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Stepan Melnyk

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPediatrics, College of Medicine
DivisionPeds Developmental Peds
Address100 ACH Research Institute
1120 Marshall Street
Mail Slot # 512-40B
Little Rock AR 72202
Phone501-364-4534
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Melnyk S, Korourian S, Levy JW, Pavliv O, Evans T, Hakkak R. Effects of Obesity on Pro-Oxidative Conditions and DNA Damage in Liver of DMBA-Induced Mammary Carcinogenesis Models. Metabolites. 2017 Jun 08; 7(2). PMID: 28594380.
      View in: PubMed
    2. Miousse IR, Tobacyk J, Melnyk S, James SJ, Cheema AK, Boerma M, Hauer-Jensen M, Koturbash I. One-carbon metabolism and ionizing radiation: a multifaceted interaction. Biomol Concepts. 2017 May 24; 8(2):83-92. PMID: 28574375.
      View in: PubMed
    3. Howsmon DP, Kruger U, Melnyk S, James SJ, Hahn J. Classification and adaptive behavior prediction of children with autism spectrum disorder based upon multivariate data analysis of markers of oxidative stress and DNA methylation. PLoS Comput Biol. 2017 Mar; 13(3):e1005385. PMID: 28301476.
      View in: PubMed
    4. Shpyleva S, Dreval K, de Conti A, Kindrat I, Melnyk S, Yan J, Chen T, Beland FA, Pogribny IP. Editor's Highlight: Organ-Specific Epigenetic Changes Induced by the Nongenotoxic Liver Carcinogen Methapyrilene in Fischer 344 Rats. Toxicol Sci. 2017 Mar 01; 156(1):190-198. PMID: 28013212.
      View in: PubMed
    5. Shpyleva S, Melnyk S, Pavliv O, Pogribny I, Jill James S. Overexpression of LINE-1 Retrotransposons in Autism Brain. Mol Neurobiol. 2017 Feb 20. PMID: 28220356.
      View in: PubMed
    6. Banerjee S, Melnyk SB, Krager KJ, Aykin-Burns N, McCullough SS, James LP, Hinson JA. Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes. Toxicol Rep. 2017; 4:134-142. PMID: 28503408.
      View in: PubMed
    7. Vargason T, Howsmon DP, Melnyk S, James SJ, Hahn J. Mathematical modeling of the methionine cycle and transsulfuration pathway in individuals with autism spectrum disorder. J Theor Biol. 2017 Mar 07; 416:28-37. PMID: 28040439.
      View in: PubMed
    8. Rose S, Bennuri SC, Wynne R, Melnyk S, James SJ, Frye RE. Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study. FASEB J. 2017 Mar; 31(3):904-909. PMID: 27864377.
      View in: PubMed
    9. Banerjee S, Aykin-Burns N, Krager KJ, Shah SK, Melnyk SB, Hauer-Jensen M, Pawar SA. Loss of C/EBPd enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction. Free Radic Biol Med. 2016 Oct; 99:296-307. PMID: 27554969.
      View in: PubMed
    10. Montales MT, Melnyk SB, Liu SJ, Simmen FA, Liu YL, Simmen RC. Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice. Endocr Relat Cancer. 2016 Sep; 23(9):677-90. PMID: 27402613; PMCID: PMC4997088 [Available on 09/01/17].
    11. Heard ME, Melnyk SB, Simmen FA, Yang Y, Pabona JM, Simmen RC. High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated With Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status. Endocrinology. 2016 Jul; 157(7):2870-82. PMID: 27175969; PMCID: PMC4929556 [Available on 07/01/17].
    12. Sridharan V, Thomas CJ, Cao M, Melnyk SB, Pavliv O, Joseph J, Singh SP, Sharma S, Moros EG, Boerma M. Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart. Radiother Oncol. 2016 May; 119(2):259-64. PMID: 27072940; PMCID: PMC4909572 [Available on 05/01/17].
    13. Kovalchuk A, Rodriguez-Juarez R, Ilnytskyy Y, Byeon B, Shpyleva S, Melnyk S, Pogribny I, Kolb B, Kovalchuk O. Sex-specific effects of cytotoxic chemotherapy agents cyclophosphamide and mitomycin C on gene expression, oxidative DNA damage, and epigenetic alterations in the prefrontal cortex and hippocampus - an aging connection. Aging (Albany NY). 2016 Apr; 8(4):697-711. PMID: 27032448; PMCID: PMC4925823.
