Keywords
Last Name
Institution

Joshua Kennedy

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPediatrics, College of Medicine
DivisionPeds Allergy
Address2062 ACH Research Institute
1120 Marshall Street
Mail Slot # 512-13
Little Rock AR 72202
Phone501-364-1060
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    Other Positions
    TitleAssistant Professor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentInternal Medicine, College of Medicine
    DivisionPulmonary & Critical Care

    Other Roles
    Department of Pediatrics Division of Allergy and Immunology Assistant Professor
    Department of Internal Medicine Division of Pulmonary and Critical Care Medicine Assistant Professor
    Arkansas Children's Research Institute

    Collapse Overview 
    Collapse overview
    Dr. Kennedy received his medical degree from UAMS in 2006 and completed an Internal Medicine and Pediatrics residency from 2006 to 2010. He went on to complete a fellowship in Allergy and Immunology at the University of Virginia. Dr. Kennedy joined the faculty of UAMS in July 2013 where he is a member of the Division of Pediatric Allergy and Immunology and the ACRI Lung Cell Biology Lab. Dr. Kennedy’s primary research focuses upon mechanisms whereby infection with the common cold virus, rhinovirus (RV), leads to exacerbations of asthma. 60% to 80% of children seen in the emergency room with an exacerbation of asthma will be infected with RV. In his previous research, it became clear that while RV infection alone increases the risk of wheezing in children with asthma; the combination of RV infection and high titer sensitization to allergen significantly increases the odds to wheeze in children seen in the emergency department. It is this synergy between allergy and RV infection that drives his current research hypotheses. To that end, he is studying epithelial cell-derived cytokines that bias a Th2 (i.e., allergic) response (IL-33, IL-25, and TSLP) associated with RV infection in subjects with asthma both in vitro and in vivo. Also, Dr. Kennedy enthusiastically contributes to the education of fellows, residents, and students at UAMS by participating in the educational mission of the Department of Pediatrics in many capacities.


    Collapse Affiliation 
    Collapse Translational Research Institute: Clinical and Translational Science Award
    Dr. Kennedy was awarded the CTSA KL2 award from 2013-2015. The award focused on the synergy associated between RV and allergy in subjects with asthma.

    Collapse clinical activities
    UAMS Allergy and Immunology Clinic
    Arkansas Children's Hospital Allergy Clinic
    Arkansas Children's Hospital Immunology Clinic

    Collapse Biography 
    Collapse awards and honors
    2010 - 2013Kendig Award in Pediatric Research, University of Virginia
    2012Von Pirquet Research Award, American College of Asthma, Allergy, and Immunology
    2012 - 2013Dr. Alexander McCausland Fellowship Award, University of Virginia
    2011Young Scientist Award, University of Virginia
    2010Donald E. Hill Memorial Award for Excellence in Research, University of Arkansas for Medical Sciences
    2006 - PresAlpha Omega Alpha, AOA
    2016 - 2017Arkansas Biosciences Institute New Investigator of the Year- Runner Up, Arkansas Biosciences Institute
    2016UAMS Student Research Award (1st prize) (Mentor), UAMS
    2014ACRI Summer Science Student Research Award (1st prize) (mentor), ACRI
    2015ACRI Summer Science Student Research Award (2nd prize) (mentor), ACRI
    2016 - 2021NIH NIAID K08 Award, National Institutes of Health

