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Michael Jennings

TitleDepartment Chairperson
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPhysiology & Biophysics, College of Medicine
Address209-2 Biomedical Research II
200 South Cedar
Mail Slot # 505
Little Rock AR 72202
Phone501-296-1438
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    R21EY021646     (JENNINGS, MICHAEL L)Dec 1, 2011 - Nov 30, 2014
    NIH/NEI
    Functional role of transporter Slc4a11 (BTR1/NaBC1) in the cornea
    Role: Principal Investigator
    R01HL037479     (JENNINGS, MICHAEL L)Sep 30, 1986 - Jul 31, 1996
    NIH/NHLBI
    ERYTHROCYTE POTASSIUM TRANSPORT AND VOLUME REGULATION
    Role: Principal Investigator
    K04AM001137     (JENNINGS, MICHAEL L)Jul 1, 1983 - Jun 30, 1988
    NIH/NIADDK
    STRUCTURE AND FUNCTION OF ERYTHROCYTE TRANSPORT PROTEINS
    Role: Principal Investigator
    K04DK001137     (JENNINGS, MICHAEL L)Jul 1, 1983 - Jun 30, 1988
    NIH/NIDDK
    STRUCTURE AND FUNCTION OF ERYTHROCYTE TRANSPORT PROTEINS
    Role: Principal Investigator
    R01GM026861     (JENNINGS, MICHAEL L)Jul 1, 1979 - Feb 29, 2008
    NIH/NIGMS
    MECHANISMS OF SULFATE TRANSPORT AND REGULATION
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Jennings ML. Carriers, exchangers, and cotransporters in the first 100 years of the Journal of General Physiology. J Gen Physiol. 2018 08 06; 150(8):1063-1080. PMID: 30030301.
      View in: PubMed
    2. Wang L, Fang B, Fujiwara T, Krager K, Gorantla A, Li C, Feng JQ, Jennings ML, Zhou J, Aykin-Burns N, Zhao H. Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesis in vitro and in vivo. J Biol Chem. 2018 06 15; 293(24):9248-9264. PMID: 29724825.
      View in: PubMed
    3. Ficici E, Faraldo-Gómez JD, Jennings ML, Forrest LR. Asymmetry of inverted-topology repeats in the AE1 anion exchanger suggests an elevator-like mechanism. J Gen Physiol. 2017 Dec 04; 149(12):1149-1164. PMID: 29167180.
      View in: PubMed
    4. Myers EJ, Marshall A, Jennings ML, Parker MD. Mouse Slc4a11 expressed in Xenopus oocytes is an ideally selective H+/OH- conductance pathway that is stimulated by rises in intracellular and extracellular pH. Am J Physiol Cell Physiol. 2016 Dec 01; 311(6):C945-C959. PMID: 27681179.
      View in: PubMed
    5. Jennings ML. Transport of H2S and HS(-) across the human red blood cell membrane: rapid H2S diffusion and AE1-mediated Cl(-)/HS(-) exchange. Am J Physiol Cell Physiol. 2013 Nov 01; 305(9):C941-50. PMID: 23864610.
      View in: PubMed
    6. Chernova MN, Stewart AK, Barry PN, Jennings ML, Alper SL. Mouse AE1 mutant E699Q mediates SO42-i/anion exchange with reversed pHo sensitivity modulated by [SO42-]o. Am J Physiol Cell Physiol. 2008; 295(2):C302-C312.
    7. Chernova MN, Stewart AK, Barry PN, Jennings ML, Alper SL. Mouse Ae1 E699Q mediates SO42-i/anion-o exchange with [SO42-]i-dependent reversal of wild-type pHo sensitivity. Am J Physiol Cell Physiol. 2008 Aug; 295(2):C302-12. PMID: 18480299.
      View in: PubMed
    8. Jennings ML, Cui J. Chloride homeostasis in Saccharomyces cerevisiae: high affinity influx, V-ATPase-dependent sequestration, and identification of a candidate Cl- sensor. J Gen Physiol. 2008 Apr; 131(4):379-91. PMID: 18378800.
      View in: PubMed
    9. Jennings ML, Howren TR, Cui J, Winters M, Hannigan R. Transport and regulatory characteristics of the yeast bicarbonate transporter homolog Bor1p. Am J Physiol Cell Physiol. 2007 Jul; 293(1):C468-76. PMID: 17459946.
      View in: PubMed
    10. Jennings ML. Evidence for a second binding/transport site for chloride in erythrocyte anion transporter AE1 modified at glutamate 681. Biophys J. 2005 Apr; 88(4):2681-91. PMID: 15653731.
