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Linda Larson-Prior

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPsychiatry, College of Medicine
DivisionPSY Mood Disorders Research
Address4224 Shuffield Dr.
Mail Slot # 755
Little Rock AR 72205
Phone501-526-8100
ORCID ORCID Icon0000-0002-9334-048X Additional info
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentBiomedical Informatics, College of Medicine

    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentNeurobiology & Developmental Science, College of Medicine

    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentNeurology, College of Medicine

    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentPediatrics, College of Medicine
    DivisionDevelopmental Nutrition


    Collapse Overview 
    Collapse overview
    My laboratory is interested in better understanding the dynamic neural network re-configurations that occur as the brain changes its state under both normal conditions such as sleep, and in abnormal conditions such as induced shifts in conscious awareness (anesthesia) or pathological shifts in cognitive awareness (fluctuating consciousness, sleep parasomnias and neurodegenerative disease states). We have developed the use of simultaneous acquisition of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) to help us better understand these shifts in network connectivity and function as the brain shifts state over the course of 24 hours. As part of the Human Connectome Project, my laboratory worked with a large international team to define the connection patterns in normal adult human subjects using magnetoencephalography (MEG) and fMRI methodologies. The connectomics approach to analysis of large, multi-modal datasets is one my laboratory is actively pursuing to better understand the role of behavioral and neural state on function across the lifespan. I am actively involved in mentoring and mentorship programs and have mentored research professionals at all levels, from high school through early faculty. In addition, I have provided formal mentorship training to both mentors and mentees through workshops and invited lectures. I believe strongly that developing strong and proactive mentorship programs early in professional training will aid students in achieving optimal performance levels throughout their careers.


    Collapse Affiliation 
    Collapse member of
    Society for Neuroscience
    American Association for the Advancement of Science
    American Academy of Sleep Medicine
    Organization for Human Brain Mapping
    IEEE-EMBS

