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Gregory Sharp

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPediatrics, College of Medicine
DivisionPeds Neurology
AddressG3112A ACH Administration
1900 Maryland Street
Mail Slot # 512-15
Little Rock AR 72202
Phone501-364-1850
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentNeurology, College of Medicine


    Collapse Research Funds 
    Collapse principal investigator
    Funding Agency: - Title: A randomized, double-blind, placebo-controlled study to investigate the efficacy and safety of cannibidiol in children and young adults with Dravet syndrome - Start Date: 2017-06-01

    Funding Agency: - Title: A Randomized, Double-Blind, Placebo-Controlled Trial to Investigate the Efficacy and Safety of Cannabidiol in Infants with Infantile Spasms Folling and Initial Open-Label Pilot Study - Start Date: 2017-06-01

    Pass Through Agency: PRA International - Funding Agency: UCB Pharma, Inc. - Title: An Open-Label Study to Determine Safety, Tolerability, and Efficacy of Long-Term Oral Lacosamide (LCM) as Adjunctive Therapy in Children with Epilepsy - Start Date: 2017-06-01

    Funding Agency: Zogenix International Limited - Title: An Open-Label Extension Trial to Assess the Long-Term Safety of ZX008 Oral Solution as an Adjunctive Therapy in Children and Young Adults with Dravet Syndrome - Start Date: 2017-05-01

    Pass Through Agency: PRA International - Funding Agency: UCB Pharma, Inc. - Title: A Multicenter, Open-Label Study to Investigate the Safety and Tolerability of IV Lacosamide in Children with Epilepsy - Start Date: 2017-03-17

    Funding Agency: Zogenix International Limited - Title: A Multicenter, Randomized, Double-Blind, Parallel Group, Placebo-controlled Trial of Two Fixed Doses of ZX008 Oral Solution as an Adjunctive Therapy in Children and Young Adults with Dravet Syndrome - Start Date: 2017-02-15

    Funding Agency: EISAI Medical Research, Inc. - Title: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial with an Open-Label Extension Phase of Perampanel as Adjunctive Treatment in Subjects at Least 2 YO with Inadequately Controlled Seizures Associated with Lennox-Gastaut Syndrome. - Start Date: 2017-01-26

    Funding Agency: EISAI Medical Research, Inc. - Title: An Open-Label, Multicenter Study with an Extension Phase to Evaluate the Safety, Tolerability, and Exposure-Efficacy Relationship of Perampanel Oral Suspension when Administered as an Adjunctive Therap in Pediatric Subjects with Inadequately Controlled Pa - Start Date: 2017-01-26

    Funding Agency: - Title: A double-blind, randomized, placebo-controlled study to investigate the efficacy and safety of cannabidiol as add-on therapy in patients with tuberous sclerosis complex who experience inadequately-controlled seizures - Start Date: 2016-04-11

    Funding Agency: Sage Therapeutics, Inc - Title: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Sage-547 Injection in the Treatment of Subjects with Super-Refractory Status Epilpticus - Start Date: 2015-08-01

    Pass Through Agency: Quintiles, Inc. - Funding Agency: Insys Therapeutics, Inc. - Title: A multicenter, randomized, double-blind, placebo-controlled, interventional study to assess the safety and efficacy of pharmaceutical Cannabidiol as an adjunctive therapy for treatment of subjects with inadequately controlled Dravet Syndrome - Start Date: 2015-04-01

    Pass Through Agency: Quintiles, Inc. - Funding Agency: Insys Therapeutics, Inc. - Title: A multicenter, open-label, flexible dose study to assess the long-term safety of pharmaceutical Cannabidiol Oral Solution as an adjunctive treatment for pediatrics and adult subjects with a treatment-resistant seizure disorder who completed INS011-14-029, - Start Date: 2015-04-01

    Funding Agency: Insys Therapeutics, Inc. - Title: A multicenter, randomized, double-blind, placebo-controlled, interventional study to assess the safety and efficacy of pharmaceutical Cannabidiol Oral Solution as an adjunctive therapy for treatment of subjects with inadequately controlled Lennox-Gastaut - Start Date: 2015-02-17

    Pass Through Agency: Emory University - Funding Agency: Patient Centered Outcomes Research Institute - Title: Cognitive AED Outcomes in Pediatric Localization Related Epilepsy (COPE) - Start Date: 2013-09-01

    Funding Agency: Emory University - Title: Cognitive AED Outcomes in Pediatric Localization Related Epilepsy (COPE) - Start Date: 2013-09-01

    Funding Agency: Pfizer - Title: A 12 Month Open-Label Study Evaluating the Safety and Tolerabilityof Flexible Doses of Pregabalin as Adjunctive Therapy in Pediatric Patients Ages 1 Month to 16 years ....A0081106 - Start Date: 2012-04-01