    14. Frye RE, Delhey L, Slattery J, Tippett M, Wynne R, Rose S, Kahler SG, Bennuri SC, Melnyk S, Sequeira JM, Quadros E. Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups. Front Neurosci. 2016; 10:80. PMID: 27013943; PMCID: PMC4783401.
    15. Koturbash I, Miousse IR, Sridharan V, Nzabarushimana E, Skinner CM, Melnyk SB, Pavliv O, Hauer-Jensen M, Nelson GA, Boerma M. Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart. Mutat Res. 2016 May; 787:43-53. PMID: 26963372; PMCID: PMC4828271 [Available on 05/01/17].
    16. Blossom SJ, Melnyk SB, Li M, Wessinger WD, Cooney CA. Inflammatory and oxidative stress-related effects associated with neurotoxicity are maintained after exclusively prenatal trichloroethylene exposure. Neurotoxicology. 2017 Mar; 59:164-174. PMID: 26812193.
      View in: PubMed
    17. Lu X, Miousse IR, Pirela SV, Moore JK, Melnyk S, Koturbash I, Demokritou P. In vivo epigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles. Nanotoxicology. 2016; 10(5):629-39. PMID: 26559097; PMCID: PMC4958020 [Available on 06/01/17].
    18. Banerjee S, Melnyk SB, Krager KJ, Aykin-Burns N, Letzig LG, James LP, Hinson JA. The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes. Free Radic Biol Med. 2015 Dec; 89:750-7. PMID: 26454079; PMCID: PMC5012542 [Available on 12/01/16].
    19. Yoo HS, Cichocki JA, Kim S, Venkatratnam A, Iwata Y, Kosyk O, Bodnar W, Sweet S, Knap A, Wade T, Campbell J, Clewell HJ, Melnyk SB, Chiu WA, Rusyn I. The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene. Toxicol Sci. 2015 Oct; 147(2):339-49. PMID: 26136231; PMCID: PMC4598794 [Available on 10/01/16].
    20. Lu X, Miousse IR, Pirela SV, Melnyk S, Koturbash I, Demokritou P. Short-term exposure to engineered nanomaterials affects cellular epigenome. Nanotoxicology. 2016; 10(2):140-50. PMID: 25938281; PMCID: PMC4633390.
    21. Sridharan V, Tripathi P, Aykin-Burns N, Krager KJ, Sharma SK, Moros EG, Melnyk SB, Pavliv O, Hauer-Jensen M, Boerma M. A tocotrienol-enriched formulation protects against radiation-induced changes in cardiac mitochondria without modifying late cardiac function or structure. Radiat Res. 2015 Mar; 183(3):357-66. PMID: 25710576; PMCID: PMC4688041.
    22. Rose S, Wynne R, Frye RE, Melnyk S, James SJ. Increased susceptibility to ethylmercury-induced mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines. J Toxicol. 2015; 2015:573701. PMID: 25688267; PMCID: PMC4320799.
    23. Shpyleva S, Ivanovsky S, de Conti A, Melnyk S, Tryndyak V, Beland FA, James SJ, Pogribny IP. Cerebellar oxidative DNA damage and altered DNA methylation in the BTBR T+tf/J mouse model of autism and similarities with human post mortem cerebellum. PLoS One. 2014; 9(11):e113712. PMID: 25423485; PMCID: PMC4244134.
    24. de Conti A, Tryndyak V, Churchwell MI, Melnyk S, Latendresse JR, Muskhelishvili L, Beland FA, Pogribny IP. Genotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver. Toxicology. 2014 Nov 05; 325:12-20. PMID: 25123088.
      View in: PubMed
    25. Montales MT, Melnyk SB, Simmen FA, Simmen RC. Maternal metabolic perturbations elicited by high-fat diet promote Wnt-1-induced mammary tumor risk in adult female offspring via long-term effects on mammary and systemic phenotypes. Carcinogenesis. 2014 Sep; 35(9):2102-12. PMID: 24832086; PMCID: PMC4146417.
    26. Aissa AF, Tryndyak V, de Conti A, Melnyk S, Gomes TD, Bianchi ML, James SJ, Beland FA, Antunes LM, Pogribny IP. Effect of methionine-deficient and methionine-supplemented diets on the hepatic one-carbon and lipid metabolism in mice. Mol Nutr Food Res. 2014 Jul; 58(7):1502-12. PMID: 24827819.
      View in: PubMed
    27. Rose S, Frye RE, Slattery J, Wynne R, Tippett M, Pavliv O, Melnyk S, James SJ. Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort. PLoS One. 2014; 9(1):e85436. PMID: 24416410; PMCID: PMC3885720.