    Collapse Educational Activities 

    Collapse Research Funds 
    Collapse research activities
    U24CA215109     (PRIOR, FRED WILLIAM)Sep 22, 2017 - Jul 31, 2022
    NIH
    TCIA Sustainment and Scalability - Platforms for Quantitative Imaging Informatics in Precision Medicine
    Role: Co-Investigator
    OIA-1632891     (LARSON-PRIOR, LINDA)Sep 1, 2016 - Aug 31, 2020
    National Science Foundation - Pass Through: Louisiana Tech University
    RII Track-2 FEC- Probing and Understanding the Brain: Micro and Macro Dynamics of Seizure and Memory Networks
    Role: Principal Investigator
    R44MH106421     (LARSON-PRIOR, LINDA)Mar 1, 2016 - Jul 31, 2018
    NIH/National Institutes of Health - Pass Through: Electrical Geodesics, Inc.
    Pediatric Head Models for Improved Imaging of Neurological Development
    Role: Principal Investigator
    R29NS030759     (LARSON-PRIOR, LINDA J)Sep 1, 1991 - Dec 31, 1992
    NIH
    SLOW SYNAPTIC TRANSMISSION IN CEREBELLUM
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
    List All   |   Timeline
    1. Walden A, Kemp AS, Larson-Prior LJ, Kim T, Gan J, McCoy H, Payakachat N, Ward W, Eswaran H. Establishing a digital health platform in an academic medical center supporting rural communities. J Clin Transl Sci. 2020 Apr 28; 4(5):384-388. PMID: 33244426.
      View in: PubMed
    2. Virmani T, Pillai L, Glover A, Doerhoff SM, Williams DK, Garcia-Rill E, Larson-Prior L. Impaired step-length setting prior to turning in Parkinson's disease patients with freezing of gait. Mov Disord. 2018 11; 33(11):1823-1825. PMID: 30306629.
      View in: PubMed
    3. Virmani T, Gupta H, Shah J, Larson-Prior L. Objective measures of gait and balance in healthy non-falling adults as a function of age. Gait Posture. 2018 09; 65:100-105. PMID: 30558914.
      View in: PubMed
    4. Shah J, Pillai L, Williams DK, Doerhoff SM, Larson-Prior L, Garcia-Rill E, Virmani T. Increased foot strike variability in Parkinson's disease patients with freezing of gait. Parkinsonism Relat Disord. 2018 08; 53:58-63. PMID: 29773512.
      View in: PubMed
    5. La Rosa PS, Brooks TL, Deych E, Shands B, Prior F, Larson-Prior LJ, Shannon WD. Gibbs distribution for statistical analysis of graphical data with a sample application to fcMRI brain images. Stat Med. 2016 Feb 20; 35(4):566-80. PMID: 26608238.
      View in: PubMed
    6. Palanca BJ, Mitra A, Larson-Prior L, Snyder AZ, Avidan MS, Raichle ME. Resting-state Functional Magnetic Resonance Imaging Correlates of Sevoflurane-induced Unconsciousness. Anesthesiology. 2015 Aug; 123(2):346-56. PMID: 26057259.
      View in: PubMed
    7. Hodge MR, Horton W, Brown T, Herrick R, Olsen T, Hileman ME, McKay M, Archie KA, Cler E, Harms MP, Burgess GC, Glasser MF, Elam JS, Curtiss SW, Barch DM, Oostenveld R, Larson-Prior LJ, Ugurbil K, Van Essen DC, Marcus DS. ConnectomeDB--Sharing human brain connectivity data. Neuroimage. 2016 Jan 01; 124(Pt B):1102-1107. PMID: 25934470.
      View in: PubMed
    8. Kelsey M, Prior FW, Larson-Prior LJ. Spatiotemporal analysis of the appearance of gamma-band Microstates in resting state MEG. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:2637-40. PMID: 26736833.
      View in: PubMed
    9. Larson-Prior LJ, Ju YE, Galvin JE. Cortical-subcortical interactions in hypersomnia disorders: mechanisms underlying cognitive and behavioral aspects of the sleep-wake cycle. Front Neurol. 2014; 5:165. PMID: 25309500.
      View in: PubMed
    10. Greve DN, Duntley SP, Larson-Prior L, Krystal AD, Diaz MT, Drummond SP, Thein SG, Kushida CA, Yang R, Thomas RJ. Effect of armodafinil on cortical activity and working memory in patients with residual excessive sleepiness associated with CPAP-Treated OSA: a multicenter fMRI study. J Clin Sleep Med. 2014 Feb 15; 10(2):143-53. PMID: 24532997.
      View in: PubMed
    11. Schwedt TJ, Larson-Prior L, Coalson RS, Nolan T, Mar S, Ances BM, Benzinger T, Schlaggar BL. Allodynia and descending pain modulation in migraine: a resting state functional connectivity analysis. Pain Med. 2014 Jan; 15(1):154-65. PMID: 24165094.
      View in: PubMed
    12. Larson-Prior LJ, Oostenveld R, Della Penna S, Michalareas G, Prior F, Babajani-Feremi A, Schoffelen JM, Marzetti L, de Pasquale F, Di Pompeo F, Stout J, Woolrich M, Luo Q, Bucholz R, Fries P, Pizzella V, Romani GL, Corbetta M, Snyder AZ. Adding dynamics to the Human Connectome Project with MEG. Neuroimage. 2013 Oct 15; 80:190-201. PMID: 23702419.
      View in: PubMed
    13. Schwedt TJ, Schlaggar BL, Mar S, Nolan T, Coalson RS, Nardos B, Benzinger T, Larson-Prior LJ. Atypical resting-state functional connectivity of affective pain regions in chronic migraine. Headache. 2013 May; 53(5):737-51. PMID: 23551164.
      View in: PubMed
    14. Smith K, Politte D, Reiker G, Nolan TS, Hildebolt C, Mattson C, Tucker D, Prior F, Turovets S, Larson-Prior LJ. Automated measurement of skull circumference, cranial index, and braincase volume from pediatric computed tomography. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:3977-80. PMID: 24110603.
      View in: PubMed
    15. Shannon BJ, Dosenbach RA, Su Y, Vlassenko AG, Larson-Prior LJ, Nolan TS, Snyder AZ, Raichle ME. Morning-evening variation in human brain metabolism and memory circuits. J Neurophysiol. 2013 Mar; 109(5):1444-56. PMID: 23197455.
