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Joshua Kennedy

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPediatrics, College of Medicine
DivisionPeds Allergy
Address2062 ACH Research Institute
1120 Marshall Street
Mail Slot # 512-13
Little Rock AR 72202
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    Other Positions
    TitleAssociate Professor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentInternal Medicine, College of Medicine
    DivisionPulmonary & Critical Care

    Other Roles
    Department of Pediatrics Division of Allergy and Immunology Assistant Professor
    Department of Internal Medicine Division of Pulmonary and Critical Care Medicine Assistant Professor
    Arkansas Children's Research Institute

    Collapse Overview 
    Collapse overview
    Dr. Kennedy received his medical degree from UAMS in 2006 and completed an Internal Medicine and Pediatrics residency from 2006 to 2010. He went on to complete a fellowship in Allergy and Immunology at the University of Virginia. Dr. Kennedy joined the faculty of UAMS in July 2013 where he is a member of the Division of Pediatric Allergy and Immunology and the ACRI Lung Cell Biology Lab. Dr. Kennedy’s primary research focuses upon mechanisms whereby infection with the common cold virus, rhinovirus (RV), leads to exacerbations of asthma. 60% to 80% of children seen in the emergency room with an exacerbation of asthma will be infected with RV. In his previous research, it became clear that while RV infection alone increases the risk of wheezing in children with asthma; the combination of RV infection and high titer sensitization to allergen significantly increases the odds to wheeze in children seen in the emergency department. It is this synergy between allergy and RV infection that drives his current research hypotheses. To that end, he is studying epithelial cell-derived cytokines that bias a Th2 (i.e., allergic) response (IL-33, IL-25, and TSLP) associated with RV infection in subjects with asthma both in vitro and in vivo. Also, Dr. Kennedy enthusiastically contributes to the education of fellows, residents, and students at UAMS by participating in the educational mission of the Department of Pediatrics in many capacities.

    Collapse Affiliation 
    Collapse Translational Research Institute: Clinical and Translational Science Award
    Dr. Kennedy was awarded the CTSA KL2 award from 2013-2015. The award focused on the synergy associated between RV and allergy in subjects with asthma.

    Collapse clinical activities
    UAMS Allergy and Immunology Clinic
    Arkansas Children's Hospital Allergy Clinic
    Arkansas Children's Hospital Immunology Clinic

    Collapse Biography 
    Collapse awards and honors
    2010 - 2013Kendig Award in Pediatric Research, University of Virginia
    2012Von Pirquet Research Award, American College of Asthma, Allergy, and Immunology
    2012 - 2013Dr. Alexander McCausland Fellowship Award, University of Virginia
    2011Young Scientist Award, University of Virginia
    2010Donald E. Hill Memorial Award for Excellence in Research, University of Arkansas for Medical Sciences
    2006 - PresAlpha Omega Alpha, AOA
    2016 - 2017Arkansas Biosciences Institute New Investigator of the Year- Runner Up, Arkansas Biosciences Institute
    2016UAMS Student Research Award (1st prize) (Mentor), UAMS
    2014ACRI Summer Science Student Research Award (1st prize) (mentor), ACRI
    2015ACRI Summer Science Student Research Award (2nd prize) (mentor), ACRI
    2016 - 2021NIH NIAID K08 Award, National Institutes of Health

    Collapse Research Funds 
    Collapse research activities
    K08AI121345     (KENNEDY, JOSHUA)May 15, 2016 - Apr 30, 2021
    Examining Mechanisms of Synergy between Asthma Exacerbations and RV Infection
    Role: Principal Investigator

    1K08AI121345-01A1     (KENNEDY, JOSHUA L)May 1, 2016 - Apr 30, 2021
    “Examining mechanisms of synergy between asthma exacerbations and RV infection.”
    Role: Principal Investigator

    1P20GM103625-02     (KENNEDY, JOSHUA L)May 1, 2016 - Apr 30, 2017
    NIGMS COBRE Pilot Project Award
    “Mechanisms for Rhinovirus Induced Airway Hyper-responsiveness in Human Lung.”
    Role: Principal Investigator

         (KENNEDY, JOSHUA L)Apr 1, 2016 - Mar 30, 2018
    ACRI Marion B Lyon New Scientist Development Award
    “Examining the intersection of rhinovirus infection and asthma exacerbations.”
    Role: Principal Investigator

         (KENNEDY, JOSHUA L)Nov 1, 2015 - Oct 31, 2016
    CTSA TRI Western Consortium
    “Host-Pathogen Genomic Determinants of Pediatric Respiratory Infection Severity.”
    Role: Principal Investigator