    28. Hamlin JC, Pauly M, Melnyk S, Pavliv O, Starrett W, Crook TA, James SJ. Dietary intake and plasma levels of choline and betaine in children with autism spectrum disorders. Autism Res Treat. 2013; 2013:578429. PMID: 24396597; PMCID: PMC3876775.
    29. Gupta S, Melnyk SB, Kruger WD. Cystathionine ß-synthase-deficient mice thrive on a low-methionine diet. FASEB J. 2014 Feb; 28(2):781-90. PMID: 24189943; PMCID: PMC3898656.
    30. Frye RE, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW, Walters L, James SJ. Effectiveness of methylcobalamin and folinic Acid treatment on adaptive behavior in children with autistic disorder is related to glutathione redox status. Autism Res Treat. 2013; 2013:609705. PMID: 24224089; PMCID: PMC3810468.
    31. Blossom SJ, Cooney CA, Melnyk SB, Rau JL, Swearingen CJ, Wessinger WD. Metabolic changes and DNA hypomethylation in cerebellum are associated with behavioral alterations in mice exposed to trichloroethylene postnatally. Toxicol Appl Pharmacol. 2013 Jun 15; 269(3):263-9. PMID: 23566951; PMCID: PMC3670756.
    32. Pogribny IP, Kutanzi K, Melnyk S, de Conti A, Tryndyak V, Montgomery B, Pogribna M, Muskhelishvili L, Latendresse JR, James SJ, Beland FA, Rusyn I. Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury. FASEB J. 2013 Jun; 27(6):2233-43. PMID: 23439872.
      View in: PubMed
    33. James SJ, Shpyleva S, Melnyk S, Pavliv O, Pogribny IP. Complex epigenetic regulation of engrailed-2 (EN-2) homeobox gene in the autism cerebellum. Transl Psychiatry. 2013 Feb 19; 3:e232. PMID: 23423141; PMCID: PMC3590998.
    34. Zhao M, Ralat MA, Da Silva V, Garrett TJ, James SJ, Gregory JF 3rd. Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells. Am J Physiol Endocrinol Metabol. 2013; 304(4):E342-51.
    35. Rose S, Frye R, Wynne RA, James SJ. Increased Susceptibility of Autism Lymphoblastoid Cells to Mitochondrial Dysfunction Following Reactive Oxygen Species Challenge. 2013 International Meeting for Autism Research. 2013.
    36. James SJ, Shpyleva S, Pavliv O, Pogribny IP. Complex Epigenetic Regulation of Engrailed-2 (EN-2) Homeobox Transcription Factor Gene in the Autism Cerebellum. 2013 International Meeting for Autism Research. 2013.
    37. Frye R, Rose S, Slattery J, Wynne RA, James SJ. Mitochondrial Reserve Capacity in Peripheral Blood Mononuclear Cells Is Related to Development and Glutathione Redox Status in Children with Autism Spectrum Disorder. 2013 International Meeting for Autism Research. 2013.
    38. Montales MT, Prior RL, Simmen RC. Maternal metabolic changes with dietary intake of blueberry during pregnancy and lactation predispose adult progeny to lower mammary tumor growth rate. The FASEB J. 2013.
    39. Montales MT, Simmen RC. Maternal high fat diet promotion of mammary tumor risk in adult progeny is associated with early expansion of mammary cancer stem-like cells and increased maternal oxidative environment. The FASEB J. 2013.
    40. Yeruva L, Spencer N, Bowlin A, Rank R. Chlamidial gastrointestinal infection: Impact of azithromicin treatment. CBRS Meeting. 2013.
    41. Uehara T, Kosyk O, Jeannot E, Bradford BU, Tech K, Macdonald JM, Boorman GA, Chatterjee S, Mason RP, Melnyk SB, Tryndyak VP, Pogribny IP, Rusyn I. Acetaminophen-induced acute liver injury in HCV transgenic mice. Toxicol Appl Pharmacol. 2013 Jan 15; 266(2):224-32. PMID: 23200774; PMCID: PMC3534780.
    42. Chowdhury S, Hobbs CA, MacLeod SL, Cleves MA, Melnyk S, James SJ, Hu P, Erickson SW. Associations between maternal genotypes and metabolites implicated in congenital heart defects. Mol Genet Metab. 2012 Nov; 107(3):596-604. PMID: 23059056; PMCID: PMC3523122.
