Last Name

Stewart Macleod

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentUAMS Human Resources, College of UAMS Finance & Administration
DivisionHR Classification & Compensation
Address100 ACH Research Institute
4301 W Markham St.
Mail Slot # 512-40
Little Rock AR 72205
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    Other Positions
    TitleAssistant Professor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentGenetics, College of Medicine

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Nembhard WN, Tang X, Hu Z, MacLeod S, Stowe Z, Webber D. Maternal and infant genetic variants, maternal periconceptional use of selective serotonin reuptake inhibitors, and risk of congenital heart defects in offspring: population based study. BMJ. 2017 Mar 06; 356:j832. PMID: 28264803.
      View in: PubMed
    2. Li M, Li J, He Z, Lu Q, Witte JS, Macleod SL, Hobbs CA, Cleves MA. Testing Allele Transmission of an SNP Set Using a Family-Based Generalized Genetic Random Field Method. Genet Epidemiol. 2016 May; 40(4):341-51. PMID: 27061818.
      View in: PubMed
    3. Li M, Li J, Wei C, Lu Q, Tang X, Erickson SW, MacLeod SL, Hobbs CA. A Three-Way Interaction among Maternal and Fetal Variants Contributing to Congenital Heart Defects. Ann Hum Genet. 2016 Jan; 80(1):20-31. PMID: 26612412; PMCID: PMC4839294 [Available on 01/01/17].
    4. Brown AR, Simmen RC, Raj VR, Van TT, MacLeod SL, Simmen FA. Kr├╝ppel-like factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling. Carcinogenesis. 2015 Sep; 36(9):946-55. PMID: 26210742; PMCID: PMC4573661.
    5. Tang X, Hobbs CA, Cleves MA, Erickson SW, MacLeod SL, Malik S. Genetic variation affects congenital heart defect susceptibility in offspring exposed to maternal tobacco use. Birth Defects Res A Clin Mol Teratol. 2015 Oct; 103(10):834-42. PMID: 26033827; PMCID: PMC4774247 [Available on 10/01/16].
    6. Webber DM, MacLeod SL, Bamshad MJ, Shaw GM, Finnell RH, Shete SS, Witte JS, Erickson SW, Murphy LD, Hobbs C. Developments in our understanding of the genetic basis of birth defects. Birth Defects Res A Clin Mol Teratol. 2015 Aug; 103(8):680-91. PMID: 26033863; PMCID: PMC4537658.
    7. Tang X, Cleves MA, Nick TG, Li M, MacLeod SL, Erickson SW, Li J, Shaw GM, Mosley BS, Hobbs CA. Obstructive heart defects associated with candidate genes, maternal obesity, and folic acid supplementation. Am J Med Genet A. 2015 Jun; 167(6):1231-42. PMID: 25846410; PMCID: PMC4675451.
    8. Tang X, Nick TG, Cleves MA, Erickson SW, Li M, Li J, MacLeod SL, Hobbs CA. Maternal obesity and tobacco use modify the impact of genetic variants on the occurrence of conotruncal heart defects. PLoS One. 2014; 9(9):e108903. PMID: 25275547; PMCID: PMC4183535.
    9. Li M, Cleves MA, Mallick H, Erickson SW, Tang X, Nick TG, Macleod SL, Hobbs CA. A genetic association study detects haplotypes associated with obstructive heart defects. Hum Genet. 2014 Sep; 133(9):1127-38. PMID: 24894164; PMCID: PMC4313870.
    10. Hobbs CA, Chowdhury S, Cleves MA, Erickson S, MacLeod SL, Shaw GM, Shete S, Witte JS, Tycko B. Genetic epidemiology and nonsyndromic structural birth defects: from candidate genes to epigenetics. JAMA Pediatr. 2014 Apr; 168(4):371-7. PMID: 24515445; PMCID: PMC3981910.
    11. Li M, Erickson SW, Hobbs CA, Li J, Tang X, Nick TG, Macleod SL, Cleves MA. Detecting maternal-fetal genotype interactions associated with conotruncal heart defects: a haplotype-based analysis with penalized logistic regression. Genet Epidemiol. 2014 Apr; 38(3):198-208. PMID: 24585533; PMCID: PMC4043210.
    12. Hobbs CA, Cleves MA, Macleod SL, Erickson SW, Tang X, Li J, Li M, Nick T, Malik S. Conotruncal heart defects and common variants in maternal and fetal genes in folate, homocysteine, and transsulfuration pathways. Birth Defects Res A Clin Mol Teratol. 2014 Feb; 100(2):116-26. PMID: 24535845; PMCID: PMC4118819.
