulation in migraine: a resting state functional connectivity analysis. Pain Med. 2014 Jan; 15(1):154-65. PMID: 24165094; PMCID: PMC4188437.
    8. Schwedt TJ, Schlaggar BL, Mar S, Nolan T, Coalson RS, Nardos B, Benzinger T, Larson-Prior LJ. Atypical resting-state functional connectivity of affective pain regions in chronic migraine. Headache. 2013 May; 53(5):737-51. PMID: 23551164; PMCID: PMC3637407.
    9. Smith K, Politte D, Reiker G, Nolan TS, Hildebolt C, Mattson C, Tucker D, Prior F, Turovets S, Larson-Prior LJ. Automated measurement of skull circumference, cranial index, and braincase volume from pediatric computed tomography. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:3977-80. PMID: 24110603; PMCID: PMC4559142.
    10. McAvoy M, Larson-Prior L, Ludwikow M, Zhang D, Snyder AZ, Gusnard DL, Raichle ME, d'Avossa G. Dissociated mean and functional connectivity BOLD signals in visual cortex during eyes closed and fixation. J Neurophysiol. 2012 Nov; 108(9):2363-72. PMID: 22875902; PMCID: PMC3545171.
    11. Zempel JM, Politte DG, Kelsey M, Verner R, Nolan TS, Babajani-Feremi A, Prior F, Larson-Prior LJ. Characterization of scale-free properties of human electrocorticography in awake and slow wave sleep States. Front Neurol. 2012; 3:76. PMID: 22701446; PMCID: PMC3373008.
    12. Ozcan A, Wong KH, Larson-Prior L, Cho ZH, Mun SK. Background and Mathematical Analysis of Diffusion MRI Methods. Int J Imaging Syst Technol. 2012 Mar 01; 22(1):44-52. PMID: 23661905.
      View in: PubMed
    13. Smith K, Politte D, Reiker G, Nolan TS, Hildebolt C, Mattson C, Tucker D, Prior F, Turovets S, Larson-Prior LJ. Automated measurement of pediatric cranial bone thickness and density from clinical computed tomography. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:4462-5. PMID: 23366918; PMCID: PMC4559077.
    14. Kelsey M, Politte D, Verner R, Zempel JM, Nolan T, Babajani-Feremi A, Prior F, Larson-Prior LJ. Determination of neural state classification metrics from the power spectrum of human ECoG. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:4336-40. PMID: 23366887.
      View in: PubMed
    15. Ju YE, Larson-Prior L, Duntley S. RBD and antidepressants. Sleep Med. 2012 Feb; 13(2):211-2. PMID: 21924952.
      View in: PubMed
    16. Ju YE, Larson-Prior L, Duntley S. Changing demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressants. Sleep Med. 2011 Mar; 12(3):278-83. PMID: 21317035.
      View in: PubMed
    17. Larson-Prior LJ, Power JD, Vincent JL, Nolan TS, Coalson RS, Zempel J, Snyder AZ, Schlaggar BL, Raichle ME, Petersen SE. Modulation of the brain's functional network architecture in the transition from wake to sleep. Prog Brain Res. 2011; 193:277-94. PMID: 21854969; PMCID: PMC3811144.
    18. Politte D, Prior F, Ponton C, Nolan T, Larson-Prior L. Sources of non-physiologic noise in simultaneous EEG-fMRI data: a phantom study. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:5129-32. PMID: 21095809.
      View in: PubMed
    19. Larson-Prior LJ, Zempel JM, Nolan TS, Prior FW, Snyder AZ, Raichle ME. Cortical network functional connectivity in the descent to sleep. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4489-94. PMID: 19255447; PMCID: PMC2657465.
    20. Prior FW, Brunsden B, Hildebolt C, Nolan TS, Pringle M, Vaishnavi SN, Larson-Prior LJ. Facial recognition from volume-rendered magnetic resonance imaging data. IEEE Trans Inf Technol Biomed. 2009 Jan; 13(1):5-9. PMID: 19129018.
      View in: PubMed
    21. McAvoy M, Larson-Prior L, Nolan TS, Vaishnavi SN, Raichle ME, d'Avossa G. Resting states affect spontaneous BOLD oscillations in sensory and paralimbic cortex. J Neurophysiol. 2008 Aug; 100(2):922-31. PMID: 18509068; PMCID: PMC2525732.
    22. Vincent JL, Larson-Prior LJ, Zempel JM, Snyder AZ. Moving GLM ballistocardiogram artifact reduction for EEG acquired simultaneously with fMRI. Clin Neurophysiol. 2007 May; 118(5):981-98. PMID: 17368972.
      View in: PubMed
    23. Jewett DL, Hart T, Larson-Prior LJ, Baird B, Olson M, Trumpis M, Makayed K, Bavafa P. Human sensory-evoked responses differ coincident with either "fusion-memory" or "flash-memory", as shown by stimulus repetition-rate effects. BMC Neurosci. 2006 Feb 23; 7:18. PMID: 16504094; PMCID: PMC1483834.
    24. Jewett DL, Caplovitz G, Baird B, Trumpis M, Olson MP, Larson-Prior LJ. The use of QSD (q-sequence deconvolution) to recover superposed, transient evoked-responses. Clin Neurophysiol. 2004 Dec; 115(12):2754-75. PMID: 15546784; PMCID: PMC1444882.
    25. Coates TD, Larson-Prior LJ, Wolpert S, Prior F. Classification of simple stimuli based on detected nerve activity. IEEE Eng Med Biol Mag. 2003 Jan-Feb; 22(1):64-76. PMID: 12683065.
      View in: PubMed

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