    43. Tryndyak V, de Conti A, Kobets T, Kutanzi K, Koturbash I, Han T, Fuscoe JC, Latendresse JR, Melnyk S, Shymonyak S, Collins L, Ross SA, Rusyn I, Beland FA, Pogribny IP. Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism. FASEB J. 2012 Nov; 26(11):4592-602. PMID: 22872676; PMCID: PMC3475259.
    44. Hakkak R. Effect of obesity on Serum Concentration of methylatio and Oxidative/Nitrisative Stress Metabolites Following DMBA Treatment of Female Zucker Rats. J Obes Wt Loss Ther. 2012; 2(6).
    45. Tsuchiya M, Ji C, Kosyk O, Shymonyak S, Melnyk S, Kono H, Tryndyak V, Muskhelishvili L, Pogribny IP, Kaplowitz N, Rusyn I. Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology. 2012 Jul; 56(1):130-9. PMID: 22307928; PMCID: PMC3350836.
    46. S. Rose, Melnyk S, T.Trusty, O.Pavliv, L.Seidel, J.Li, T.Nick, S.J.James. Free Radical Generation in Primary Immune Cells from Children with Autism. Autism Research and Treatment. 2012; 2012(1):1-10.
    47. Tryndyak V, Kobets T, Kutanzi K, Koturbash I, Melnyk S, Rusyn I, Beland FA, Pogribny IP. Gene expression profiling identifiers the underlying mechanisms associated with inter-strain differences in the severity of liver injury induced by methyl donor deficiency in mice. Hepatology,. 2012.
    48. Blossom SJ, Melnyk S, Cooney CA, Gilbert KM, James SJ. Postnatal exposure to trichloroethylene alters glutathione redox homeostasis, methylation potential, and neurotrophin expression in the mouse hippocampus. Neurotoxicology. 2012 Dec; 33(6):1518-27. PMID: 22421312; PMCID: PMC3383874.
    49. Melnyk S, Fuchs GJ, Schulz E, Lopez M, Kahler SG, Fussell JJ, Bellando J, Pavliv O, Rose S, Seidel L, Gaylor DW, James SJ. Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism. J Autism Dev Disord. 2012 Mar; 42(3):367-77. PMID: 21519954; PMCID: PMC3342663.
    50. R.E. Frye, R. DeLaTorre, H.Taylor, S. Melnyk, S.J.James. Metabolic Effects of Tetrahydrobiopterin Treatment. IMFAR. 2012.
    51. J. James, S. Melnyk. Evidence of abnormal folate metabolism, RFC1. Clinical Chemistry and Laboratory Medicine. 2012.
    52. S.J.James, S. Melnyk, L.A. Croen, M.D. Fallin, I. Hertz-Picciotto, C.J. Newschaffer. Prenatal Biomarkers of Oxidative Stress and Reduced Methylation Capacity in Autism High Risk Pregnancy Cohort. IMFAR. 2012.
    53. Koturbash I, Melnyk S, James SJ, Beland FA, Pogribny IP. Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene. Mol Carcinog. 2013 Apr; 52(4):318-27. PMID: 22213190.
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    54. Rose S, Melnyk S, Trusty TA, Pavliv O, Seidel L, Li J, Nick T, James SJ. Intracellular and extracellular redox status and free radical generation in primary immune cells from children with autism. Autism Res Treat. 2012; 2012:986519. PMID: 22928106; PMCID: PMC3420377.
    55. Jeannot E, Boorman GA, Kosyk O, Bradford BU, Shymoniak S, Tumurbaatar B, Weinman SA, Melnyk SB, Tryndyak V, Pogribny IP, Rusyn I. Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice. Int J Cancer. 2012 Mar 15; 130(6):1347-56. PMID: 21500192; PMCID: PMC3161148.
    56. Burris RL, Xie CH, Thampi P, Wu X, Melnyk SB, Nagarajan S. Dietary rice protein isolate attenuates atherosclerosis in apoE-deficient mice by upregulating antioxidant enzymes. Atherosclerosis. 2010 Sep; 212(1):107-15. PMID: 20839391.
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    57. James SJ, Melnyk S, Jernigan S, Pavliv O, Trusty T, Lehman S, Seidel L, Gaylor DW, Cleves MA. A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism. Am J Med Genet B Neuropsychiatr Genet. 2010 Sep; 153B(6):1209-20. PMID: 20468076; PMCID: PMC2943349.
    58. Powell CL, Bradford BU, Craig CP, Tsuchiya M, Uehara T, O'Connell TM, Pogribny IP, Melnyk S, Koop DR, Bleyle L, Threadgill DW, Rusyn I. Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors. Toxicol Sci. 2010 May; 115(1):131-9. PMID: 20118189; PMCID: PMC2855354.