    P20GM103625     (SMELTZER, MARK S)Aug 15, 2012 - Apr 30, 2022
    Center for Microbial Pathogenesis and Host Inflammatory Responses
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Parikh V, Scala J, Patel R, Corbi C, Lo D, Bochkov YA, Kennedy JL, Kurten RC, Liggett SB, Gern JE, Koziol-White CJ. Rhinovirus C15 Induces Airway Hyperresponsiveness Via Calcium Mobilization in Airway Smooth Muscle. Am J Respir Cell Mol Biol. 2019 Sep 18. PMID: 31533004.
      View in: PubMed
    2. Kennedy JL, Pham S, Borish L. Rhinovirus and Asthma Exacerbations. Immunol Allergy Clin North Am. 2019 08; 39(3):335-344. PMID: 31284924.
      View in: PubMed
    3. Dilley MA, Rettiganti M, Christie L, O'Brien E, Patterson M, Weeks C, Aronson J, Scurlock AM, Perry TT, Pesek RD, Bell MC, Kennedy JL, Chandler P, Magee J, Simmons L, Chervinskiy SK, Casey P, Jones SM. Impact of food allergy on food insecurity and health literacy in a tertiary care pediatric allergy population. Pediatr Allergy Immunol. 2019 05; 30(3):363-369. PMID: 30672621.
      View in: PubMed
    4. Kennedy JL, Kurten RC, McCullough S, Panettieri RA, Koziol-White C, Jones SM, Caid K, Gill PS, Roberts D, Jaeschke H, McGill MR, James L. Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways. Xenobiotica. 2019 Sep; 49(9):1106-1115. PMID: 30328361.
      View in: PubMed
    5. Dinwiddie DL, Denson JL, Kennedy JL. Role of the Airway Microbiome in Respiratory Infections and Asthma in Children. Pediatr Allergy Immunol Pulmonol. 2018 Dec 01; 31(4):236-240. PMID: 30595952.
      View in: PubMed
    6. Lo D, Kennedy JL, Kurten RC, Panettieri RA, Koziol-White CJ. Modulation of airway hyperresponsiveness by rhinovirus exposure. Respir Res. 2018 Oct 29; 19(1):208. PMID: 30373568.
      View in: PubMed
    7. Carlisle A, Kennedy JL, Chervinskiy S, Jones SM, Pesek RD. Successful desensitization in a pediatric patient with acetazolamide allergy. Ann Allergy Asthma Immunol. 2018 10; 121(4):508-509. PMID: 29966705.
      View in: PubMed
    8. Heath J, Hartzell L, Putt C, Kennedy JL. Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management. Curr Allergy Asthma Rep. 2018 05 29; 18(7):37. PMID: 29845321.
      View in: PubMed
    9. Dinwiddie DL, Hardin O, Denson JL, Kincaid JC, Schwalm KC, Stoner AN, Abramo TJ, Thompson TM, Putt CM, Young SA, Dehority WN, Kennedy JL. Complete Genome Sequences of Four Novel Human Coronavirus OC43 Isolates Associated with Severe Acute Respiratory Infection. Genome Announc. 2018 May 24; 6(21). PMID: 29798929.
      View in: PubMed
    10. Kennedy JL, Koziol-White CJ, Jeffus S, Rettiganti MR, Fisher P, Kurten M, Eze A, House S, Sikes JD, Askew E, Putt C, Panettieri RA, Jones SM, Kurten RC. Effects of rhinovirus 39 infection on airway hyperresponsiveness to carbachol in human airways precision cut lung slices. J Allergy Clin Immunol. 2018 05; 141(5):1887-1890.e1. PMID: 29317243.
      View in: PubMed
    11. Pesek RD, Rettiganti M, O'Brien E, Beckwith S, Daniel C, Luo C, Scurlock AM, Chandler P, Levy RA, Perry TT, Kennedy JL, Chervinskiy S, Vonlanthen M, Casteel H, Fiedorek SC, Gibbons T, Jones SM. Effects of allergen sensitization on response to therapy in children with eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2017 08; 119(2):177-183. PMID: 28676207.
      View in: PubMed
    12. Kothari A, Burgess MJ, Crescencio JCR, Kennedy JL, Denson JL, Schwalm KC, Stoner AN, Kincaid JC, Davies FE, Dinwiddie DL. The role of next generation sequencing in infection prevention in human parainfluenza virus 3 infections in immunocompromised patients. J Clin Virol. 2017 07; 92:53-55. PMID: 28531552.
