Last Name

Kathleen Neville

InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPediatrics, College of Medicine
DivisionPeds Pharmacology
Address800 Marshall Street
Mail Slot # 512-23
Little Rock AR 72202
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    Collapse Research Funds 
    Collapse principal investigator
    Pass Through Agency: Medical University of South Carolina - Funding Agency: National Heart, Lung, and Blood Institute - Title: DISPLACE: Dissemination and Implementation of Stroke Prevention: Looking at the Care Environment - Start Date: 2017-08-01

    Funding Agency: Memorial Sloan Kettering Cancer Center - Title: A Phase I/II Study of Neratinib in Pediatric Patients with Relapsed/Refractory Solid Tumors or Hematologic Malignancies - Start Date: 2017-05-01

    Pass Through Agency: Quintiles, Inc. - Funding Agency: Takeda Global Research and Development - Title: An Open-Label Study of Brentuximab Vedotin + Adriamycin, Vinblastine and Dacarbazine in Pediatric Patient with Advanced Stage Newly Diagnosed Hodgkin Lymphoma - Start Date: 2017-03-14

    Pass Through Agency: Mary Crowley Medical Research Center - Funding Agency: Gradalis, Inc. - Title: Randomized Phase IIb Trial of Vigil versus gemcitabine + docetaxel for Ewing's Sarcoma - Start Date: 2016-11-02

    Funding Agency: ACHRI/ABI - Title: Pupillometry Changes to Detect Pain and Analgesic Response in Vaso-Occlusive Pediatric Sickle Cell Disease Patients. - Start Date: 2016-11-01

    Pass Through Agency: Memorial Sloan Kettering Cancer Center - Funding Agency: Onyx Pharmaceuticals - Title: Phase I Study of Carfilzomib in Combination with Cyclophosphamide and Etoposide for Children with Relapsed and Refractory Solid Tumors and Leukemias - Start Date: 2016-05-19

    Funding Agency: - Title: A Post-Marketing Study to Further Assess the Immunogenicity and Safety of Unituxin in High-Risk Neuroblastoma Patients - Start Date: 2016-05-01

    Funding Agency: Spectrum Health Hospitals - Title: A Two-Part Study of TB-403 in Pediatric Subjects with Relapsed or Refractory Medulloblastoma, Neuroblastoma, Ewing Sarcoma or Alveolar Rhabdomyosarcoma - Start Date: 2016-05-01

    Funding Agency: Millennium Pharmaceuticals, Inc. - Title: A Phase 1/2 Study of Brentuximab Vedotin in Pediatric Patients with Relapsed or Refractory Systemic Anaplastic Large Cell Lymphoma or Hodgkin Lymphoma - Start Date: 2016-04-07

    Funding Agency: Spectrum Health Hospitals - Title: Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers - Start Date: 2016-03-01

    Funding Agency: Genentech, Inc. - Title: A Phase I/II, Multicenter, Open-Level, Dose Escalation Study of the Safety and Pharmacokinetics of Cobimetinib in Pediatric and Young Adult Patients with Previously Treated Solid Tumors - Start Date: 2016-03-01

    Funding Agency: Spectrum Health Hospitals - Title: A Phase I Trial of Tolcapone alone and in Combination with Oxaliplatin in Patients with Relapsed or Refractory Neuroblastoma or Medulloblastoma - Start Date: 2016-02-22

    Funding Agency: Spectrum Health Hospitals - Title: Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO) - Start Date: 2016-02-15

    Funding Agency: Genentech, Inc. - Title: An Early-Phase, Multicenter, Open-Label Study of the Safety and Pharmacokinetics of ATEZOLIZUMAB (MPDL3280A) in Pediatric and Young Adults Patients with Previously Treated Solid Tumors - Start Date: 2016-02-08

    Funding Agency: Spectrum Health Hospitals - Title: PEDS-PLAN- Pediatric Percision Laboratory Advanced Neuroblastoma Therapy. A Pilot Study Using Molecular Guided Therapy with Induction Chemotherapy followed by maintenance with DFMO for Subjects with Newly Diagnosed High-Risk Neuroblastoma - Start Date: 2015-12-01