    59. Tang B, Mustafa A, Gupta S, Melnyk S, James SJ, Kruger WD. Methionone-deficient diet induces post-translational dowregulation of cystathionine-beta-synthase. Nutrition. 2010; 26(11-12):1170-5.
    60. Tang B, Mustafa A, Gupta S, Melnyk S, James SJ, Kruger WD. Methionine-deficient diet induces post-transcriptional downregulation of cystathionine ß-synthase. Nutrition. 2010 Nov-Dec; 26(11-12):1170-5. PMID: 20036517; PMCID: PMC2956870.
    61. Pogribny I, Tryndyak V, Bagnyukova T, Melnyk S, Montgomery B, Ross A, Latendresse J, Rusyn I, Beland F. Hepatic epigenetic phenotipe predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet. J Hepatol. 2009; 51(1):176-86.
    62. Pogribny IP, Tryndyak VP, Bagnyukova TV, Melnyk S, Montgomery B, Ross SA, Latendresse JR, Rusyn I, Beland FA. Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet. J Hepatol. 2009 Jul; 51(1):176-86. PMID: 19450891; PMCID: PMC2773516.
    63. James SJ, Rose S, Melnyk S, Jernigan S, Blossom S, Pavliv O, Gaylor DW. Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism. FASEB J. 2009 Aug; 23(8):2374-83. PMID: 19307255; PMCID: PMC2717775.
    64. James J, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor D. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status and core behaviors in children with autism. Am J Clin Nutr. 2009; 89:425-430.
    65. James SJ, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. Am J Clin Nutr. 2009 Jan; 89(1):425-30. PMID: 19056591; PMCID: PMC2647708.
    66. James SJ, Melnyk S, Jernigan S, Hubanks A, Rose S, Gaylor DW. Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism. J Autism Dev Disord. 2008 Nov; 38(10):1976. PMID: 19011973.
      View in: PubMed
    67. Pogribny IP, Karpf AR, James SR, Melnyk S, Han T, Tryndyak VP. Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet. Brain Res. 2008 Oct 27; 1237:25-34. PMID: 18694733.
      View in: PubMed
    68. Pogribny IP, Tryndyak VP, Boureiko A, Melnyk S, Bagnyukova TV, Montgomery B, Rusyn I. Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver. Mutat Res. 2008 Sep 26; 644(1-2):17-23. PMID: 18639561; PMCID: PMC2571982.
    69. Celtikci B, Leclerc D, Lawrance AK, Deng L, Friedman HC, Krupenko NI, Krupenko SA, Melnyk S, James SJ, Peterson AC, Rozen R. Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice. Pharmacogenet Genomics. 2008 Jul; 18(7):577-89. PMID: 18551038.
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    70. Celtikci B, Leclerc D, Lawrance AK, Deng L, Friedman HC, Krupenko NI, Krupenko SA, Melnyk S, James SJ, Peterson AC, Rozen R. Altered Expression of Methyltetrahydofolate Reductase Modifies Response to methotrexate in mice. Pharmacogenet. Genomics. 2008; 18(7):577-589.
    71. James SJ, Jill James S, Melnyk S, Jernigan S, Hubanks A, Rose S, Gaylor DW. Abnormal transmethylation/transsulfuration metabolism and DNA hypomethylation among parents of children with autism. J Autism Dev Disord. 2008 Nov; 38(10):1966-75. PMID: 18512136; PMCID: PMC2584168.
    72. Blossom SJ, Doss JC, Hennings LJ, Jernigan S, Melnyk S, James SJ. Developmental exposure to trichloroethylene promotes CD4+ T cell differentiation and hyperactivity in association with oxidative stress and neurobehavioral deficits in MRL+/+ mice. Toxicol Appl Pharmacol. 2008 Sep 15; 231(3):344-53. PMID: 18579175.
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    73. Prajitha Thampi, Bradford W. Stewart, Lijja Joseph, Stepan B. Melnyk, Leah J. Hennings, Shanmugam Nagarajan. Dietary homocysteine promotes atheroscclerosis in hyperlipidemic apoE-deficient mice by up inducing scavenger receptors. Atherosclerosis. 2008; 197:620-629.
    74. Sarah J. Blossom, Jason C Doss, Hennings LJ, Gernigan S, Melnyk S, S. Jill James. Developmental Exposure to Trichloroethylene Promotes CD4 T cell differenciation and hyperactivity in association with oxidative stress and neurobehavioral deficits in MRL+/+ mice. Toxicology and Appl Pharmacology. 2008; 15(231):344-53.