      View in: PubMed
    13. Heath JL, Heath RD, Tamboli C, Johnson L, Wilson AS, Chervinskiy S, Bell MC, Kennedy JL. Mesalamine desensitization in a patient with treatment refractory ulcerative colitis and aspirin and nonsteroidal anti-inflammatory drug hypersensitivity. Ann Allergy Asthma Immunol. 2017 Apr; 118(4):518-520. PMID: 28284977.
      View in: PubMed
    14. Kennedy JL, Denson JL, Schwalm KS, Stoner AN, Kincaid JC, Abramo TJ, Thompson TM, Ulloa EM, Burchiel SW, Dinwiddie DL. Complete Genome Sequence of a Novel WU Polyomavirus Isolate from Arkansas, USA, Associated with Acute Respiratory Infection. Genome Announc. 2017 Jan 12; 5(2). PMID: 28082496.
      View in: PubMed
    15. Kennedy JL, Steinke JW, Liu L, Negri J, Borish L, Payne SC. Failure of itraconazole to prevent T-helper type 2 cell immune deviation: Implications for chronic rhinosinusitis. Am J Rhinol Allergy. 2016 Nov 01; 30(6):379-384. PMID: 28124646.
      View in: PubMed
    16. Kennedy JL, Stoner AN, Borish L. Aspirin-exacerbated respiratory disease: Prevalence, diagnosis, treatment, and considerations for the future. Am J Rhinol Allergy. 2016 Nov 01; 30(6):407-413. PMID: 28124651.
      View in: PubMed
    17. Denson JL, Kennedy JL, Dehority WN, Eickman MM, Schwalm KS, Stoner AN, Kincaid JC, Abramo TJ, Thompson TM, Ulloa EM, Burchiel SW, Young SA, Dinwiddie DL. Complete Genome Sequences of Two Novel Isolates of Human Parainfluenza Virus 1 Associated with Acute Respiratory Infection. Genome Announc. 2016 Oct 13; 4(5). PMID: 27738046.
      View in: PubMed
    18. Patterson MF, Borish L, Kennedy JL. The past, present, and future of monoclonal antibodies to IL-5 and eosinophilic asthma: a review. J Asthma Allergy. 2015; 8:125-34. PMID: 26604804.
      View in: PubMed
    19. Wagner KD, Bell MC, Pesek RD, Kennedy JL. Fifty-six-year-old man with anaphylaxis: A novel delayed food hypersensitivity reaction. J Ark Med Soc. 2015 Nov; 112(7):110-2. PMID: 26625604.
      View in: PubMed
    20. Hammond C, Kurten M, Kennedy JL. Rhinovirus and asthma: a storied history of incompatibility. Curr Allergy Asthma Rep. 2015 Feb; 15(2):502. PMID: 25612798.
      View in: PubMed
    21. Agrawal R, Wisniewski J, Yu MD, Kennedy JL, Platts-Mills T, Heymann PW, Woodfolk JA. Infection with human rhinovirus 16 promotes enhanced IgE responsiveness in basophils of atopic asthmatics. Clin Exp Allergy. 2014 Oct; 44(10):1266-73. PMID: 25113532.
      View in: PubMed
    22. Kennedy JL, Schroeder N, Palacios T, Rosen LB, Martinez B, Browne S, Borish L. Fifty-five-year-old man with chronic yeast infections. Allergy Asthma Proc. 2014 Sep-Oct; 35(5):415-22. PMID: 25295810.
      View in: PubMed
    23. Kennedy JL, Borish L, Christophel J, Payne SC. Response. Am J Rhinol Allergy. 2014 Jul-Aug; 28(4):353-4. PMID: 25197924.
      View in: PubMed
    24. Kennedy JL, Shaker M, McMeen V, Gern J, Carper H, Murphy D, Lee WM, Bochkov YA, Vrtis RF, Platts-Mills T, Patrie J, Borish L, Steinke JW, Woods WA, Heymann PW. Comparison of viral load in individuals with and without asthma during infections with rhinovirus. Am J Respir Crit Care Med. 2014 Mar 01; 189(5):532-9. PMID: 24471509.
      View in: PubMed
    25. Kennedy JL, Robinson D, Christophel J, Borish L, Payne S. Decision-making analysis for allergen immunotherapy versus nasal steroids in the treatment of nasal steroid-responsive allergic rhinitis. Am J Rhinol Allergy. 2014 Jan-Feb; 28(1):59-64. PMID: 24717886.