    Funding Agency: Spectrum Health Hospitals - Title: A Phase I/II Trial of DFMO in Combination with Bortezomib in Patients with Relapsed or Refractory Neuroblastoma - Start Date: 2015-11-16

    Funding Agency: Spectrum Health Hospitals - Title: A Phase II Preventative Trial of DFMO as a Single Agent in Patients with High Risk Neuroblastoma in Remission - Start Date: 2015-10-12

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Estepp JH, Wiczling P, Moen J, Kang G, Mack JM, Liem R, Panepinto JA, Garg U, Kearns G, Neville KA. Hydroxycarbamide in children with sickle cell anaemia after first-dose vs. chronic therapy: pharmacokinetics and predictive models for drug exposure. Br J Clin Pharmacol. 2017 Sep 08. PMID: 28884840.
      View in: PubMed
    2. Galadanci NA, Umar Abdullahi S, Vance LD, Musa Tabari A, Ali S, Belonwu R, Salihu A, Amal Galadanci A, Wudil Jibir B, Bello-Manga H, Neville K, Kirkham FJ, Shyr Y, Phillips S, Covert BV, Kassim AA, Jordan LC, Aliyu MH, DeBaun MR. Feasibility trial for primary stroke prevention in children with sickle cell anemia in Nigeria (SPIN trial). Am J Hematol. 2017 Aug; 92(8):780-788. PMID: 28439953.
      View in: PubMed
    3. Tolbert JA, Bai S, Abdel-Rahman SM, August KJ, Weir SJ, Kearns GL, Neville KA. Pharmacokinetics of two 6-mercaptopurine liquid formulations in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2017 Aug; 64(8). PMID: 28295989.
      View in: PubMed
    4. Bai S, Dormer N, Shoults C, Meyer A, Pierce CD, Neville KA, Kearns GL. Palatability of a novel oral formulation of prednisone in healthy young adults. J Pharm Pharmacol. 2017 Apr; 69(4):489-496. PMID: 28271493.
      View in: PubMed
    5. Pessetto ZY, Chen B, Alturkmani H, Hyter S, Flynn CA, Baltezor M, Ma Y, Rosenthal HG, Neville KA, Weir SJ, Butte AJ, Godwin AK. In silico and in vitro drug screening identifies new therapeutic approaches for Ewing sarcoma. Oncotarget. 2017 Jan 17; 8(3):4079-4095. PMID: 27863422.
      View in: PubMed
    6. Angulo P, Kaushik G, Subramaniam D, Dandawate P, Neville K, Chastain K, Anant S. Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy. J Hematol Oncol. 2017 01 07; 10(1):10. PMID: 28061797.
      View in: PubMed
    7. Secola R, Marachelian A, Cohn SL, Toy B, Neville K, Granger M, Brentlinger A, Martin G. The Role of Nursing Professionals in the Management of Patients With High-Risk Neuroblastoma Receiving Dinutuximab Therapy. J Pediatr Oncol Nurs. 2017 May/Jun; 34(3):160-172. PMID: 28061552.
      View in: PubMed
    8. Marek E, Momper JD, Hines RN, Takao CM, Gill JC, Pravica V, Gaedigk A, Burckart GJ, Neville KA. Prediction of Warfarin Dose in Pediatric Patients: An Evaluation of the Predictive Performance of Several Models. J Pediatr Pharmacol Ther. 2016 May-Jun; 21(3):224-32. PMID: 27453700; PMCID: PMC4956330.
    9. Marachelian A, Desai A, Balis F, Katzenstein H, Qayed M, Armstrong M, Neville KA, Cohn SL, Bush M, Gunawan R, Lim AP, Smith MA, Smith LM. Comparative pharmacokinetics, safety, and tolerability of two sources of ch14.18 in pediatric patients with high-risk neuroblastoma following myeloablative therapy. Cancer Chemother Pharmacol. 2016 Feb; 77(2):405-12. PMID: 26791869; PMCID: PMC4747995.
