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Sarah Blossom

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPediatrics, College of Medicine
DivisionPeds Allergy
Address ACH Research Institute
1120 Marshall Street
Mail Slot # 512-40
Little Rock AR 72202
Phone501-364-2861
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    Collapse Research Funds 
    Collapse principal investigator/co-principal investigator research activities
    U01DD001285     (NEMBHARD, WENDY N)Dec 1, 2018 - Aug 31, 2023
    CDC/NCBDD
    RFA-DD-18-001 Birth Defects Study To Evaluate Pregnancy exposureS (BD-STEPS) II
    Role: Co-Investigator

    K02ES024387     (BLOSSOM, SARAH J)Sep 10, 2014 - Aug 31, 2019
    NIH/NIEHS
    CD4+ T cell-mediated neurotoxicity with continuous trichloroethylene exposure
    Role: Principal Investigator

    R01ES021484     (GILBERT, KATHLEEN M)Dec 1, 2012 - Oct 31, 2016
    NIH/NIEHS
    Developmental programming of TCE induced autoimmune disease
    Role: Co-Principal Investigator

    R21ES017311     (BLOSSOM, SARAH J)Sep 1, 2010 - Aug 31, 2013
    NIH/NIEHS
    Neuroimmune dysregulation with developmental exposure to trichloroethylene
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Kim DJ, Blossom SJ, Delgado PL, Carbajal JM, Cáceda R. Examination of pain threshold and neuropeptides in patients with acute suicide risk. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Dec 20; 95:109705. PMID: 31326514.
      View in: PubMed
    2. DeWitt JC, Blossom SJ, Schaider LA. Exposure to per-fluoroalkyl and polyfluoroalkyl substances leads to immunotoxicity: epidemiological and toxicological evidence. J Expo Sci Environ Epidemiol. 2019 Mar; 29(2):148-156. PMID: 30482935.
      View in: PubMed
    3. Khare S, Gokulan K, Williams K, Bai S, Gilbert KM, Blossom SJ. Irreversible effects of trichloroethylene on the gut microbial community and gut-associated immune responses in autoimmune-prone mice. J Appl Toxicol. 2019 Feb; 39(2):209-220. PMID: 30187502.
      View in: PubMed
    4. Blossom SJ, Fernandes L, Bai S, Khare S, Gokulan K, Yuan Y, Dewall M, Simmen FA, Gilbert KM. Opposing Actions of Developmental Trichloroethylene and High-Fat Diet Coexposure on Markers of Lipogenesis and Inflammation in Autoimmune-Prone Mice. Toxicol Sci. 2018 07 01; 164(1):313-327. PMID: 29669109.
      View in: PubMed
    5. Blossom SJ, Gilbert KM. Epigenetic underpinnings of developmental immunotoxicity and autoimmune disease. Curr Opin Toxicol. 2018 Aug; 10:23-30. PMID: 30613805.
      View in: PubMed
    6. Meadows JR, Parker C, Gilbert KM, Blossom SJ, DeWitt JC. A single dose of trichloroethylene given during development does not substantially alter markers of neuroinflammation in brains of adult mice. J Immunotoxicol. 2017 12; 14(1):95-102. PMID: 28366041.
      View in: PubMed
    7. Gilbert KM, Blossom SJ, Reisfeld B, Erickson SW, Vyas K, Maher M, Broadfoot B, West K, Bai S, Cooney CA, Bhattacharyya S. Trichloroethylene-induced alterations in DNA methylation were enriched in polycomb protein binding sites in effector/memory CD4+ T cells. Environ Epigenet. 2017 Jul; 3(3). PMID: 29129997.
      View in: PubMed
    8. Kim J, Swartz MD, Langlois PH, Romitti PA, Weyer P, Mitchell LE, Luben TJ, Ramakrishnan A, Malik S, Lupo PJ, Feldkamp ML, Meyer RE, Winston JJ, Reefhuis J, Blossom SJ, Bell E, Agopian AJ. Estimated Maternal Pesticide Exposure from Drinking Water and Heart Defects in Offspring. Int J Environ Res Public Health. 2017 08 08; 14(8). PMID: 28786932.
      View in: PubMed
    9. Frye RE, Rose S, Wynne R, Bennuri SC, Blossom S, Gilbert KM, Heilbrun L, Palmer RF. Oxidative Stress Challenge Uncovers Trichloroacetaldehyde Hydrate-Induced Mitoplasticity in Autistic and Control Lymphoblastoid Cell Lines. Sci Rep. 2017 06 30; 7(1):4478. PMID: 28667285.
      View in: PubMed
    10. Gilbert KM, Bai S, Barnette D, Blossom SJ. Exposure Cessation During Adulthood Did Not Prevent Immunotoxicity Caused by Developmental Exposure to Low-Level Trichloroethylene in Drinking Water. Toxicol Sci. 2017 06 01; 157(2):429-437. PMID: 28369519.