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Bradley L, Bahgat D, Sharp G, Willis E, Ocal E, Albert G, Serletis D. Disconnective Hemispherotomy for Medically Intractable Status Epilepticus in an 8-Year-Old Child. J Ark Med Soc. 2015 Oct; 112(6):86-7. PMID: 26552284.
      View in: PubMed
    2. Gupta HV, Ramakrishnaiah RH, Sharp GB, Lee RW, Walters WD. A combination of chorea, myoclonus, and dystonia in a patient with pontocerebellar hypoplasia type 2: a video case presentation. Acta Neurol Belg. 2015 Dec; 115(4):783-5. PMID: 25837317.
      View in: PubMed
    3. Sharp GB, Samanta D, Willis E. Options for pharmacoresistant epilepsy in children: when medications don't work. Pediatr Ann. 2015 Feb; 44(2):e43-8. PMID: 25658218.
      View in: PubMed
    4. Samanta D, Willis E, Sharp GB. Absence status after starting clobazam in a patient with syndrome of continuous spike and wave during slow sleep (CSWS). Neurol India. 2014 Nov-Dec; 62(6):685-7. PMID: 25591691.
      View in: PubMed
    5. Asghar SJ, Milesi-Hallé A, Kaushik C, Glasier C, Sharp GB. Variable manifestations of familial hemiplegic migraine associated with reversible cerebral edema in children. Pediatr Neurol. 2012 Sep; 47(3):201-4. PMID: 22883286.
      View in: PubMed
    6. Aburahma S, Khassawneh M, Griebel M, Sharp G, Gibson J. Pitfalls in measuring cerebrospinal fluid glycine levels in infants with encephalopathy. J Child Neurol. 2011 Jun; 26(6):703-6. PMID: 21335543.
      View in: PubMed
    7. Mulkey SB, Glasier CM, El-Nabbout B, Walters WD, Ionita C, McCarthy MH, Sharp GB, Shbarou RM. Nerve root enhancement on spinal MRI in pediatric Guillain-Barré syndrome. Pediatr Neurol. 2010 Oct; 43(4):263-9. PMID: 20837305.
      View in: PubMed
    8. Bowman SM, Aitken ME, Sharp GB. Disparities in hospital outcomes for injured people with epilepsy/seizures. Epilepsia. 2010 May; 51(5):862-7. PMID: 20067501.
      View in: PubMed
    9. Bowman SM, Aitken ME, Sharp GB. Disparities in injury death location for people with epilepsy/seizures. Epilepsy Behav. 2010 Mar; 17(3):369-72. PMID: 20056495.
      View in: PubMed
    10. Mulkey SB, Glasier CM, El-Nabbout B, W David Walters, Ionita C, McCarthy MH, Sharp GB, Shbarou RM. Nerve root enhancement on spinal MRI in pediatric Guillian-Barre' Syndrome. Pediatric Neurology. 2010; 43:263-269.
    11. De Los Reyes EC, Sharp GB, Williams JP, Hale SE. Levetiracetam in the treatment of Lennox-Gastaut syndrome. Pediatr Neurol. 2004 Apr; 30(4):254-6. PMID: 15087103.
      View in: PubMed
    12. Sharp GB, Van Lierop AE. Diazepam rectal gel for the treatment of breakthrough seizures in patients with intrathecal balcofen pumps. Epilepsia. 2004; 45 (Suppl.7).
    13. Van Lierop AE, Sharp GB. Diazepam rectal gel as part of a rescue treatment protocol for baclofen withdrawal. Epilepsia. 2004; 45 (Suppl.7), 144.
    14. Williams J, Steel C, Sharp GB, DelosReyes E, Phillips T, Bates S, Lange B, Griebel ML. Anxiety in children with epilepsy. Epilepsy Behav. 2003 Dec; 4(6):729-32. PMID: 14698708.
      View in: PubMed
    15. Williams J, Steel C, Sharp GB, DelosReyes E, Phillips T, Bates S, Lange B, Griebel ML. Parental anxiety and quality of life in children with epilepsy. Epilepsy Behav. 2003 Oct; 4(5):483-6. PMID: 14527488.
      View in: PubMed
    16. Williams J, Lange B, Phillips T, Sharp GB, DelosReyes E, Bates S, Griebel ML, Simpson P. The course of inattentive and hyperactive-impulsive symptoms in children with new onset seizures. Epilepsy Behav. 2002 Dec; 3(6):517-521. PMID: 12609244.
      View in: PubMed
    17. Williams J, Griebel ML, Sharp GB, Lange B, Phillips T, Delosreyes E, Bates S, Schulz EG, Simpson P. Differentiating between seizures and attention deficit hyperactivity disorder (ADHD) in a pediatric population. Clin Pediatr (Phila). 2002 Oct; 41(8):565-8. PMID: 12403372.
      View in: PubMed