      View in: PubMed
    26. Kennedy JL, Borish L. Chronic rhinosinusitis and antibiotics: the good, the bad, and the ugly. Am J Rhinol Allergy. 2013 Nov-Dec; 27(6):467-72. PMID: 24274221.
      View in: PubMed
    27. Kennedy JL, Jones SM, Porter N, White ML, Gephardt G, Hill T, Cantrell M, Nick TG, Melguizo M, Smith C, Boateng BA, Perry TT, Scurlock AM, Thompson TM. High-fidelity hybrid simulation of allergic emergencies demonstrates improved preparedness for office emergencies in pediatric allergy clinics. J Allergy Clin Immunol Pract. 2013 Nov-Dec; 1(6):608-17.e1-14. PMID: 24565708.
      View in: PubMed
    28. Kennedy JL, Hubbard MA, Huyett P, Patrie JT, Borish L, Payne SC. Sino-nasal outcome test (SNOT-22): a predictor of postsurgical improvement in patients with chronic sinusitis. Ann Allergy Asthma Immunol. 2013 Oct; 111(4):246-251.e2. PMID: 24054358.
      View in: PubMed
    29. Kennedy JL, Stallings AP, Platts-Mills TA, Oliveira WM, Workman L, James HR, Tripathi A, Lane CJ, Matos L, Heymann PW, Commins SP. Galactose-alpha-1,3-galactose and delayed anaphylaxis, angioedema, and urticaria in children. Pediatrics. 2013; 131(5):e1545-52.
    30. Kennedy JL, Borish L. Chronic sinusitis pathophysiology: the role of allergy. Am J Rhinol Allergy. 2013 Sep-Oct; 27(5):367-71. PMID: 23601202.
      View in: PubMed
    31. Kennedy JL, Stallings AP, Platts-Mills TA, Oliveira WM, Workman L, James HR, Tripathi A, Lane CJ, Matos L, Heymann PW, Commins SP. Galactose-a-1,3-galactose and delayed anaphylaxis, angioedema, and urticaria in children. Pediatrics. 2013 May; 131(5):e1545-52. PMID: 23569097.
      View in: PubMed
    32. Kennedy JL, Jeffus SK, Platts-Mills TA, Tripathi A, Divjan A, Perzanowski MS, Heymann PW. Seventeen-year-old girl hospitalized for localized swelling, pruritus, tenderness, and lymphatic streaking with eosinophilia. J Allergy Clin Immunol Pract. 2013 May-Jun; 1(3):299-301. PMID: 24565490.
      View in: PubMed
    33. Heymann PW, Kennedy JL. Rhinovirus-induced asthma exacerbations during childhood: the importance of understanding the atopic status of the host. J Allergy Clin Immunol. 2012 Dec; 130(6):1315-6. PMID: 23195527.
      View in: PubMed
    34. Soto-Quiros M, Avila L, Platts-Mills TA, Hunt JF, Erdman DD, Carper H, Murphy DD, Odio S, James HR, Patrie JT, Hunt W, O'Rourke AK, Davis MD, Steinke JW, Lu X, Kennedy J, Heymann PW. High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus. J Allergy Clin Immunol. 2012; 129(6):1499-1505.e5.
    35. Soto-Quiros M, Avila L, Platts-Mills TA, Hunt JF, Erdman DD, Carper H, Murphy DD, Odio S, James HR, Patrie JT, Hunt W, O'Rourke AK, Davis MD, Steinke JW, Lu X, Kennedy J, Heymann PW. High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus. J Allergy Clin Immunol. 2012 Jun; 129(6):1499-1505.e5. PMID: 22560151.
      View in: PubMed
    36. Kennedy JL, Heymann PW, Platts-Mills TA. The role of allergy in severe asthma. Clin Exp Allergy. 2012; 42(5):659-69.
    37. Kennedy JL, Turner RB, Braciale T, Heymann PW, Borish L. Pathogenesis of rhinovirus infection. Curr Opin Virol. 2012 Jun; 2(3):287-93. PMID: 22542099.
      View in: PubMed
    38. Steinke JW, Kennedy JL. Leukotriene Inhibitors in Sinusitis. Curr Infect Dis Rep. 2012 Jan 29. PMID: 22286339.
      View in: PubMed
    39. Hopkins R, Kennedy J, Magee J, Perry T. Adolescent and adult asthma: guidelines for stepwise treatment. J Ark Med Soc. 2008 Dec; 105(6):132-3. PMID: 19119754.
      View in: PubMed
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