    Collapse Research Funds 
    Collapse principal investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Pesek RD, Rettiganti M, O'Brien E, Beckwith S, Daniel C, Luo C, Scurlock AM, Chandler P, Levy RA, Perry TT, Kennedy JL, Chervinskiy S, Vonlanthen M, Casteel H, Fiedorek SC, Gibbons T, Jones SM. Effects of allergen sensitization on response to therapy in children with eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2017 Aug; 119(2):177-183. PMID: 28676207.
      View in: PubMed
    2. Heath JL, Heath RD, Tamboli C, Johnson L, Wilson AS, Chervinskiy S, Bell MC, Kennedy JL. Mesalamine desensitization in a patient with treatment refractory ulcerative colitis and aspirin and nonsteroidal anti-inflammatory drug hypersensitivity. Ann Allergy Asthma Immunol. 2017 Apr; 118(4):518-520. PMID: 28284977.
      View in: PubMed
    3. Kennedy JL, Denson JL, Schwalm KS, Stoner AN, Kincaid JC, Abramo TJ, Thompson TM, Ulloa EM, Burchiel SW, Dinwiddie DL. Complete Genome Sequence of a Novel WU Polyomavirus Isolate from Arkansas, USA, Associated with Acute Respiratory Infection. Genome Announc. 2017 Jan 12; 5(2). PMID: 28082496.
      View in: PubMed
    4. Kennedy JL, Steinke JW, Liu L, Negri J, Borish L, Payne SC. Failure of itraconazole to prevent T-helper type 2 cell immune deviation: Implications for chronic rhinosinusitis. Am J Rhinol Allergy. 2016 Nov 01; 30(6):379-384. PMID: 28124646.
      View in: PubMed
    5. Kennedy JL, Stoner AN, Borish L. Aspirin-exacerbated respiratory disease: Prevalence, diagnosis, treatment, and considerations for the future. Am J Rhinol Allergy. 2016 Nov 01; 30(6):407-413. PMID: 28124651.
      View in: PubMed
    6. Denson JL, Kennedy JL, Dehority WN, Eickman MM, Schwalm KS, Stoner AN, Kincaid JC, Abramo TJ, Thompson TM, Ulloa EM, Burchiel SW, Young SA, Dinwiddie DL. Complete Genome Sequences of Two Novel Isolates of Human Parainfluenza Virus 1 Associated with Acute Respiratory Infection. Genome Announc. 2016 Oct 13; 4(5). PMID: 27738046.
      View in: PubMed
    7. Patterson MF, Borish L, Kennedy JL. The past, present, and future of monoclonal antibodies to IL-5 and eosinophilic asthma: a review. J Asthma Allergy. 2015; 8:125-34. PMID: 26604804; PMCID: PMC4639549.
    8. Wagner KD, Bell MC, Pesek RD, Kennedy JL. Fifty-six-year-old man with anaphylaxis: A novel delayed food hypersensitivity reaction. J Ark Med Soc. 2015 Nov; 112(7):110-2. PMID: 26625604.
      View in: PubMed
    9. Hammond C, Kurten M, Kennedy JL. Rhinovirus and asthma: a storied history of incompatibility. Curr Allergy Asthma Rep. 2015 Feb; 15(2):502. PMID: 25612798; PMCID: PMC4327812.
    10. Agrawal R, Wisniewski J, Yu MD, Kennedy JL, Platts-Mills T, Heymann PW, Woodfolk JA. Infection with human rhinovirus 16 promotes enhanced IgE responsiveness in basophils of atopic asthmatics. Clin Exp Allergy. 2014 Oct; 44(10):1266-73. PMID: 25113532; PMCID: PMC4191843.
    11. Kennedy JL, Schroeder N, Palacios T, Rosen LB, Martinez B, Browne S, Borish L. Fifty-five-year-old man with chronic yeast infections. Allergy Asthma Proc. 2014 Sep-Oct; 35(5):415-22. PMID: 25295810; PMCID: PMC4147028.
    12. Kennedy JL, Borish L, Christophel J, Payne SC. Response. Am J Rhinol Allergy. 2014 Jul-Aug; 28(4):353-4. PMID: 25197924.
      View in: PubMed
    13. Kennedy JL, Shaker M, McMeen V, Gern J, Carper H, Murphy D, Lee WM, Bochkov YA, Vrtis RF, Platts-Mills T, Patrie J, Borish L, Steinke JW, Woods WA, Heymann PW. Comparison of viral load in individuals with and without asthma during infections with rhinovirus. Am J Respir Crit Care Med. 2014 Mar 01; 189(5):532-9. PMID: 24471509; PMCID: PMC3977713.