    10. Estepp JH, Melloni C, Thornburg CD, Wiczling P, Rogers Z, Rothman JA, Green NS, Liem R, Brandow AM, Crary SE, Howard TH, Morris MH, Lewandowski A, Garg U, Jusko WJ, Neville KA. Pharmacokinetics and bioequivalence of a liquid formulation of hydroxyurea in children with sickle cell anemia. J Clin Pharmacol. 2016 Mar; 56(3):298-306. PMID: 26201504; PMCID: PMC4892120 [Available on 03/01/17].
    11. Garg U, Scott D, Frazee C, Kearns G, Neville K. Isotope-dilution gas chromatography-mass spectrometry method for the analysis of hydroxyurea. Ther Drug Monit. 2015 Jun; 37(3):325-30. PMID: 25970508.
      View in: PubMed
    12. Saulnier Sholler GL, Gerner EW, Bergendahl G, MacArthur RB, VanderWerff A, Ashikaga T, Bond JP, Ferguson W, Roberts W, Wada RK, Eslin D, Kraveka JM, Kaplan J, Mitchell D, Parikh NS, Neville K, Sender L, Higgins T, Kawakita M, Hiramatsu K, Moriya SS, Bachmann AS. A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma. PLoS One. 2015; 10(5):e0127246. PMID: 26018967; PMCID: PMC4446210.
    13. Brown JT, Connelly M, Nickols C, Neville KA. Developmental Changes of Normal Pupil Size and Reactivity in Children. J Pediatr Ophthalmol Strabismus. 2015 May-Jun; 52(3):147-51. PMID: 26225382.
      View in: PubMed
    14. Saulnier Sholler GL, Bond JP, Bergendahl G, Dutta A, Dragon J, Neville K, Ferguson W, Roberts W, Eslin D, Kraveka J, Kaplan J, Mitchell D, Parikh N, Merchant M, Ashikaga T, Hanna G, Lescault PJ, Siniard A, Corneveaux J, Huentelman M, Trent J. Feasibility of implementing molecular-guided therapy for the treatment of patients with relapsed or refractory neuroblastoma. Cancer Med. 2015 Jun; 4(6):871-86. PMID: 25720842; PMCID: PMC4472210.
    15. Beverung LM, Strouse JJ, Hulbert ML, Neville K, Liem RI, Inusa B, Fuh B, King A, Meier ER, Casella J, DeBaun MR, Panepinto JA. Health-related quality of life in children with sickle cell anemia: impact of blood transfusion therapy. Am J Hematol. 2015 Feb; 90(2):139-43. PMID: 25345798; PMCID: PMC4304929.
    16. Neville KA, Panepinto JA. Pharmacotherapy of Sickle Cell Disease in Children. Curr Pharm Des. 2015; 21(39):5660-7. PMID: 26517528.
      View in: PubMed
    17. Galadanci NA, Abdullahi SU, Tabari MA, Abubakar S, Belonwu R, Salihu A, Neville K, Kirkham F, Inusa B, Shyr Y, Phillips S, Kassim AA, Jordan LC, Aliyu MH, Covert BV, DeBaun MR. Primary stroke prevention in Nigerian children with sickle cell disease (SPIN): challenges of conducting a feasibility trial. Pediatr Blood Cancer. 2015 Mar; 62(3):395-401. PMID: 25399822; PMCID: PMC4304992.
    18. Liu W, Dutta S, Kearns G, Awni W, Neville KA. Pharmacokinetics of hydrocodone/acetaminophen combination product in children ages 6-17 with moderate to moderately severe postoperative pain. J Clin Pharmacol. 2015 Feb; 55(2):204-11. PMID: 25196888.
      View in: PubMed
    19. Connelly MA, Brown JT, Kearns GL, Anderson RA, St Peter SD, Neville KA. Pupillometry: a non-invasive technique for pain assessment in paediatric patients. Arch Dis Child. 2014 Dec; 99(12):1125-31. PMID: 25187497; PMCID: PMC4395877.