      View in: PubMed
    11. Jennings ML. Structure of Biological Membranes. The inorganic anion exchanger AE1. 2004.
    12. Mardach R, Zempleni J, Wolf B, Cannon MJ, Jennings ML, Cress S, Boylan J, Roth S, Cederbaum S, Mock DM. Biotin dependency due to a defect in biotin transport. J Clin Invest. 2002 Jun; 109(12):1617-23. PMID: 12070309.
      View in: PubMed
    13. Kuma H, Shinde AA, Howren TR, Jennings ML. Topology of the anion exchange protein AE1: the controversial sidedness of lysine 743. Biochemistry. 2002 Mar 12; 41(10):3380-8. PMID: 11876646.
      View in: PubMed
    14. Deen PM, Van Balkom BW, Savelkoul PJ, Kamsteeg EJ, Van Raak M, Jennings ML, Muth TR, Rajendran V, Caplan MJ. Aquaporin-2: COOH terminus is necessary but not sufficient for routing to the apical membrane. Am J Physiol Renal Physiol. 2002 Feb; 282(2):F330-40. PMID: 11788448.
      View in: PubMed
    15. Jennings ML, Adame MF. Direct estimate of 1:1 stoichiometry of K(+)-Cl(-) cotransport in rabbit erythrocytes. Am J Physiol Cell Physiol. 2001 Sep; 281(3):C825-32. PMID: 11502559.
      View in: PubMed
    16. Jennings ML, Adame MF. Direct estimate of 1:1 stoichiometry of the erythrocyte K+-Cl- cotransporter. Am J Physiol Cell Physiol. 2001; 281:C825 - C832.
    17. Jennings ML. Volume-sensitive K(+)/Cl(-) cotransport in rabbit erythrocytes. Analysis of the rate-limiting activation and inactivation events. J Gen Physiol. 1999 Dec; 114(6):743-58. PMID: 10578012.
      View in: PubMed
    18. Kloth S, Gmeiner T, Aigner J, Jennings ML, Rockl W, Minuth WW. Transitional stages in the development of the rabbit renal collecting duct. Differentiation. 1998; 63:21-32.
    19. Jennings ML, Whitlock J, Shinde A. Pre-steady state transport by erythrocyte band 3 protein: uphill countertransport induced by the impermeant inhibitor H2DIDS. Biochem Cell Biol. 1998; 76(5):807-13. PMID: 10353715.
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    20. Jennings ML. International Symposium on Membrane Proteins. Regulation of erythrocyte potassium transport and cell volume by protein phosphorylation. 1997.
    21. Minuth WW, Aigner J, Kloth S, Steiner P, Tauc M, Jennings ML. Culture of embryonic renal collecting duct epithelia in a gradient container. Pediatr Nephrol. 1997; 11:140-147.
    22. Jennings ML, Milanick MA. Handbook of Physiology. Membrane transport in single cells. 1997.
    23. Schuster VL, Lu R, Kanai N, Bao Y, Rosenberg S, Prié D, Ronco P, Jennings ML. Cloning of the rabbit homologue of mouse 'basigin' and rat 'OX-47': kidney cell type-specific expression, and regulation in collecting duct cells. Biochim Biophys Acta. 1996 Mar 27; 1311(1):13-9. PMID: 8603097.
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    24. Namboodiripad AN, Jennings ML. Permeability characteristics of erythrocyte membrane to okadaic acid and calyculin A. Am J Physiol. 1996 Feb; 270(2 Pt 1):C449-56. PMID: 8779906.
      View in: PubMed
    25. Jennings ML, Adame MF. Characterization of oxalate transport by the human erythrocyte band 3 protein. J Gen Physiol. 1996 Jan; 107(1):145-59. PMID: 8741736.
      View in: PubMed
    26. Godinich MJ, Jennings ML. Renal chloride-bicarbonate exchangers. Curr Opin Nephrol Hypertens. 1995 Sep; 4(5):398-401. PMID: 8564441.
      View in: PubMed
    27. Jennings ML, Gosselink PG. Anion exchange protein in Southeast Asian ovalocytes: heterodimer formation between normal and variant subunits. Biochemistry. 1995 Mar 21; 34(11):3588-95. PMID: 7893655.
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    28. Jennings ML. Rapid electrogenic sulfate-chloride exchange mediated by chemically modified band 3 in human erythrocytes. J Gen Physiol. 1995 Jan; 105(1):21-47. PMID: 7537324.