      View in: PubMed
    11. Howley MM, Browne ML, Van Zutphen AR, Richardson SD, Blossom SJ, Broussard CS, Carmichael SL, Druschel CM. Maternal autoimmune disease and birth defects in the National Birth Defects Prevention Study. Birth Defects Res A Clin Mol Teratol. 2016 Nov; 106(11):950-962. PMID: 27891777.
      View in: PubMed
    12. Gilbert KM, Blossom SJ, Erickson SW, Broadfoot B, West K, Bai S, Li J, Cooney CA. Chronic exposure to trichloroethylene increases DNA methylation of the Ifng promoter in CD4+ T cells. Toxicol Lett. 2016 Oct 17; 260:1-7. PMID: 27553676.
      View in: PubMed
    13. Gilbert KM, Blossom SJ, Erickson SW, Reisfeld B, Zurlinden TJ, Broadfoot B, West K, Bai S, Cooney CA. Chronic exposure to water pollutant trichloroethylene increased epigenetic drift in CD4(+) T cells. Epigenomics. 2016 05; 8(5):633-49. PMID: 27092578.
      View in: PubMed
    14. Blossom SJ, Melnyk SB, Li M, Wessinger WD, Cooney CA. Inflammatory and oxidative stress-related effects associated with neurotoxicity are maintained after exclusively prenatal trichloroethylene exposure. Neurotoxicology. 2017 03; 59:164-174. PMID: 26812193.
      View in: PubMed
    15. Gilbert KM, Reisfeld B, Zurlinden TJ, Kreps MN, Erickson SW, Blossom SJ. Modeling toxicodynamic effects of trichloroethylene on liver in mouse model of autoimmune hepatitis. Toxicol Appl Pharmacol. 2014 Sep 15; 279(3):284-93. PMID: 25026505.
      View in: PubMed
    16. Gilbert KM, Woodruff W, Blossom SJ. Differential immunotoxicity induced by two different windows of developmental trichloroethylene exposure. Autoimmune Dis. 2014; 2014:982073. PMID: 24696780.
      View in: PubMed
    17. Gilbert, KM, Zurlindin, T, Reisfeld, B, Kreps, MN, Erickson, SW, Blossom SJ. Modeling mechanism by which trichloroethylene inhibits liver repair in mouse model of autoimmunity. Tox. Sci. 2013.
    18. Blossom SJ, Cooney CA, Melnyk SB, Rau JL, Swearingen CJ, Wessinger WD. Metabolic changes and DNA hypomethylation in cerebellum are associated with behavioral alterations in mice exposed to trichloroethylene postnatally. Toxicol Appl Pharmacol. 2013 Jun 15; 269(3):263-9. PMID: 23566951.
      View in: PubMed
    19. Blossom SJ, Rau JL, Best TH, Bornemeier RA, Hobbs CA. Increased maternal cytokine production and congenital heart defects. J Reprod Immunol. 2013 Apr; 97(2):204-10. PMID: 23428339.
      View in: PubMed
    20. Gilbert KM, Nelson AR, Cooney CA, Reisfeld B, Blossom SJ. Epigenetic alterations may regulate temporary reversal of CD4(+) T cell activation caused by trichloroethylene exposure. Toxicol Sci. 2012 May; 127(1):169-78. PMID: 22407948.
      View in: PubMed
    21. Blossom SJ, Melnyk S, Cooney CA, Gilbert KM, James SJ. Postnatal exposure to trichloroethylene alters glutathione redox homeostasis, methylation potential, and neurotrophin expression in the mouse hippocampus. Neurotoxicology. 2012 Dec; 33(6):1518-1527. PMID: 22421312.
      View in: PubMed
    22. Gilbert, KM, Rowley, B, Gomez-Acevedo, H, Blossom, SJ. Co-exposure to HgCl2 increases immunotoxicity of trichloroethylene. Toxicol. Sci. 2011; 119(2):281-292.
    23. Gilbert KM, Rowley B, Gomez-Acevedo H, Blossom SJ. Coexposure to mercury increases immunotoxicity of trichloroethylene. Toxicol Sci. 2011 Feb; 119(2):281-92. PMID: 21084432.
      View in: PubMed
    24. Gilbert KM, Przybyla B, Pumford NR, Han T, Fuscoe J, Schnackenberg LK, Holland RD, Doss JC, Macmillan-Crow LA, Blossom SJ. Delineating liver events in trichloroethylene-induced autoimmune hepatitis. Chem Res Toxicol. 2009 Apr; 22(4):626-32. PMID: 19254012.
      View in: PubMed
    25. James SJ, Rose S, Melnyk S, Jernigan S, Blossom S, Pavliv O, Gaylor DW. Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism. FASEB J. 2009 Aug; 23(8):2374-83. PMID: 19307255.