    20. Wiczling P, Liem RI, Panepinto JA, Garg U, Abdel-Rahman SM, Kearns GL, Neville KA. Population pharmacokinetics of hydroxyurea for children and adolescents with sickle cell disease. J Clin Pharmacol. 2014 Sep; 54(9):1016-22. PMID: 24729271.
      View in: PubMed
    21. Frattarelli DA, Galinkin JL, Green TP, Johnson TD, Neville KA, Paul IM, Van Den Anker JN. Off-label use of drugs in children. Pediatrics. 2014 Mar; 133(3):563-7. PMID: 24567009.
      View in: PubMed
    22. Shaw K, Amstutz U, Hildebrand C, Rassekh SR, Hosking M, Neville K, Leeder JS, Hayden MR, Ross CJ, Carleton BC. VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children. Pediatr Blood Cancer. 2014 Jun; 61(6):1055-62. PMID: 24474498.
      View in: PubMed
    23. Jones BL, Kearns G, Neville KA, Sherwin CM, Spigarelli MM, Leeder JS. Variability of histamine pharmacodynamic response in children with allergic rhinitis. J Clin Pharmacol. 2013 Jul; 53(7):731-7. PMID: 23681823.
      View in: PubMed
    24. August KJ, Narendran A, Neville KA. Pediatric relapsed or refractory leukemia: new pharmacotherapeutic developments and future directions. Drugs. 2013 Apr; 73(5):439-61. PMID: 23568274.
      View in: PubMed
    25. Green NS, Ender KL, Pashankar F, Driscoll C, Giardina PJ, Mullen CA, Clark LN, Manwani D, Crotty J, Kisselev S, Neville KA, Hoppe C, Barral S. Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea. PLoS One. 2013; 8(2):e55709. PMID: 23409025; PMCID: PMC3567082.
    26. Myers AL, Gaedigk A, Dai H, James LP, Jones BL, Neville KA. Defining risk factors for red man syndrome in children and adults. Pediatr Infect Dis J. 2012 May; 31(5):464-8. PMID: 22327873; PMCID: PMC3333837.
    27. Flatt T, Neville K, Lewing K, Dalal J. Successful treatment of fanconi anemia and T-cell acute lymphoblastic leukemia. Case Rep Hematol. 2012; 2012:396395. PMID: 22937327; PMCID: PMC3420437.
    28. Neville KA, Becker ML, Goldman JL, Kearns GL. Developmental pharmacogenomics. Paediatr Anaesth. 2011 Mar; 21(3):255-65. PMID: 21320234.
      View in: PubMed
    29. Guest EM, Neville KA, Hoyer JD, Safo MK, Garg U, Saunders CJ, Abdulmalik O, Zwick DL. Hb Lake Tapawingo [a46(CE4)Phe?Ser; HBA2:c.140T>C]: a new unstable a chain hemoglobin variant associated with low systemic arterial saturation. Hemoglobin. 2011; 35(4):411-6. PMID: 21797707; PMCID: PMC3616395.
    30. Heruth DP, Hawkins T, Logsdon DP, Gibson MI, Sokolovsky IV, Nsumu NN, Major SL, Fegley B, Woods GM, Lewing KB, Neville KA, Cornetta K, Peterson KR, White RA. Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model. Genomics. 2010 Nov; 96(5):303-7. PMID: 20691777.
      View in: PubMed
    31. Connelly M, Neville K. Comparative prospective evaluation of the responsiveness of single-item pediatric pain-intensity self-report scales and their uniqueness from negative affect in a hospital setting. J Pain. 2010 Dec; 11(12):1451-60. PMID: 20646966.
      View in: PubMed
    32. Dalal J, Neville KA. Busulfan in children: impact of development on dose-exposure-response relationship? Pediatr Blood Cancer. 2010 Feb; 54(2):191-2. PMID: 19953643.
      View in: PubMed