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    29. Godinich MJ, Jennings ML. Molecular Biology of the Kidney in Health and Disease. Anion Exchangers. 1995.
    30. Godinich MJ, Jennings ML. Renal chloride-bicarbonate exchangers. Curr Opin Nephrol Hypertens. 1995; 21:398-401.
    31. Jennings ML, Gosselink PG. Anion exchange in Southeast Asian ovalocytes: Heterodimer formation between normal and variant subunits. Biochemistry. 1995; 34(11):3588 - 3595.
    32. Aigner J, Kloth S, Jennings ML, Minuth WW. Transitional differentiation patterns of principal and intercalated cells during renal collecting duct development. Epithelial Cell Biol. 1995; 4:121-130.
    33. Okubo K, Kang D, Hamasaki N, Jennings ML. Red blood cell band 3. Lysine 539 and lysine 851 react with the same H2DIDS (4,4'-diisothiocyanodihydrostilbene-2,2'-disulfonic acid) molecule. J Biol Chem. 1994 Jan 21; 269(3):1918-26. PMID: 8294441.
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    34. Okubo K, Kang D, Hamasaki N, Jennings ML. Red blood cell band 3: lysine-539 and lysine 851 react with the same 4,4'-diisothiocyanodihydrostilbene-2,2'-disulfonate molecule. J Biol Chem. 1994; 269:1918 - 1926.
    35. Starke LC, Jennings ML. K-Cl cotransport in rabbit red cells: further evidence for regulation by protein phosphatase type 1. Am J Physiol. 1993 Jan; 264(1 Pt 1):C118-24. PMID: 8381587.
      View in: PubMed
    36. Jennings ML, Smith JS. Anion-proton cotransport through the human red blood cell band 3 protein. Role of glutamate 681. J Biol Chem. 1992 Jul 15; 267(20):13964-71. PMID: 1352774.
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    37. Jennings ML. The Kidney. Anion transport proteins. 1992.
    38. Jennings ML. The Band 3 Proteins: Anion Transporters, Binding Proteins, and Senescent Antigens. Chemical labeling of a glutamate residue involved in proton-sulfate cotransport catalyzed by band 3. 1992.
    39. Reuss L, Russell JM, Jennings ML, (Editors). Molecular Biology and Function of Carrier Proteins. Society of General Physiologists 46th Annual Symposium. Rockefeller University Press. 1992.
    40. Jennings ML. The Kidney. Cellular Anion Transport. 1992.
    41. Jennings ML, Schulz RK. Okadaic acid inhibition of KCl cotransport. Evidence that protein dephosphorylation is necessary for activation of transport by either cell swelling or N-ethylmaleimide. J Gen Physiol. 1991 Apr; 97(4):799-817. PMID: 1647439.
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    42. Ostedgaard LS, Jennings ML, Karniski LP, Schuster VL. A 45-kDa protein antigenically related to band 3 is selectively expressed in kidney mitochondria. Proc Natl Acad Sci U S A. 1991 Feb 01; 88(3):981-5. PMID: 1704136.
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    43. Jennings ML, Schulz RK. Swelling-activated KCl cotransport in rabbit red cells: flux is determined mainly by cell volume rather than shape. Am J Physiol. 1990 Dec; 259(6 Pt 1):C960-7. PMID: 2260643.
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    44. Jennings ML, Schulz RK, Allen M. Effects of membrane potential on electrically silent transport. Potential-independent translocation and asymmetric potential-dependent substrate binding to the red blood cell anion exchange protein. J Gen Physiol. 1990 Nov; 96(5):991-1012. PMID: 2280255.
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    45. Jennings ML, al-Rohil N. Kinetics of activation and inactivation of swelling-stimulated K+/Cl- transport. The volume-sensitive parameter is the rate constant for inactivation. J Gen Physiol. 1990 Jun; 95(6):1021-40. PMID: 2373997.
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    46. Jennings ML. The Red Cell: A Model for Transport. The anion exchange protein. 1990.
    47. Jennings ML, Al-Rohil N. Kinetics of activation and inactivation of swelling-stimulated K+/Cl- cotransport. Volume-sensitive parameter is the rate constant for inactivation. J Gen Physiol. 1990; 95:1021 - 1040.
    48. Jennings ML, Schulz RK, Allen M. Effects of membrane potential on electrically silent transport. J Gen Physiol. 1990; 96:991 - 1012.
    49. al-Rohil N, Jennings ML. Volume-dependent K+ transport in rabbit red blood cells comparison with oxygenated human SS cells. Am J Physiol. 1989 Jul; 257(1 Pt 1):C114-21. PMID: 2750884.