    18. Williams J, Sharp GB, DelosReyes E, Bates S, Phillips T, Lange B, Griebel ML, Edwards M, Simpson P. Symptom differences in children with absence seizures versus inattention. Epilepsy Behav. 2002 Jun; 3(3):245-248. PMID: 12662604.
      View in: PubMed
    19. Williams J, Lange B, Phillips T, Sharp GB, De los Reyes E, Bates S, Griebel ML, Simpson P. the course of inattentive and hyperactive-impulsive symptoms in children with new onset seizures. Epilepsy Behavior. 2002; 3(6):517-521.
    20. Williams J, Griebel ML, Sharp GB, Lange B, Phillips T, De los Reyes E, Bates S, Schulz EG, Simpson P. Differentiating between seizures and attention deficity hyperactivity disorder (ADHD) in a pediatric population. Clinical Pediatrics. 2002; 41(8):565-568.
    21. Williams J, Sharp GB, De los Reyes E, Bates S, Phillips T, Lange B, Griebel M, Edwards M, Simpson P. Symptoms differences in children with absence seizures versus inattention. Epilepsy and Behavior. 2002; 3(3):245-248.
    22. Williams J, Sharp G. Reply. Epilepsy Behav. 2001 Dec; 2(6):610-611. PMID: 12609403.
      View in: PubMed
    23. Williams J, Phillips T, Griebel ML, Sharp GB, Lange B, Edgar T, Simpson P. Factors Associated with Academic Achievement in Children with Controlled Epilepsy. Epilepsy Behav. 2001 Jun; 2(3):217-223. PMID: 12609366.
      View in: PubMed
    24. Griebel ML, Williams JP, Sharp GB, Simpson P. Differentiating between seizure disorders and attention deficit hyperactivity disorder (ADHD) in a pediatric population. Epilepsia. 2001; 42 (Suppl.7), 104.
    25. Williams J, Phillips T, Griebel ML, Sharp GB, Lange B, Edgar T, Simpson P. Factors associated with academic achievement in children with controlled epilepsy. Epilepsy and Behavior. 2001; 2(3):217-233.
    26. Williams J, Lange B, Sharp GB, Griebel M, Edgar T, Haley T, Frindik P, Casey S, Dykman R. Altered Sleeping Arrangments I Pediatric Patients with Epilepsy. Clinical Pediatrics. 2000; 635-642.
    27. Sharp GB, Williams JP, Griebel ML, Simpson P. Verbal learning and memory in children with controlled seizures. Epilepsia. 2000; 41 (Supp.7), 152-153.
    28. Williams JP, Phillips T, Griebel ML, Sharp GB, Lange B, Edgar T, Simpson P. Factors associated with academic achievement in children with controlled epilepsy. Epilepsia. 2000; 41 (Supp.7), 247.
    29. Mitchell WG, Conry JA, Kriel RL, Cereghino JJ, Groves L, Rosenfield WE, North American Disastat Group. An open-label study of repeated use of diazepam rectal gel (Diastat) for episodes of acute breakthrough seizures and clusters: safety, efficacy, and tolerance. Epilepsia. 1999; 40(11):1610-1617.
    30. Kriel RL, Cloyd JC, Pellock JM, Mithcell WG, Cereghino JJ, Rosman NP, North American Diastat Study Group. Rectal diazepam gel for the treatment of acute repetitive seizures. Pediatric Neurology. 1999; 20(4):282-288.
    31. Williams J, Sharp GB. Pediatric Neuropsychology. Epilepsy. 1999.
    32. Cereghino JJ, Mitchell WG, Murphy J, Kriel RL, Rosenfield WE, Trevathan E, North American Diastat Study Group. Treating repetitive seizures with a rectal diazepam foundation, a randomized study. Neurology. 1998; 51(5):1274-1282.
    33. Dreifus FE, Rosman PN, Cloyd JC, Pellock JM, Kuzneicky RI, Lo WD, Matsuo F, Sharp GB, Conry JA, Bergen DC, Bell WE. A comparison of rectal diazapam gel and placebo for acute repetitive seizures. The New England Journal of Medicine. 1998; 338:1869-1875.
    34. Williams J, Sharp GB, Bates S, Griebel M, Lange B, Spence GT, Thomas P. Academic achievement and behavioral ratings in children with absence and complex partial epilepsy. Education and Treatment of Children. 1996; 19(2):143-152.
    35. Williams J, Sharp GB, Lange B, Bates S, Spence GT, Thomas P. The effects of seizure type, level of seizure control, and antiepileptic drugs on memory and attention skills in children with epilepsy. Developmental Neuropsychology. 1996; 12:241-253.