      View in: PubMed
    26. Todorova V, Vanderpool D, Blossom S, Nwokedi E, Hennings L, Mrak R, Klimberg VS. Oral glutamine protects against cyclophosphamide-induced cardiotoxicity in experimental rats through increase of cardiac glutathione. Nutrition. 2009 Jul-Aug; 25(7-8):812-7. PMID: 19251394.
      View in: PubMed
    27. Gilbert KM, Blossom SJ, Pumford NR. Comments on "Lifetime exposure to trichloroethylene (TCE) does not accelerate autoimmune disease in MRL+/- mice. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2009 Jan; 44(1):116; author reply 117-22. PMID: 19085602.
      View in: PubMed
    28. Blossom SJ, Doss JC, Hennings LJ, Jernigan S, Melnyk S, James SJ. Developmental exposure to trichloroethylene promotes CD4+ T cell differentiation and hyperactivity in association with oxidative stress and neurobehavioral deficits in MRL+/+ mice. Toxicol Appl Pharmacol. 2008 Sep 15; 231(3):344-53. PMID: 18579175.
      View in: PubMed
    29. Blossom SJ, Doss JC. Trichloroethylene alters central and peripheral immune function in autoimmune-prone MRL(+/+) mice following continuous developmental and early life exposure. J Immunotoxicol. 2007 Apr; 4(2):129-41. PMID: 18958721.
      View in: PubMed
    30. Blossom, S.J, Doss, J.C, Gilbert, K.M. Ability of Environmental Toxicant trichloroethylene to promote immune pathology is strain specific. J. Immunotox. 2007; 3:179-187.
    31. Blossom, S.J, Doss, J.C. Developmental exposure to the environmental toxicant trichloroethylene alters central and peripheral immune function in autoimmune-prone MRL+/+ mice. J. Immunotox. 2007; 4(2):129-141.
    32. Gilbert KM, Pumford NR, Blossom SJ. Environmental contaminant trichloroethylene promotes autoimmune disease and inhibits T-cell apoptosis in MRL(+/+) mice. J Immunotoxicol. 2006 Dec 01; 3(4):263-7. PMID: 18958707.
      View in: PubMed
    33. Blossom SJ, Doss JC, Gilbert KM. Ability of trichloroethylene metabolite to promote immune pathology is strain-specific. J Immunotoxicol. 2006 Dec 01; 3(4):179-87. PMID: 18958699.
      View in: PubMed
    34. Blossom SJ, Doss JC, Gilbert KM. Chronic exposure to a trichloroethylene metabolite in autoimmune-prone MRL+/+ mice promotes immune modulation and alopecia. Toxicol Sci. 2007 Feb; 95(2):401-11. PMID: 17077186.
      View in: PubMed
    35. Blossom SJ, Gilbert KM. Exposure to a metabolite of the environmental toxicant, trichloroethylene, attenuates CD4+ T cell activation-induced cell death by metalloproteinase-dependent FasL shedding. Toxicol Sci. 2006 Jul; 92(1):103-14. PMID: 16641322.
      View in: PubMed
    36. Blossom, S.J, Gilbert, K.M. Exposure to an environmental toxicant, trichloroethylene, attenuates CD4+ T cell activation induced cell death by metalloproteinase-dependent FasL shedding. Tox. Sci. 2006; 92(1):103-114.
    37. Blossom SJ, Pumford NR, Gilbert KM. Activation and attenuation of apoptosis of CD4+ T cells following in vivo exposure to two common environmental toxicants, trichloroacetaldehyde hydrate and trichloroacetic acid. J Autoimmun. 2004 Nov; 23(3):211-20. PMID: 15501392.
      View in: PubMed
    38. Blossom, S.J, Pumford, N.R, Gilbert, K.M. Activation and apoptosis of CD4+T cells following in vivo exposure to two common environmental toxicants, trichloroacetaldehyde hydrate and trichloroacetic acid. J. Autoimmun. 2004; 23:211-220.
    39. Blossom SJ, Gilbert KM. B cells from autoimmune BXSB mice are hyporesponsive to signals provided by CD4+ T cells. Immunol Invest. 2000 Aug; 29(3):287-97. PMID: 10933611.
      View in: PubMed
    40. Griffin JM, Blossom SJ, Jackson SK, Gilbert KM, Pumford NR. Trichloroethylene accelerates an autoimmune response by Th1 T cell activation in MRL +/+ mice. Immunopharmacology. 2000 Feb; 46(2):123-37. PMID: 10647871.
      View in: PubMed
    41. Blossom, S, Chu, E.B, Weigle, W.O, Gilbert, K.M. CD40L expressed on B cells in the BXSB mouse model of systemic lupus erythematosus. J. Immunol. 1997; 159:4580-4586.
    42. Fahr, M.J, Kornbluth, J, Blossom, S, Schaeffer, R. Glutamine Enhances Immunoregulation of Tumor growth. JPEN. 1994; 18(6):471-476.
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