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    50. Karniski LP, Jennings ML. Identification and partial purification of a band 3-like protein from rabbit renal brush border membranes. J Biol Chem. 1989 Mar 15; 264(8):4564-70. PMID: 2466837.
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    51. Jennings ML. Anion Transport Protein of the Red Cell Membrane. Evidence for an access channel leading to the outward facing substrate site in human red blood cell band 3. 1989.
    52. Jennings ML. Topography of membrane proteins. Annu Rev Biochem. 1989; 58:999 - 1027.
    53. Jennings ML. Characteristics of the binding site for extracellular anions in human red blood cell band 3. Ann N Y Acad Sci. 1989; 574:84 - 95.
    54. Jennings ML. Characteristics of the binding site for extracellular substrate anions in human red blood cell band 3. Ann N Y Acad Sci. 1989; 574:84-95. PMID: 2634359.
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    55. Jennings ML. Structure and function of the red blood cell anion transport protein. Annu Rev Biophys Biophys Chem. 1989; 18:397-430. PMID: 2660831.
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    56. Jennings ML. Structure and function of the red blood cell anion exchange protein. Prog Clin Biol Res. 1989; 292:327-38. PMID: 2657769.
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    57. Hamasaki N, Jennings ML, (Editors). Anion Transport Protein of the Red Blood Cell Membrane. Elsevier. 1989.
    58. Swanson ML, Keast RK, Jennings ML, Pessin JE. Heterogeneity in the human erythrocyte band 3 anion-transporter revealed by Triton X-114 phase partitioning. Biochem J. 1988 Oct 01; 255(1):229-34. PMID: 3196316.
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    59. Jennings ML, Al-Rhaiyel S. Modification of a carboxyl group that appears to cross the permeability barrier in the red blood cell anion transporter. J Gen Physiol. 1988 Aug; 92(2):161-78. PMID: 3171537.
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    60. Jennings ML, Anderson MP, McCormick SJ. Functional roles of carboxyl groups in human red blood cell anion exchange. Soc Gen Physiol Ser. 1988; 43:163-80. PMID: 3077543.
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    61. Swanson ML, Keast RK, Jennings M.L, Pessin JE. Heterogeneity in the human erythrocyte band 3 anion-transporter revealed by Triton X-114 partitioning. Biochem J. 1988; 255:229-234.
    62. Jennings ML, Anderson MP. Chemical modification and labeling of glutamate residues at the stilbenedisulfonate site of human red blood cell band 3 protein. J Biol Chem. 1987 Feb 05; 262(4):1691-7. PMID: 2879841.
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    63. Jennings ML, Anderson MP. Chemical modification of glutamate residues at the stilbenedisulfonate site of human red blood cell band 3 protein. J Biol Chem. 1987; 262:1691 - 1697.
    64. Schuster VL, Bonsib SM, Jennings ML. Two types of collecting duct mitochondria-rich (intercalated) cells: lectin and band 3 cytochemistry. Am J Physiol. 1986 Sep; 251(3 Pt 1):C347-55. PMID: 3529979.
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    65. Jennings ML, Anderson MP, Monaghan R. Monoclonal antibodies against human erythrocyte band 3 protein. Localization of proteolytic cleavage sites and stilbenedisulfonate-binding lysine residues. J Biol Chem. 1986 Jul 05; 261(19):9002-10. PMID: 3087983.
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    66. Jennings ML, Douglas SM, McAndrew PE. Amiloride-sensitive sodium-hydrogen exchange in osmotically shrunken rabbit red blood cells. Am J Physiol. 1986 Jul; 251(1 Pt 1):C32-40. PMID: 2425629.
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    67. Donovan JA, Jennings ML. N-hydroxysulfosuccinimido active esters and the L-(+)-lactate transport protein in rabbit erythrocytes. Biochemistry. 1986 Apr 08; 25(7):1538-45. PMID: 3707891.
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    68. Jennings ML, Douglas SM, McAndrew PE. Amiloride-sensitive sodium-hydrogen exchange in osmotically shrunken rebbit red blood cells. Am. J. Physiol. Cell Physiol. 1986; 251:C32-C40.
    69. Jennings ML, Monaghan R, Douglas SM, Nicknish JS. Functions of extracellular lysine residues in the human erythrocyte anion transport protein. J Gen Physiol. 1985 Nov; 86(5):653-69. PMID: 3934327.