    13. Knecht KR, MacLeod SL, Hobbs CA, Li M, Morrow WR. Gene expression profiling in pediatric heart transplant rejection. Int J Cardiol. 2013 Oct 12; 168(5):5052-3. PMID: 23972362.
      View in: PubMed
    14. Chowdhury S, Hobbs CA, MacLeod SL, Cleves MA, Melnyk S, James SJ, Hu P, Erickson SW. Associations between maternal genotypes and metabolites implicated in congenital heart defects. Mol Genet Metab. 2012 Nov; 107(3):596-604. PMID: 23059056; PMCID: PMC3523122.
    15. Erickson SW, MacLeod SL, Hobbs CA. Cheek swabs, SNP chips, and CNVs: assessing the quality of copy number variant calls generated with subject-collected mail-in buccal brush DNA samples on a high-density genotyping microarray. BMC Med Genet. 2012 Jun 26; 13:51. PMID: 22734463; PMCID: PMC3506514.
    16. Hobbs CA, MacLeod SL, Jill James S, Cleves MA. Congenital heart defects and maternal genetic, metabolic, and lifestyle factors. Birth Defects Res A Clin Mol Teratol. 2011 Apr; 91(4):195-203. PMID: 21384532.
      View in: PubMed
    17. Cleves MA, Hobbs CA, Zhao W, Krakowiak PA, MacLeod SL. National Birth Defects Prevention Study. Association between selected folate pathway polymorphisms and nonsyndromic limb reduction defects: a case-parental analysis. Paediatric and Perinatal Epidemiology. 2011; 25:124-134.
    18. Chowdhury S, Erickson SW, MacLeod SL, Cleves MA, Hu P, Karim MA, Hobbs CA. Maternal genome-wide DNA methylation patterns and congenital heart defects. PLoS One. 2011 Jan 24; 6(1):e16506. PMID: 21297937; PMCID: PMC3031146.
    19. Chowdhury S, Cleves MA, MacLeod SL, James SJ, Zhao W, Hobbs CA. Maternal DNA hypomethylation and congenital heart defects. Birth Defects Res A Clin Mol Teratol. 2011 Feb; 91(2):69-76. PMID: 21254366; PMCID: PMC3168545.
    20. Cleves MA, Hobbs CA, Zhao W, Krakowiak PA, MacLeod SL. Association between selected folate pathway polymorphisms and nonsyndromic limb reduction defects: a case-parental analysis. Paediatr Perinat Epidemiol. 2011 Mar; 25(2):124-34. PMID: 21281325; PMCID: PMC3050483.
    21. Hakkak R, Shaaf S, Jo CH, Macleod S, Korourian S. Effects of high-isoflavone soy diet vs. casein protein diet and obesity on DMBA-induced mammary tumor development. Oncol Lett. 2011 Jan; 2(1):29-36. PMID: 22870124.
      View in: PubMed
    22. Hobbs CA, Cleves MA, Karim MA, Zhao W, MacLeod SL. Maternal folate-related gene environment interactions and congenital heart defects. Obstet Gynecol. 2010 Aug; 116(2 Pt 1):316-22. PMID: 20664391; PMCID: PMC3027124.
    23. Hakkak R, Shaaf S, Jo CH, MacLeod S, Korourian S. Dehydroepiandrosterone intake protects against 7,12-dimethylbenz(a)anthracene-induced mammary tumor development in the obese Zucker rat model. Oncol Rep. 2010 Aug; 24(2):357-62. PMID: 20596621.
      View in: PubMed
    24. Chowdhury S, Cleves MA, MacLeod SL, Erickson SW, Zhao W, Hu P, Hobbs CA. Alterations in Gene-Specific Methylation and Congenital Heart Defects. Folic Acid, Vitamin B12, and One Carbon Metabolism Meeting. 2010.
    25. Chowdhury S, Cleves MA, MacLeod SL, Zhao W, Hobbs CA. Maternal DNA Hypomethylation, Methionine Pathway Metabolites, Lifestyle Factors and CHDs. Teratology Society 50th Annual Meeting. 2010.
    26. Chowdhury S, MacLeod SL, Cleves MA, Hobbs CA. Maternal DNA Hypomethylation as a Risk Factor for Congenital Heart Defects. American Society of Human Genetics 59th Annual Meeting. 2009.