    14. Kennedy JL, Robinson D, Christophel J, Borish L, Payne S. Decision-making analysis for allergen immunotherapy versus nasal steroids in the treatment of nasal steroid-responsive allergic rhinitis. Am J Rhinol Allergy. 2014 Jan-Feb; 28(1):59-64. PMID: 24717886; PMCID: PMC3899446.
    15. Kennedy JL, Borish L. Chronic rhinosinusitis and antibiotics: the good, the bad, and the ugly. Am J Rhinol Allergy. 2013 Nov-Dec; 27(6):467-72. PMID: 24274221; PMCID: PMC3836217.
    16. Kennedy JL, Jones SM, Porter N, White ML, Gephardt G, Hill T, Cantrell M, Nick TG, Melguizo M, Smith C, Boateng BA, Perry TT, Scurlock AM, Thompson TM. High-fidelity hybrid simulation of allergic emergencies demonstrates improved preparedness for office emergencies in pediatric allergy clinics. J Allergy Clin Immunol Pract. 2013 Nov-Dec; 1(6):608-17.e1-14. PMID: 24565708.
      View in: PubMed
    17. Kennedy JL, Hubbard MA, Huyett P, Patrie JT, Borish L, Payne SC. Sino-nasal outcome test (SNOT-22): a predictor of postsurgical improvement in patients with chronic sinusitis. Ann Allergy Asthma Immunol. 2013 Oct; 111(4):246-251.e2. PMID: 24054358; PMCID: PMC3977600.
    18. Kennedy JL, Stallings AP, Platts-Mills TA, Oliveira WM, Workman L, James HR, Tripathi A, Lane CJ, Matos L, Heymann PW, Commins SP. Galactose-alpha-1,3-galactose and delayed anaphylaxis, angioedema, and urticaria in children. Pediatrics. 2013; 131(5):e1545-52.
    19. Kennedy JL, Borish L. Chronic sinusitis pathophysiology: the role of allergy. Am J Rhinol Allergy. 2013 Sep-Oct; 27(5):367-71. PMID: 23601202; PMCID: PMC3781389.
    20. Kennedy JL, Stallings AP, Platts-Mills TA, Oliveira WM, Workman L, James HR, Tripathi A, Lane CJ, Matos L, Heymann PW, Commins SP. Galactose-a-1,3-galactose and delayed anaphylaxis, angioedema, and urticaria in children. Pediatrics. 2013 May; 131(5):e1545-52. PMID: 23569097; PMCID: PMC3639458.
    21. Kennedy JL, Jeffus SK, Platts-Mills TA, Tripathi A, Divjan A, Perzanowski MS, Heymann PW. Seventeen-year-old girl hospitalized for localized swelling, pruritus, tenderness, and lymphatic streaking with eosinophilia. J Allergy Clin Immunol Pract. 2013 May-Jun; 1(3):299-301. PMID: 24565490; PMCID: PMC4106365.
    22. Heymann PW, Kennedy JL. Rhinovirus-induced asthma exacerbations during childhood: the importance of understanding the atopic status of the host. J Allergy Clin Immunol. 2012 Dec; 130(6):1315-6. PMID: 23195527; PMCID: PMC4379703.
    23. Soto-Quiros M, Avila L, Platts-Mills TA, Hunt JF, Erdman DD, Carper H, Murphy DD, Odio S, James HR, Patrie JT, Hunt W, O'Rourke AK, Davis MD, Steinke JW, Lu X, Kennedy J, Heymann PW. High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus. J Allergy Clin Immunol. 2012; 129(6):1499-1505.e5.
    24. Soto-Quiros M, Avila L, Platts-Mills TA, Hunt JF, Erdman DD, Carper H, Murphy DD, Odio S, James HR, Patrie JT, Hunt W, O'Rourke AK, Davis MD, Steinke JW, Lu X, Kennedy J, Heymann PW. High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus. J Allergy Clin Immunol. 2012 Jun; 129(6):1499-1505.e5. PMID: 22560151; PMCID: PMC3792652.
    25. Kennedy JL, Heymann PW, Platts-Mills TA. The role of allergy in severe asthma. Clin Exp Allergy. 2012; 42(5):659-69.
    26. Kennedy JL, Turner RB, Braciale T, Heymann PW, Borish L. Pathogenesis of rhinovirus infection. Curr Opin Virol. 2012 Jun; 2(3):287-93. PMID: 22542099; PMCID: PMC3378761.
    27. Steinke JW, Kennedy JL. Leukotriene Inhibitors in Sinusitis. Curr Infect Dis Rep. 2012 Jan 29. PMID: 22286339.
      View in: PubMed
    28. Hopkins R, Kennedy J, Magee J, Perry T. Adolescent and adult asthma: guidelines for stepwise treatment. J Ark Med Soc. 2008 Dec; 105(6):132-3. PMID: 19119754.
      View in: PubMed
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