    75. Pogribny I, Tryndyak V, Boureiko A, Melnyk S, Bagnyukova T, Montgomery B, Rusyn I. Mechanism of peroxisome proliferator-induced DNA hypomethylation in rat liver. Mutat Res. 2008; 26(644):17-23.
    76. Shannon Rose, Stepan Melnyk, Alena Savenka, Amanda Hubanks, Stefanie Jernigan, Mario Cleves, S. Jill James. The Frequency of Polymorphysms Affecting Lead and Mercury Toxicity among Children with Autism. Amer J of Biochem and Biotechnology. 2008; 4(2):85-94.
    77. Rossignol DA, Rossignol LW, James SJ, Melnyk S, Mumper E. The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study. BMC Pediatr. 2007 Nov 16; 7:36. PMID: 18005455; PMCID: PMC2244616.
    78. Thampi P, Stewart BW, Joseph L, Melnyk SB, Hennings LJ, Nagarajan S. Dietary homocysteine promotes atherosclerosis in apoE-deficient mice by inducing scavenger receptors expression. Atherosclerosis. 2008 Apr; 197(2):620-9. PMID: 17950295.
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    79. Tryndyak VP, Kovalchuk O, Muskhelishvili L, Montgomery B, Rodriguez-Juarez R, Melnyk S, Ross SA, Beland FA, Pogribny IP. Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis. Mol Carcinog. 2007 Mar; 46(3):187-97. PMID: 17219426.
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    80. Innis SM, Davidson AG, Melnyk S, James SJ. Choline-related supplements improve abnormal plasma methionine-homocysteine metabolites and glutathione status in children with cystic fibrosis. Am J Clin Nutr. 2007; 85(3):702-708.
    81. Volodymyr P. Tryndyak, Olga Kovalchuk, Levan Muskhelishvili, Beverly Montgomery, Rocio Rodriguez-Juarez, Stepan Melnyk, Sharon A. Ross, Frederick A. Epigenetic Reprogramming of Liver Cells in Tamoxifen-Induced Rat Hepatocarcigenesis. Mol Carcinog. 2007; 46(3):187-197.
    82. James SJ, Melnyk S, Jernigan S, Cleves MA, Halsted CH, Wong DH, Cutler P, Bock K, Boris M, Bradstreet JJ, Baker SM, Gaylor DW. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 05; 141B(8):947-56. PMID: 16917939; PMCID: PMC2610366.
    83. Villanueva JA, Esfandiari F, Wong DH, Ahmad I, Melnyk S, James SJ, Halsted CH. Abnormal transsulfuration and glutathione metabolism in the micropig model of alcoholic liver disease. Alcohol Clin Exp Res. 2006 Jul; 30(7):1262-70. PMID: 16792574.
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    84. Zhao W, Mosley BS, Cleves MA, Melnyk S, James SJ, Hobbs CA. Neural tube defects and maternal biomarkers of folate, homocysteine, and glutathione metabolism. Birth Defects Res A Clin Mol Teratol. 2006 Apr; 76(4):230-6. PMID: 16575882; PMCID: PMC2964004.
    85. Hobbs CA, Malik S, Zhao W, James SJ, Melnyk S, Cleves MA. Maternal homocysteine and congenital heart defects. J Am Coll Cardiol. 2006 Feb 07; 47(3):683-5. PMID: 16458157.
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    86. Charlotte A. Hobbs, Sadia Malik, Weizhi Zhao, S. Jill James, Stepan Melnyk, Mario Cleves. Maternal Homoysteine and Congenital Heart Defects. J Am Coll Cardiol. 2006; 7;47 (3):683-685.
    87. Hobbs CA, James SJ, Jernigan S, Melnyk S, Lu Y, Malik S, Cleves MA. Congenital heart defects, maternal homocysteine, smoking, and the 677 C>T polymorphism in the methylenetetrahydrofolate reductase gene: evaluating gene-environment interactions. Am J Obstet Gynecol. 2006 Jan; 194(1):218-24. PMID: 16389035.
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    88. MELNYK. Maternal Homoysteine and Congenital Heart Defects. J Am Coll Cardiol. 2006; 7;47(3):683-685.
    89. C. Hobbs, S.J. James, S. Jernigan, S. Melnyk, Y. Lu, S. Malik, M. Cleves. Congenital heart defects, maternal homocysteine, smoking, and the 677 C>T plymorphism in the methylenetetrahydrofolate reductase gene: evaluating gene-environment interactions. Am J Obstet Gynecol. 2006; 194(1):218-224.