    27. Chowdhury S, Cleves MA, MacLeod SL, Erickson S, Hobbs CA. Methods to Investigate Maternal Gene-Specific Methylation in Congenital Heart Defects. Arkansas Biosciences Institute Fall Research Symposium. 2009.
    28. Chowdhury S, MacLeod SL, Cleves MA, Hobbs CA. Maternal Alu and LINE-1 Hypomethylation Association with Congenital Heart Defects. UAMS Research Week. 2009.
    29. Ross CC, MacLeod SL, Plaxco JR, Froude JW, Fink LM, Wang J, Stites WE, Hauer-Jensen M. Inactivation of thrombomodulin by ionizing radiation in a cell-free system: possible implications for radiation responses in vascular endothelium. Radiat Res. 2008 Apr; 169(4):408-16. PMID: 18363428; PMCID: PMC2568889.
    30. Chowdhury S, Cleves MA, Karim M, Randolph CE, MacLeod SL, Zhao W, Hobbs CA. Risk of Congenital Limb Defects and Polymorphisms in Folate Pathway Genes. Arkansas Biosciences Institute Fall Research Symposium. 2008.
    31. Ali N, Macleod SL, Hine J, Chowdhury P. Apoptosis in Carcinogenesis and Chemotherapy. Cellular Signaling Mechanisms in Pancreatic Apoptosis. 2008.
    32. Hakkak R, MacLeod S, Shaaf S, Holley AW, Simpson P, Fuchs G, Jo CH, Kieber-Emmons T, Korourian S. Obesity increases the incidence of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in an ovariectomized Zucker rat model. Int J Oncol. 2007 Mar; 30(3):557-63. PMID: 17273756.
      View in: PubMed
    33. Cleves MA, Karim M, MacLeod SL, Chowdhury S, Hobbs CA. Congenital Heart Defects, Maternal Genetic Susceptibility and Pro-oxidant Lifestyle Factors. International Genetic Epidemiology Society. 2007.
    34. MacLeod SL, Karim M, Randolph CE, Chowdhury S, Cleves MA, Hobbs CA. Smoking, Maternal Genetic Susceptibility and Congenital Heart Defects. International Society for the Prevention of Tobacco Induced Diseases. 2007.
    35. MacLeod SL, Chowdhury P. The genetics of nicotine dependence: relationship to pancreatic cancer. World J Gastroenterol. 2006 Dec 14; 12(46):7433-9. PMID: 17167830; PMCID: PMC4087587.
    36. Pashov A, Canziani G, Monzavi-Karbassi B, Kaveri SV, Macleod S, Saha R, Perry M, Vancott TC, Kieber-Emmons T. Antigenic properties of peptide mimotopes of HIV-1-associated carbohydrate antigens. J Biol Chem. 2005 Aug 12; 280(32):28959-65. PMID: 15955803.
      View in: PubMed
    37. Hakkak R, Holley AW, Macleod SL, Simpson PM, Fuchs GJ, Jo CH, Kieber-Emmons T, Korourian S. Obesity promotes 7,12-dimethylbenz(a)anthracene-induced mammary tumor development in female zucker rats. Breast Cancer Res. 2005; 7(5):R627-33. PMID: 16168107; PMCID: PMC1242129.
    38. Nowell SA, Ahn J, Rae JM, Scheys JO, Trovato A, Sweeney C, MacLeod SL, Kadlubar FF, Ambrosone CB. Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients. Breast Cancer Res Treat. 2005 Jun; 91(3):249-58. PMID: 15952058.
      View in: PubMed
    39. Pashov A, MacLeod S, Saha R, Perry M, VanCott TC, Kieber-Emmons T. Concanavalin A binding to HIV envelope protein is less sensitive to mutations in glycosylation sites than monoclonal antibody 2G12. Glycobiology. 2005 Oct; 15(10):994-1001. PMID: 15917430.
      View in: PubMed
    40. Pashov A, Canziani G, Macleod S, Plaxco J, Monzavi-Karbassi B, Kieber-Emmons T. Targeting carbohydrate antigens in HIV vaccine development. Vaccine. 2005 Mar 18; 23(17-18):2168-75. PMID: 15755589.
      View in: PubMed
    41. Hakkak R, Holley AW, Macleod SL, Simpson P, Korourian S. Obesity Promotes DMBA-Induced Mammary Tumor Development in Female Zucker Rats. 2005; A774.