    36. Mitchell WG, Shellenberger K, Groves L, Cereghino J, Murphy J, Rosenfeld W, Farwell JR, Diastat Study Group. Rectal diazepam gel (Diastat) for acute repetitive seizures: Results of a double-blind placebo controlled study in children and adults with epilepsy. Epilepsia. 1996; Vol. 37 (Suppl.5), 154.
    37. Fink JK, Wu CB, Jones SM, Sharp GB, Lange BM, Lesecki A, Reinglass T, Varvil T, Otterrud B, Leppert M. Autosomal dominant, familial spastic paraplegia: Tight linkage to cromosome 15q. The American Journal of Human Genetics. 1995; 56(188-192).
    38. Fiser RT, Hickerson St, Sharp GB, Schutze GE. Myelopathy as a presenting sign of acquired immuodeficiency syndrome. Pediatric Infectious Disease Journal. 1995; 14:808-809.
    39. Williams J., Griebel M., Sharp GB. A standardized protocol for the intracarotid ambarbital procedure (IAP) in children. Neuropsychological Society. 1995; Vol.1, 134.
    40. Griebel ML, Williams J, Sharp GB, Shema S. Prediction of seizure focus from selected neuropsychological tests in pediatric presurgical patients. Epilepsia. 1995; Vol.36 (Suppl.4), 110.
    41. Williams J, Griebel M, Sharp GB. Differentiation of seizure and non-ictal events based on the seizure behavior checklist. Epilepsia. 1995; Vol.36 (supp.4), 111.
    42. Groves L, Shellenberger K, Franklin J, US Diastat Safety Study Group. Safety and tolerability of a single dose administration of Diastat (diazepam rectal gel) to patients with epilepsy on antiepileptic drugs (AED's). Epilepsia. 1995; Vol.37 (Suppl.5), 154.
    43. Williams J., Griebel ML, Sharp GB. The effects of seizure type and level of control on behavior and academics in non-handicapped children with epilepsy. Epilepsia. 1994; 35 (Suppl 8), 1994.
    44. Griebel ML, Williams J, Sharp GB, Rickert V. Factors affecting seizure control in children. Epilepsia. 1994; 35 (Suppl.8), 112.
    45. Sharp GB, Williams J, Griebel ML, Yeager L, Arnold D. A computer based medical record and data base system for epilepsy patients. Epilepsia. 1994; 35 (suppl.8), 51.
    46. Williams J, Sharp GB, Griebel ML, Knabe MD, Spence GT, Weinberger N. Referral patterns from a multidisciplinary clinic for children with epilepsy. Epilepsia. 1993; 34 (Suppl. 6), 32.
    47. Sharp GB, Williams J, Griebel ML, Boop F. Patterns of psychopathology in children and adolescents evaluated for epilepsy surgery. Epilepsia. 1993; 34 (Supp.6), 33.
    48. Baran GA, Sowell MK, Sharp GB, Glasier CM. MR findings in a child with Guillain-Barre syndrome. American Journal of Roentgenology. 1993; 161(1):161-163.
    49. Brodsky MC, Sharp GB, Fritz KJ, Corbett JJ. Idiopathic alternating anisocoria. American Journal of Ophthalmology. 1992; 114(4):509-510.
    50. Sharp G. Immunoglobulin proves successful for treatment of AIDP (Guillian Barre Syndrome). Pediatric Commentary. 1992; 1(3):5-6.
    51. Williams J, Sharp GB, Griebel ML. Memory performance in children with epilepsy on the WRAML. Epilepsia. 1992; 33 (Supp.3), 137.
    52. Williams J, Sharp GB, Griebel ML. Neuropsychological functioning in clinically referred children with epilepsy. Epilepsia. 1992; 33 (Supp.3), 17.
    53. Sharp GB, Laney S, Westmoreland B, Groover R. Atypical electroencephalographic pattern in a patient with subacute sclerosing panencephalitis. Electroencephalography and Clinical neurophysiology. 1991; 78:311-313.
    54. Woody RC, Kearns G, Turley P, Brewster M, Sharp GB. Neurotoxicity of cyclotrimethylenetrinitramine (RDX) in a child: A clinical and pharmacokinetic evaluation. Journal of Toxicology-Clinical Toxicology. 1986; 24(4):305-319.
    55. Williams J, Sharp GB, Griebel M, Spence GT, Thomas P. memory function in children with epilepsy based on seizure type, level of control, and medications.
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