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    70. Jennings ML, Adams-Lackey M, Cook KW. Absence of significant sodium-hydrogen exchange by rabbit erythrocyte sodium-lithium countertransporter. Am J Physiol. 1985 Jul; 249(1 Pt 1):C63-8. PMID: 4014452.
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    71. Jennings ML, Nicknish JS. Localization of a site of intermolecular cross-linking in human red blood cell band 3 protein. J Biol Chem. 1985 May 10; 260(9):5472-9. PMID: 3988763.
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    72. Donovan JA, Jennings ML. Membrane polypeptide in rabbit erythrocytes associated with the inhibition of L-lactate transport by a synthetic anhydride of lactic acid. Biochemistry. 1985 Jan 29; 24(3):561-4. PMID: 2986679.
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    73. Jennings ML. Kinetics and mechanism of anion transport in red blood cells. Annu Rev Physiol. 1985; 47:519-33. PMID: 3922288.
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    74. Jennings ML, Nicknish JS. Erythrocyte band 3 protein: evidence for multiple membrane-crossing segments in the 17 000-dalton chymotryptic fragment. Biochemistry. 1984 Dec 18; 23(26):6432-6. PMID: 6529560.
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    75. Jennings ML, Adams-Lackey M, Denney GH. Peptides of human erythrocyte band 3 protein produced by extracellular papain cleavage. J Biol Chem. 1984 Apr 10; 259(7):4652-60. PMID: 6707024.
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    76. Jennings ML. Oligomeric structure and the anion transport function of human erythrocyte band 3 protein. J Membr Biol. 1984; 80(2):105-17. PMID: 6090668.
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    77. Jennings ML, Adams-Lackey M. A rabbit erythrocyte membrane protein associated with L-lactate transport. J Biol Chem. 1982 Nov 10; 257(21):12866-71. PMID: 7130184.
      View in: PubMed
    78. Jennings ML. Reductive methylation of the two 4,4'-diisothiocyanodihydrostilbene-2,2'-disulfonate-binding lysine residues of band 3, the human erythrocyte anion transport protein. J Biol Chem. 1982 Jul 10; 257(13):7554-9. PMID: 6806279.
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    79. Jennings ML. Stoichiometry of a half-turnover of band 3, the chloride transport protein of human erythrocytes. J Gen Physiol. 1982 Feb; 79(2):169-85. PMID: 6276495.
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    80. Passow H, Kampmann L, Fasold H, Jennings ML, Lepke S. Chloride Transport in Biological Membranes. The study of the anion transport protein (band 3 protein) in the red cell membrane by means of tritiated 4,4' diisothiocyano dihydrostilbene 2,2' disulfonic acid (3H2DIDS). 1982.
    81. Jennings ML, Adams MF. Modification by papain of the structure and function of band 3, the erythrocyte anion transport protein. Biochemistry. 1981 Dec 08; 20(25):7118-23. PMID: 7317371.
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    82. Jennings ML. Membrane Transport in Erythrocytes. Alfred Benzon Symposium 14. Apparent "recruitment" of sulfate transport sites by the chloride gradient across the human erythrocyte membrane. 1980.
    83. Jennings ML, Passow H. Anion transport across the erythrocyte membrane, in situ proteolysis of band 3 protein, and cross-linking of proteolytic fragments by 4,4'-diisothiocyano dihydrostilbene-2,2'-disulfonate. Biochim Biophys Acta. 1979 Jul 05; 554(2):498-519. PMID: 486455.
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    84. Ku CP, Jennings ML, Passow H. A comparison of the inhibitory potency of reversibly acting inhibitors of anion transport on chloride and sulfate movements across the human red cell membrane. Biochim Biophys Acta. 1979 May 03; 553(1):132-41. PMID: 454583.
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    85. Ku C, Jennings ML, Passow H. A comparison of the inhibitory potency of reversibly action inhibitors of anion transport on chloride and sulfate movements across the human red cell membrane. Biochim Biophys Acta. 1979; 553:132 - 141.
    86. Jennings ML. Characteristics of CO2-independent pH equilibration in human red blood cells. J Membr Biol. 1978 Jun 09; 40(4):365-91. PMID: 671517.
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    87. Jennings ML. Proton fluxes associated with erythrocyte membrane anion exchange. J Membr Biol. 1976 Aug 26; 28(2-3):187-205. PMID: 9514.
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    88. Jennings ML, Solomon AK. Interaction between phloretin and the red blood cell membrane. J Gen Physiol. 1976 Apr; 67(4):381-97. PMID: 5575.
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