    42. Macleod SL, Stanley SJ, Karbassi B, Plaxco J, Suva L, Kieber-Emmons T. Epigenetic regulation of GlcNac 2-epimerase alters cell surface sialylation of MDA-MB-231 cells. 2005; 2785.
    43. Hakkak R, Holley AW, Bunn RC, Winters A, Macleod SL. Effects of obesity on serum Insulin Growth Factor 1 (IGF-1) levels in lean and obese female Zucker rats following DMBA treatment. 2005; A993.
    44. Nowell S, Coles B, Sinha R, MacLeod S, Luke Ratnasinghe D, Stotts C, Kadlubar FF, Ambrosone CB, Lang NP. Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk. Mutat Res. 2002 Sep 30; 506-507:175-85. PMID: 12351157.
      View in: PubMed
    45. Chowdhury P, MacLeod S, Udupa KB, Rayford PL. Pathophysiological effects of nicotine on the pancreas: an update. Exp Biol Med (Maywood). 2002 Jul; 227(7):445-54. PMID: 12094008.
      View in: PubMed
    46. MacLeod SL, Plaxco JR, Lang NP. The GSTM1 null genotype and consumption of meat cooked very well done influence colorectal cancer risk. 2002; 796.
    47. MacLeod SL, Plaxco JR, Shinde A, Lang NP. The e-cadherin promoter polymorphism in prostate cancer: Association with Gleason's score. 2001; 796.
    48. Hanna E, MacLeod SL, Vural E, Lang N. Gentetic deletions of glutathione-S-transferase as risk factors in squamous cell carcinoma of the larynx: a preliminary report. American Journal of Otolaryngology. 2001; 22:121-123.
    49. Coles B, Nowell SA, MacLeod SL, Sweeney C, Lang NP, Kadlubar FF. The role of human glutathione S-transferases (hGSTs) in the detoxification of the food-derived carcinogen metabolite N-acetoxy-PhIP, and teh effect of a polymorphism in hGSTA1 on colorectal cancer risk. Mutation Research. 2001; 482:3-10.
    50. MacLeod SL, Nowell SA, Lang NP. Heterocyclic Amines. Genetic Polymorphisms in Food Borne Carcinogens. 2000.
    51. MacLeod SL, Nowell S, Plaxco J, Lang NP. An allele-specific polymerase chain reaction method for the determination of the D85Y polymorphism in the human UDP-glucoronosyltransferase 2B15 gene in a case-control study of prostate cancer. Annals of Surgical Oncology. 2000; 7:777-782.
    52. Nowell S, Ambrosone CB, MacLeod SL, Williams S, Mrackova G, Plaxco J, Ozawa S, Kadlubar FF, Lang NP. Relationship of phenol sulfotransferase (SULT1A1) genotype to sulfotransferase activity phenotype in platelet cytosol. Pharmacogenetics. 2000; 10:789-797.
    53. Nowell SA, Ozawa S, Ambrosone CB, Macleod SL, Kadlubar FF, Lang NP. Relationship of SULT1A1 genotype to sulfotransferase activity phenotype in platelet cytosol: Effect of genotype on heterocyclic amine activation. 2000; 550.
    54. Malfatti MA, Kulp KS, Knize MG, Davis C, Massengill J, Williams S, Nowell S, Macleod SL, Dingley KH, Turtletaub KW, Lang NP, Felton JS. The identification of [2-14C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humans. Carcinogenesis. 1999; 20:705-713.
    55. Malfatti M, Kulp K, Knize M, Davis C, Massengill J, Williams S, Nowell S, Macleod SL, Dingley K, Turteltaub K, Lang N, Felton J. The identification of PhIP metabolites in human urine and blood: A correlation of metabolite profiles and phenotype. 1999; 151.
    56. Nowell S, Massengill J, Williams S, Radominska-Pandya A, Tephly T, Cheng Z, Strassburg C, Tukey R, MacLeod SL, Lang NP, Kadlubar FF. Glucuronidation of N-OH-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human microsomal UDP-glucuronosyltransferases: Identification of specific UGT1A family isoforms involved. Carcinogenesis. 1999; 20:1107-1114.
    57. MacLeod SL, Shinde AA, Plaxco JR, Lang NP. A genetic polymorphism in UGT2B15 as a risk factor for breast and prostate cancer. 1999.