      View in: PubMed
    16. McAvoy M, Larson-Prior L, Ludwikow M, Zhang D, Snyder AZ, Gusnard DL, Raichle ME, d'Avossa G. Dissociated mean and functional connectivity BOLD signals in visual cortex during eyes closed and fixation. J Neurophysiol. 2012 Nov; 108(9):2363-72. PMID: 22875902.
      View in: PubMed
    17. Zempel JM, Politte DG, Kelsey M, Verner R, Nolan TS, Babajani-Feremi A, Prior F, Larson-Prior LJ. Characterization of scale-free properties of human electrocorticography in awake and slow wave sleep States. Front Neurol. 2012; 3:76. PMID: 22701446.
      View in: PubMed
    18. Ozcan A, Wong KH, Larson-Prior L, Cho ZH, Mun SK. Background and Mathematical Analysis of Diffusion MRI Methods. Int J Imaging Syst Technol. 2012 Mar 01; 22(1):44-52. PMID: 23661905.
      View in: PubMed
    19. Van Essen DC, Ugurbil K, Auerbach E, Barch D, Behrens TE, Bucholz R, Chang A, Chen L, Corbetta M, Curtiss SW, Della Penna S, Feinberg D, Glasser MF, Harel N, Heath AC, Larson-Prior L, Marcus D, Michalareas G, Moeller S, Oostenveld R, Petersen SE, Prior F, Schlaggar BL, Smith SM, Snyder AZ, Xu J, Yacoub E. The Human Connectome Project: a data acquisition perspective. Neuroimage. 2012 Oct 01; 62(4):2222-31. PMID: 22366334.
      View in: PubMed
    20. Smith K, Politte D, Reiker G, Nolan TS, Hildebolt C, Mattson C, Tucker D, Prior F, Turovets S, Larson-Prior LJ. Automated measurement of pediatric cranial bone thickness and density from clinical computed tomography. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:4462-5. PMID: 23366918.
      View in: PubMed
    21. Kelsey M, Politte D, Verner R, Zempel JM, Nolan T, Babajani-Feremi A, Prior F, Larson-Prior LJ. Determination of neural state classification metrics from the power spectrum of human ECoG. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:4336-40. PMID: 23366887.
      View in: PubMed
    22. Ju YE, Larson-Prior L, Duntley S. RBD and antidepressants. Sleep Med. 2012 Feb; 13(2):211-2. PMID: 21924952.
      View in: PubMed
    23. Ju YE, Larson-Prior L, Duntley S. Changing demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressants. Sleep Med. 2011 Mar; 12(3):278-83. PMID: 21317035.
      View in: PubMed
    24. Larson-Prior LJ, Power JD, Vincent JL, Nolan TS, Coalson RS, Zempel J, Snyder AZ, Schlaggar BL, Raichle ME, Petersen SE. Modulation of the brain's functional network architecture in the transition from wake to sleep. Prog Brain Res. 2011; 193:277-94. PMID: 21854969.
      View in: PubMed
    25. Politte D, Prior F, Ponton C, Nolan T, Larson-Prior L. Sources of non-physiologic noise in simultaneous EEG-fMRI data: a phantom study. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:5129-32. PMID: 21095809.
      View in: PubMed
    26. Larson-Prior LJ, Zempel JM, Nolan TS, Prior FW, Snyder AZ, Raichle ME. Cortical network functional connectivity in the descent to sleep. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4489-94. PMID: 19255447.
      View in: PubMed
    27. Prior FW, Brunsden B, Hildebolt C, Nolan TS, Pringle M, Vaishnavi SN, Larson-Prior LJ. Facial recognition from volume-rendered magnetic resonance imaging data. IEEE Trans Inf Technol Biomed. 2009 Jan; 13(1):5-9. PMID: 19129018.
      View in: PubMed
    28. McAvoy M, Larson-Prior L, Nolan TS, Vaishnavi SN, Raichle ME, d'Avossa G. Resting states affect spontaneous BOLD oscillations in sensory and paralimbic cortex. J Neurophysiol. 2008 Aug; 100(2):922-31. PMID: 18509068.
      View in: PubMed
    29. Vincent JL, Larson-Prior LJ, Zempel JM, Snyder AZ. Moving GLM ballistocardiogram artifact reduction for EEG acquired simultaneously with fMRI. Clin Neurophysiol. 2007 May; 118(5):981-98. PMID: 17368972.
      View in: PubMed
    30. Jewett DL, Hart T, Larson-Prior LJ, Baird B, Olson M, Trumpis M, Makayed K, Bavafa P. Human sensory-evoked responses differ coincident with either "fusion-memory" or "flash-memory", as shown by stimulus repetition-rate effects. BMC Neurosci. 2006 Feb 23; 7:18. PMID: 16504094.
      View in: PubMed
    31. Jewett DL, Caplovitz G, Baird B, Trumpis M, Olson MP, Larson-Prior LJ. The use of QSD (q-sequence deconvolution) to recover superposed, transient evoked-responses. Clin Neurophysiol. 2004 Dec; 115(12):2754-75. PMID: 15546784.
      View in: PubMed
    32. Coates TD, Larson-Prior LJ, Wolpert S, Prior F. Classification of simple stimuli based on detected nerve activity. IEEE Eng Med Biol Mag. 2003 Jan-Feb; 22(1):64-76. PMID: 12683065.
      View in: PubMed
    33. Lu H, Larson-Prior LJ. Serotonergic modulation of evoked responses in turtle cerebellar Purkinje cells. J Neurophysiol. 1996 Nov; 76(5):3102-13. PMID: 8930258.
      View in: PubMed
    34. Larson-Prior LJ, Ulinski PS, Slater NT. Excitatory amino acid receptor-mediated transmission in geniculocortical and intracortical pathways within visual cortex. J Neurophysiol. 1991 Jul; 66(1):293-306. PMID: 1681038.
      View in: PubMed
    35. Larson-Prior LJ, McCrimmon DR, Slater NT. Slow excitatory amino acid receptor-mediated synaptic transmission in turtle cerebellar Purkinje cells. J Neurophysiol. 1990 Mar; 63(3):637-50. PMID: 1970354.
      View in: PubMed

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