    33. Scott DK, Neville K, Garg U. Determination of hydroxyurea in serum or plasma using gas chromatography-mass spectrometry (GC-MS). Methods Mol Biol. 2010; 603:279-87. PMID: 20077079.
      View in: PubMed
    34. von Baeyer CL, Spagrud LJ, McCormick JC, Choo E, Neville K, Connelly MA. Three new datasets supporting use of the Numerical Rating Scale (NRS-11) for children's self-reports of pain intensity. Pain. 2009 Jun; 143(3):223-7. PMID: 19359097.
      View in: PubMed
    35. Jones BL, Abdel-Rahman SM, Simon SD, Kearns GL, Neville KA. Assessment of histamine pharmacodynamics by microvasculature response of histamine using histamine iontophoresis laser Doppler flowimetry. J Clin Pharmacol. 2009 May; 49(5):600-5. PMID: 19318525.
      View in: PubMed
    36. Neville KA, Wicklund BM, Kearns GL. Genetics of warfarin response. N Engl J Med. 2008 Jun 19; 358(25):2742. PMID: 18572452.
      View in: PubMed
    37. Neville KA, Szefler SJ, Abdel-Rahman SM, Lahu G, Zech K, Herzog R, Bethke TD, Gleason MC, Kearns GL. Single-dose pharmacokinetics of roflumilast in children and adolescents. J Clin Pharmacol. 2008 Aug; 48(8):978-85. PMID: 18508947.
      View in: PubMed
    38. Iyengar SS, Olitsky SE, Neville KA. Diagnosis of Factor XI deficiency following congenital cataract extraction. J AAPOS. 2008 Jun; 12(3):297-8. PMID: 18329924.
      View in: PubMed
    39. Adams DM, Zhou T, Berg SL, Bernstein M, Neville K, Blaney SM. Phase 1 trial of O6-benzylguanine and BCNU in children with CNS tumors: a Children's Oncology Group study. Pediatr Blood Cancer. 2008 Mar; 50(3):549-53. PMID: 17941066.
      View in: PubMed
    40. Bernard S, Neville KA, Nguyen AT, Flockhart DA. Interethnic differences in genetic polymorphisms of CYP2D6 in the U.S. population: clinical implications. Oncologist. 2006 Feb; 11(2):126-35. PMID: 16476833.
      View in: PubMed
    41. Neville KA, Blaney SM. Leptomeningeal cancer in the pediatric patient. Cancer Treat Res. 2005; 125:87-106. PMID: 16211885.
      View in: PubMed
    42. Blaney SM, Bernstein M, Neville K, Ginsberg J, Kitchen B, Horton T, Berg SL, Krailo M, Adamson PC. Phase I study of the proteasome inhibitor bortezomib in pediatric patients with refractory solid tumors: a Children's Oncology Group study (ADVL0015). J Clin Oncol. 2004 Dec 01; 22(23):4804-9. PMID: 15570082.
      View in: PubMed
    43. Neville K, Blaney S, Bernstein M, Thompson P, Adams D, Aleksic A, Berg S. Pharmacokinetics of O(6)-benzylguanine in pediatric patients with central nervous system tumors: a pediatric oncology group study. Clin Cancer Res. 2004 Aug 01; 10(15):5072-5. PMID: 15297409.
      View in: PubMed
    44. Neville K, Parise RA, Thompson P, Aleksic A, Egorin MJ, Balis FM, McGuffey L, McCully C, Berg SL, Blaney SM. Plasma and cerebrospinal fluid pharmacokinetics of imatinib after administration to nonhuman primates. Clin Cancer Res. 2004 Apr 01; 10(7):2525-9. PMID: 15073132.
      View in: PubMed
    45. Neville K, Renbarger J, Dreyer Z. Pneumonia in the immunocompromised pediatric cancer patient. Semin Respir Infect. 2002 Mar; 17(1):21-32. PMID: 11891516.
      View in: PubMed
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