    58. Malfatti MA, Knize MG, Kulp KS, Lawson B, Davis C, Massengill J, Nowell S, Macleod SL, Dingley K, Mauthe R, Turteltaub KW, Lang NP, Felton JS. The detection of [2-14C]2-amino-1-mehyl-6-phenylimidazo[4,5-b]pyridine metabolites in urine from two colon cancer patients. 1998; 635.
    59. MacLeod SL, Tang Y-M, Yokoi T, Kamataki T, Doublin S, Lawson B, Massengill J, Kadlubar FF, Lang NP. The role of a recently discovered genetic polymorphism in the regulation of the human CYP1A2 gene. 1998; 396.
    60. MacLeod SL, Nowell SA, Plaxco JR, Lang NP. Determination of genetic polymorphisms in UGT2B15 by allele-specific PCR. 1998; 200.
    61. Frame LT, Gatlin T, Nowell SA, Leakey JEA, MacLeod SL, Lang NP. Lowering oxygen increases 3-methylcholanthrene (3-MC)-mediated induction of CYP1A1 activity in cultured HEPG2 cells. 1997; 295.
    62. Macleod SL, Frame L, Ambrosone C, Stotts C, Lawson B, Massengill J, Kadlubar F, Lang N. Genetic and environmental risk factors for prostate cancer. 1997; 3074.
    63. MacLeod SL, Bellido TM, Epstein J, Manolagas SC, Barlogie B, Hardin JW. Transcription factor binding to IL-6 promoter correlates with IL-6 production by 6 multiple myeloma cell lines. 1995; 3187.
    64. Grigorieva I, Woodliff J, MacLeod SL, Hardin J, Barlogie B, Epstein J. Interleukin-6 negates dexamethasone cytotoxicity in myeloma. 1995; 128.
    65. Hardin JW, MacLeod SL, Grigorieva I, Chjang R, Xiao H, Epstein J. Dexamethasone controls myeoloma through Il-6 deprivation. Blood. 1994; 84(9):3063-3070.
    66. MacLeod SL, Bellido T, Grigorieva I, Wang A, Epstein J, Barlogie B, Jilka RL, Manolagas SC, Hardin JW. Constitutive expression of NF-?B in human myeloma cell lines: correlation with interleukin-6 production. 1994; 492.
    67. Macleod SL. The role of interleukin-6 in the development of glucocorticoid resistance in human multiple myeloma. 1994.
    68. Lin SC, MacLeod SL, Hardin JW. Effects of glucocorticoids on expression of the fos proto-ncogene in AtT-20 cells. Endocrinology. 1992; 1130:257-262.
    69. Norris JS, Schwartz DA, MacLeod SL, Fan W, O'Brien TJ, Harris SE, Trifiletti R, Cornett LE, Cooper TM, Levi WM, Smith RG. Cloning of an M-Class glutathione S-transferase complementary DNA and characterization of its glucorticoid inducibility in a smooth muscle tumor cell line. Molec. Endocrin. 1991; 5:979-986.
    70. Vesely DL, Cornett LE, MacLeod SL, Nash AA, Norris JS. Specific binding sites for prohormone atrial natriuretic peptides 1-20, 31-67 and 99-126. Peptides. 1990; 11:193-197.
    71. Norris JS, Brown P, Cohen J, Cornett LE, Kohler PO, MacLeod SL, Popovitch K, Robey RB, Sifford M, Syms AJ, Smith RG. Glucocorticoid induction of -adrenergic receptors in the DDT1, MF-2 smooth cell line involves synthesis of a new receptor. Mol. Cell Biochem. 1987; 74:21-27.
    72. Norris JS, Cornett LE, Harris SE, Nag A, Rossby P, Srivastiva A, MacLeod SL, Smith RG. Advances in Gene Technology: Molecular Biology of the Endocrine System. Investigation of glucocorticoid receptor regulation of autocrine growth in a smooth muscle tumor cell line. 1986.
    73. Norris JS, Cornett LE, Kohler PO, MacLeod SL, Syms AJ, Smith RG. Glucocorticoids induce a 29,000 Mr-protein in a glucocorticoid sensitive smooth muscle cell line (DDT1, MF-2) but not in a glucocorticoid resistant variant (DDT1, MF-2, GR). Mol. Cell Biochem. 1985; 68:79-85.
    74. Norris JS, Cornett LE, Hardin JW, MacLeod SL, Srivastava A, Syms AJ, Smith RG. Autocrine regulation of growth II: glucocorticoids inhibit transcription of c-cis proto-oncogene specific RNA transcripts. Biochem Biophys Res Comm. 1984; 122:124-128.
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