    90. X. Ke, Q. Lei, S. L. Kelleher, S. Melnyk, S. Jernigan, S.J. James, X. Yu, L. Wang, C.W. Calloway, K.H. Albertine, R.A. McKnight, R.H. Lane. Uteroplacental Insufficiency Affects Epigenetic Determinants of Chromatin Structure in the Brains of Neonatal and Juvenal IUGR Rats. Physiol Genomics. 2006; 25(1):16-28.
    91. Hobbs CA, Cleves MA, Zhao W, Melnyk S, James SJ. Congenital heart defects and maternal biomarkers of oxidative stress. Am J Clin Nutr. 2005 Sep; 82(3):598-604. PMID: 16155273.
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    92. Spiegelstein O, Gould A, Wlodarczyk B, Tsie M, Lu X, Le C, Troen A, Selhub J, Piedrahita JA, Salbaum JM, Kappen C, Melnyk S, James J, Finnell RH. Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies. Toxicol Appl Pharmacol. 2005 Feb 15; 203(1):18-26. PMID: 15694460; PMCID: PMC3938173.
    93. James SJ, Slikker W, Melnyk S, New E, Pogribna M, Jernigan S. Thimerosal neurotoxicity is associated with glutathione depletion: protection with glutathione precursors. Neurotoxicology. 2005 Jan; 26(1):1-8. PMID: 15527868.
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    94. Hobbs CA, Cleves MA, Melnyk S, Zhao W, James SJ. Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism. Am J Clin Nutr. 2005 Jan; 81(1):147-53. PMID: 15640474.
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    95. Spiegelstein O, Lu X, Le XC, Troen A, Selhub J, Melnyk S, James SJ, Finnell RH. Effects of dietary folate intake and folate binding protein-2 (Folbp2) on urinary speciation of sodium arsenate in mice. Environ Toxicol Pharmacol. 2005 Jan; 19(1):1-7. PMID: 21783456.
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    96. MELNYK. Thimerasol Neurotoxicity is Associated with Glutathione Depletion: Protection with Nutrition Supplementation. Neurotoxicology. 2005; 26:1-8.
    97. James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr. 2004 Dec; 80(6):1611-7. PMID: 15585776.
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    98. Schwahn BC, Laryea MD, Chen Z, Melnyk S, Pogribny I, Garrow T, James SJ, Rozen R. Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency. Biochem J. 2004 Sep 15; 382(Pt 3):831-40. PMID: 15217352; PMCID: PMC1133958.
    99. MELNYK. Uteroplacental Insufficiency Alters DNA Methylation, One Carbon Metabolism, and Histone Acetylation in IUGR Rats. Physiol Genomics. 2004; 18:43-50.
    100. MELNYK. Betaine rescue of a animal model with methylenetetrahydrofolate reductase deficiency. Biochem J. 2004; 382(3):831-840.
    101. Spiegelstein O, Lu X, Le XC, Troen A, Selhub J, Melnyk S, James SJ, Finnell RH. Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice. Toxicol Lett. 2003 Nov 30; 145(2):167-74. PMID: 14581169.
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    102. James SJ, Pogribny IP, Pogribna M, Miller BJ, Jernigan S, Melnyk S. Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis. J Nutr. 2003 Nov; 133(11 Suppl 1):3740S-3747S. PMID: 14608108.
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    103. Innis SM, Davidson AG, Chen A, Dyer R, Melnyk S, James SJ. Increased plasma homocysteine and S-adenosylhomocysteine and decreased methionine is associated with altered phosphatidylcholine and phosphatidylethanolamine in cystic fibrosis. J Pediatr. 2003 Sep; 143(3):351-6. PMID: 14517519.
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    104. Winter-Vann AM, Kamen BA, Bergo MO, Young SG, Melnyk S, James SJ, Casey PJ. Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6529-34. PMID: 12750467; PMCID: PMC164480.
    105. Trasler J, Deng L, Melnyk S, Pogribny I, Hiou-Tim F, Sibani S, Oakes C, Li E, James SJ, Rozen R. Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice. Carcinogenesis. 2003 Jan; 24(1):39-45. PMID: 12538347.
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    106. MELNYK. Mechanisms of DNA Damage, DNA Hypomethylation, and Tumor Progression in Folate/Methyl-Deficient Rat Model of Hepatocarcinogenesis. Journal of Nutrition. 2003; 133:3740S-3747S.
    107. MELNYK. Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and methylation in Min mice. Carcinogenesis. 2003; 24:39-45.
    108. MELNYK. Differences in homocysteine-related metaolites in cobalamin-deficient patients with and without neurologic involvement. Blood. 2003; 101:3302-3308.
    109. Carmel R, Melnyk S, James SJ. Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism. Blood. 2003 Apr 15; 101(8):3302-8. PMID: 12515717.
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    110. Finnell RH, Spiegelstein O, Wlodarczyk B, Triplett A, Pogribny IP, Melnyk S, James JS. DNA methylation in Folbp1 knockout mice supplemented with folic acid during gestation. J Nutr. 2002 Aug; 132(8 Suppl):2457S-2461S. PMID: 12163711.
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    111. James SJ, Melnyk S, Pogribna M, Pogribny IP, Caudill MA. Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr. 2002 Aug; 132(8 Suppl):2361S-2366S. PMID: 12163693.
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    112. Halsted CH, Villanueva JA, Devlin AM, Niemelä O, Parkkila S, Garrow TA, Wallock LM, Shigenaga MK, Melnyk S, James SJ. Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):10072-7. PMID: 12122204; PMCID: PMC126626.
    113. Drachtman RA, Cole PD, Golden CB, James SJ, Melnyk S, Aisner J, Kamen BA. Dextromethorphan is effective in the treatment of subacute methotrexate neurotoxicity. Pediatr Hematol Oncol. 2002 Jul-Aug; 19(5):319-27. PMID: 12078863.
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    114. Christopher SA, Melnyk S, James SJ, Kruger WD. S-adenosylhomocysteine, but not homocysteine, is toxic to yeast lacking cystathionine beta-synthase. Mol Genet Metab. 2002 Apr; 75(4):335-43. PMID: 12051965.
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    115. Sibani S, Melnyk S, Pogribny IP, Wang W, Hiou-Tim F, Deng L, Trasler J, James SJ, Rozen R. Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice. Carcinogenesis. 2002 Jan; 23(1):61-5. PMID: 11756224.
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    116. MELNYK. DNA methylation in Folbp1 knockout mice supplemented with folinic acid during gestation. Journal of Nutrition. 2002; 132:2457S-2461S.
    117. MELNYK. Dextromethorphan is effective in the treatment of substance methotrexate neurotoxicity. Pediatr Hematology Oncol. 2002; 19:319-322.
    118. MELNYK. S-adenosylhomocysteine, But NotHomocysteine, Is Toxic To Yeast. Molec Genetcs and Metabolism. 2002; 75:335-343.
    119. MELNYK. Evaluation in S-Adenosylcysteine and DNA Hypomethylation: Potential Epigenetic Mechanism for Homocysteine-Related Pathology. Journal of Nutrition. 2002; 132:2361S-2361S.
    120. MELNYK. Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol fed micropigs. PNAS. 2002; 99:10072-10077.
    121. MELNYK. Studies of Methionine Cycle Intermediates, DNA Methylation and Impact on Folate Deficiency. Carcinogenesis. 2002; 23:61-65.
    122. Melnyk SB. Abnormal Folate Metabolism and Genetic Polymorphism In The Folate Pathway In A Child With Down Syndrome. Am. J. Med. Genet. 2001; 103:128-132.
    123. Melnyk SB. Mice deficient in methylenetetrahydrofolate. Human Molecular Genetics. 2001; 10:433-443.
    124. MELNYK. Homocysteine Methabolism in Children With Down Syndrome. Am J Human Genetics. 2001; 69:88-95.
    125. MELNYK. Intracellular S-adenosylhomocysteine Concentration predict Global DNA Hypomethylation. Journal of Nutrition. 2001; 131:2811-2818.
    126. Melnyk SB. Lack of Embryotoxicity of Homocysteine. Reproductive Toxicology. 2001; 15:239-244.
    127. Melnyk SB. Measurement of Plasma and Intracellular S-Andenosylmethionine. Clinical Chemistry. 2000; 46:265-272.
    128. Melnyk SB. Increase in Plasma homocysteine. Journal Biol. Chem. 2000; 275:29318-29323.
    129. Melnyk SB. Abnormal Folate Metabolism and Mutation in Methylenetetrahydrofolate. American Journal of Clinical Nutrition. 1999; 70:495-501.
    130. Melnyk SB. Uracil Misincorporation, DNA strand Breaks. Cancer Letters. 1999; 142:1-10.
    131. Melnyk SB. A New HPLC Method for Simultaneous Detrmination of Oxidized and Reduced Plasma Aminothiols Using Coulometeric Electrochemical Detection. Journal of Nutritional Biochemistry. 1999; 10:490-497.
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